Is HEPATIC FAILURE a side effect of SORAFENIB (RAF KINASE INHIBITOR) ? ( FactMed.com )

About this FactMed analysis covering adverse side effect reports of SORAFENIB (RAF KINASE INHIBITOR) patients who developed HEPATIC FAILURE.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 378 individuals taking SORAFENIB (RAF KINASE INHIBITOR) reported HEPATIC FAILURE to the FDA. A total of 3329 SORAFENIB (RAF KINASE INHIBITOR) drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between SORAFENIB (RAF KINASE INHIBITOR) and HEPATIC FAILURE. In doing so, we compare SORAFENIB (RAF KINASE INHIBITOR) with other drugs that cause HEPATIC FAILURE, to help you evaluate whether or not SORAFENIB (RAF KINASE INHIBITOR) causes HEPATIC FAILURE. Likewise, this page shows the most highly-reported side effects of SORAFENIB (RAF KINASE INHIBITOR), so you can see if HEPATIC FAILURE ranks among SORAFENIB (RAF KINASE INHIBITOR)'s most well-known side effects.

Summary Statistics
Reports of SORAFENIB (RAF KINASE INHIBITOR) causing HEPATIC FAILURE: 378
Reports of any side effect of SORAFENIB (RAF KINASE INHIBITOR) : 3329
Percentage of SORAFENIB (RAF KINASE INHIBITOR) patients where HEPATIC FAILURE is a reported side effect: 11.3548%

FDA reports of any drug causing HEPATIC FAILURE : 14485
Average percentage for all medicated patients where HEPATIC FAILURE is reported as a complication: 0.0908%

Physician opinion on SORAFENIB (RAF KINASE INHIBITOR) as adverse event culprit:

Overall opinion for all reports of this drug:

Most frequent diagnoses/indications for prescribing SORAFENIB (RAF KINASE INHIBITOR):

