Is FEAR a side effect of SORAFENIB (RAF KINASE INHIBITOR) ? ( FactMed.com )

About this FactMed analysis covering adverse side effect reports of SORAFENIB (RAF KINASE INHIBITOR) patients who developed FEAR.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 16 individuals taking SORAFENIB (RAF KINASE INHIBITOR) reported FEAR to the FDA. A total of 3329 SORAFENIB (RAF KINASE INHIBITOR) drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between SORAFENIB (RAF KINASE INHIBITOR) and FEAR. In doing so, we compare SORAFENIB (RAF KINASE INHIBITOR) with other drugs that cause FEAR, to help you evaluate whether or not SORAFENIB (RAF KINASE INHIBITOR) causes FEAR. Likewise, this page shows the most highly-reported side effects of SORAFENIB (RAF KINASE INHIBITOR), so you can see if FEAR ranks among SORAFENIB (RAF KINASE INHIBITOR)'s most well-known side effects.

Summary Statistics
Reports of SORAFENIB (RAF KINASE INHIBITOR) causing FEAR: 16
Reports of any side effect of SORAFENIB (RAF KINASE INHIBITOR) : 3329
Percentage of SORAFENIB (RAF KINASE INHIBITOR) patients where FEAR is a reported side effect: 0.4806%

FDA reports of any drug causing FEAR : 18658
Average percentage for all medicated patients where FEAR is reported as a complication: 0.1169%

Physician opinion on SORAFENIB (RAF KINASE INHIBITOR) as adverse event culprit:

Overall opinion for all reports of this drug:

Most frequent diagnoses/indications for prescribing SORAFENIB (RAF KINASE INHIBITOR):

HEPATIC NEOPLASM MALIGNANT ( 770 patients )
RENAL CELL CARCINOMA ( 114 patients )
THYROID CANCER ( 65 patients )
METASTATIC RENAL CELL CARCINOMA ( 44 patients )
THYROID CANCER METASTATIC ( 35 patients )
BREAST CANCER ( 31 patients )
BREAST CANCER METASTATIC ( 27 patients )
GASTRIC CANCER ( 25 patients )
NON-SMALL CELL LUNG CANCER ( 25 patients )
COLORECTAL CANCER METASTATIC ( 22 patients )
RENAL CANCER ( 17 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 14 patients )
BILE DUCT CANCER ( 14 patients )
SALIVARY GLAND CANCER ( 7 patients )
HEPATIC CANCER METASTATIC ( 7 patients )
COLORECTAL CANCER ( 7 patients )
SMALL CELL LUNG CANCER STAGE UNSPECIFIED ( 6 patients )
RECTAL CANCER ( 5 patients )
