Is myopathy a side effect of RAPAMUNE ? ( FactMed.com )

About this FactMed analysis covering adverse side effect reports of RAPAMUNE patients who developed myopathy.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 43 individuals taking RAPAMUNE reported myopathy to the FDA. A total of 5466 RAPAMUNE drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between RAPAMUNE and myopathy. In doing so, we compare RAPAMUNE with other drugs that cause myopathy, to help you evaluate whether or not RAPAMUNE causes myopathy. Likewise, this page shows the most highly-reported side effects of RAPAMUNE, so you can see if myopathy ranks among RAPAMUNE's most well-known side effects.

Summary Statistics
Reports of RAPAMUNE causing myopathy: 43
Reports of any side effect of RAPAMUNE : 5466
Percentage of RAPAMUNE patients where myopathy is a reported side effect: 0.7867%

FDA reports of any drug causing myopathy : 3605
Average percentage for all medicated patients where myopathy is reported as a complication: 0.0226%

Physician opinion on RAPAMUNE as adverse event culprit:

Overall opinion for all reports of this drug:

Most frequent diagnoses/indications for prescribing RAPAMUNE:

PROPHYLAXIS AGAINST TRANSPLANT REJECTION ( 2570 patients )
RENAL TRANSPLANT ( 349 patients )
IMMUNOSUPPRESSANT DRUG THERAPY ( 236 patients )
IMMUNOSUPPRESSION ( 132 patients )
GRAFT VERSUS HOST DISEASE ( 79 patients )
LIVER TRANSPLANT ( 78 patients )
HEART TRANSPLANT ( 61 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 46 patients )
DRUG USE FOR UNKNOWN INDICATION ( 42 patients )
LUNG TRANSPLANT ( 31 patients )
GLIOBLASTOMA MULTIFORME ( 31 patients )
TRANSPLANT ( 25 patients )
PROPHYLAXIS ( 18 patients )
PANCREAS ISLET CELL TRANSPLANT ( 17 patients )
KIDNEY TRANSPLANT REJECTION ( 17 patients )
BONE MARROW TRANSPLANT ( 11 patients )
LYMPHANGIOLEIOMYOMATOSIS ( 10 patients )
RENAL AND PANCREAS TRANSPLANT ( 10 patients )
TRANSPLANT REJECTION ( 10 patients )
KAPOSI'S SARCOMA ( 9 patients )
PROPHYLAXIS AGAINST GRAFT VERSUS HOST DISEASE ( 9 patients )
STEM CELL TRANSPLANT ( 8 patients )
METASTATIC RENAL CELL CARCINOMA ( 7 patients )
BLOOD CREATININE INCREASED ( 7 patients )
INTESTINAL TRANSPLANT ( 7 patients )
RENAL IMPAIRMENT ( 7 patients )
ACUTE MYELOID LEUKAEMIA ( 7 patients )
HEPATIC NEOPLASM MALIGNANT RECURRENT ( 7 patients )
GLIOMA ( 6 patients )
RENAL DISORDER ( 6 patients )
RECURRENT CANCER ( 6 patients )
ORGAN TRANSPLANT ( 6 patients )
PANCREAS TRANSPLANT ( 6 patients )
SARCOMA ( 5 patients )
TUBEROUS SCLEROSIS ( 5 patients )
LIVER DISORDER ( 5 patients )
SMALL CELL LUNG CANCER STAGE UNSPECIFIED ( 5 patients )
GLOMERULONEPHRITIS CHRONIC ( 4 patients )
WEGENER'S GRANULOMATOSIS ( 4 patients )
ANGIOMYOLIPOMA ( 4 patients )