HEPATIC NEOPLASM MALIGNANT ( 770 patients )
RENAL CELL CARCINOMA ( 114 patients )
THYROID CANCER ( 65 patients )
METASTATIC RENAL CELL CARCINOMA ( 44 patients )
THYROID CANCER METASTATIC ( 35 patients )
BREAST CANCER ( 31 patients )
BREAST CANCER METASTATIC ( 27 patients )
GASTRIC CANCER ( 25 patients )
NON-SMALL CELL LUNG CANCER ( 25 patients )
COLORECTAL CANCER METASTATIC ( 22 patients )
RENAL CANCER ( 17 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 14 patients )
BILE DUCT CANCER ( 14 patients )
SALIVARY GLAND CANCER ( 7 patients )
HEPATIC CANCER METASTATIC ( 7 patients )
COLORECTAL CANCER ( 7 patients )
SMALL CELL LUNG CANCER STAGE UNSPECIFIED ( 6 patients )
RECTAL CANCER ( 5 patients )
PANCREATIC CARCINOMA ( 4 patients )
PROSTATE CANCER ( 4 patients )
INTRAOCULAR MELANOMA ( 4 patients )
HEPATIC NEOPLASM MALIGNANT RECURRENT ( 3 patients )
NEOPLASM ( 3 patients )
LIVER DISORDER ( 3 patients )
ANGIOSARCOMA ( 3 patients )
NON-SMALL CELL LUNG CANCER STAGE IV ( 3 patients )
METASTASES TO LUNG ( 3 patients )
HEPATIC NEOPLASM MALIGNANT NON-RESECTABLE ( 3 patients )
COLORECTAL CANCER STAGE IV ( 3 patients )
NEOPLASM MALIGNANT ( 3 patients )
GALLBLADDER CANCER METASTATIC ( 3 patients )
BILIARY CANCER METASTATIC ( 3 patients )
METASTASIS ( 3 patients )
COLON CANCER METASTATIC ( 2 patients )
HYPOPHARYNGEAL CANCER ( 2 patients )
DESMOID TUMOUR ( 2 patients )
NEUROENDOCRINE CARCINOMA ( 2 patients )
ACUTE MYELOID LEUKAEMIA (IN REMISSION) ( 2 patients )
LUNG NEOPLASM MALIGNANT ( 2 patients )
OESOPHAGEAL CARCINOMA ( 2 patients )
METASTATIC MALIGNANT MELANOMA ( 2 patients )
TONGUE NEOPLASM MALIGNANT STAGE UNSPECIFIED ( 2 patients )
METASTATIC SQUAMOUS CELL CARCINOMA ( 2 patients )
ANGINA PECTORIS ( 2 patients )
RENAL CELL CARCINOMA STAGE IV ( 2 patients )
OSTEOSARCOMA METASTATIC ( 2 patients )
BONE SARCOMA ( 2 patients )
METASTATIC OCULAR MELANOMA ( 2 patients )
METASTATIC SALIVARY GLAND CANCER ( 2 patients )
TONSIL CANCER ( 2 patients )
MYELODYSPLASTIC SYNDROME ( 1 patients )
PROSTATE CANCER METASTATIC ( 1 patients )
GALLBLADDER CANCER ( 1 patients )
NEUROENDOCRINE TUMOUR ( 1 patients )
MALIGNANT NEOPLASM OF RENAL PELVIS ( 1 patients )
GLIOMA ( 1 patients )
BLADDER CANCER ( 1 patients )
OVARIAN CANCER METASTATIC ( 1 patients )
CAROTID ARTERY DISEASE ( 1 patients )
HEPATOBLASTOMA ( 1 patients )
NASOPHARYNGEAL CANCER ( 1 patients )
ACUTE MYELOID LEUKAEMIA ( 1 patients )
LUNG ADENOCARCINOMA ( 1 patients )
RENAL CANCER METASTATIC ( 1 patients )
DIFFUSE LARGE B-CELL LYMPHOMA ( 1 patients )
NEUROENDOCRINE CARCINOMA OF THE SKIN ( 1 patients )
MALIGNANT HISTIOCYTOSIS ( 1 patients )
ANTICOAGULANT THERAPY ( 1 patients )
MALIGNANT SOFT TISSUE NEOPLASM ( 1 patients )
SARCOMA ( 1 patients )
GERM CELL CANCER ( 1 patients )
OESOPHAGEAL ADENOCARCINOMA ( 1 patients )
SQUAMOUS CELL CARCINOMA ( 1 patients )
HEAD AND NECK CANCER ( 1 patients )
OVARIAN EPITHELIAL CANCER ( 1 patients )
( 0 patients )

Drugs with high FDA adverse event association with HEPATIC FAILURE:

ACETAMINOPHEN (1285 patients)
HEPARIN SODIUM INJECTION (1219 patients)
LASIX (812 patients)
ASPIRIN (714 patients)
NEXAVAR (639 patients)
FUROSEMIDE (561 patients)
PREDNISOLONE (514 patients)
METHOTREXATE (504 patients)
PREDNISONE (499 patients)
OMEPRAZOLE (457 patients)
CYCLOPHOSPHAMIDE (412 patients)
HEPARIN SODIUM 5,000 UNITS IN DEXTROSE 5% (393 patients)
REMICADE (385 patients)
SORAFENIB (RAF KINASE INHIBITOR) (378 patients)
LIPITOR (360 patients)
IBUPROFEN (339 patients)
SPIRONOLACTONE (338 patients)
AVANDIA (325 patients)
ALDACTONE (321 patients)
ALLOPURINOL (317 patients)
PARACETAMOL (311 patients)
POTASSIUM CHLORIDE (300 patients)
LEVOTHYROXINE SODIUM (285 patients)
HUMIRA (276 patients)
DEXAMETHASONE (257 patients)
HEPARIN SODIUM (257 patients)
CYCLOSPORINE (253 patients)
CIPROFLOXACIN (252 patients)
CYMBALTA (249 patients)
INSULIN (247 patients)
LAMIVUDINE (245 patients)
PROGRAF (241 patients)
LACTULOSE (236 patients)
NEXIUM (235 patients)
KETEK (235 patients)
LISINOPRIL (234 patients)
DIGOXIN (231 patients)
RIBAVIRIN (231 patients)
DOXORUBICIN HCL (230 patients)
FLUOROURACIL (228 patients)
VANCOMYCIN (227 patients)
NORVASC (224 patients)
FLUCONAZOLE (223 patients)
FOLIC ACID (223 patients)
SEROQUEL (214 patients)
METFORMIN HCL (213 patients)
ATENOLOL (212 patients)
URSO 250 (211 patients)
NEURONTIN (204 patients)
FENTANYL (204 patients)
PLAVIX (203 patients)
LORAZEPAM (201 patients)
PREDNISONE TAB (199 patients)
TYLENOL (CAPLET) (197 patients)
SIMVASTATIN (193 patients)
COUMADIN (193 patients)
AVONEX (192 patients)
HEPARIN (191 patients)
EXJADE (191 patients)
FAMOTIDINE (188 patients)
TYLENOL (184 patients)
EXTRA STRENGTH TYLENOL (183 patients)
SYNTHROID (181 patients)
AMBIEN (179 patients)
ZYPREXA (178 patients)
ZOCOR (177 patients)
VIOXX (176 patients)
ALBUTEROL (175 patients)
MORPHINE (175 patients)
METHYLPREDNISOLONE (175 patients)
BACTRIM (174 patients)
OXALIPLATIN (174 patients)
VINCRISTINE (174 patients)
SOLU-MEDROL (171 patients)
TACROLIMUS (171 patients)
LANSOPRAZOLE (169 patients)
HYDROCHLOROTHIAZIDE (166 patients)
AVASTIN (164 patients)
WARFARIN SODIUM (163 patients)
ZOMETA (163 patients)
RAMIPRIL (163 patients)
OXYCONTIN (161 patients)
KALETRA (159 patients)
CYTARABINE (159 patients)
XANAX (159 patients)
ACYCLOVIR (159 patients)
PEG-INTRON (157 patients)
XELODA (156 patients)
LEVAQUIN (152 patients)
TRACLEER (152 patients)
PROPOFOL (152 patients)
AVELOX (151 patients)
METRONIDAZOLE (150 patients)
REVLIMID (150 patients)
MYCOPHENOLATE MOFETIL (148 patients)
DECADRON (144 patients)
CAPECITABINE (144 patients)
PEGASYS (143 patients)
PROTONIX (143 patients)
TRAMADOL HCL (141 patients)
ZANTAC (140 patients)
MORPHINE SULFATE (139 patients)
PANTOPRAZOLE (137 patients)
SANDOSTATIN LAR (136 patients)
