Is ATRIAL FIBRILLATION a side effect of SORAFENIB (RAF KINASE INHIBITOR) ? ( FactMed.com )

About this FactMed analysis covering adverse side effect reports of SORAFENIB (RAF KINASE INHIBITOR) patients who developed ATRIAL FIBRILLATION.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 30 individuals taking SORAFENIB (RAF KINASE INHIBITOR) reported ATRIAL FIBRILLATION to the FDA. A total of 3329 SORAFENIB (RAF KINASE INHIBITOR) drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between SORAFENIB (RAF KINASE INHIBITOR) and ATRIAL FIBRILLATION. In doing so, we compare SORAFENIB (RAF KINASE INHIBITOR) with other drugs that cause ATRIAL FIBRILLATION, to help you evaluate whether or not SORAFENIB (RAF KINASE INHIBITOR) causes ATRIAL FIBRILLATION. Likewise, this page shows the most highly-reported side effects of SORAFENIB (RAF KINASE INHIBITOR), so you can see if ATRIAL FIBRILLATION ranks among SORAFENIB (RAF KINASE INHIBITOR)'s most well-known side effects.

Summary Statistics
Reports of SORAFENIB (RAF KINASE INHIBITOR) causing ATRIAL FIBRILLATION: 30
Reports of any side effect of SORAFENIB (RAF KINASE INHIBITOR) : 3329
Percentage of SORAFENIB (RAF KINASE INHIBITOR) patients where ATRIAL FIBRILLATION is a reported side effect: 0.9012%

FDA reports of any drug causing ATRIAL FIBRILLATION : 32327
Average percentage for all medicated patients where ATRIAL FIBRILLATION is reported as a complication: 0.2026%

Physician opinion on SORAFENIB (RAF KINASE INHIBITOR) as adverse event culprit:

Overall opinion for all reports of this drug:

Most frequent diagnoses/indications for prescribing SORAFENIB (RAF KINASE INHIBITOR):

