Is BLOOD ALKALINE PHOSPHATASE INCREASED a side effect of SORAFENIB (RAF KINASE INHIBITOR) ? ( FactMed.com )

About this FactMed analysis covering adverse side effect reports of SORAFENIB (RAF KINASE INHIBITOR) patients who developed BLOOD ALKALINE PHOSPHATASE INCREASED.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 38 individuals taking SORAFENIB (RAF KINASE INHIBITOR) reported BLOOD ALKALINE PHOSPHATASE INCREASED to the FDA. A total of 3329 SORAFENIB (RAF KINASE INHIBITOR) drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between SORAFENIB (RAF KINASE INHIBITOR) and BLOOD ALKALINE PHOSPHATASE INCREASED. In doing so, we compare SORAFENIB (RAF KINASE INHIBITOR) with other drugs that cause BLOOD ALKALINE PHOSPHATASE INCREASED, to help you evaluate whether or not SORAFENIB (RAF KINASE INHIBITOR) causes BLOOD ALKALINE PHOSPHATASE INCREASED. Likewise, this page shows the most highly-reported side effects of SORAFENIB (RAF KINASE INHIBITOR), so you can see if BLOOD ALKALINE PHOSPHATASE INCREASED ranks among SORAFENIB (RAF KINASE INHIBITOR)'s most well-known side effects.

Summary Statistics
Reports of SORAFENIB (RAF KINASE INHIBITOR) causing BLOOD ALKALINE PHOSPHATASE INCREASED: 38
Reports of any side effect of SORAFENIB (RAF KINASE INHIBITOR) : 3329
Percentage of SORAFENIB (RAF KINASE INHIBITOR) patients where BLOOD ALKALINE PHOSPHATASE INCREASED is a reported side effect: 1.1415%

FDA reports of any drug causing BLOOD ALKALINE PHOSPHATASE INCREASED : 16929
Average percentage for all medicated patients where BLOOD ALKALINE PHOSPHATASE INCREASED is reported as a complication: 0.1061%

Physician opinion on SORAFENIB (RAF KINASE INHIBITOR) as adverse event culprit:

Overall opinion for all reports of this drug:

Most frequent diagnoses/indications for prescribing SORAFENIB (RAF KINASE INHIBITOR):