GASTROINTESTINAL STROMAL TUMOUR ( 4 patients )
IMMUNOSUPPRESSANT DRUG LEVEL ( 4 patients )
NEOPLASM PROPHYLAXIS ( 4 patients )
EWING'S SARCOMA ( 4 patients )
NEUROFIBROMATOSIS ( 3 patients )
COMPLICATIONS OF TRANSPLANT SURGERY ( 3 patients )
SKIN CANCER ( 3 patients )
SQUAMOUS CELL CARCINOMA ( 3 patients )
HEART TRANSPLANT REJECTION ( 3 patients )
GLIOBLASTOMA ( 2 patients )
BONE MARROW DISORDER ( 2 patients )
LYMPHANGIOSARCOMA ( 2 patients )
OFF LABEL USE ( 2 patients )
LYMPHOMA ( 2 patients )
RENAL FAILURE CHRONIC ( 2 patients )
PANCREATIC CARCINOMA ( 2 patients )
LEUKAEMIA ( 2 patients )
PSORIASIS ( 2 patients )
ASTROCYTOMA ( 2 patients )
HYPERTENSION ( 2 patients )
LYMPHANGIOPATHY ( 2 patients )
RENAL CELL CARCINOMA STAGE UNSPECIFIED ( 2 patients )
GLIONEURONAL TUMOUR ( 2 patients )
LYMPHATIC DISORDER ( 2 patients )
CHRONIC ALLOGRAFT NEPHROPATHY ( 2 patients )
ACTINIC KERATOSIS ( 2 patients )
LYMPHOPROLIFERATIVE DISORDER ( 2 patients )
COLON CANCER METASTATIC ( 2 patients )
RHEUMATOID ARTHRITIS ( 2 patients )
POSTOPERATIVE CARE ( 2 patients )
SECONDARY IMMUNODEFICIENCY ( 2 patients )
CORONARY ARTERY STENOSIS ( 2 patients )
MYELOID LEUKAEMIA ( 2 patients )
LIVER TRANSPLANT REJECTION ( 2 patients )
ARTERIAL DISORDER ( 2 patients )
SQUAMOUS CELL CARCINOMA OF SKIN ( 2 patients )
PULMONARY HYPERTENSION ( 2 patients )
ILL-DEFINED DISORDER ( 2 patients )
CARDIAC DISORDER ( 1 patients )
INFECTION PROPHYLAXIS ( 1 patients )
TUBERCULOSIS ( 1 patients )
CHRONIC GRAFT VERSUS HOST DISEASE ( 1 patients )
UTERINE CANCER ( 1 patients )
ACUTE GRAFT VERSUS HOST DISEASE IN SKIN ( 1 patients )
GLOMERULONEPHRITIS MEMBRANOUS ( 1 patients )
MALIGNANT MELANOMA ( 1 patients )
ANAEMIA ( 1 patients )
CORONARY ARTERY DISEASE ( 1 patients )
MYELODYSPLASTIC SYNDROME ( 1 patients )
DISEASE RECURRENCE ( 1 patients )
ANGIOPLASTY ( 1 patients )
HEPATIC NEOPLASM MALIGNANT ( 1 patients )
NEOPLASM MALIGNANT ( 1 patients )
LUNG CARCINOMA CELL TYPE UNSPECIFIED STAGE 0 ( 1 patients )
NEOPLASM RECURRENCE ( 1 patients )
NEPHROPATHY ( 1 patients )
THERAPEUTIC AGENT TOXICITY ( 1 patients )
NEUROPATHY ( 1 patients )
RENAL FAILURE ( 1 patients )
GLOMERULONEPHRITIS FOCAL ( 1 patients )
KAPOSI'S SARCOMA AIDS RELATED ( 1 patients )
VASCULAR NEOPLASM ( 1 patients )
GRAFT DYSFUNCTION ( 1 patients )
METASTATIC MALIGNANT MELANOMA ( 1 patients )
CONGENITAL CYSTIC KIDNEY DISEASE ( 1 patients )
KNEE ARTHROPLASTY ( 1 patients )
ANAEMIA HAEMOLYTIC AUTOIMMUNE ( 1 patients )
HEADACHE ( 1 patients )
MULTIPLE SCLEROSIS ( 1 patients )
ANGIOPATHY ( 1 patients )
DRUG INTOLERANCE ( 1 patients )
LUNG DISORDER ( 1 patients )
AUTOIMMUNE DISORDER ( 1 patients )
NEOPLASM SKIN ( 1 patients )
T-LYMPHOCYTE COUNT INCREASED ( 1 patients )
( 0 patients )