METOPROLOL TARTRATE (136 patients)
NEORAL (136 patients)
ALPRAZOLAM (136 patients)
PACLITAXEL (135 patients)
GEMZAR (134 patients)
OXYCODONE HCL (134 patients)
PANTOPRAZOLE SODIUM (132 patients)
CRESTOR (131 patients)
ATORVASTATIN CALCIUM (131 patients)
GLUCOPHAGE (131 patients)
PREVACID (130 patients)
GLEEVEC (130 patients)
SUTENT (127 patients)
RANITIDINE (127 patients)
BLINDED SORAFENIB (RAF KINASE INHIBITOR) (126 patients)
METOCLOPRAMIDE (125 patients)
SORAFENIB (124 patients)
LANTUS (123 patients)
ZOLOFT (123 patients)
TOPROL-XL (123 patients)
DIOVAN (122 patients)
RITUXIMAB (122 patients)
ARAVA (121 patients)
REBETOL (119 patients)
LEVOFLOXACIN (119 patients)
AUGMENTIN '125' (118 patients)
PAXIL (118 patients)
DIDANOSINE (118 patients)
CLONAZEPAM (116 patients)
CLARITHROMYCIN (116 patients)
EFFEXOR (115 patients)
AMARYL (113 patients)
ZOFRAN (112 patients)
PERCOCET (112 patients)
GABAPENTIN (112 patients)
NITROGLYCERIN (110 patients)
ACCUTANE (110 patients)
CISPLATIN (110 patients)
MAGNESIUM OXIDE (109 patients)
PRILOSEC (109 patients)
ADVAIR DISKUS 100/50 (108 patients)
LAMICTAL (108 patients)
PHENYTOIN (107 patients)
AMLODIPINE (106 patients)
ATIVAN (104 patients)
AMIODARONE HCL (103 patients)
ENALAPRIL MALEATE (103 patients)
MULTI-VITAMINS (103 patients)
VELCADE (102 patients)
DOCETAXEL (101 patients)
MUCOSTA (100 patients)
DIFLUCAN (99 patients)
DURAGESIC-100 (99 patients)
FLUDARA (98 patients)
FLUDARABINE PHOSPHATE (98 patients)
^BLOOD BOTTLES^ (98 patients)
AMOXICILLIN (98 patients)
NEVIRAPINE (97 patients)
PREDONINE (97 patients)
VOLTAREN (97 patients)
LOVENOX (95 patients)
ENBREL (94 patients)
TRUVADA (94 patients)
CELLCEPT (94 patients)
PROPRANOLOL (94 patients)
RITONAVIR (94 patients)
CELEBREX (93 patients)
KEPPRA (93 patients)
CARBOPLATIN (93 patients)
SOLIRIS (93 patients)
HERCEPTIN (92 patients)
ETOPOSIDE (92 patients)
SANDIMMUNE (92 patients)
ACETYLCYSTEINE (92 patients)
ZITHROMAX (92 patients)
METOPROLOL (91 patients)
TRASYLOL (91 patients)
VICODIN (91 patients)
TAXOTERE (91 patients)
MEROPENEM (90 patients)
LEXAPRO (90 patients)
MEK INHIBITOR (DIHYDROXYPROP-DIFLU-METHOXYPHEN-CYCLOPROPA-SULFAMI) (90 patients)
HYDROCORTISONE (89 patients)
RITUXAN (89 patients)
NYSTATIN (89 patients)
CAMPATH (88 patients)
BEVACIZUMAB (88 patients)
VALPROATE SODIUM (87 patients)
VITAMIN D (86 patients)
GLYBURIDE (86 patients)
ZETIA (86 patients)
LIVACT (86 patients)
CORDARONE (86 patients)
SODIUM CHLORIDE (85 patients)
URSODIOL (85 patients)
FERROUS SULFATE TAB (85 patients)
ISONIAZID (85 patients)
ALBUMIN (HUMAN) (85 patients)
SUNITINIB MALATE (85 patients)
PEPCID (85 patients)
GASMOTIN (84 patients)
ARANESP (84 patients)
BENADRYL (84 patients)
METHADONE HCL (84 patients)
RIFAMPICIN (83 patients)
VIREAD (83 patients)