HEPATIC NEOPLASM MALIGNANT ( 770 patients )
RENAL CELL CARCINOMA ( 114 patients )
THYROID CANCER ( 65 patients )
METASTATIC RENAL CELL CARCINOMA ( 44 patients )
THYROID CANCER METASTATIC ( 35 patients )
BREAST CANCER ( 31 patients )
BREAST CANCER METASTATIC ( 27 patients )
GASTRIC CANCER ( 25 patients )
NON-SMALL CELL LUNG CANCER ( 25 patients )
COLORECTAL CANCER METASTATIC ( 22 patients )
RENAL CANCER ( 17 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 14 patients )
BILE DUCT CANCER ( 14 patients )
SALIVARY GLAND CANCER ( 7 patients )
HEPATIC CANCER METASTATIC ( 7 patients )
COLORECTAL CANCER ( 7 patients )
SMALL CELL LUNG CANCER STAGE UNSPECIFIED ( 6 patients )
RECTAL CANCER ( 5 patients )
PANCREATIC CARCINOMA ( 4 patients )
PROSTATE CANCER ( 4 patients )
INTRAOCULAR MELANOMA ( 4 patients )
HEPATIC NEOPLASM MALIGNANT RECURRENT ( 3 patients )
NEOPLASM ( 3 patients )
LIVER DISORDER ( 3 patients )
ANGIOSARCOMA ( 3 patients )
NON-SMALL CELL LUNG CANCER STAGE IV ( 3 patients )
METASTASES TO LUNG ( 3 patients )
HEPATIC NEOPLASM MALIGNANT NON-RESECTABLE ( 3 patients )
COLORECTAL CANCER STAGE IV ( 3 patients )
NEOPLASM MALIGNANT ( 3 patients )
GALLBLADDER CANCER METASTATIC ( 3 patients )
BILIARY CANCER METASTATIC ( 3 patients )
METASTASIS ( 3 patients )
COLON CANCER METASTATIC ( 2 patients )
HYPOPHARYNGEAL CANCER ( 2 patients )
DESMOID TUMOUR ( 2 patients )
NEUROENDOCRINE CARCINOMA ( 2 patients )
ACUTE MYELOID LEUKAEMIA (IN REMISSION) ( 2 patients )
LUNG NEOPLASM MALIGNANT ( 2 patients )
OESOPHAGEAL CARCINOMA ( 2 patients )
METASTATIC MALIGNANT MELANOMA ( 2 patients )
TONGUE NEOPLASM MALIGNANT STAGE UNSPECIFIED ( 2 patients )
METASTATIC SQUAMOUS CELL CARCINOMA ( 2 patients )
ANGINA PECTORIS ( 2 patients )
RENAL CELL CARCINOMA STAGE IV ( 2 patients )
OSTEOSARCOMA METASTATIC ( 2 patients )
BONE SARCOMA ( 2 patients )
METASTATIC OCULAR MELANOMA ( 2 patients )
METASTATIC SALIVARY GLAND CANCER ( 2 patients )
TONSIL CANCER ( 2 patients )
MYELODYSPLASTIC SYNDROME ( 1 patients )
PROSTATE CANCER METASTATIC ( 1 patients )
GALLBLADDER CANCER ( 1 patients )
NEUROENDOCRINE TUMOUR ( 1 patients )
MALIGNANT NEOPLASM OF RENAL PELVIS ( 1 patients )
GLIOMA ( 1 patients )
BLADDER CANCER ( 1 patients )
OVARIAN CANCER METASTATIC ( 1 patients )
CAROTID ARTERY DISEASE ( 1 patients )
HEPATOBLASTOMA ( 1 patients )
NASOPHARYNGEAL CANCER ( 1 patients )
ACUTE MYELOID LEUKAEMIA ( 1 patients )
LUNG ADENOCARCINOMA ( 1 patients )
RENAL CANCER METASTATIC ( 1 patients )
DIFFUSE LARGE B-CELL LYMPHOMA ( 1 patients )
NEUROENDOCRINE CARCINOMA OF THE SKIN ( 1 patients )
MALIGNANT HISTIOCYTOSIS ( 1 patients )
ANTICOAGULANT THERAPY ( 1 patients )
MALIGNANT SOFT TISSUE NEOPLASM ( 1 patients )
SARCOMA ( 1 patients )
GERM CELL CANCER ( 1 patients )
OESOPHAGEAL ADENOCARCINOMA ( 1 patients )
SQUAMOUS CELL CARCINOMA ( 1 patients )
HEAD AND NECK CANCER ( 1 patients )
OVARIAN EPITHELIAL CANCER ( 1 patients )
( 0 patients )

Drugs with high FDA adverse event association with BLOOD ALKALINE PHOSPHATASE INCREASED:

ASPIRIN (1324 patients)
TRACLEER (984 patients)
PREDNISOLONE (894 patients)
LASIX (809 patients)
ZOMETA (778 patients)
LIPITOR (731 patients)
FOSAMAX (727 patients)
ACETAMINOPHEN (653 patients)
OMEPRAZOLE (653 patients)
ALLOPURINOL (581 patients)
FUROSEMIDE (572 patients)
METHOTREXATE (524 patients)
CLOZARIL (518 patients)
CYMBALTA (493 patients)
ARAVA (491 patients)
PREDNISONE (455 patients)
FORTEO (435 patients)
NEXIUM (427 patients)
NORVASC (424 patients)
GLEEVEC (417 patients)
TEGRETOL (410 patients)
EXJADE (407 patients)
COUMADIN (387 patients)
FOLIC ACID (379 patients)
LEVOTHYROXINE SODIUM (379 patients)
SYNTHROID (367 patients)
DIOVAN (360 patients)
KETEK (360 patients)
ATENOLOL (355 patients)
LANSOPRAZOLE (352 patients)
FAMOTIDINE (347 patients)
REMICADE (345 patients)
SIMVASTATIN (343 patients)
LISINOPRIL (333 patients)
NEURONTIN (332 patients)
VOLTAREN (327 patients)
AMBIEN (327 patients)
PREDONINE (322 patients)
DECADRON (319 patients)
POTASSIUM CHLORIDE (316 patients)
IBUPROFEN (312 patients)
ZYPREXA (311 patients)
CLOZAPINE (310 patients)
NEORAL (305 patients)
SEROQUEL (304 patients)
ACCUTANE (295 patients)
DIGOXIN (291 patients)
VIOXX (290 patients)
DEXAMETHASONE (287 patients)
OXYCONTIN (283 patients)
LOVENOX (278 patients)
WARFARIN SODIUM (271 patients)
ZOCOR (271 patients)
LAMISIL (265 patients)
KALETRA (265 patients)
PROTONIX (264 patients)
LORAZEPAM (264 patients)
PLAVIX (262 patients)
CARBOPLATIN (258 patients)
AUGMENTIN '125' (257 patients)
ZOFRAN (256 patients)
AMLODIPINE (256 patients)
AREDIA (254 patients)
LAMIVUDINE (254 patients)
ACYCLOVIR (251 patients)
ATIVAN (250 patients)
NEXAVAR (249 patients)
FLUCONAZOLE (246 patients)
MORPHINE (246 patients)
BACTRIM (242 patients)
PRILOSEC (238 patients)
MYLOTARG (237 patients)
ALBUTEROL (237 patients)
NORVIR (234 patients)
CYCLOPHOSPHAMIDE (233 patients)
ZOLOFT (232 patients)
CIPROFLOXACIN (222 patients)
METFORMIN HCL (221 patients)
ALDACTONE (220 patients)
HYDROCHLOROTHIAZIDE (220 patients)
OXYCODONE HCL (220 patients)
XANAX (219 patients)
DIFLUCAN (218 patients)
VANCOMYCIN (217 patients)
MAGNESIUM OXIDE (216 patients)
CELEBREX (216 patients)
FLUOROURACIL (216 patients)
SPIRONOLACTONE (214 patients)
CLARITHROMYCIN (211 patients)
LAMICTAL (208 patients)
PREVACID (208 patients)
PAXIL (204 patients)
PERCOCET (203 patients)
RISPERDAL (201 patients)
CYCLOSPORINE (200 patients)
VITAMIN D (200 patients)
MUCOSTA (198 patients)
LOXONIN (194 patients)
PREDNISONE TAB (192 patients)
VICODIN (190 patients)
TAXOTERE (190 patients)
PROGRAF (189 patients)
INSULIN (183 patients)
EFAVIRENZ (179 patients)
AVASTIN (178 patients)
VELCADE (178 patients)