Drugs with high FDA adverse event association with myopathy:

LIPITOR (517 patients)
ZOCOR (480 patients)
ASPIRIN (474 patients)
SIMVASTATIN (410 patients)
FOSAMAX (309 patients)
PREDNISONE (241 patients)
CRESTOR (239 patients)
ZOMETA (201 patients)
PREDNISOLONE (199 patients)
LASIX (177 patients)
FUROSEMIDE (162 patients)
ZETIA (153 patients)
HYDROCHLOROTHIAZIDE (144 patients)
PREDNISONE TAB (139 patients)
LEVOTHYROXINE SODIUM (138 patients)
VIOXX (130 patients)
ALLOPURINOL (125 patients)
DEXAMETHASONE (124 patients)
INSULIN (120 patients)
COUMADIN (118 patients)
CYCLOSPORINE (113 patients)
ATENOLOL (112 patients)
ATORVASTATIN CALCIUM (110 patients)
NORVASC (108 patients)
CLARITHROMYCIN (107 patients)
AMBIEN (104 patients)
MYCOPHENOLATE MOFETIL (103 patients)
LISINOPRIL (99 patients)
NOROXIN (98 patients)
DECADRON (97 patients)
OMEPRAZOLE (97 patients)
POTASSIUM CHLORIDE (96 patients)
SORAFENIB (RAF KINASE INHIBITOR) (95 patients)
GABAPENTIN (94 patients)
SYNTHROID (94 patients)
LAMIVUDINE (90 patients)
AMLODIPINE (90 patients)
RAMIPRIL (89 patients)
NEXIUM (88 patients)
PRILOSEC (87 patients)
METHYLPREDNISOLONE (85 patients)
WARFARIN SODIUM (83 patients)
ZIDOVUDINE (82 patients)
ALBUTEROL (82 patients)
LANSOPRAZOLE (80 patients)
MEK INHIBITOR (DIHYDROXYPROP-DIFLU-METHOXYPHEN-CYCLOPROPA-SULFAMI) (80 patients)
PROTONIX (79 patients)
ACETAMINOPHEN (77 patients)
FOLIC ACID (77 patients)
MULTI-VITAMINS (75 patients)
XANAX (75 patients)
COZAAR (73 patients)
NEURONTIN (73 patients)
REMICADE (71 patients)
REVLIMID (69 patients)
HUMIRA (68 patients)
AMIODARONE HCL (67 patients)
FLONASE (65 patients)
CELEXA (64 patients)
FERROUS SULFATE TAB (64 patients)
ATORVASTATIN (64 patients)
AMLODIPINE BESYLATE (64 patients)
SPIRONOLACTONE (63 patients)
MAGNEVIST (62 patients)
VYTORIN (62 patients)
ZOLOFT (61 patients)
PEPCID (60 patients)
PROGRAF (60 patients)
CITALOPRAM HYDROBROMIDE (59 patients)
VICODIN (59 patients)
ADVAIR DISKUS 100/50 (59 patients)
ULTRAVIST 150 (59 patients)
PLAVIX (59 patients)
METHOTREXATE (58 patients)
COLCHICINE (58 patients)
AREDIA (57 patients)
OXYCONTIN (57 patients)
LYRICA (57 patients)
DIDANOSINE (56 patients)
ENALAPRIL MALEATE (55 patients)
HEPARIN SODIUM INJECTION (55 patients)
TAMOXIFEN CITRATE (55 patients)
ACYCLOVIR (52 patients)
FENOFIBRATE (52 patients)
PRAVASTATIN (52 patients)
CLONAZEPAM (51 patients)
ITRACONAZOLE (51 patients)
CYCLOPHOSPHAMIDE (51 patients)
DIGOXIN (49 patients)
SEBIVO (49 patients)
TOPROL-XL (49 patients)
LORAZEPAM (48 patients)
DILTIAZEM (48 patients)
LORTAB (48 patients)
ELAVIL (47 patients)
DIFLUCAN (47 patients)
METOPROLOL TARTRATE (46 patients)
ATIVAN (46 patients)
VELCADE (45 patients)
ALENDRONATE SODIUM (45 patients)
VITAMIN D (45 patients)