Most common side effects for patients taking SORAFENIB (RAF KINASE INHIBITOR):

DIARRHOEA (613 patients)
HEPATIC FAILURE (378 patients)
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME (342 patients)
HEPATIC ENCEPHALOPATHY (320 patients)
FATIGUE (300 patients)
RASH (276 patients)
ASCITES (253 patients)
ABDOMINAL PAIN (237 patients)
DECREASED APPETITE (226 patients)
UPPER GASTROINTESTINAL HAEMORRHAGE (198 patients)
PYREXIA (191 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (179 patients)
NAUSEA (165 patients)
HYPERTENSION (160 patients)
ASTHENIA (154 patients)
DEHYDRATION (140 patients)
HEPATIC FUNCTION ABNORMAL (133 patients)
DYSPNOEA (131 patients)
CONFUSIONAL STATE (131 patients)
HYPOKALAEMIA (125 patients)
ALOPECIA (124 patients)
VOMITING (118 patients)
CONSTIPATION (115 patients)
INTERSTITIAL LUNG DISEASE (114 patients)
LEFT VENTRICULAR DYSFUNCTION (113 patients)
DEATH (113 patients)
ENDOCARDITIS (112 patients)
ARTHRALGIA (111 patients)
STOMATITIS (111 patients)
ABDOMINAL PAIN UPPER (110 patients)
JAUNDICE (108 patients)
HEPATIC NEOPLASM MALIGNANT (106 patients)
GASTROINTESTINAL HAEMORRHAGE (106 patients)
RETINAL VASCULAR THROMBOSIS (103 patients)
LOWER GASTROINTESTINAL HAEMORRHAGE (103 patients)
LIVER CARCINOMA RUPTURED (101 patients)
OEDEMA PERIPHERAL (97 patients)
PLEURAL EFFUSION (97 patients)
STAPHYLOCOCCAL INFECTION (96 patients)
PNEUMONIA BACTERIAL (96 patients)
ENTEROBACTER INFECTION (96 patients)
MYOPATHY (95 patients)
DRY MOUTH (94 patients)
PAIN IN EXTREMITY (93 patients)
ANXIETY (90 patients)
MALAISE (89 patients)
PULMONARY EMBOLISM (85 patients)
ANAEMIA (84 patients)
PLATELET COUNT DECREASED (81 patients)
BACK PAIN (79 patients)
SEPSIS (78 patients)
PRURITUS (78 patients)
DUODENAL ULCER (77 patients)
MIGRAINE (76 patients)
MITRAL VALVE INCOMPETENCE (76 patients)
HYPOGLYCAEMIA (76 patients)
C-REACTIVE PROTEIN INCREASED (74 patients)
BLOOD PRESSURE INCREASED (73 patients)
VARICES OESOPHAGEAL (73 patients)
HEADACHE (72 patients)
RETINAL VEIN OCCLUSION (72 patients)
ABASIA (69 patients)
RENAL FAILURE ACUTE (69 patients)
WEIGHT DECREASED (67 patients)
DEEP VEIN THROMBOSIS (67 patients)
DIZZINESS (65 patients)
ERYTHEMA (65 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (64 patients)
CONVULSION (63 patients)
ALANINE AMINOTRANSFERASE INCREASED (62 patients)
DYSPHONIA (62 patients)
CEREBRAL HAEMORRHAGE (60 patients)
APHAGIA (58 patients)
COLITIS (58 patients)
PNEUMONIA (57 patients)
GASTRIC ULCER (56 patients)
HYPONATRAEMIA (55 patients)
HAEMOGLOBIN DECREASED (53 patients)
RESPIRATORY FAILURE (52 patients)
LUNG DISORDER (52 patients)
CEREBRAL ISCHAEMIA (49 patients)
PARAESTHESIA (49 patients)
BLOOD BILIRUBIN INCREASED (48 patients)
GAIT DISTURBANCE (48 patients)
THYROID CANCER METASTATIC (44 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (43 patients)
PERICARDIAL EFFUSION (41 patients)
THROMBOCYTOPENIA (41 patients)
BLISTER (41 patients)
FEBRILE NEUTROPENIA (40 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (40 patients)
HALLUCINATION (40 patients)
CHILLS (40 patients)
AMMONIA INCREASED (39 patients)
SKIN ULCER (39 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (38 patients)
PAIN (38 patients)
HYPOALBUMINAEMIA (38 patients)
HYPOCALCAEMIA (37 patients)
FALL (37 patients)
POLLAKIURIA (37 patients)
BLOOD PRESSURE DECREASED (37 patients)
SKIN EXFOLIATION (37 patients)
INSOMNIA (36 patients)
CARDIAC ARREST (36 patients)