PLATELETS (178 patients)
AMOXICILLIN (178 patients)
AMARYL (177 patients)
ZANTAC (174 patients)
CRESTOR (172 patients)
SELBEX (171 patients)
COMPAZINE (170 patients)
METOCLOPRAMIDE (170 patients)
CLONAZEPAM (170 patients)
ALPRAZOLAM (169 patients)
TOPROL-XL (167 patients)
CYTARABINE (166 patients)
LYRICA (164 patients)
LANTUS (163 patients)
ALLEGRA (162 patients)
HEPARIN (161 patients)
LEVAQUIN (161 patients)
MORPHINE SULFATE (161 patients)
TRAMADOL HCL (160 patients)
AMLODIPINE BESYLATE (159 patients)
RAMIPRIL (159 patients)
CISPLATIN (156 patients)
TYLENOL (156 patients)
MULTI-VITAMINS (155 patients)
STRATTERA (155 patients)
LEXAPRO (155 patients)
SOLU-MEDROL (153 patients)
CALCIUM (152 patients)
SINGULAIR (152 patients)
FENTANYL (152 patients)
EFFEXOR (149 patients)
RHEUMATREX (148 patients)
DEPAKENE (146 patients)
ENBREL (146 patients)
GASTER (145 patients)
ARIMIDEX (144 patients)
REVLIMID (144 patients)
LEVOFLOXACIN (144 patients)
AFINITOR (144 patients)
AVONEX (144 patients)
BENADRYL (143 patients)
CALCIUM CARBONATE (143 patients)
DIAZEPAM (143 patients)
TAXOL (142 patients)
GLYBURIDE (142 patients)
GABAPENTIN (141 patients)
PARACETAMOL (139 patients)
FLAGYL (138 patients)
LORTAB (138 patients)
ZYRTEC (138 patients)
XELODA (137 patients)
GEMZAR (135 patients)
MS CONTIN (135 patients)
ACTONEL (135 patients)
EPIVIR (134 patients)
HYDROCORTISONE (133 patients)
ATORVASTATIN CALCIUM (133 patients)
VIREAD (132 patients)
LACTULOSE (132 patients)
ZETIA (131 patients)
VFEND (131 patients)
METOPROLOL TARTRATE (131 patients)
ZIDOVUDINE (130 patients)
DICLOFENAC SODIUM (129 patients)
KEPPRA (128 patients)
MEDROL (128 patients)
PREMARIN (128 patients)
SORAFENIB (126 patients)
CERTICAN (126 patients)
TRUVADA (123 patients)
CARBAMAZEPINE (123 patients)
ADVAIR DISKUS 100/50 (123 patients)
ONDANSETRON (122 patients)
PROZAC (122 patients)
PEPCID (122 patients)
CITALOPRAM HYDROBROMIDE (121 patients)
DURAGESIC-100 (119 patients)
RANITIDINE (119 patients)
PANTOPRAZOLE SODIUM (118 patients)
PANTOPRAZOLE (118 patients)
TAKEPRON (118 patients)
ADALAT (116 patients)
VALTREX (114 patients)
DILAUDID (114 patients)
ACTOS (113 patients)
VALPROATE SODIUM (113 patients)
PACLITAXEL (112 patients)
ZOLPIDEM TARTRATE (112 patients)
WELLBUTRIN (112 patients)
RITONAVIR (112 patients)
HUMIRA (111 patients)
METHYLPREDNISOLONE (111 patients)
ADRIAMYCIN PFS (110 patients)
TACROLIMUS (110 patients)
CLARITIN (110 patients)
NEUPOGEN (109 patients)
CIPRO (109 patients)
ATARAX (109 patients)
MULTI-VITAMIN (108 patients)
ZOVIRAX (108 patients)
FEMARA (108 patients)
VITAMIN B-12 (107 patients)
MOBIC (107 patients)
TORSEMIDE (107 patients)