KLOR-CON (45 patients)
PRAVACHOL (45 patients)
WELLBUTRIN (44 patients)
TRICOR (44 patients)
DARVOCET-N 100 (44 patients)
PERCOCET (44 patients)
RAPAMUNE (43 patients)
ASCORBIC ACID (43 patients)
LEVAQUIN (43 patients)
AROMASIN (43 patients)
DIAZEPAM (43 patients)
ZANTAC (43 patients)
GEMFIBROZIL (41 patients)
CELEBREX (41 patients)
OXYCODONE HCL (41 patients)
ABACAVIR (40 patients)
LEXAPRO (40 patients)
NIFEDIPINE (40 patients)
RADIATION THERAPY (39 patients)
ACETYLSALICYLIC ACID SRT (39 patients)
ACIPHEX (39 patients)
METFORMIN HCL (39 patients)
IRON (39 patients)
ALTACE (39 patients)
TACROLIMUS (38 patients)
EFAVIRENZ (38 patients)
ZYPREXA (38 patients)
ZYRTEC (38 patients)
LESCOL (37 patients)
[THERAPY UNSPECIFIED] (37 patients)
METOPROLOL (37 patients)
GLEEVEC (37 patients)
PANTOPRAZOLE SODIUM (36 patients)
FOSAMAX PLUS D (36 patients)
PROPRANOLOL HYDROCHLORIDE (36 patients)
EFFEXOR (36 patients)
AMIODARONE (36 patients)
CEFTRIAXONE (36 patients)
HERCEPTIN (35 patients)
THALIDOMIDE (35 patients)
FUSIDIC ACID (35 patients)
SINGULAIR (35 patients)
IBUPROFEN (35 patients)
SPIRIVA (35 patients)
LOSARTAN POTASSIUM (35 patients)
VANCOMYCIN (35 patients)
WARFARIN (34 patients)
PERIDEX (34 patients)
BISOPROLOL (34 patients)
HYZAAR (34 patients)
SIROLIMUS (34 patients)
SOLU-MEDROL (34 patients)
ALPRAZOLAM (34 patients)
CO-TRIMOXAZOLE (34 patients)
AMITRIPTYLINE HCL (34 patients)
COREG (34 patients)
VITAMINS (UNSPECIFIED) (33 patients)
ACETYLSALICYLIC ACID (33 patients)
AZATHIOPRINE (33 patients)
ZOFRAN (33 patients)
CALTRATE +D (33 patients)
PROTEINASE INHIBITORS (33 patients)
CARTIA /USA/ (33 patients)
NIASPAN (33 patients)
PANTOPRAZOLE (33 patients)
MEGESTROL ACETATE (32 patients)
COMPAZINE (32 patients)
ADENOSINE (32 patients)
ALDACTONE (32 patients)
LANTUS (32 patients)
GASMOTIN (32 patients)
PROZAC (32 patients)
ARIMIDEX (31 patients)
AVELOX (31 patients)
FENTANYL (31 patients)
CALCIUM (UNSPECIFIED) (31 patients)
PAXIL (31 patients)
GLIPIZIDE (31 patients)
FLUCONAZOLE (31 patients)
ARANESP (31 patients)
CLARITIN (31 patients)
DILAUDID (31 patients)
NEUPOGEN (31 patients)
AVANDIA (31 patients)
B12 ^RECIP^ (30 patients)
K-DUR (30 patients)
CALCIUM CARBONATE (30 patients)
CELLCEPT (30 patients)
METFORMIN (30 patients)
CLOPIDOGREL (30 patients)
TRAMADOL HCL (30 patients)
REQUIP (29 patients)
CARVEDILOL (29 patients)
GLUCOPHAGE (29 patients)
FLOMAX (29 patients)
ZESTRIL (29 patients)
MIRTAZAPINE (29 patients)
TIAZAC (29 patients)
CAPECITABINE (29 patients)
KETEK (29 patients)
NICORANDIL (29 patients)
VERAPAMIL (29 patients)
CYMBALTA (28 patients)
RALTEGRAVIR (28 patients)
LOVASTATIN (28 patients)
CALCIUM (28 patients)
ACTOS (28 patients)
MICARDIS (28 patients)
DILTIAZEM HYDROCHLORIDE (28 patients)