HEPATIC NEOPLASM MALIGNANT ( 770 patients )
RENAL CELL CARCINOMA ( 114 patients )
THYROID CANCER ( 65 patients )
METASTATIC RENAL CELL CARCINOMA ( 44 patients )
THYROID CANCER METASTATIC ( 35 patients )
BREAST CANCER ( 31 patients )
BREAST CANCER METASTATIC ( 27 patients )
GASTRIC CANCER ( 25 patients )
NON-SMALL CELL LUNG CANCER ( 25 patients )
COLORECTAL CANCER METASTATIC ( 22 patients )
RENAL CANCER ( 17 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 14 patients )
BILE DUCT CANCER ( 14 patients )
SALIVARY GLAND CANCER ( 7 patients )
HEPATIC CANCER METASTATIC ( 7 patients )
COLORECTAL CANCER ( 7 patients )
SMALL CELL LUNG CANCER STAGE UNSPECIFIED ( 6 patients )
RECTAL CANCER ( 5 patients )
PANCREATIC CARCINOMA ( 4 patients )
PROSTATE CANCER ( 4 patients )
INTRAOCULAR MELANOMA ( 4 patients )
HEPATIC NEOPLASM MALIGNANT RECURRENT ( 3 patients )
NEOPLASM ( 3 patients )
LIVER DISORDER ( 3 patients )
ANGIOSARCOMA ( 3 patients )
NON-SMALL CELL LUNG CANCER STAGE IV ( 3 patients )
METASTASES TO LUNG ( 3 patients )
HEPATIC NEOPLASM MALIGNANT NON-RESECTABLE ( 3 patients )
COLORECTAL CANCER STAGE IV ( 3 patients )
NEOPLASM MALIGNANT ( 3 patients )
GALLBLADDER CANCER METASTATIC ( 3 patients )
BILIARY CANCER METASTATIC ( 3 patients )
METASTASIS ( 3 patients )
COLON CANCER METASTATIC ( 2 patients )
HYPOPHARYNGEAL CANCER ( 2 patients )
DESMOID TUMOUR ( 2 patients )
NEUROENDOCRINE CARCINOMA ( 2 patients )
ACUTE MYELOID LEUKAEMIA (IN REMISSION) ( 2 patients )
LUNG NEOPLASM MALIGNANT ( 2 patients )
OESOPHAGEAL CARCINOMA ( 2 patients )
METASTATIC MALIGNANT MELANOMA ( 2 patients )
TONGUE NEOPLASM MALIGNANT STAGE UNSPECIFIED ( 2 patients )
METASTATIC SQUAMOUS CELL CARCINOMA ( 2 patients )
ANGINA PECTORIS ( 2 patients )
RENAL CELL CARCINOMA STAGE IV ( 2 patients )
OSTEOSARCOMA METASTATIC ( 2 patients )
BONE SARCOMA ( 2 patients )
METASTATIC OCULAR MELANOMA ( 2 patients )
METASTATIC SALIVARY GLAND CANCER ( 2 patients )
TONSIL CANCER ( 2 patients )
MYELODYSPLASTIC SYNDROME ( 1 patients )
PROSTATE CANCER METASTATIC ( 1 patients )
GALLBLADDER CANCER ( 1 patients )
NEUROENDOCRINE TUMOUR ( 1 patients )
MALIGNANT NEOPLASM OF RENAL PELVIS ( 1 patients )
GLIOMA ( 1 patients )
BLADDER CANCER ( 1 patients )
OVARIAN CANCER METASTATIC ( 1 patients )
CAROTID ARTERY DISEASE ( 1 patients )
HEPATOBLASTOMA ( 1 patients )
NASOPHARYNGEAL CANCER ( 1 patients )
ACUTE MYELOID LEUKAEMIA ( 1 patients )
LUNG ADENOCARCINOMA ( 1 patients )
RENAL CANCER METASTATIC ( 1 patients )
DIFFUSE LARGE B-CELL LYMPHOMA ( 1 patients )
NEUROENDOCRINE CARCINOMA OF THE SKIN ( 1 patients )
MALIGNANT HISTIOCYTOSIS ( 1 patients )
ANTICOAGULANT THERAPY ( 1 patients )
MALIGNANT SOFT TISSUE NEOPLASM ( 1 patients )
SARCOMA ( 1 patients )
GERM CELL CANCER ( 1 patients )
OESOPHAGEAL ADENOCARCINOMA ( 1 patients )
SQUAMOUS CELL CARCINOMA ( 1 patients )
HEAD AND NECK CANCER ( 1 patients )
OVARIAN EPITHELIAL CANCER ( 1 patients )
( 0 patients )

Drugs with high FDA adverse event association with ATRIAL FIBRILLATION:

ASPIRIN (5696 patients)
HEPARIN SODIUM INJECTION (4396 patients)
DIGOXIN (4092 patients)
VIOXX (3901 patients)
COUMADIN (3367 patients)
LASIX (2982 patients)
FOSAMAX (2601 patients)
FUROSEMIDE (2543 patients)
WARFARIN SODIUM (2109 patients)
LISINOPRIL (2029 patients)
LIPITOR (1943 patients)
ATENOLOL (1643 patients)
PREDNISONE (1610 patients)
SIMVASTATIN (1569 patients)
AVANDIA (1504 patients)
POTASSIUM CHLORIDE (1459 patients)
TOPROL-XL (1400 patients)
PLAVIX (1387 patients)
SYNTHROID (1320 patients)
OMEPRAZOLE (1300 patients)
MULTAQ (1295 patients)
NEXIUM (1271 patients)
METOPROLOL TARTRATE (1247 patients)
ZOCOR (1222 patients)
PROTONIX (1206 patients)
ALLOPURINOL (1204 patients)
FOLIC ACID (1161 patients)
HYDROCHLOROTHIAZIDE (1158 patients)
AMIODARONE HCL (1148 patients)
ACETAMINOPHEN (1120 patients)
NORVASC (1105 patients)
ZOMETA (1087 patients)
COREG (1060 patients)
ALBUTEROL (1054 patients)
LEVOTHYROXINE SODIUM (988 patients)
METHOTREXATE (965 patients)
PRILOSEC (955 patients)
REVLIMID (946 patients)
SPIRONOLACTONE (944 patients)
REMICADE (941 patients)
NITROGLYCERIN (925 patients)
LEVAQUIN (911 patients)
CARDIZEM (876 patients)
METFORMIN HCL (867 patients)
DEXAMETHASONE (858 patients)
METOPROLOL (857 patients)
CELEBREX (852 patients)
FORTEO (845 patients)
PREDNISOLONE (836 patients)
DIOVAN (808 patients)
AMBIEN (779 patients)
RAMIPRIL (768 patients)
CRESTOR (766 patients)
XANAX (755 patients)
VITAMIN D (751 patients)
LOPRESSOR (745 patients)
CARVEDILOL (738 patients)
PREVACID (723 patients)
LANTUS (723 patients)
HUMIRA (721 patients)
INSULIN (699 patients)
AMLODIPINE (668 patients)
SPIRIVA (659 patients)
LOVENOX (656 patients)
AREDIA (649 patients)
ZOFRAN (641 patients)
FLOMAX (625 patients)
PREDNISONE TAB (621 patients)
NEURONTIN (616 patients)
CALCIUM (615 patients)
ADVAIR DISKUS 100/50 (611 patients)
LORAZEPAM (603 patients)
BISOPROLOL FUMARATE (596 patients)
COZAAR (595 patients)
HEPARIN (587 patients)
DILTIAZEM (582 patients)
ZOLOFT (579 patients)
TIKOSYN (575 patients)
GLUCOPHAGE (570 patients)
PREMARIN (562 patients)
ENALAPRIL MALEATE (556 patients)
MULTI-VITAMINS (552 patients)
HEPARIN SODIUM (550 patients)
METOPROLOL SUCCINATE (546 patients)
ALDACTONE (533 patients)
CORDARONE (530 patients)
VELCADE (525 patients)
AMIODARONE (524 patients)
VICODIN (523 patients)
ALTACE (514 patients)
ATIVAN (507 patients)
SINGULAIR (503 patients)
MULTI-VITAMIN (500 patients)
WARFARIN (496 patients)
PERCOCET (490 patients)
VERAPAMIL (489 patients)
LANOXIN (485 patients)
ALPRAZOLAM (483 patients)
LANSOPRAZOLE (481 patients)
LEXAPRO (477 patients)
GLYBURIDE (474 patients)
AMOXICILLIN (471 patients)
MORPHINE (470 patients)
DECADRON (464 patients)
IBUPROFEN (461 patients)
AVONEX (459 patients)
