Is DYSPHONIA a side effect of SORAFENIB (RAF KINASE INHIBITOR) ? ( FactMed.com )

About this FactMed analysis covering adverse side effect reports of SORAFENIB (RAF KINASE INHIBITOR) patients who developed DYSPHONIA.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 62 individuals taking SORAFENIB (RAF KINASE INHIBITOR) reported DYSPHONIA to the FDA. A total of 3329 SORAFENIB (RAF KINASE INHIBITOR) drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between SORAFENIB (RAF KINASE INHIBITOR) and DYSPHONIA. In doing so, we compare SORAFENIB (RAF KINASE INHIBITOR) with other drugs that cause DYSPHONIA, to help you evaluate whether or not SORAFENIB (RAF KINASE INHIBITOR) causes DYSPHONIA. Likewise, this page shows the most highly-reported side effects of SORAFENIB (RAF KINASE INHIBITOR), so you can see if DYSPHONIA ranks among SORAFENIB (RAF KINASE INHIBITOR)'s most well-known side effects.

Summary Statistics
Reports of SORAFENIB (RAF KINASE INHIBITOR) causing DYSPHONIA: 62
Reports of any side effect of SORAFENIB (RAF KINASE INHIBITOR) : 3329
Percentage of SORAFENIB (RAF KINASE INHIBITOR) patients where DYSPHONIA is a reported side effect: 1.8624%

FDA reports of any drug causing DYSPHONIA : 12519
Average percentage for all medicated patients where DYSPHONIA is reported as a complication: 0.0785%

Physician opinion on SORAFENIB (RAF KINASE INHIBITOR) as adverse event culprit:

Overall opinion for all reports of this drug:

Most frequent diagnoses/indications for prescribing SORAFENIB (RAF KINASE INHIBITOR):