Most common side effects for patients taking RAPAMUNE:

KIDNEY TRANSPLANT REJECTION (637 patients)
BLOOD CREATININE INCREASED (384 patients)
PYREXIA (313 patients)
DIARRHOEA (294 patients)
DRUG INEFFECTIVE (293 patients)
HAEMOGLOBIN DECREASED (260 patients)
COMPLICATIONS OF TRANSPLANTED KIDNEY (248 patients)
ANAEMIA (236 patients)
RENAL FAILURE ACUTE (231 patients)
PNEUMONIA (216 patients)
DEATH (202 patients)
VOMITING (183 patients)
DYSPNOEA (182 patients)
RENAL TUBULAR NECROSIS (180 patients)
RENAL IMPAIRMENT (179 patients)
HAEMATOCRIT DECREASED (175 patients)
DEHYDRATION (174 patients)
CONDITION AGGRAVATED (171 patients)
OEDEMA PERIPHERAL (164 patients)
TRANSPLANT REJECTION (160 patients)
NAUSEA (159 patients)
RENAL FAILURE (158 patients)
HAEMODIALYSIS (156 patients)
ASTHENIA (146 patients)
IMMUNOSUPPRESSANT DRUG LEVEL INCREASED (145 patients)
DRUG INTERACTION (137 patients)
THROMBOCYTOPENIA (126 patients)
HYPERTENSION (117 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (114 patients)
PNEUMONITIS (109 patients)
WEIGHT DECREASED (109 patients)
HYPOTENSION (109 patients)
DRUG TOXICITY (106 patients)
BLOOD GLUCOSE INCREASED (104 patients)
PLATELET COUNT DECREASED (102 patients)
THROMBOTIC MICROANGIOPATHY (100 patients)
PLEURAL EFFUSION (99 patients)
BLOOD UREA INCREASED (97 patients)
LIVER TRANSPLANT REJECTION (97 patients)
LEUKOPENIA (96 patients)
SEPSIS (96 patients)
MULTI-ORGAN FAILURE (92 patients)
DIALYSIS (92 patients)
VENOOCCLUSIVE LIVER DISEASE (89 patients)
DIABETES MELLITUS (88 patients)
PROTEINURIA (88 patients)
LYMPHOCELE (87 patients)
CYTOMEGALOVIRUS INFECTION (85 patients)
CONVULSION (83 patients)
URINARY TRACT INFECTION (82 patients)
PAIN (81 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (78 patients)
RESPIRATORY FAILURE (77 patients)
MYOCARDIAL INFARCTION (76 patients)
INFECTION (76 patients)
INTERSTITIAL LUNG DISEASE (76 patients)
DEEP VEIN THROMBOSIS (76 patients)
RASH (75 patients)
FATIGUE (75 patients)
OEDEMA (74 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (74 patients)
ALANINE AMINOTRANSFERASE INCREASED (73 patients)
CARDIAC ARREST (73 patients)
ABDOMINAL PAIN (71 patients)
COUGH (71 patients)
WHITE BLOOD CELL COUNT DECREASED (71 patients)
IMMUNOSUPPRESSION (71 patients)
ATRIAL FIBRILLATION (71 patients)
ARTHRALGIA (68 patients)
POST PROCEDURAL COMPLICATION (65 patients)
GRAFT DYSFUNCTION (64 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (64 patients)
MALAISE (63 patients)
CHEST PAIN (63 patients)
DISEASE RECURRENCE (62 patients)
PULMONARY OEDEMA (62 patients)
IMPAIRED HEALING (62 patients)
HYPERLIPIDAEMIA (61 patients)
PAIN IN EXTREMITY (61 patients)
CEREBROVASCULAR ACCIDENT (61 patients)
CARDIAC FAILURE (59 patients)
TREMOR (58 patients)
DISEASE PROGRESSION (57 patients)
NEPHROPATHY TOXIC (56 patients)
C-REACTIVE PROTEIN INCREASED (56 patients)
HEADACHE (56 patients)
PERICARDIAL EFFUSION (56 patients)
BLOOD CREATINE INCREASED (54 patients)
BLOOD TRIGLYCERIDES INCREASED (54 patients)
DRUG LEVEL INCREASED (54 patients)
CHOLESTASIS (54 patients)
RENAL FAILURE CHRONIC (53 patients)
CHILLS (53 patients)
FLUID OVERLOAD (53 patients)
LUNG DISORDER (53 patients)
STAPHYLOCOCCAL INFECTION (53 patients)
LUNG INFILTRATION (52 patients)
HYDRONEPHROSIS (51 patients)
IMMUNOSUPPRESSANT DRUG LEVEL DECREASED (50 patients)
CARDIAC FAILURE CONGESTIVE (48 patients)
BLOOD CHOLESTEROL INCREASED (48 patients)
ATELECTASIS (48 patients)
CELLULITIS (48 patients)
GASTROINTESTINAL HAEMORRHAGE (47 patients)
