Is CARDIAC ARREST a side effect of SORAFENIB (RAF KINASE INHIBITOR) ? ( FactMed.com )

About this FactMed analysis covering adverse side effect reports of SORAFENIB (RAF KINASE INHIBITOR) patients who developed CARDIAC ARREST.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 36 individuals taking SORAFENIB (RAF KINASE INHIBITOR) reported CARDIAC ARREST to the FDA. A total of 3329 SORAFENIB (RAF KINASE INHIBITOR) drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between SORAFENIB (RAF KINASE INHIBITOR) and CARDIAC ARREST. In doing so, we compare SORAFENIB (RAF KINASE INHIBITOR) with other drugs that cause CARDIAC ARREST, to help you evaluate whether or not SORAFENIB (RAF KINASE INHIBITOR) causes CARDIAC ARREST. Likewise, this page shows the most highly-reported side effects of SORAFENIB (RAF KINASE INHIBITOR), so you can see if CARDIAC ARREST ranks among SORAFENIB (RAF KINASE INHIBITOR)'s most well-known side effects.

Summary Statistics
Reports of SORAFENIB (RAF KINASE INHIBITOR) causing CARDIAC ARREST: 36
Reports of any side effect of SORAFENIB (RAF KINASE INHIBITOR) : 3329
Percentage of SORAFENIB (RAF KINASE INHIBITOR) patients where CARDIAC ARREST is a reported side effect: 1.0814%

FDA reports of any drug causing CARDIAC ARREST : 34334
Average percentage for all medicated patients where CARDIAC ARREST is reported as a complication: 0.2152%

Physician opinion on SORAFENIB (RAF KINASE INHIBITOR) as adverse event culprit:

Overall opinion for all reports of this drug:

Most frequent diagnoses/indications for prescribing SORAFENIB (RAF KINASE INHIBITOR):