HEPATIC NEOPLASM MALIGNANT ( 770 patients )
RENAL CELL CARCINOMA ( 114 patients )
THYROID CANCER ( 65 patients )
METASTATIC RENAL CELL CARCINOMA ( 44 patients )
THYROID CANCER METASTATIC ( 35 patients )
BREAST CANCER ( 31 patients )
BREAST CANCER METASTATIC ( 27 patients )
GASTRIC CANCER ( 25 patients )
NON-SMALL CELL LUNG CANCER ( 25 patients )
COLORECTAL CANCER METASTATIC ( 22 patients )
RENAL CANCER ( 17 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 14 patients )
BILE DUCT CANCER ( 14 patients )
SALIVARY GLAND CANCER ( 7 patients )
HEPATIC CANCER METASTATIC ( 7 patients )
COLORECTAL CANCER ( 7 patients )
SMALL CELL LUNG CANCER STAGE UNSPECIFIED ( 6 patients )
RECTAL CANCER ( 5 patients )
PANCREATIC CARCINOMA ( 4 patients )
PROSTATE CANCER ( 4 patients )
INTRAOCULAR MELANOMA ( 4 patients )
HEPATIC NEOPLASM MALIGNANT RECURRENT ( 3 patients )
NEOPLASM ( 3 patients )
LIVER DISORDER ( 3 patients )
ANGIOSARCOMA ( 3 patients )
NON-SMALL CELL LUNG CANCER STAGE IV ( 3 patients )
METASTASES TO LUNG ( 3 patients )
HEPATIC NEOPLASM MALIGNANT NON-RESECTABLE ( 3 patients )
COLORECTAL CANCER STAGE IV ( 3 patients )
NEOPLASM MALIGNANT ( 3 patients )
GALLBLADDER CANCER METASTATIC ( 3 patients )
METASTASIS ( 3 patients )
BILIARY CANCER METASTATIC ( 3 patients )
COLON CANCER METASTATIC ( 2 patients )
HYPOPHARYNGEAL CANCER ( 2 patients )
DESMOID TUMOUR ( 2 patients )
NEUROENDOCRINE CARCINOMA ( 2 patients )
LUNG NEOPLASM MALIGNANT ( 2 patients )
ACUTE MYELOID LEUKAEMIA (IN REMISSION) ( 2 patients )
OESOPHAGEAL CARCINOMA ( 2 patients )
METASTATIC MALIGNANT MELANOMA ( 2 patients )
TONGUE NEOPLASM MALIGNANT STAGE UNSPECIFIED ( 2 patients )
METASTATIC SQUAMOUS CELL CARCINOMA ( 2 patients )
RENAL CELL CARCINOMA STAGE IV ( 2 patients )
ANGINA PECTORIS ( 2 patients )
OSTEOSARCOMA METASTATIC ( 2 patients )
METASTATIC OCULAR MELANOMA ( 2 patients )
BONE SARCOMA ( 2 patients )
METASTATIC SALIVARY GLAND CANCER ( 2 patients )
TONSIL CANCER ( 2 patients )
MYELODYSPLASTIC SYNDROME ( 1 patients )
PROSTATE CANCER METASTATIC ( 1 patients )
GALLBLADDER CANCER ( 1 patients )
NEUROENDOCRINE TUMOUR ( 1 patients )
MALIGNANT NEOPLASM OF RENAL PELVIS ( 1 patients )
GLIOMA ( 1 patients )
BLADDER CANCER ( 1 patients )
OVARIAN CANCER METASTATIC ( 1 patients )
CAROTID ARTERY DISEASE ( 1 patients )
HEPATOBLASTOMA ( 1 patients )
NASOPHARYNGEAL CANCER ( 1 patients )
LUNG ADENOCARCINOMA ( 1 patients )
RENAL CANCER METASTATIC ( 1 patients )
ACUTE MYELOID LEUKAEMIA ( 1 patients )
DIFFUSE LARGE B-CELL LYMPHOMA ( 1 patients )
NEUROENDOCRINE CARCINOMA OF THE SKIN ( 1 patients )
MALIGNANT HISTIOCYTOSIS ( 1 patients )
MALIGNANT SOFT TISSUE NEOPLASM ( 1 patients )
SARCOMA ( 1 patients )
ANTICOAGULANT THERAPY ( 1 patients )
GERM CELL CANCER ( 1 patients )
OESOPHAGEAL ADENOCARCINOMA ( 1 patients )
SQUAMOUS CELL CARCINOMA ( 1 patients )
HEAD AND NECK CANCER ( 1 patients )
OVARIAN EPITHELIAL CANCER ( 1 patients )
( 0 patients )

Drugs with high FDA adverse event association with DYSPHONIA:

ADVAIR DISKUS 100/50 (1743 patients)
FOSAMAX (1267 patients)
SPIRIVA (1236 patients)
ASPIRIN (1059 patients)
NEXAVAR (1008 patients)
NEXIUM (900 patients)
ALBUTEROL (609 patients)
SYMBICORT (584 patients)
LIPITOR (573 patients)
SYNTHROID (556 patients)
PREDNISONE (503 patients)
LISINOPRIL (479 patients)
ENBREL (473 patients)
FORTEO (470 patients)
ZOMETA (454 patients)
HUMIRA (434 patients)
SINGULAIR (433 patients)
SEROQUEL (418 patients)
LASIX (416 patients)
PRILOSEC (408 patients)
XANAX (357 patients)
COUMADIN (348 patients)
METHOTREXATE (338 patients)
ADVAIR HFA (330 patients)
ATENOLOL (327 patients)
VIOXX (327 patients)
HYDROCHLOROTHIAZIDE (326 patients)
OMEPRAZOLE (322 patients)
SIMVASTATIN (308 patients)
NEURONTIN (307 patients)
PROTONIX (295 patients)
PLAVIX (291 patients)
PREVACID (289 patients)
REMICADE (286 patients)
TOPROL-XL (284 patients)
VITAMIN D (283 patients)
LEVOTHYROXINE SODIUM (279 patients)
DIOVAN (277 patients)
LYRICA (276 patients)
FLOVENT (276 patients)
FOLIC ACID (275 patients)
XOLAIR (275 patients)
CELEBREX (273 patients)
AREDIA (262 patients)
TYSABRI (261 patients)
CYMBALTA (251 patients)
ZOCOR (246 patients)
CRESTOR (243 patients)
OXYCONTIN (243 patients)
ZOLOFT (243 patients)
AMBIEN (243 patients)
FUROSEMIDE (240 patients)
NORVASC (230 patients)
ACETAMINOPHEN (224 patients)
CALCIUM (224 patients)
ATIVAN (223 patients)
AVONEX (210 patients)
METFORMIN HCL (208 patients)
PAXIL (202 patients)
COMBIVENT (199 patients)
DIAZEPAM (198 patients)
FLONASE (198 patients)
BOTOX (196 patients)
VICODIN (193 patients)
ZYRTEC (191 patients)
LEVAQUIN (190 patients)
LEXAPRO (182 patients)
ALENDRONATE SODIUM (181 patients)
LEVOXYL (178 patients)
FORASEQ (178 patients)
GABAPENTIN (177 patients)
VENTOLIN (177 patients)
RANITIDINE (175 patients)
PREDNISONE TAB (171 patients)
MULTI-VITAMIN (169 patients)
ALDACTONE (169 patients)
REVLIMID (166 patients)
LORAZEPAM (162 patients)
EFFEXOR (162 patients)
DIGOXIN (162 patients)
PREMARIN (161 patients)
IBUPROFEN (161 patients)
PERCOCET (157 patients)
ZANTAC (157 patients)
POTASSIUM CHLORIDE (155 patients)
METOPROLOL TARTRATE (155 patients)
DEXAMETHASONE (154 patients)
CHANTIX (150 patients)
KLONOPIN (148 patients)
CLONAZEPAM (147 patients)
ZETIA (142 patients)
ACTONEL (141 patients)
DECADRON (139 patients)
FLEXERIL (138 patients)
OMALIZUMAB (135 patients)
ALLOPURINOL (135 patients)
OXYCODONE HCL (134 patients)
SEREVENT (133 patients)
MULTI-VITAMINS (130 patients)
COZAAR (129 patients)
ASCORBIC ACID (128 patients)
LANTUS (126 patients)
DURAGESIC-100 (126 patients)
ALPRAZOLAM (125 patients)
FISH OIL (124 patients)
MORPHINE (124 patients)
BENADRYL (124 patients)