POTASSIUM (458 patients)
TYLENOL (CAPLET) (449 patients)
COLACE (447 patients)
OXYCONTIN (446 patients)
GLIPIZIDE (444 patients)
CIPROFLOXACIN (438 patients)
ATROVENT (434 patients)
CYCLOPHOSPHAMIDE (433 patients)
KLOR-CON (433 patients)
ENBREL (428 patients)
ASCORBIC ACID (426 patients)
LYRICA (423 patients)
PAXIL (409 patients)
ZETIA (405 patients)
FLUOROURACIL (397 patients)
VITAMIN E (397 patients)
ACTOS (397 patients)
LORTAB (389 patients)
ZESTRIL (385 patients)
OXYCODONE HCL (384 patients)
BYETTA (383 patients)
VANCOMYCIN (382 patients)
BISOPROLOL (381 patients)
HEPARIN SODIUM 5,000 UNITS IN DEXTROSE 5% (378 patients)
FLUCONAZOLE (376 patients)
PRADAXA (373 patients)
AMARYL (369 patients)
CISPLATIN (368 patients)
CYMBALTA (367 patients)
CARBOPLATIN (366 patients)
TRAMADOL HCL (362 patients)
GABAPENTIN (358 patients)
FISH OIL (350 patients)
CALCIUM CARBONATE (346 patients)
ACTONEL (346 patients)
METFORMIN (344 patients)
FERROUS SULFATE TAB (343 patients)
ZANTAC (343 patients)
PANTOPRAZOLE (339 patients)
IMDUR (339 patients)
TORSEMIDE (339 patients)
SOTALOL HCL (334 patients)
HUMALOG (332 patients)
TYLENOL (331 patients)
ACYCLOVIR (326 patients)
VITAMIN B-12 (323 patients)
CLONIDINE (323 patients)
FENTANYL (320 patients)
PEPCID (320 patients)
COMBIVENT (317 patients)
MAGNESIUM (315 patients)
TRACLEER (314 patients)
REGLAN (313 patients)
VALSARTAN (313 patients)
IRON (309 patients)
RANITIDINE (304 patients)
METOCLOPRAMIDE (303 patients)
[THERAPY UNSPECIFIED] (300 patients)
HYDROCODONE (300 patients)
TASIGNA (298 patients)
ATORVASTATIN CALCIUM (298 patients)
ACETYLSALICYLIC ACID SRT (298 patients)
TENORMIN (295 patients)
SEROQUEL (290 patients)
VYTORIN (288 patients)
BENADRYL (287 patients)
TRICOR (283 patients)
ZYRTEC (283 patients)
LOVASTATIN (282 patients)
CLONAZEPAM (281 patients)
ARICEPT (281 patients)
DILTIAZEM HCL (281 patients)
PRAVASTATIN (280 patients)
NIASPAN (279 patients)
ARANESP (279 patients)
AVELOX (277 patients)
ISOSORBIDE MONONITRATE (277 patients)
FLONASE (275 patients)
METOLAZONE (272 patients)
EFFEXOR (272 patients)
DURAGESIC-100 (269 patients)
PRAVACHOL (269 patients)
ALENDRONATE SODIUM (268 patients)
NYSTATIN (267 patients)
ALLEGRA (267 patients)
PANTOPRAZOLE SODIUM (264 patients)
CELEXA (263 patients)
NOVOLOG (262 patients)
NAPROXEN (262 patients)
FLECAINIDE ACETATE (256 patients)
ATORVASTATIN (254 patients)
SOLU-MEDROL (254 patients)
MAGNESIUM OXIDE (252 patients)
LIDOCAINE (252 patients)
AVANDAMET (251 patients)
TEMAZEPAM (247 patients)
CEPHALEXIN (247 patients)
GLEEVEC (247 patients)
HYDRALAZINE HCL (247 patients)
ZITHROMAX (247 patients)
AZITHROMYCIN (246 patients)
VALIUM (246 patients)
DEXAMETHASONE TAB (246 patients)
ELAVIL (246 patients)