Most common side effects for patients taking SORAFENIB (RAF KINASE INHIBITOR):

DIARRHOEA (613 patients)
HEPATIC FAILURE (378 patients)
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME (342 patients)
HEPATIC ENCEPHALOPATHY (320 patients)
FATIGUE (300 patients)
RASH (276 patients)
ASCITES (253 patients)
ABDOMINAL PAIN (237 patients)
DECREASED APPETITE (226 patients)
UPPER GASTROINTESTINAL HAEMORRHAGE (198 patients)
PYREXIA (191 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (179 patients)
NAUSEA (165 patients)
HYPERTENSION (160 patients)
ASTHENIA (154 patients)
DEHYDRATION (140 patients)
HEPATIC FUNCTION ABNORMAL (133 patients)
DYSPNOEA (131 patients)
CONFUSIONAL STATE (131 patients)
HYPOKALAEMIA (125 patients)
ALOPECIA (124 patients)
VOMITING (118 patients)
CONSTIPATION (115 patients)
INTERSTITIAL LUNG DISEASE (114 patients)
LEFT VENTRICULAR DYSFUNCTION (113 patients)
DEATH (113 patients)
ENDOCARDITIS (112 patients)
ARTHRALGIA (111 patients)
STOMATITIS (111 patients)
ABDOMINAL PAIN UPPER (110 patients)
JAUNDICE (108 patients)
HEPATIC NEOPLASM MALIGNANT (106 patients)
GASTROINTESTINAL HAEMORRHAGE (106 patients)
RETINAL VASCULAR THROMBOSIS (103 patients)
LOWER GASTROINTESTINAL HAEMORRHAGE (103 patients)
LIVER CARCINOMA RUPTURED (101 patients)
OEDEMA PERIPHERAL (97 patients)
PLEURAL EFFUSION (97 patients)
STAPHYLOCOCCAL INFECTION (96 patients)
PNEUMONIA BACTERIAL (96 patients)
ENTEROBACTER INFECTION (96 patients)
MYOPATHY (95 patients)
DRY MOUTH (94 patients)
PAIN IN EXTREMITY (93 patients)
ANXIETY (90 patients)
MALAISE (89 patients)
PULMONARY EMBOLISM (85 patients)
ANAEMIA (84 patients)
PLATELET COUNT DECREASED (81 patients)
BACK PAIN (79 patients)
SEPSIS (78 patients)
PRURITUS (78 patients)
DUODENAL ULCER (77 patients)
MIGRAINE (76 patients)
MITRAL VALVE INCOMPETENCE (76 patients)
HYPOGLYCAEMIA (76 patients)
C-REACTIVE PROTEIN INCREASED (74 patients)
BLOOD PRESSURE INCREASED (73 patients)
VARICES OESOPHAGEAL (73 patients)
HEADACHE (72 patients)
RETINAL VEIN OCCLUSION (72 patients)
ABASIA (69 patients)
RENAL FAILURE ACUTE (69 patients)
WEIGHT DECREASED (67 patients)
DEEP VEIN THROMBOSIS (67 patients)
DIZZINESS (65 patients)
ERYTHEMA (65 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (64 patients)
CONVULSION (63 patients)
ALANINE AMINOTRANSFERASE INCREASED (62 patients)
DYSPHONIA (62 patients)
CEREBRAL HAEMORRHAGE (60 patients)
APHAGIA (58 patients)
COLITIS (58 patients)
PNEUMONIA (57 patients)
GASTRIC ULCER (56 patients)
HYPONATRAEMIA (55 patients)
HAEMOGLOBIN DECREASED (53 patients)
RESPIRATORY FAILURE (52 patients)
LUNG DISORDER (52 patients)
CEREBRAL ISCHAEMIA (49 patients)
PARAESTHESIA (49 patients)
BLOOD BILIRUBIN INCREASED (48 patients)
GAIT DISTURBANCE (48 patients)
THYROID CANCER METASTATIC (44 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (43 patients)
PERICARDIAL EFFUSION (41 patients)
THROMBOCYTOPENIA (41 patients)
BLISTER (41 patients)
FEBRILE NEUTROPENIA (40 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (40 patients)
HALLUCINATION (40 patients)
CHILLS (40 patients)
AMMONIA INCREASED (39 patients)
SKIN ULCER (39 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (38 patients)
PAIN (38 patients)
HYPOALBUMINAEMIA (38 patients)
HYPOCALCAEMIA (37 patients)
FALL (37 patients)
POLLAKIURIA (37 patients)
BLOOD PRESSURE DECREASED (37 patients)
SKIN EXFOLIATION (37 patients)
INSOMNIA (36 patients)
CARDIAC ARREST (36 patients)