PANCREATIC CARCINOMA ( 4 patients )
PROSTATE CANCER ( 4 patients )
INTRAOCULAR MELANOMA ( 4 patients )
HEPATIC NEOPLASM MALIGNANT RECURRENT ( 3 patients )
NEOPLASM ( 3 patients )
LIVER DISORDER ( 3 patients )
ANGIOSARCOMA ( 3 patients )
NON-SMALL CELL LUNG CANCER STAGE IV ( 3 patients )
METASTASES TO LUNG ( 3 patients )
HEPATIC NEOPLASM MALIGNANT NON-RESECTABLE ( 3 patients )
COLORECTAL CANCER STAGE IV ( 3 patients )
NEOPLASM MALIGNANT ( 3 patients )
GALLBLADDER CANCER METASTATIC ( 3 patients )
METASTASIS ( 3 patients )
BILIARY CANCER METASTATIC ( 3 patients )
COLON CANCER METASTATIC ( 2 patients )
HYPOPHARYNGEAL CANCER ( 2 patients )
DESMOID TUMOUR ( 2 patients )
NEUROENDOCRINE CARCINOMA ( 2 patients )
LUNG NEOPLASM MALIGNANT ( 2 patients )
ACUTE MYELOID LEUKAEMIA (IN REMISSION) ( 2 patients )
OESOPHAGEAL CARCINOMA ( 2 patients )
METASTATIC MALIGNANT MELANOMA ( 2 patients )
TONGUE NEOPLASM MALIGNANT STAGE UNSPECIFIED ( 2 patients )
METASTATIC SQUAMOUS CELL CARCINOMA ( 2 patients )
RENAL CELL CARCINOMA STAGE IV ( 2 patients )
ANGINA PECTORIS ( 2 patients )
OSTEOSARCOMA METASTATIC ( 2 patients )
METASTATIC OCULAR MELANOMA ( 2 patients )
BONE SARCOMA ( 2 patients )
METASTATIC SALIVARY GLAND CANCER ( 2 patients )
TONSIL CANCER ( 2 patients )
MYELODYSPLASTIC SYNDROME ( 1 patients )
PROSTATE CANCER METASTATIC ( 1 patients )
GALLBLADDER CANCER ( 1 patients )
NEUROENDOCRINE TUMOUR ( 1 patients )
MALIGNANT NEOPLASM OF RENAL PELVIS ( 1 patients )
GLIOMA ( 1 patients )
BLADDER CANCER ( 1 patients )
OVARIAN CANCER METASTATIC ( 1 patients )
CAROTID ARTERY DISEASE ( 1 patients )
HEPATOBLASTOMA ( 1 patients )
NASOPHARYNGEAL CANCER ( 1 patients )
LUNG ADENOCARCINOMA ( 1 patients )
RENAL CANCER METASTATIC ( 1 patients )
ACUTE MYELOID LEUKAEMIA ( 1 patients )
DIFFUSE LARGE B-CELL LYMPHOMA ( 1 patients )
NEUROENDOCRINE CARCINOMA OF THE SKIN ( 1 patients )
MALIGNANT HISTIOCYTOSIS ( 1 patients )
MALIGNANT SOFT TISSUE NEOPLASM ( 1 patients )
SARCOMA ( 1 patients )
ANTICOAGULANT THERAPY ( 1 patients )
GERM CELL CANCER ( 1 patients )
OESOPHAGEAL ADENOCARCINOMA ( 1 patients )
SQUAMOUS CELL CARCINOMA ( 1 patients )
HEAD AND NECK CANCER ( 1 patients )
OVARIAN EPITHELIAL CANCER ( 1 patients )
( 0 patients )