HEPATIC NEOPLASM MALIGNANT ( 770 patients )
RENAL CELL CARCINOMA ( 114 patients )
THYROID CANCER ( 65 patients )
METASTATIC RENAL CELL CARCINOMA ( 44 patients )
THYROID CANCER METASTATIC ( 35 patients )
BREAST CANCER ( 31 patients )
BREAST CANCER METASTATIC ( 27 patients )
GASTRIC CANCER ( 25 patients )
NON-SMALL CELL LUNG CANCER ( 25 patients )
COLORECTAL CANCER METASTATIC ( 22 patients )
RENAL CANCER ( 17 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 14 patients )
BILE DUCT CANCER ( 14 patients )
SALIVARY GLAND CANCER ( 7 patients )
HEPATIC CANCER METASTATIC ( 7 patients )
COLORECTAL CANCER ( 7 patients )
SMALL CELL LUNG CANCER STAGE UNSPECIFIED ( 6 patients )
RECTAL CANCER ( 5 patients )
PANCREATIC CARCINOMA ( 4 patients )
PROSTATE CANCER ( 4 patients )
INTRAOCULAR MELANOMA ( 4 patients )
HEPATIC NEOPLASM MALIGNANT RECURRENT ( 3 patients )
NEOPLASM ( 3 patients )
LIVER DISORDER ( 3 patients )
ANGIOSARCOMA ( 3 patients )
NON-SMALL CELL LUNG CANCER STAGE IV ( 3 patients )
METASTASES TO LUNG ( 3 patients )
HEPATIC NEOPLASM MALIGNANT NON-RESECTABLE ( 3 patients )
COLORECTAL CANCER STAGE IV ( 3 patients )
NEOPLASM MALIGNANT ( 3 patients )
GALLBLADDER CANCER METASTATIC ( 3 patients )
BILIARY CANCER METASTATIC ( 3 patients )
METASTASIS ( 3 patients )
COLON CANCER METASTATIC ( 2 patients )
HYPOPHARYNGEAL CANCER ( 2 patients )
DESMOID TUMOUR ( 2 patients )
NEUROENDOCRINE CARCINOMA ( 2 patients )
ACUTE MYELOID LEUKAEMIA (IN REMISSION) ( 2 patients )
LUNG NEOPLASM MALIGNANT ( 2 patients )
OESOPHAGEAL CARCINOMA ( 2 patients )
METASTATIC MALIGNANT MELANOMA ( 2 patients )
TONGUE NEOPLASM MALIGNANT STAGE UNSPECIFIED ( 2 patients )
METASTATIC SQUAMOUS CELL CARCINOMA ( 2 patients )
ANGINA PECTORIS ( 2 patients )
RENAL CELL CARCINOMA STAGE IV ( 2 patients )
OSTEOSARCOMA METASTATIC ( 2 patients )
BONE SARCOMA ( 2 patients )
METASTATIC OCULAR MELANOMA ( 2 patients )
METASTATIC SALIVARY GLAND CANCER ( 2 patients )
TONSIL CANCER ( 2 patients )
MYELODYSPLASTIC SYNDROME ( 1 patients )
PROSTATE CANCER METASTATIC ( 1 patients )
GALLBLADDER CANCER ( 1 patients )
NEUROENDOCRINE TUMOUR ( 1 patients )
MALIGNANT NEOPLASM OF RENAL PELVIS ( 1 patients )
GLIOMA ( 1 patients )
BLADDER CANCER ( 1 patients )
OVARIAN CANCER METASTATIC ( 1 patients )
CAROTID ARTERY DISEASE ( 1 patients )
HEPATOBLASTOMA ( 1 patients )
NASOPHARYNGEAL CANCER ( 1 patients )
ACUTE MYELOID LEUKAEMIA ( 1 patients )
LUNG ADENOCARCINOMA ( 1 patients )
RENAL CANCER METASTATIC ( 1 patients )
DIFFUSE LARGE B-CELL LYMPHOMA ( 1 patients )
NEUROENDOCRINE CARCINOMA OF THE SKIN ( 1 patients )
MALIGNANT HISTIOCYTOSIS ( 1 patients )
ANTICOAGULANT THERAPY ( 1 patients )
MALIGNANT SOFT TISSUE NEOPLASM ( 1 patients )
SARCOMA ( 1 patients )
GERM CELL CANCER ( 1 patients )
OESOPHAGEAL ADENOCARCINOMA ( 1 patients )
SQUAMOUS CELL CARCINOMA ( 1 patients )
HEAD AND NECK CANCER ( 1 patients )
OVARIAN EPITHELIAL CANCER ( 1 patients )
( 0 patients )

Drugs with high FDA adverse event association with CARDIAC ARREST:

HEPARIN SODIUM INJECTION (3739 patients)
ASPIRIN (2723 patients)
DIANEAL (2401 patients)
VIOXX (2031 patients)
ALPRAZOLAM (1679 patients)
LASIX (1462 patients)
DIGOXIN (1313 patients)
AVANDIA (1186 patients)
FUROSEMIDE (1179 patients)
DIAZEPAM (1149 patients)
ACETAMINOPHEN (1142 patients)
LISINOPRIL (1019 patients)
LIPITOR (898 patients)
PLAVIX (888 patients)
CLONAZEPAM (847 patients)
OXYCODONE HCL (788 patients)
PREDNISONE (767 patients)
OMEPRAZOLE (766 patients)
ATENOLOL (764 patients)
METHADONE HCL (764 patients)
POTASSIUM CHLORIDE (763 patients)
SIMVASTATIN (746 patients)
COUMADIN (745 patients)
MORPHINE (739 patients)
FENTANYL (699 patients)
LORAZEPAM (674 patients)
ALLOPURINOL (650 patients)
INSULIN (635 patients)
NEXIUM (621 patients)
ETHANOL (594 patients)
METHOTREXATE (585 patients)
METFORMIN HCL (583 patients)
HEPARIN (578 patients)
WARFARIN SODIUM (574 patients)
METOPROLOL TARTRATE (553 patients)
PROPOFOL (551 patients)
ALBUTEROL (548 patients)
FOLIC ACID (548 patients)
SEROQUEL (537 patients)
ACETAMINOPHEN AND HYDROCODONE BITARTRATE (534 patients)
PREDNISOLONE (529 patients)
AMLODIPINE (509 patients)
HEPARIN SODIUM (507 patients)
ZOCOR (507 patients)
GABAPENTIN (506 patients)
NITROGLYCERIN (505 patients)
CITALOPRAM HYDROBROMIDE (505 patients)
SYNTHROID (494 patients)
IBUPROFEN (492 patients)
NORVASC (486 patients)
FLUOXETINE (486 patients)
CELEBREX (484 patients)
AVONEX (474 patients)
AMITRIPTYLINE HCL (473 patients)
NEURONTIN (461 patients)
HUMIRA (450 patients)
DEXAMETHASONE (450 patients)
PROTONIX (432 patients)
AMIODARONE HCL (430 patients)
SPIRONOLACTONE (428 patients)
OXYCONTIN (426 patients)
CARISOPRODOL (418 patients)
TRAMADOL HCL (416 patients)
ZOLOFT (410 patients)
COREG (410 patients)
PRILOSEC (400 patients)
REMICADE (393 patients)
METOPROLOL (390 patients)
HYDROCHLOROTHIAZIDE (390 patients)
LANTUS (384 patients)
VANCOMYCIN (381 patients)
XANAX (380 patients)
REVLIMID (379 patients)
LEVOTHYROXINE SODIUM (374 patients)
ZOLPIDEM (368 patients)
TRAZODONE HCL (367 patients)
ZYPREXA (366 patients)
DIPHENHYDRAMINE HCL (364 patients)
CARVEDILOL (359 patients)
CYCLOPHOSPHAMIDE (359 patients)
AMBIEN (350 patients)
TOPROL-XL (345 patients)
RAMIPRIL (344 patients)
PREDNISONE TAB (343 patients)
DIOVAN (338 patients)
ATIVAN (338 patients)
LOVENOX (337 patients)
ADVAIR DISKUS 100/50 (334 patients)
DILTIAZEM (334 patients)
VICODIN (328 patients)
MORPHINE SULFATE (322 patients)
MIRTAZAPINE (322 patients)
RANITIDINE (316 patients)
CLONIDINE (315 patients)
FLUOROURACIL (313 patients)
ALDACTONE (307 patients)
PREVACID (307 patients)
OXYGEN (301 patients)
ZOFRAN (298 patients)
TRACLEER (298 patients)
LOPRESSOR (295 patients)
CLOZAPINE (293 patients)
ZOMETA (292 patients)
COCAINE (283 patients)
PROPRANOLOL (283 patients)
VERAPAMIL (280 patients)