BETASERON (123 patients)
ZITHROMAX (123 patients)
PREDNISOLONE (122 patients)
PULMICORT (122 patients)
ATROVENT (121 patients)
NASONEX (120 patients)
WELLBUTRIN (120 patients)
AMLODIPINE (119 patients)
WARFARIN SODIUM (118 patients)
VALIUM (117 patients)
ALLEGRA (116 patients)
PROZAC (114 patients)
COREG (114 patients)
ZOFRAN (114 patients)
VITAMINS (113 patients)
FLOMAX (113 patients)
CELEXA (113 patients)
PRAVACHOL (113 patients)
ENALAPRIL MALEATE (112 patients)
AMOXICILLIN (109 patients)
CALCIUM CARBONATE (109 patients)
VITAMIN B-12 (108 patients)
BONIVA (108 patients)
PROAIR HFA (108 patients)
ARIMIDEX (108 patients)
INSULIN (106 patients)
TRAMADOL HCL (105 patients)
BYETTA (105 patients)
BACLOFEN (104 patients)
AVASTIN (103 patients)
AMITRIPTYLINE HCL (102 patients)
MORPHINE SULFATE (102 patients)
XOPENEX (100 patients)
TRAZODONE HCL (99 patients)
BENICAR (97 patients)
FLUTICASONE PROPIONATE (96 patients)
OXYGEN (94 patients)
RISPERDAL (94 patients)
FENTANYL (93 patients)
LOPRESSOR (92 patients)
SPIRONOLACTONE (92 patients)
NO CONCURRENT MEDICATION (91 patients)
POTASSIUM (91 patients)
PEPCID (91 patients)
NITROGLYCERIN (90 patients)
ALTACE (90 patients)
ACIPHEX (90 patients)
TEMAZEPAM (90 patients)
METOPROLOL (90 patients)
COLACE (89 patients)
RIBAVIRIN (89 patients)
SANDOSTATIN LAR (89 patients)
PULMICORT FLEXHALER (89 patients)
SERETIDE (87 patients)
VITAMIN E (87 patients)
LAMICTAL (86 patients)
TEGRETOL (86 patients)
TAMOXIFEN CITRATE (86 patients)
CLARITIN (85 patients)
COMPAZINE (85 patients)
VERAPAMIL (84 patients)
CENTRUM SILVER (83 patients)
RHINOCORT (83 patients)
METOCLOPRAMIDE (82 patients)
EVISTA (82 patients)
[THERAPY UNSPECIFIED] (81 patients)
VYTORIN (81 patients)
FEMARA (80 patients)
BOTULINUM TOXIN TYPE A (79 patients)
RAMIPRIL (79 patients)
PROVENTIL (79 patients)
RESTORIL (79 patients)
PANTOPRAZOLE (78 patients)
RADIATION THERAPY (77 patients)
CALCIUM (UNSPECIFIED) (77 patients)
UNKNOWN MEDICATION (75 patients)
DILAUDID (75 patients)
METFORMIN (75 patients)
GLEEVEC (74 patients)
ELAVIL (73 patients)
CARVEDILOL (73 patients)
ACTOS (72 patients)
FOSAMAX PLUS D (71 patients)
VELCADE (71 patients)
NAPROXEN (71 patients)
AVELOX (70 patients)
HUMALOG (70 patients)
CIPROFLOXACIN (70 patients)
LOVAZA (70 patients)
TYLENOL (70 patients)
GLYBURIDE (70 patients)
ATACAND (70 patients)
LOSARTAN POTASSIUM (70 patients)
ONDANSETRON (69 patients)
PROCHLORPERAZINE (68 patients)
ZYPREXA (67 patients)
DOXYCYCLINE (67 patients)
PRAVASTATIN (67 patients)
METOPROLOL SUCCINATE (67 patients)
PULMICORT RESPULES (67 patients)
FLUOXETINE (66 patients)
PROPRANOLOL (66 patients)
CITALOPRAM HYDROBROMIDE (66 patients)