PANCYTOPENIA (47 patients)
HYPOXIA (46 patients)
ACUTE RESPIRATORY DISTRESS SYNDROME (46 patients)
ASCITES (46 patients)
TRANSPLANT FAILURE (45 patients)
HAEMATURIA (45 patients)
CARDIOMEGALY (44 patients)
NEPHROTIC SYNDROME (43 patients)
MYOPATHY (43 patients)
DECREASED APPETITE (42 patients)
BACK PAIN (42 patients)
LYMPHADENOPATHY (41 patients)
PULMONARY EMBOLISM (41 patients)
BLOOD BILIRUBIN INCREASED (41 patients)
MUSCULAR WEAKNESS (40 patients)
EPISTAXIS (40 patients)
ABDOMINAL PAIN UPPER (40 patients)
HYPERGLYCAEMIA (40 patients)
MYALGIA (40 patients)
LIVER FUNCTION TEST ABNORMAL (39 patients)
WEIGHT INCREASED (39 patients)
CONFUSIONAL STATE (38 patients)
CANDIDIASIS (38 patients)
HEART TRANSPLANT REJECTION (37 patients)
BLOOD POTASSIUM INCREASED (37 patients)
DEPRESSION (36 patients)
DIZZINESS (36 patients)
GASTRITIS (36 patients)
OSTEONECROSIS (36 patients)
COMPLICATIONS OF TRANSPLANT SURGERY (36 patients)
HEPATIC FAILURE (35 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (35 patients)
WHITE BLOOD CELL COUNT INCREASED (35 patients)
SEPTIC SHOCK (34 patients)
HYPERKALAEMIA (34 patients)
OVERDOSE (34 patients)
BLOOD PRESSURE INCREASED (34 patients)
HAEMOPTYSIS (34 patients)
CLOSTRIDIUM DIFFICILE COLITIS (33 patients)
PSEUDOMONAS INFECTION (33 patients)
BACTERIAL INFECTION (33 patients)
FALL (33 patients)
ANXIETY (33 patients)
INFLAMMATION (32 patients)
DRUG EXPOSURE DURING PREGNANCY (32 patients)
CACHEXIA (32 patients)
NEUTROPENIA (32 patients)
PULMONARY CONGESTION (31 patients)
HAEMOLYTIC URAEMIC SYNDROME (31 patients)
UPPER RESPIRATORY TRACT INFECTION (31 patients)
STOMATITIS (31 patients)
NEPHROGENIC SYSTEMIC FIBROSIS (31 patients)
GRAFT VERSUS HOST DISEASE (31 patients)
PRURITUS (31 patients)
PHARYNGITIS (31 patients)
MITRAL VALVE INCOMPETENCE (30 patients)
ESCHERICHIA URINARY TRACT INFECTION (29 patients)
RED BLOOD CELL COUNT DECREASED (29 patients)
BRONCHOPNEUMONIA (29 patients)
ANURIA (29 patients)
RENAL DISORDER (29 patients)
BODY TEMPERATURE INCREASED (29 patients)
MOUTH ULCERATION (29 patients)
HYPOKALAEMIA (28 patients)
NEPHRITIS INTERSTITIAL (28 patients)
BLOOD SODIUM DECREASED (28 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (28 patients)
BACTERAEMIA (28 patients)
MOBILITY DECREASED (28 patients)
COLITIS (28 patients)
ERYTHEMA (28 patients)
APHTHOUS STOMATITIS (28 patients)
TREATMENT NONCOMPLIANCE (28 patients)
BLOOD BICARBONATE DECREASED (27 patients)
JAUNDICE (27 patients)
BRONCHITIS (27 patients)
METABOLIC ACIDOSIS (27 patients)
LOWER RESPIRATORY TRACT INFECTION (27 patients)
LETHARGY (27 patients)
HEPATIC ENZYME INCREASED (27 patients)
ABDOMINAL DISTENSION (26 patients)
OXYGEN SATURATION DECREASED (26 patients)
BLOOD CREATINE PHOSPHOKINASE INCREASED (26 patients)
WOUND INFECTION (26 patients)
FEBRILE NEUTROPENIA (26 patients)
INSOMNIA (26 patients)
ENTEROCOCCAL INFECTION (26 patients)
TACHYCARDIA (26 patients)
ABDOMINAL PAIN LOWER (25 patients)
HYPOVOLAEMIA (25 patients)
KLEBSIELLA INFECTION (25 patients)
HYPONATRAEMIA (25 patients)
RENAL TRANSPLANT (25 patients)
BASAL CELL CARCINOMA (25 patients)
OFF LABEL USE (25 patients)
BK VIRUS INFECTION (25 patients)
DRUG LEVEL BELOW THERAPEUTIC (24 patients)
ACNE (24 patients)
AMNESIA (24 patients)
GAIT DISTURBANCE (24 patients)
GASTROENTERITIS (24 patients)
BALANCE DISORDER (24 patients)
HIV INFECTION (24 patients)
PARAESTHESIA (23 patients)
THROMBOSIS (23 patients)
HEPATIC NEOPLASM MALIGNANT RECURRENT (23 patients)