SPIRIVA (278 patients)
ENALAPRIL MALEATE (276 patients)
LANSOPRAZOLE (273 patients)
RISPERDAL (272 patients)
CLOZARIL (269 patients)
TEMAZEPAM (268 patients)
ZANTAC (267 patients)
BUPROPION HCL (267 patients)
LIDOCAINE (265 patients)
EPINEPHRINE (265 patients)
SEVOFLURANE (265 patients)
PROMETHAZINE (264 patients)
CRESTOR (263 patients)
FORTEO (263 patients)
CLOPIDOGREL (263 patients)
LEVAQUIN (262 patients)
ONDANSETRON (262 patients)
PAXIL (261 patients)
EFFEXOR (256 patients)
GLYBURIDE (255 patients)
METOCLOPRAMIDE (253 patients)
GLUCOPHAGE (252 patients)
HYDROCODONE (251 patients)
SOLU-MEDROL (251 patients)
QUETIAPINE FUMARATE (249 patients)
OLANZAPINE (249 patients)
FAMOTIDINE (247 patients)
CARBOPLATIN (247 patients)
PROGRAF (246 patients)
LEXAPRO (246 patients)
QUETIAPINE (244 patients)
CYTARABINE (242 patients)
AVELOX (241 patients)
NAPROXEN (240 patients)
AREDIA (240 patients)
COZAAR (239 patients)
METFORMIN (239 patients)
CISPLATIN (239 patients)
CIPROFLOXACIN (238 patients)
MIDAZOLAM HCL (238 patients)
NIFEDIPINE (235 patients)
OXYCODONE (233 patients)
OXALIPLATIN (232 patients)
METOPROLOL SUCCINATE (232 patients)
SINGULAIR (232 patients)
MULTI-VITAMINS (232 patients)
DURAGESIC-100 (231 patients)
DECADRON (230 patients)
CYMBALTA (230 patients)
TYLENOL (CAPLET) (227 patients)
BEXTRA (224 patients)
FOSAMAX (224 patients)
AVASTIN (223 patients)
FERROUS SULFATE TAB (219 patients)
LYRICA (218 patients)
GLIPIZIDE (217 patients)
ALTACE (215 patients)
LAMOTRIGINE (214 patients)
EXTRANEAL (212 patients)
FLUCONAZOLE (211 patients)
ENBREL (211 patients)
METHYLPREDNISOLONE (210 patients)
ACETYLSALICYLIC ACID SRT (209 patients)
VITAMIN D (208 patients)
PANTOPRAZOLE (206 patients)
PROZAC (206 patients)
AVANDAMET (205 patients)
ATORVASTATIN CALCIUM (205 patients)
ETOPOSIDE (203 patients)
PARACETAMOL (202 patients)
ATROVENT (201 patients)
MYCOPHENOLATE MOFETIL (201 patients)
LORTAB (201 patients)
PREGABALIN (200 patients)
RISPERIDONE (200 patients)
DIPRIVAN (199 patients)
BACLOFEN (199 patients)
METHADONE (198 patients)
HEPARIN SODIUM 5,000 UNITS IN DEXTROSE 5% (197 patients)
FENTANYL CITRATE (197 patients)
EPOGEN (197 patients)
TRASYLOL (197 patients)
LACTULOSE (197 patients)
COLACE (196 patients)
PERCOCET (195 patients)
AMARYL (195 patients)
ATORVASTATIN (194 patients)
CALCIUM CARBONATE (193 patients)
CYCLOBENZAPRINE (193 patients)
NYSTATIN (193 patients)
AMOXICILLIN (191 patients)
DILTIAZEM HCL (190 patients)
HYDROCODONE BITARTRATE (190 patients)
ATROPINE (189 patients)
VELCADE (188 patients)
HALDOL (186 patients)
BISOPROLOL FUMARATE (185 patients)
TYLENOL (184 patients)
BENADRYL (183 patients)
BACTRIM (180 patients)
VINCRISTINE (179 patients)
HYDROCODONE BITARTRATE AND ACETAMINOPHEN (178 patients)
CORDARONE (178 patients)
PREMARIN (178 patients)