Drugs with high FDA adverse event association with FEAR:

TRASYLOL (11184 patients)
HEPARIN (2772 patients)
LASIX (1958 patients)
YAZ (1697 patients)
METOCLOPRAMIDE (1675 patients)
YASMIN (1591 patients)
PROTAMINE SULFATE (1508 patients)
NITROGLYCERIN (1397 patients)
RED BLOOD CELLS (1250 patients)
ACETYLSALICYLIC ACID SRT (1220 patients)
VERSED (1057 patients)
ASPIRIN (933 patients)
VANCOMYCIN (921 patients)
FENTANYL (911 patients)
LIPITOR (886 patients)
LISINOPRIL (809 patients)
INSULIN (789 patients)
PLATELETS (787 patients)
PLAVIX (739 patients)
MANNITOL (699 patients)
CHANTIX (667 patients)
EPINEPHRINE (658 patients)
FORTEO (655 patients)
ANCEF (615 patients)
DOPAMINE HCL (610 patients)
COUMADIN (591 patients)
LIDOCAINE (579 patients)
TOPROL-XL (572 patients)
NORVASC (571 patients)
DIGOXIN (565 patients)
ZOCOR (537 patients)
VIOXX (535 patients)
ATENOLOL (530 patients)
FOSAMAX (525 patients)
SYNTHROID (519 patients)
FRESH FROZEN PLASMA (503 patients)
LOPRESSOR (473 patients)
AMIODARONE HCL (458 patients)
MILRINONE (447 patients)
DROSPIRENONE AND ETHINYL ESTRADIOL (431 patients)
SEROQUEL (421 patients)
LEVOPHED (417 patients)
FUROSEMIDE (413 patients)
XANAX (412 patients)
ALBUMIN (HUMAN) (401 patients)
HYDROCHLOROTHIAZIDE (399 patients)
ZOLOFT (399 patients)
PROPOFOL (394 patients)
PAXIL (381 patients)
COREG (372 patients)
CYMBALTA (363 patients)
POTASSIUM CHLORIDE (363 patients)
SODIUM BICARBONATE (359 patients)
IBUPROFEN (349 patients)
PROTONIX (344 patients)
CALCIUM CHLORIDE (338 patients)
METOPROLOL TARTRATE (326 patients)
LYRICA (322 patients)
NEURONTIN (321 patients)
ACCUTANE (308 patients)
AVONEX (307 patients)
LEVAQUIN (304 patients)
SINGULAIR (300 patients)
CEFAZOLIN (296 patients)
PLASMA (294 patients)
CELEBREX (293 patients)
NEXIUM (289 patients)
PHENYLEPHRINE HCL (285 patients)
LEXAPRO (282 patients)
PRILOSEC (280 patients)
PREVACID (276 patients)
SIMVASTATIN (273 patients)
DIOVAN (271 patients)
CONTRAST MEDIA (269 patients)
AMBIEN (268 patients)
ACETAMINOPHEN (266 patients)
LOVENOX (266 patients)
ATIVAN (256 patients)
SOLU-MEDROL (254 patients)
MAGNESIUM SULFATE (249 patients)
AMICAR (249 patients)
MORPHINE (248 patients)
LORAZEPAM (244 patients)
PREDNISONE (238 patients)
DOBUTAMINE HCL (229 patients)
IMDUR (229 patients)
MIRAPEX (228 patients)
PAVULON (226 patients)
PROZAC (225 patients)
CLONAZEPAM (221 patients)
METFORMIN HCL (220 patients)
KLONOPIN (218 patients)
ALBUTEROL (218 patients)
SPIRONOLACTONE (216 patients)
LANTUS (216 patients)
ETOMIDATE (211 patients)
LEVOTHYROXINE SODIUM (211 patients)
HUMALOG (209 patients)
CLONIDINE (209 patients)
ZINACEF (207 patients)
EFFEXOR XR (203 patients)
MIDAZOLAM HCL (202 patients)
METOPROLOL (200 patients)
AVANDIA (199 patients)
WELLBUTRIN (198 patients)