Most common side effects for patients taking SORAFENIB (RAF KINASE INHIBITOR):

DIARRHOEA (613 patients)
HEPATIC FAILURE (378 patients)
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME (342 patients)
HEPATIC ENCEPHALOPATHY (320 patients)
FATIGUE (300 patients)
RASH (276 patients)
ASCITES (253 patients)
ABDOMINAL PAIN (237 patients)
DECREASED APPETITE (226 patients)
UPPER GASTROINTESTINAL HAEMORRHAGE (198 patients)
PYREXIA (191 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (179 patients)
NAUSEA (165 patients)
HYPERTENSION (160 patients)
ASTHENIA (154 patients)
DEHYDRATION (140 patients)
HEPATIC FUNCTION ABNORMAL (133 patients)
DYSPNOEA (131 patients)
CONFUSIONAL STATE (131 patients)
HYPOKALAEMIA (125 patients)
ALOPECIA (124 patients)
VOMITING (118 patients)
CONSTIPATION (115 patients)
INTERSTITIAL LUNG DISEASE (114 patients)
LEFT VENTRICULAR DYSFUNCTION (113 patients)
DEATH (113 patients)
ENDOCARDITIS (112 patients)
ARTHRALGIA (111 patients)
STOMATITIS (111 patients)
ABDOMINAL PAIN UPPER (110 patients)
JAUNDICE (108 patients)
HEPATIC NEOPLASM MALIGNANT (106 patients)
GASTROINTESTINAL HAEMORRHAGE (106 patients)
RETINAL VASCULAR THROMBOSIS (103 patients)
LOWER GASTROINTESTINAL HAEMORRHAGE (103 patients)
LIVER CARCINOMA RUPTURED (101 patients)
OEDEMA PERIPHERAL (97 patients)
PLEURAL EFFUSION (97 patients)
STAPHYLOCOCCAL INFECTION (96 patients)
PNEUMONIA BACTERIAL (96 patients)
ENTEROBACTER INFECTION (96 patients)
MYOPATHY (95 patients)
DRY MOUTH (94 patients)
PAIN IN EXTREMITY (93 patients)
ANXIETY (90 patients)
MALAISE (89 patients)
PULMONARY EMBOLISM (85 patients)
ANAEMIA (84 patients)
PLATELET COUNT DECREASED (81 patients)
BACK PAIN (79 patients)
SEPSIS (78 patients)
PRURITUS (78 patients)
DUODENAL ULCER (77 patients)
MIGRAINE (76 patients)
MITRAL VALVE INCOMPETENCE (76 patients)
HYPOGLYCAEMIA (76 patients)
C-REACTIVE PROTEIN INCREASED (74 patients)
BLOOD PRESSURE INCREASED (73 patients)
VARICES OESOPHAGEAL (73 patients)
HEADACHE (72 patients)
RETINAL VEIN OCCLUSION (72 patients)
ABASIA (69 patients)
RENAL FAILURE ACUTE (69 patients)
WEIGHT DECREASED (67 patients)
DEEP VEIN THROMBOSIS (67 patients)
DIZZINESS (65 patients)
ERYTHEMA (65 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (64 patients)
CONVULSION (63 patients)
ALANINE AMINOTRANSFERASE INCREASED (62 patients)
DYSPHONIA (62 patients)
CEREBRAL HAEMORRHAGE (60 patients)
APHAGIA (58 patients)
COLITIS (58 patients)
PNEUMONIA (57 patients)
GASTRIC ULCER (56 patients)
HYPONATRAEMIA (55 patients)
HAEMOGLOBIN DECREASED (53 patients)
RESPIRATORY FAILURE (52 patients)
LUNG DISORDER (52 patients)
CEREBRAL ISCHAEMIA (49 patients)
PARAESTHESIA (49 patients)
BLOOD BILIRUBIN INCREASED (48 patients)
GAIT DISTURBANCE (48 patients)
THYROID CANCER METASTATIC (44 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (43 patients)
PERICARDIAL EFFUSION (41 patients)
THROMBOCYTOPENIA (41 patients)
BLISTER (41 patients)
FEBRILE NEUTROPENIA (40 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (40 patients)
HALLUCINATION (40 patients)
CHILLS (40 patients)
AMMONIA INCREASED (39 patients)
SKIN ULCER (39 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (38 patients)
PAIN (38 patients)
HYPOALBUMINAEMIA (38 patients)
HYPOCALCAEMIA (37 patients)
FALL (37 patients)
POLLAKIURIA (37 patients)
BLOOD PRESSURE DECREASED (37 patients)
SKIN EXFOLIATION (37 patients)
INSOMNIA (36 patients)
CARDIAC ARREST (36 patients)