HYPOAESTHESIA (35 patients)
INFECTIOUS PERITONITIS (35 patients)
MYOCARDIAL INFARCTION (35 patients)
RETINAL VASCULAR DISORDER (34 patients)
RENAL FAILURE (34 patients)
LIPASE INCREASED (34 patients)
HYPERKALAEMIA (33 patients)
HYPERGLYCAEMIA (33 patients)
HAEMOPTYSIS (31 patients)
ATRIAL FIBRILLATION (30 patients)
GENERALISED OEDEMA (30 patients)
FAECAL INCONTINENCE (30 patients)
WHITE BLOOD CELL COUNT DECREASED (30 patients)
CELLULITIS (29 patients)
CHEST PAIN (29 patients)
SOMNOLENCE (29 patients)
HYPERBILIRUBINAEMIA (28 patients)
HYPOTENSION (28 patients)
MUSCLE SPASMS (28 patients)
ABDOMINAL DISTENSION (27 patients)
WHITE BLOOD CELL COUNT INCREASED (27 patients)
VISION BLURRED (27 patients)
HEPATIC PAIN (26 patients)
BLOOD ALBUMIN DECREASED (26 patients)
DYSURIA (25 patients)
RASH GENERALISED (25 patients)
BLOOD SODIUM DECREASED (25 patients)
BLOOD URIC ACID INCREASED (25 patients)
COMA (25 patients)
COUGH (25 patients)
PANCYTOPENIA (25 patients)
ACUTE ABDOMEN (24 patients)
EOSINOPHIL COUNT INCREASED (24 patients)
CEREBROVASCULAR ACCIDENT (24 patients)
METASTASES TO CENTRAL NERVOUS SYSTEM (23 patients)
CEREBRAL INFARCTION (23 patients)
HYPOMAGNESAEMIA (23 patients)
RETINAL VEIN THROMBOSIS (23 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (23 patients)
TUMOUR LYSIS SYNDROME (22 patients)
HYPOPHOSPHATAEMIA (22 patients)
INFECTION (22 patients)
ORAL PAIN (22 patients)
BLOOD CREATININE INCREASED (22 patients)
NEUTROPENIA (22 patients)
RENAL IMPAIRMENT (22 patients)
LETHARGY (22 patients)
SKIN TOXICITY (21 patients)
TONGUE BLISTERING (21 patients)
LIVER ABSCESS (21 patients)
HAEMATEMESIS (21 patients)
OESOPHAGEAL VARICES HAEMORRHAGE (20 patients)
MENTAL IMPAIRMENT (20 patients)
NERVOUSNESS (20 patients)
NEPHROTIC SYNDROME (20 patients)
HYPOPHAGIA (20 patients)
ADRENAL INSUFFICIENCY (19 patients)
DRY SKIN (19 patients)
BLOOD AMYLASE INCREASED (19 patients)
OEDEMA (19 patients)
INFECTIOUS PLEURAL EFFUSION (19 patients)
DYSPEPSIA (19 patients)
COMA HEPATIC (19 patients)
HEART RATE INCREASED (18 patients)
HYPERTENSIVE CRISIS (18 patients)
MYALGIA (18 patients)
ECZEMA (18 patients)
URINARY TRACT INFECTION (18 patients)
NEUROMYOPATHY (18 patients)
MEDICAL DEVICE COMPLICATION (18 patients)
DIVERTICULITIS (18 patients)
OSTEOMYELITIS (18 patients)
CEREBRAL ATROPHY (18 patients)
CEREBRAL VENTRICLE DILATATION (18 patients)
DIABETIC FOOT INFECTION (18 patients)
NECK PAIN (18 patients)
OLIGURIA (17 patients)
GASTROINTESTINAL DISORDER (17 patients)
HAEMATOCHEZIA (17 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (17 patients)
HYPOTHYROIDISM (17 patients)
TRANSAMINASES INCREASED (17 patients)
OROPHARYNGEAL PAIN (17 patients)
CHRONIC MYELOID LEUKAEMIA (17 patients)
NEOPLASM PROGRESSION (17 patients)
METASTASES TO ADRENALS (16 patients)
LYMPHOCYTE COUNT DECREASED (16 patients)
INTERNATIONAL NORMALISED RATIO INCREASED (16 patients)
MULTI-ORGAN FAILURE (16 patients)
FEAR (16 patients)
PANCREATIC CARCINOMA (16 patients)
HYPERSOMNIA (16 patients)
EPILEPSY (16 patients)
SUBARACHNOID HAEMORRHAGE (16 patients)
METASTASES TO LUNG (16 patients)
TACHYCARDIA (16 patients)
MUSCULAR WEAKNESS (16 patients)
KLEBSIELLA SEPSIS (16 patients)
MYOCARDIAL ISCHAEMIA (16 patients)
DYSGEUSIA (16 patients)
LUNG INFECTION (16 patients)
FAECES DISCOLOURED (16 patients)
PAIN OF SKIN (16 patients)
SPINAL FRACTURE (16 patients)
PANIC REACTION (16 patients)

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