Most common side effects for patients taking SORAFENIB (RAF KINASE INHIBITOR):

DIARRHOEA (613 patients)
HEPATIC FAILURE (378 patients)
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME (342 patients)
HEPATIC ENCEPHALOPATHY (320 patients)
FATIGUE (300 patients)
RASH (276 patients)
ASCITES (253 patients)
ABDOMINAL PAIN (237 patients)
DECREASED APPETITE (226 patients)
UPPER GASTROINTESTINAL HAEMORRHAGE (198 patients)
PYREXIA (191 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (179 patients)
NAUSEA (165 patients)
HYPERTENSION (160 patients)
ASTHENIA (154 patients)
DEHYDRATION (140 patients)
HEPATIC FUNCTION ABNORMAL (133 patients)
DYSPNOEA (131 patients)
CONFUSIONAL STATE (131 patients)
HYPOKALAEMIA (125 patients)
ALOPECIA (124 patients)
VOMITING (118 patients)
CONSTIPATION (115 patients)
INTERSTITIAL LUNG DISEASE (114 patients)
LEFT VENTRICULAR DYSFUNCTION (113 patients)
DEATH (113 patients)
ENDOCARDITIS (112 patients)
ARTHRALGIA (111 patients)
STOMATITIS (111 patients)
ABDOMINAL PAIN UPPER (110 patients)
JAUNDICE (108 patients)
HEPATIC NEOPLASM MALIGNANT (106 patients)
GASTROINTESTINAL HAEMORRHAGE (106 patients)
RETINAL VASCULAR THROMBOSIS (103 patients)
LOWER GASTROINTESTINAL HAEMORRHAGE (103 patients)
LIVER CARCINOMA RUPTURED (101 patients)
OEDEMA PERIPHERAL (97 patients)
PLEURAL EFFUSION (97 patients)
STAPHYLOCOCCAL INFECTION (96 patients)
PNEUMONIA BACTERIAL (96 patients)
ENTEROBACTER INFECTION (96 patients)
MYOPATHY (95 patients)
DRY MOUTH (94 patients)
PAIN IN EXTREMITY (93 patients)
ANXIETY (90 patients)
MALAISE (89 patients)
PULMONARY EMBOLISM (85 patients)
ANAEMIA (84 patients)
PLATELET COUNT DECREASED (81 patients)
BACK PAIN (79 patients)
SEPSIS (78 patients)
PRURITUS (78 patients)
DUODENAL ULCER (77 patients)
MIGRAINE (76 patients)
MITRAL VALVE INCOMPETENCE (76 patients)
HYPOGLYCAEMIA (76 patients)
C-REACTIVE PROTEIN INCREASED (74 patients)
BLOOD PRESSURE INCREASED (73 patients)
VARICES OESOPHAGEAL (73 patients)
HEADACHE (72 patients)
RETINAL VEIN OCCLUSION (72 patients)
ABASIA (69 patients)
RENAL FAILURE ACUTE (69 patients)
WEIGHT DECREASED (67 patients)
DEEP VEIN THROMBOSIS (67 patients)
DIZZINESS (65 patients)
ERYTHEMA (65 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (64 patients)
CONVULSION (63 patients)
ALANINE AMINOTRANSFERASE INCREASED (62 patients)
DYSPHONIA (62 patients)
CEREBRAL HAEMORRHAGE (60 patients)
APHAGIA (58 patients)
COLITIS (58 patients)
PNEUMONIA (57 patients)
GASTRIC ULCER (56 patients)
HYPONATRAEMIA (55 patients)
HAEMOGLOBIN DECREASED (53 patients)
RESPIRATORY FAILURE (52 patients)
LUNG DISORDER (52 patients)
CEREBRAL ISCHAEMIA (49 patients)
PARAESTHESIA (49 patients)
BLOOD BILIRUBIN INCREASED (48 patients)
GAIT DISTURBANCE (48 patients)
THYROID CANCER METASTATIC (44 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (43 patients)
PERICARDIAL EFFUSION (41 patients)
THROMBOCYTOPENIA (41 patients)
BLISTER (41 patients)
FEBRILE NEUTROPENIA (40 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (40 patients)
HALLUCINATION (40 patients)
CHILLS (40 patients)
AMMONIA INCREASED (39 patients)
SKIN ULCER (39 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (38 patients)
PAIN (38 patients)
HYPOALBUMINAEMIA (38 patients)
HYPOCALCAEMIA (37 patients)
FALL (37 patients)
POLLAKIURIA (37 patients)
BLOOD PRESSURE DECREASED (37 patients)
SKIN EXFOLIATION (37 patients)
INSOMNIA (36 patients)
CARDIAC ARREST (36 patients)