ALPRAZOLAM (194 patients)
OMEPRAZOLE (192 patients)
COZAAR (190 patients)
BENADRYL (190 patients)
ZYPREXA (187 patients)
PROTAMINE (186 patients)
EFFEXOR (186 patients)
VASOPRESSIN (184 patients)
PRIMACOR (183 patients)
ALTACE (182 patients)
GLUCOPHAGE (178 patients)
ZESTRIL (174 patients)
GLYBURIDE (173 patients)
DIAZEPAM (171 patients)
ADVAIR DISKUS 100/50 (171 patients)
CELEXA (171 patients)
VICODIN (171 patients)
CARDIZEM (166 patients)
LANOXIN (166 patients)
ALLOPURINOL (165 patients)
CEFUROXIME (160 patients)
VECURONIUM BROMIDE (159 patients)
AMIODARONE (159 patients)
GLIPIZIDE (158 patients)
HEPARIN SODIUM (158 patients)
GABAPENTIN (156 patients)
TOPAMAX (153 patients)
NIPRIDE (152 patients)
ACTOS (151 patients)
MOTRIN (151 patients)
PERCOCET (150 patients)
CARDIOPLEGIA (150 patients)
LORTAB (149 patients)
MIDAZOLAM (149 patients)
PEPCID (149 patients)
FENTANYL-100 (147 patients)
NOREPINEPHRINE BITARTRATE (147 patients)
ZANTAC (145 patients)
CRESTOR (145 patients)
OMNIPAQUE 140 (145 patients)
MULTI-VITAMIN (144 patients)
VALIUM (143 patients)
PAPAVERINE (143 patients)
CALCIUM (142 patients)
ENALAPRIL MALEATE (141 patients)
FLEXERIL (140 patients)
NAPROXEN (140 patients)
BUMEX (139 patients)
AMOXICILLIN (139 patients)
TRAZODONE HCL (138 patients)
VITAMIN D (138 patients)
PANCURONIUM BROMIDE (136 patients)
REGLAN (135 patients)
SUCCINYLCHOLINE CHLORIDE (135 patients)
ZYRTEC (134 patients)
PAROXETINE HCL (134 patients)
TYSABRI (133 patients)
METOPROLOL SUCCINATE (131 patients)
ACCUPRIL (128 patients)
ZETIA (128 patients)
LOVASTATIN (126 patients)
CRYOPRECIPITATES (126 patients)
INSULIN [INSULIN] (126 patients)
FOLIC ACID (126 patients)
DOBUTAMINE HYDROCHLORIDE (125 patients)
VYTORIN (122 patients)
REQUIP (121 patients)
CEPHALEXIN (120 patients)
GENTAMICIN (120 patients)
DARVOCET (120 patients)
FLUOXETINE (119 patients)
ZAROXOLYN (119 patients)
PREMARIN (118 patients)
HYDRALAZINE HCL (114 patients)
ALDACTONE (114 patients)
HEPARIN SODIUM INJECTION (113 patients)
TRICOR (111 patients)
AMITRIPTYLINE HCL (111 patients)
WARFARIN SODIUM (111 patients)
LAMICTAL (110 patients)
DOPAMINE (110 patients)
OXYCONTIN (110 patients)
ABILIFY (109 patients)
CITALOPRAM HYDROBROMIDE (109 patients)
DURAGESIC-100 (109 patients)
RISPERDAL (109 patients)
SERTRALINE HYDROCHLORIDE (109 patients)
ALLI (109 patients)
AMLODIPINE (109 patients)
ALLEGRA (109 patients)
PRAVACHOL (108 patients)
AVAPRO (108 patients)
NEO-SYNEPHRINOL (107 patients)
VITAMIN E (107 patients)
POTASSIUM (107 patients)
ASCORBIC ACID (106 patients)
DILTIAZEM (105 patients)
LEVOXYL (105 patients)
VERAPAMIL (105 patients)
CIPROFLOXACIN (105 patients)
TEMAZEPAM (105 patients)
MULTI-VITAMINS (104 patients)
AVELOX (102 patients)
ZITHROMAX (102 patients)
TOPIRAMATE (101 patients)