Most common side effects for patients taking SORAFENIB (RAF KINASE INHIBITOR):

DIARRHOEA (613 patients)
HEPATIC FAILURE (378 patients)
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME (342 patients)
HEPATIC ENCEPHALOPATHY (320 patients)
FATIGUE (300 patients)
RASH (276 patients)
ASCITES (253 patients)
ABDOMINAL PAIN (237 patients)
DECREASED APPETITE (226 patients)
UPPER GASTROINTESTINAL HAEMORRHAGE (198 patients)
PYREXIA (191 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (179 patients)
NAUSEA (165 patients)
HYPERTENSION (160 patients)
ASTHENIA (154 patients)
DEHYDRATION (140 patients)
HEPATIC FUNCTION ABNORMAL (133 patients)
DYSPNOEA (131 patients)
CONFUSIONAL STATE (131 patients)
HYPOKALAEMIA (125 patients)
ALOPECIA (124 patients)
VOMITING (118 patients)
CONSTIPATION (115 patients)
INTERSTITIAL LUNG DISEASE (114 patients)
LEFT VENTRICULAR DYSFUNCTION (113 patients)
DEATH (113 patients)
ENDOCARDITIS (112 patients)
ARTHRALGIA (111 patients)
STOMATITIS (111 patients)
ABDOMINAL PAIN UPPER (110 patients)
JAUNDICE (108 patients)
HEPATIC NEOPLASM MALIGNANT (106 patients)
GASTROINTESTINAL HAEMORRHAGE (106 patients)
RETINAL VASCULAR THROMBOSIS (103 patients)
LOWER GASTROINTESTINAL HAEMORRHAGE (103 patients)
LIVER CARCINOMA RUPTURED (101 patients)
OEDEMA PERIPHERAL (97 patients)
PLEURAL EFFUSION (97 patients)
STAPHYLOCOCCAL INFECTION (96 patients)
PNEUMONIA BACTERIAL (96 patients)
ENTEROBACTER INFECTION (96 patients)
MYOPATHY (95 patients)
DRY MOUTH (94 patients)
PAIN IN EXTREMITY (93 patients)
ANXIETY (90 patients)
MALAISE (89 patients)
PULMONARY EMBOLISM (85 patients)
ANAEMIA (84 patients)
PLATELET COUNT DECREASED (81 patients)
BACK PAIN (79 patients)
SEPSIS (78 patients)
PRURITUS (78 patients)
DUODENAL ULCER (77 patients)
MIGRAINE (76 patients)
MITRAL VALVE INCOMPETENCE (76 patients)
HYPOGLYCAEMIA (76 patients)
C-REACTIVE PROTEIN INCREASED (74 patients)
BLOOD PRESSURE INCREASED (73 patients)
VARICES OESOPHAGEAL (73 patients)
HEADACHE (72 patients)
RETINAL VEIN OCCLUSION (72 patients)
ABASIA (69 patients)
RENAL FAILURE ACUTE (69 patients)
WEIGHT DECREASED (67 patients)
DEEP VEIN THROMBOSIS (67 patients)
DIZZINESS (65 patients)
ERYTHEMA (65 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (64 patients)
CONVULSION (63 patients)
ALANINE AMINOTRANSFERASE INCREASED (62 patients)
DYSPHONIA (62 patients)
CEREBRAL HAEMORRHAGE (60 patients)
APHAGIA (58 patients)
COLITIS (58 patients)
PNEUMONIA (57 patients)
GASTRIC ULCER (56 patients)
HYPONATRAEMIA (55 patients)
HAEMOGLOBIN DECREASED (53 patients)
RESPIRATORY FAILURE (52 patients)
LUNG DISORDER (52 patients)
CEREBRAL ISCHAEMIA (49 patients)
PARAESTHESIA (49 patients)
BLOOD BILIRUBIN INCREASED (48 patients)
GAIT DISTURBANCE (48 patients)
THYROID CANCER METASTATIC (44 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (43 patients)
PERICARDIAL EFFUSION (41 patients)
THROMBOCYTOPENIA (41 patients)
BLISTER (41 patients)
FEBRILE NEUTROPENIA (40 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (40 patients)
HALLUCINATION (40 patients)
CHILLS (40 patients)
AMMONIA INCREASED (39 patients)
SKIN ULCER (39 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (38 patients)
PAIN (38 patients)
HYPOALBUMINAEMIA (38 patients)
HYPOCALCAEMIA (37 patients)
FALL (37 patients)
POLLAKIURIA (37 patients)
BLOOD PRESSURE DECREASED (37 patients)
SKIN EXFOLIATION (37 patients)
INSOMNIA (36 patients)
CARDIAC ARREST (36 patients)