HYPOAESTHESIA (35 patients)
INFECTIOUS PERITONITIS (35 patients)
MYOCARDIAL INFARCTION (35 patients)
RETINAL VASCULAR DISORDER (34 patients)
RENAL FAILURE (34 patients)
LIPASE INCREASED (34 patients)
HYPERKALAEMIA (33 patients)
HYPERGLYCAEMIA (33 patients)
HAEMOPTYSIS (31 patients)
ATRIAL FIBRILLATION (30 patients)
GENERALISED OEDEMA (30 patients)
FAECAL INCONTINENCE (30 patients)
WHITE BLOOD CELL COUNT DECREASED (30 patients)
CELLULITIS (29 patients)
CHEST PAIN (29 patients)
SOMNOLENCE (29 patients)
HYPERBILIRUBINAEMIA (28 patients)
HYPOTENSION (28 patients)
MUSCLE SPASMS (28 patients)
ABDOMINAL DISTENSION (27 patients)
WHITE BLOOD CELL COUNT INCREASED (27 patients)
VISION BLURRED (27 patients)
HEPATIC PAIN (26 patients)
BLOOD ALBUMIN DECREASED (26 patients)
DYSURIA (25 patients)
RASH GENERALISED (25 patients)
BLOOD SODIUM DECREASED (25 patients)
BLOOD URIC ACID INCREASED (25 patients)
COMA (25 patients)
COUGH (25 patients)
PANCYTOPENIA (25 patients)
ACUTE ABDOMEN (24 patients)
EOSINOPHIL COUNT INCREASED (24 patients)
CEREBROVASCULAR ACCIDENT (24 patients)
METASTASES TO CENTRAL NERVOUS SYSTEM (23 patients)
CEREBRAL INFARCTION (23 patients)
HYPOMAGNESAEMIA (23 patients)
RETINAL VEIN THROMBOSIS (23 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (23 patients)
TUMOUR LYSIS SYNDROME (22 patients)
HYPOPHOSPHATAEMIA (22 patients)
INFECTION (22 patients)
ORAL PAIN (22 patients)
BLOOD CREATININE INCREASED (22 patients)
NEUTROPENIA (22 patients)
RENAL IMPAIRMENT (22 patients)
LETHARGY (22 patients)
SKIN TOXICITY (21 patients)
TONGUE BLISTERING (21 patients)
LIVER ABSCESS (21 patients)
HAEMATEMESIS (21 patients)
OESOPHAGEAL VARICES HAEMORRHAGE (20 patients)
MENTAL IMPAIRMENT (20 patients)
NERVOUSNESS (20 patients)
NEPHROTIC SYNDROME (20 patients)
HYPOPHAGIA (20 patients)
ADRENAL INSUFFICIENCY (19 patients)
DRY SKIN (19 patients)
BLOOD AMYLASE INCREASED (19 patients)
OEDEMA (19 patients)
INFECTIOUS PLEURAL EFFUSION (19 patients)
DYSPEPSIA (19 patients)
COMA HEPATIC (19 patients)
HEART RATE INCREASED (18 patients)
HYPERTENSIVE CRISIS (18 patients)
MYALGIA (18 patients)
ECZEMA (18 patients)
URINARY TRACT INFECTION (18 patients)
NEUROMYOPATHY (18 patients)
MEDICAL DEVICE COMPLICATION (18 patients)
DIVERTICULITIS (18 patients)
OSTEOMYELITIS (18 patients)
CEREBRAL ATROPHY (18 patients)
CEREBRAL VENTRICLE DILATATION (18 patients)
DIABETIC FOOT INFECTION (18 patients)
NECK PAIN (18 patients)
OLIGURIA (17 patients)
GASTROINTESTINAL DISORDER (17 patients)
HAEMATOCHEZIA (17 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (17 patients)
HYPOTHYROIDISM (17 patients)
TRANSAMINASES INCREASED (17 patients)
OROPHARYNGEAL PAIN (17 patients)
CHRONIC MYELOID LEUKAEMIA (17 patients)
NEOPLASM PROGRESSION (17 patients)
METASTASES TO ADRENALS (16 patients)
LYMPHOCYTE COUNT DECREASED (16 patients)
INTERNATIONAL NORMALISED RATIO INCREASED (16 patients)
MULTI-ORGAN FAILURE (16 patients)
FEAR (16 patients)
PANCREATIC CARCINOMA (16 patients)
HYPERSOMNIA (16 patients)
EPILEPSY (16 patients)
SUBARACHNOID HAEMORRHAGE (16 patients)
METASTASES TO LUNG (16 patients)
TACHYCARDIA (16 patients)
MUSCULAR WEAKNESS (16 patients)
KLEBSIELLA SEPSIS (16 patients)
MYOCARDIAL ISCHAEMIA (16 patients)
DYSGEUSIA (16 patients)
LUNG INFECTION (16 patients)
FAECES DISCOLOURED (16 patients)
PAIN OF SKIN (16 patients)
SPINAL FRACTURE (16 patients)
PANIC REACTION (16 patients)

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