Most common side effects for patients taking SORAFENIB (RAF KINASE INHIBITOR):

DIARRHOEA (613 patients)
HEPATIC FAILURE (378 patients)
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME (342 patients)
HEPATIC ENCEPHALOPATHY (320 patients)
FATIGUE (300 patients)
RASH (276 patients)
ASCITES (253 patients)
ABDOMINAL PAIN (237 patients)
DECREASED APPETITE (226 patients)
UPPER GASTROINTESTINAL HAEMORRHAGE (198 patients)
PYREXIA (191 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (179 patients)
NAUSEA (165 patients)
HYPERTENSION (160 patients)
ASTHENIA (154 patients)
DEHYDRATION (140 patients)
HEPATIC FUNCTION ABNORMAL (133 patients)
DYSPNOEA (131 patients)
CONFUSIONAL STATE (131 patients)
HYPOKALAEMIA (125 patients)
ALOPECIA (124 patients)
VOMITING (118 patients)
CONSTIPATION (115 patients)
INTERSTITIAL LUNG DISEASE (114 patients)
LEFT VENTRICULAR DYSFUNCTION (113 patients)
DEATH (113 patients)
ENDOCARDITIS (112 patients)
ARTHRALGIA (111 patients)
STOMATITIS (111 patients)
ABDOMINAL PAIN UPPER (110 patients)
JAUNDICE (108 patients)
HEPATIC NEOPLASM MALIGNANT (106 patients)
GASTROINTESTINAL HAEMORRHAGE (106 patients)
RETINAL VASCULAR THROMBOSIS (103 patients)
LOWER GASTROINTESTINAL HAEMORRHAGE (103 patients)
LIVER CARCINOMA RUPTURED (101 patients)
OEDEMA PERIPHERAL (97 patients)
PLEURAL EFFUSION (97 patients)
STAPHYLOCOCCAL INFECTION (96 patients)
PNEUMONIA BACTERIAL (96 patients)
ENTEROBACTER INFECTION (96 patients)
MYOPATHY (95 patients)
DRY MOUTH (94 patients)
PAIN IN EXTREMITY (93 patients)
ANXIETY (90 patients)
MALAISE (89 patients)
PULMONARY EMBOLISM (85 patients)
ANAEMIA (84 patients)
PLATELET COUNT DECREASED (81 patients)
BACK PAIN (79 patients)
SEPSIS (78 patients)
PRURITUS (78 patients)
DUODENAL ULCER (77 patients)
MIGRAINE (76 patients)
MITRAL VALVE INCOMPETENCE (76 patients)
HYPOGLYCAEMIA (76 patients)
C-REACTIVE PROTEIN INCREASED (74 patients)
BLOOD PRESSURE INCREASED (73 patients)
VARICES OESOPHAGEAL (73 patients)
HEADACHE (72 patients)
RETINAL VEIN OCCLUSION (72 patients)
ABASIA (69 patients)
RENAL FAILURE ACUTE (69 patients)
WEIGHT DECREASED (67 patients)
DEEP VEIN THROMBOSIS (67 patients)
DIZZINESS (65 patients)
ERYTHEMA (65 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (64 patients)
CONVULSION (63 patients)
ALANINE AMINOTRANSFERASE INCREASED (62 patients)
DYSPHONIA (62 patients)
CEREBRAL HAEMORRHAGE (60 patients)
APHAGIA (58 patients)
COLITIS (58 patients)
PNEUMONIA (57 patients)
GASTRIC ULCER (56 patients)
HYPONATRAEMIA (55 patients)
HAEMOGLOBIN DECREASED (53 patients)
RESPIRATORY FAILURE (52 patients)
LUNG DISORDER (52 patients)
CEREBRAL ISCHAEMIA (49 patients)
PARAESTHESIA (49 patients)
BLOOD BILIRUBIN INCREASED (48 patients)
GAIT DISTURBANCE (48 patients)
THYROID CANCER METASTATIC (44 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (43 patients)
PERICARDIAL EFFUSION (41 patients)
THROMBOCYTOPENIA (41 patients)
BLISTER (41 patients)
FEBRILE NEUTROPENIA (40 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (40 patients)
HALLUCINATION (40 patients)
CHILLS (40 patients)
AMMONIA INCREASED (39 patients)
SKIN ULCER (39 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (38 patients)
PAIN (38 patients)
HYPOALBUMINAEMIA (38 patients)
HYPOCALCAEMIA (37 patients)
FALL (37 patients)
POLLAKIURIA (37 patients)
BLOOD PRESSURE DECREASED (37 patients)
SKIN EXFOLIATION (37 patients)
INSOMNIA (36 patients)
CARDIAC ARREST (36 patients)