HYPOAESTHESIA (35 patients)
INFECTIOUS PERITONITIS (35 patients)
MYOCARDIAL INFARCTION (35 patients)
RETINAL VASCULAR DISORDER (34 patients)
RENAL FAILURE (34 patients)
LIPASE INCREASED (34 patients)
HYPERKALAEMIA (33 patients)
HYPERGLYCAEMIA (33 patients)
HAEMOPTYSIS (31 patients)
ATRIAL FIBRILLATION (30 patients)
GENERALISED OEDEMA (30 patients)
FAECAL INCONTINENCE (30 patients)
WHITE BLOOD CELL COUNT DECREASED (30 patients)
CELLULITIS (29 patients)
CHEST PAIN (29 patients)
SOMNOLENCE (29 patients)
HYPERBILIRUBINAEMIA (28 patients)
HYPOTENSION (28 patients)
MUSCLE SPASMS (28 patients)
ABDOMINAL DISTENSION (27 patients)
WHITE BLOOD CELL COUNT INCREASED (27 patients)
VISION BLURRED (27 patients)
HEPATIC PAIN (26 patients)
BLOOD ALBUMIN DECREASED (26 patients)
DYSURIA (25 patients)
RASH GENERALISED (25 patients)
BLOOD SODIUM DECREASED (25 patients)
BLOOD URIC ACID INCREASED (25 patients)
COMA (25 patients)
COUGH (25 patients)
PANCYTOPENIA (25 patients)
ACUTE ABDOMEN (24 patients)
EOSINOPHIL COUNT INCREASED (24 patients)
CEREBROVASCULAR ACCIDENT (24 patients)
METASTASES TO CENTRAL NERVOUS SYSTEM (23 patients)
CEREBRAL INFARCTION (23 patients)
HYPOMAGNESAEMIA (23 patients)
RETINAL VEIN THROMBOSIS (23 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (23 patients)
TUMOUR LYSIS SYNDROME (22 patients)
HYPOPHOSPHATAEMIA (22 patients)
INFECTION (22 patients)
ORAL PAIN (22 patients)
BLOOD CREATININE INCREASED (22 patients)
NEUTROPENIA (22 patients)
RENAL IMPAIRMENT (22 patients)
LETHARGY (22 patients)
SKIN TOXICITY (21 patients)
TONGUE BLISTERING (21 patients)
LIVER ABSCESS (21 patients)
HAEMATEMESIS (21 patients)
OESOPHAGEAL VARICES HAEMORRHAGE (20 patients)
MENTAL IMPAIRMENT (20 patients)
NERVOUSNESS (20 patients)
NEPHROTIC SYNDROME (20 patients)
HYPOPHAGIA (20 patients)
ADRENAL INSUFFICIENCY (19 patients)
DRY SKIN (19 patients)
BLOOD AMYLASE INCREASED (19 patients)
OEDEMA (19 patients)
INFECTIOUS PLEURAL EFFUSION (19 patients)
DYSPEPSIA (19 patients)
COMA HEPATIC (19 patients)
HEART RATE INCREASED (18 patients)
HYPERTENSIVE CRISIS (18 patients)
MYALGIA (18 patients)
ECZEMA (18 patients)
URINARY TRACT INFECTION (18 patients)
NEUROMYOPATHY (18 patients)
MEDICAL DEVICE COMPLICATION (18 patients)
DIVERTICULITIS (18 patients)
OSTEOMYELITIS (18 patients)
CEREBRAL ATROPHY (18 patients)
CEREBRAL VENTRICLE DILATATION (18 patients)
DIABETIC FOOT INFECTION (18 patients)
NECK PAIN (18 patients)
OLIGURIA (17 patients)
GASTROINTESTINAL DISORDER (17 patients)
HAEMATOCHEZIA (17 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (17 patients)
HYPOTHYROIDISM (17 patients)
TRANSAMINASES INCREASED (17 patients)
OROPHARYNGEAL PAIN (17 patients)
CHRONIC MYELOID LEUKAEMIA (17 patients)
NEOPLASM PROGRESSION (17 patients)
METASTASES TO ADRENALS (16 patients)
LYMPHOCYTE COUNT DECREASED (16 patients)
INTERNATIONAL NORMALISED RATIO INCREASED (16 patients)
MULTI-ORGAN FAILURE (16 patients)
FEAR (16 patients)
PANCREATIC CARCINOMA (16 patients)
HYPERSOMNIA (16 patients)
EPILEPSY (16 patients)
SUBARACHNOID HAEMORRHAGE (16 patients)
METASTASES TO LUNG (16 patients)
TACHYCARDIA (16 patients)
MUSCULAR WEAKNESS (16 patients)
KLEBSIELLA SEPSIS (16 patients)
MYOCARDIAL ISCHAEMIA (16 patients)
DYSGEUSIA (16 patients)
LUNG INFECTION (16 patients)
FAECES DISCOLOURED (16 patients)
PAIN OF SKIN (16 patients)
SPINAL FRACTURE (16 patients)
PANIC REACTION (16 patients)

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