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Recent FactMed Activity for RAPAMUNE

Issue	Description / Topic	Timestamp
QUESTION CYCLIC VOMITING SYNDROME	My son takes Rapamune and has CVS. He had a kidney transplant in 2002. The CVS has gotten out of control the last year with numerous repeated episodes. Every 2-4 weeks in the ER with SEVERE stomach pain, nausea and vomiting. It is getting more and more difficult for treatment as so many ER's really don't know what to do to treat it. I am wondering if the Rapamune could be the cause and because he continues to use it if it could be continually making the CVS worse and worse. He is very hesitant to change the Rapamune as his kidney has favored very well through all of this. He has a real fear of rejecting his kidney and having to deal with that again. Along with the CVS he has peripheral neuropathy, syncope, type 2 heart block, blood pressure issues,severe weight loss etc. What we need is a doctor who can look at his whole picture which I know is very compicated, but someone who cares enough to help him. We live in northern Ohio. If anyone knows of a doctor or specialist that would fit this I would really appreciate you forwarding the information as my fear is one of these times it is just going to be to much for him. PLEASE any advise is appreciated.	2015-01-15 14:48:55
QUESTION male infertility	My husband has been taking 1mg of Rapamune daily for the last 5 years. We are trying to find out the likelihood that this medication has made him sterile. Any help is greatly appreciated!	2015-11-06 18:32:22

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