HYPOAESTHESIA (35 patients)
INFECTIOUS PERITONITIS (35 patients)
MYOCARDIAL INFARCTION (35 patients)
RETINAL VASCULAR DISORDER (34 patients)
RENAL FAILURE (34 patients)
LIPASE INCREASED (34 patients)
HYPERKALAEMIA (33 patients)
HYPERGLYCAEMIA (33 patients)
HAEMOPTYSIS (31 patients)
ATRIAL FIBRILLATION (30 patients)
GENERALISED OEDEMA (30 patients)
FAECAL INCONTINENCE (30 patients)
WHITE BLOOD CELL COUNT DECREASED (30 patients)
CELLULITIS (29 patients)
CHEST PAIN (29 patients)
SOMNOLENCE (29 patients)
HYPERBILIRUBINAEMIA (28 patients)
HYPOTENSION (28 patients)
MUSCLE SPASMS (28 patients)
ABDOMINAL DISTENSION (27 patients)
WHITE BLOOD CELL COUNT INCREASED (27 patients)
VISION BLURRED (27 patients)
HEPATIC PAIN (26 patients)
BLOOD ALBUMIN DECREASED (26 patients)
DYSURIA (25 patients)
RASH GENERALISED (25 patients)
BLOOD SODIUM DECREASED (25 patients)
BLOOD URIC ACID INCREASED (25 patients)
COMA (25 patients)
COUGH (25 patients)
PANCYTOPENIA (25 patients)
ACUTE ABDOMEN (24 patients)
EOSINOPHIL COUNT INCREASED (24 patients)
CEREBROVASCULAR ACCIDENT (24 patients)
METASTASES TO CENTRAL NERVOUS SYSTEM (23 patients)
CEREBRAL INFARCTION (23 patients)
HYPOMAGNESAEMIA (23 patients)
RETINAL VEIN THROMBOSIS (23 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (23 patients)
TUMOUR LYSIS SYNDROME (22 patients)
HYPOPHOSPHATAEMIA (22 patients)
INFECTION (22 patients)
ORAL PAIN (22 patients)
BLOOD CREATININE INCREASED (22 patients)
NEUTROPENIA (22 patients)
RENAL IMPAIRMENT (22 patients)
LETHARGY (22 patients)
SKIN TOXICITY (21 patients)
TONGUE BLISTERING (21 patients)
LIVER ABSCESS (21 patients)
HAEMATEMESIS (21 patients)
OESOPHAGEAL VARICES HAEMORRHAGE (20 patients)
MENTAL IMPAIRMENT (20 patients)
NERVOUSNESS (20 patients)
NEPHROTIC SYNDROME (20 patients)
HYPOPHAGIA (20 patients)
ADRENAL INSUFFICIENCY (19 patients)
DRY SKIN (19 patients)
BLOOD AMYLASE INCREASED (19 patients)
OEDEMA (19 patients)
INFECTIOUS PLEURAL EFFUSION (19 patients)
DYSPEPSIA (19 patients)
COMA HEPATIC (19 patients)
HEART RATE INCREASED (18 patients)
HYPERTENSIVE CRISIS (18 patients)
MYALGIA (18 patients)
ECZEMA (18 patients)
URINARY TRACT INFECTION (18 patients)
NEUROMYOPATHY (18 patients)
MEDICAL DEVICE COMPLICATION (18 patients)
DIVERTICULITIS (18 patients)
OSTEOMYELITIS (18 patients)
CEREBRAL ATROPHY (18 patients)
CEREBRAL VENTRICLE DILATATION (18 patients)
DIABETIC FOOT INFECTION (18 patients)
NECK PAIN (18 patients)
OLIGURIA (17 patients)
GASTROINTESTINAL DISORDER (17 patients)
HAEMATOCHEZIA (17 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (17 patients)
HYPOTHYROIDISM (17 patients)
TRANSAMINASES INCREASED (17 patients)
OROPHARYNGEAL PAIN (17 patients)
CHRONIC MYELOID LEUKAEMIA (17 patients)
NEOPLASM PROGRESSION (17 patients)
METASTASES TO ADRENALS (16 patients)
LYMPHOCYTE COUNT DECREASED (16 patients)
INTERNATIONAL NORMALISED RATIO INCREASED (16 patients)
MULTI-ORGAN FAILURE (16 patients)
FEAR (16 patients)
PANCREATIC CARCINOMA (16 patients)
HYPERSOMNIA (16 patients)
EPILEPSY (16 patients)
SUBARACHNOID HAEMORRHAGE (16 patients)
METASTASES TO LUNG (16 patients)
TACHYCARDIA (16 patients)
MUSCULAR WEAKNESS (16 patients)
KLEBSIELLA SEPSIS (16 patients)
MYOCARDIAL ISCHAEMIA (16 patients)
DYSGEUSIA (16 patients)
LUNG INFECTION (16 patients)
FAECES DISCOLOURED (16 patients)
PAIN OF SKIN (16 patients)
SPINAL FRACTURE (16 patients)
PANIC REACTION (16 patients)

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