HYPOAESTHESIA (35 patients)
INFECTIOUS PERITONITIS (35 patients)
MYOCARDIAL INFARCTION (35 patients)
RETINAL VASCULAR DISORDER (34 patients)
RENAL FAILURE (34 patients)
LIPASE INCREASED (34 patients)
HYPERKALAEMIA (33 patients)
HYPERGLYCAEMIA (33 patients)
HAEMOPTYSIS (31 patients)
ATRIAL FIBRILLATION (30 patients)
GENERALISED OEDEMA (30 patients)
FAECAL INCONTINENCE (30 patients)
WHITE BLOOD CELL COUNT DECREASED (30 patients)
CELLULITIS (29 patients)
CHEST PAIN (29 patients)
SOMNOLENCE (29 patients)
HYPERBILIRUBINAEMIA (28 patients)
HYPOTENSION (28 patients)
MUSCLE SPASMS (28 patients)
ABDOMINAL DISTENSION (27 patients)
WHITE BLOOD CELL COUNT INCREASED (27 patients)
VISION BLURRED (27 patients)
HEPATIC PAIN (26 patients)
BLOOD ALBUMIN DECREASED (26 patients)
DYSURIA (25 patients)
RASH GENERALISED (25 patients)
BLOOD SODIUM DECREASED (25 patients)
BLOOD URIC ACID INCREASED (25 patients)
COMA (25 patients)
COUGH (25 patients)
PANCYTOPENIA (25 patients)
ACUTE ABDOMEN (24 patients)
EOSINOPHIL COUNT INCREASED (24 patients)
CEREBROVASCULAR ACCIDENT (24 patients)
METASTASES TO CENTRAL NERVOUS SYSTEM (23 patients)
CEREBRAL INFARCTION (23 patients)
HYPOMAGNESAEMIA (23 patients)
RETINAL VEIN THROMBOSIS (23 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (23 patients)
TUMOUR LYSIS SYNDROME (22 patients)
HYPOPHOSPHATAEMIA (22 patients)
INFECTION (22 patients)
ORAL PAIN (22 patients)
BLOOD CREATININE INCREASED (22 patients)
NEUTROPENIA (22 patients)
RENAL IMPAIRMENT (22 patients)
LETHARGY (22 patients)
SKIN TOXICITY (21 patients)
TONGUE BLISTERING (21 patients)
LIVER ABSCESS (21 patients)
HAEMATEMESIS (21 patients)
OESOPHAGEAL VARICES HAEMORRHAGE (20 patients)
MENTAL IMPAIRMENT (20 patients)
NERVOUSNESS (20 patients)
NEPHROTIC SYNDROME (20 patients)
HYPOPHAGIA (20 patients)
ADRENAL INSUFFICIENCY (19 patients)
DRY SKIN (19 patients)
BLOOD AMYLASE INCREASED (19 patients)
OEDEMA (19 patients)
INFECTIOUS PLEURAL EFFUSION (19 patients)
DYSPEPSIA (19 patients)
COMA HEPATIC (19 patients)
HEART RATE INCREASED (18 patients)
HYPERTENSIVE CRISIS (18 patients)
MYALGIA (18 patients)
ECZEMA (18 patients)
URINARY TRACT INFECTION (18 patients)
NEUROMYOPATHY (18 patients)
MEDICAL DEVICE COMPLICATION (18 patients)
DIVERTICULITIS (18 patients)
OSTEOMYELITIS (18 patients)
CEREBRAL ATROPHY (18 patients)
CEREBRAL VENTRICLE DILATATION (18 patients)
DIABETIC FOOT INFECTION (18 patients)
NECK PAIN (18 patients)
OLIGURIA (17 patients)
GASTROINTESTINAL DISORDER (17 patients)
HAEMATOCHEZIA (17 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (17 patients)
HYPOTHYROIDISM (17 patients)
TRANSAMINASES INCREASED (17 patients)
OROPHARYNGEAL PAIN (17 patients)
CHRONIC MYELOID LEUKAEMIA (17 patients)
NEOPLASM PROGRESSION (17 patients)
METASTASES TO ADRENALS (16 patients)
LYMPHOCYTE COUNT DECREASED (16 patients)
INTERNATIONAL NORMALISED RATIO INCREASED (16 patients)
MULTI-ORGAN FAILURE (16 patients)
FEAR (16 patients)
PANCREATIC CARCINOMA (16 patients)
HYPERSOMNIA (16 patients)
EPILEPSY (16 patients)
SUBARACHNOID HAEMORRHAGE (16 patients)
METASTASES TO LUNG (16 patients)
TACHYCARDIA (16 patients)
MUSCULAR WEAKNESS (16 patients)
KLEBSIELLA SEPSIS (16 patients)
MYOCARDIAL ISCHAEMIA (16 patients)
DYSGEUSIA (16 patients)
LUNG INFECTION (16 patients)
FAECES DISCOLOURED (16 patients)
PAIN OF SKIN (16 patients)
SPINAL FRACTURE (16 patients)
PANIC REACTION (16 patients)

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