HYPOAESTHESIA (35 patients)
INFECTIOUS PERITONITIS (35 patients)
MYOCARDIAL INFARCTION (35 patients)
RETINAL VASCULAR DISORDER (34 patients)
RENAL FAILURE (34 patients)
LIPASE INCREASED (34 patients)
HYPERKALAEMIA (33 patients)
HYPERGLYCAEMIA (33 patients)
HAEMOPTYSIS (31 patients)
ATRIAL FIBRILLATION (30 patients)
GENERALISED OEDEMA (30 patients)
FAECAL INCONTINENCE (30 patients)
WHITE BLOOD CELL COUNT DECREASED (30 patients)
CELLULITIS (29 patients)
CHEST PAIN (29 patients)
SOMNOLENCE (29 patients)
HYPERBILIRUBINAEMIA (28 patients)
HYPOTENSION (28 patients)
MUSCLE SPASMS (28 patients)
ABDOMINAL DISTENSION (27 patients)
WHITE BLOOD CELL COUNT INCREASED (27 patients)
VISION BLURRED (27 patients)
HEPATIC PAIN (26 patients)
BLOOD ALBUMIN DECREASED (26 patients)
DYSURIA (25 patients)
RASH GENERALISED (25 patients)
BLOOD SODIUM DECREASED (25 patients)
BLOOD URIC ACID INCREASED (25 patients)
COMA (25 patients)
COUGH (25 patients)
PANCYTOPENIA (25 patients)
ACUTE ABDOMEN (24 patients)
EOSINOPHIL COUNT INCREASED (24 patients)
CEREBROVASCULAR ACCIDENT (24 patients)
METASTASES TO CENTRAL NERVOUS SYSTEM (23 patients)
CEREBRAL INFARCTION (23 patients)
HYPOMAGNESAEMIA (23 patients)
RETINAL VEIN THROMBOSIS (23 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (23 patients)
TUMOUR LYSIS SYNDROME (22 patients)
HYPOPHOSPHATAEMIA (22 patients)
INFECTION (22 patients)
ORAL PAIN (22 patients)
BLOOD CREATININE INCREASED (22 patients)
NEUTROPENIA (22 patients)
RENAL IMPAIRMENT (22 patients)
LETHARGY (22 patients)
SKIN TOXICITY (21 patients)
TONGUE BLISTERING (21 patients)
LIVER ABSCESS (21 patients)
HAEMATEMESIS (21 patients)
OESOPHAGEAL VARICES HAEMORRHAGE (20 patients)
MENTAL IMPAIRMENT (20 patients)
NERVOUSNESS (20 patients)
NEPHROTIC SYNDROME (20 patients)
HYPOPHAGIA (20 patients)
ADRENAL INSUFFICIENCY (19 patients)
DRY SKIN (19 patients)
BLOOD AMYLASE INCREASED (19 patients)
OEDEMA (19 patients)
INFECTIOUS PLEURAL EFFUSION (19 patients)
DYSPEPSIA (19 patients)
COMA HEPATIC (19 patients)
HEART RATE INCREASED (18 patients)
HYPERTENSIVE CRISIS (18 patients)
MYALGIA (18 patients)
ECZEMA (18 patients)
URINARY TRACT INFECTION (18 patients)
NEUROMYOPATHY (18 patients)
MEDICAL DEVICE COMPLICATION (18 patients)
DIVERTICULITIS (18 patients)
OSTEOMYELITIS (18 patients)
CEREBRAL ATROPHY (18 patients)
CEREBRAL VENTRICLE DILATATION (18 patients)
DIABETIC FOOT INFECTION (18 patients)
NECK PAIN (18 patients)
OLIGURIA (17 patients)
GASTROINTESTINAL DISORDER (17 patients)
HAEMATOCHEZIA (17 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (17 patients)
HYPOTHYROIDISM (17 patients)
TRANSAMINASES INCREASED (17 patients)
OROPHARYNGEAL PAIN (17 patients)
CHRONIC MYELOID LEUKAEMIA (17 patients)
NEOPLASM PROGRESSION (17 patients)
METASTASES TO ADRENALS (16 patients)
LYMPHOCYTE COUNT DECREASED (16 patients)
INTERNATIONAL NORMALISED RATIO INCREASED (16 patients)
MULTI-ORGAN FAILURE (16 patients)
FEAR (16 patients)
PANCREATIC CARCINOMA (16 patients)
HYPERSOMNIA (16 patients)
EPILEPSY (16 patients)
SUBARACHNOID HAEMORRHAGE (16 patients)
METASTASES TO LUNG (16 patients)
TACHYCARDIA (16 patients)
MUSCULAR WEAKNESS (16 patients)
KLEBSIELLA SEPSIS (16 patients)
MYOCARDIAL ISCHAEMIA (16 patients)
DYSGEUSIA (16 patients)
LUNG INFECTION (16 patients)
FAECES DISCOLOURED (16 patients)
PAIN OF SKIN (16 patients)
SPINAL FRACTURE (16 patients)
PANIC REACTION (16 patients)

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