Is HYPERKALAEMIA a side effect of SORAFENIB (RAF KINASE INHIBITOR) ? ( FactMed.com )

About this FactMed analysis covering adverse side effect reports of SORAFENIB (RAF KINASE INHIBITOR) patients who developed HYPERKALAEMIA.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 33 individuals taking SORAFENIB (RAF KINASE INHIBITOR) reported HYPERKALAEMIA to the FDA. A total of 3329 SORAFENIB (RAF KINASE INHIBITOR) drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between SORAFENIB (RAF KINASE INHIBITOR) and HYPERKALAEMIA. In doing so, we compare SORAFENIB (RAF KINASE INHIBITOR) with other drugs that cause HYPERKALAEMIA, to help you evaluate whether or not SORAFENIB (RAF KINASE INHIBITOR) causes HYPERKALAEMIA. Likewise, this page shows the most highly-reported side effects of SORAFENIB (RAF KINASE INHIBITOR), so you can see if HYPERKALAEMIA ranks among SORAFENIB (RAF KINASE INHIBITOR)'s most well-known side effects.

Summary Statistics
Reports of SORAFENIB (RAF KINASE INHIBITOR) causing HYPERKALAEMIA: 33
Reports of any side effect of SORAFENIB (RAF KINASE INHIBITOR) : 3329
Percentage of SORAFENIB (RAF KINASE INHIBITOR) patients where HYPERKALAEMIA is a reported side effect: 0.9913%

FDA reports of any drug causing HYPERKALAEMIA : 12458
Average percentage for all medicated patients where HYPERKALAEMIA is reported as a complication: 0.0781%

Physician opinion on SORAFENIB (RAF KINASE INHIBITOR) as adverse event culprit:

Overall opinion for all reports of this drug:

Most frequent diagnoses/indications for prescribing SORAFENIB (RAF KINASE INHIBITOR):

HEPATIC NEOPLASM MALIGNANT ( 770 patients )
RENAL CELL CARCINOMA ( 114 patients )
THYROID CANCER ( 65 patients )
METASTATIC RENAL CELL CARCINOMA ( 44 patients )
THYROID CANCER METASTATIC ( 35 patients )
BREAST CANCER ( 31 patients )
BREAST CANCER METASTATIC ( 27 patients )
GASTRIC CANCER ( 25 patients )
NON-SMALL CELL LUNG CANCER ( 25 patients )
COLORECTAL CANCER METASTATIC ( 22 patients )
RENAL CANCER ( 17 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 14 patients )
BILE DUCT CANCER ( 14 patients )
SALIVARY GLAND CANCER ( 7 patients )
HEPATIC CANCER METASTATIC ( 7 patients )
COLORECTAL CANCER ( 7 patients )
SMALL CELL LUNG CANCER STAGE UNSPECIFIED ( 6 patients )
RECTAL CANCER ( 5 patients )
PANCREATIC CARCINOMA ( 4 patients )
PROSTATE CANCER ( 4 patients )
INTRAOCULAR MELANOMA ( 4 patients )
HEPATIC NEOPLASM MALIGNANT RECURRENT ( 3 patients )
NEOPLASM ( 3 patients )
LIVER DISORDER ( 3 patients )
ANGIOSARCOMA ( 3 patients )
NON-SMALL CELL LUNG CANCER STAGE IV ( 3 patients )
METASTASES TO LUNG ( 3 patients )
HEPATIC NEOPLASM MALIGNANT NON-RESECTABLE ( 3 patients )
COLORECTAL CANCER STAGE IV ( 3 patients )
NEOPLASM MALIGNANT ( 3 patients )
GALLBLADDER CANCER METASTATIC ( 3 patients )
BILIARY CANCER METASTATIC ( 3 patients )
METASTASIS ( 3 patients )
COLON CANCER METASTATIC ( 2 patients )
HYPOPHARYNGEAL CANCER ( 2 patients )
DESMOID TUMOUR ( 2 patients )
NEUROENDOCRINE CARCINOMA ( 2 patients )
ACUTE MYELOID LEUKAEMIA (IN REMISSION) ( 2 patients )
LUNG NEOPLASM MALIGNANT ( 2 patients )
OESOPHAGEAL CARCINOMA ( 2 patients )
METASTATIC MALIGNANT MELANOMA ( 2 patients )
TONGUE NEOPLASM MALIGNANT STAGE UNSPECIFIED ( 2 patients )
METASTATIC SQUAMOUS CELL CARCINOMA ( 2 patients )
ANGINA PECTORIS ( 2 patients )
RENAL CELL CARCINOMA STAGE IV ( 2 patients )
OSTEOSARCOMA METASTATIC ( 2 patients )
BONE SARCOMA ( 2 patients )
METASTATIC OCULAR MELANOMA ( 2 patients )
METASTATIC SALIVARY GLAND CANCER ( 2 patients )
TONSIL CANCER ( 2 patients )
MYELODYSPLASTIC SYNDROME ( 1 patients )
PROSTATE CANCER METASTATIC ( 1 patients )
GALLBLADDER CANCER ( 1 patients )
NEUROENDOCRINE TUMOUR ( 1 patients )
MALIGNANT NEOPLASM OF RENAL PELVIS ( 1 patients )
GLIOMA ( 1 patients )
BLADDER CANCER ( 1 patients )
OVARIAN CANCER METASTATIC ( 1 patients )
CAROTID ARTERY DISEASE ( 1 patients )
HEPATOBLASTOMA ( 1 patients )
NASOPHARYNGEAL CANCER ( 1 patients )
ACUTE MYELOID LEUKAEMIA ( 1 patients )
LUNG ADENOCARCINOMA ( 1 patients )
RENAL CANCER METASTATIC ( 1 patients )
DIFFUSE LARGE B-CELL LYMPHOMA ( 1 patients )
NEUROENDOCRINE CARCINOMA OF THE SKIN ( 1 patients )
MALIGNANT HISTIOCYTOSIS ( 1 patients )
ANTICOAGULANT THERAPY ( 1 patients )
MALIGNANT SOFT TISSUE NEOPLASM ( 1 patients )
SARCOMA ( 1 patients )
GERM CELL CANCER ( 1 patients )
OESOPHAGEAL ADENOCARCINOMA ( 1 patients )
SQUAMOUS CELL CARCINOMA ( 1 patients )
HEAD AND NECK CANCER ( 1 patients )
OVARIAN EPITHELIAL CANCER ( 1 patients )
( 0 patients )

Drugs with high FDA adverse event association with HYPERKALAEMIA:

HEPARIN SODIUM INJECTION (1919 patients)
ASPIRIN (1796 patients)
LASIX (1557 patients)
FUROSEMIDE (1383 patients)
LISINOPRIL (1186 patients)
SPIRONOLACTONE (1115 patients)
ALDACTONE (1106 patients)
DIGOXIN (981 patients)
ALLOPURINOL (751 patients)
OMEPRAZOLE (697 patients)
METFORMIN HCL (673 patients)
SIMVASTATIN (609 patients)
RAMIPRIL (605 patients)
PLAVIX (598 patients)
VIOXX (582 patients)
ENALAPRIL MALEATE (579 patients)
POTASSIUM CHLORIDE (564 patients)
ATENOLOL (563 patients)
ACETAMINOPHEN (518 patients)
AMLODIPINE (518 patients)
NORVASC (505 patients)
FOSAMAX (482 patients)
PREDNISONE (464 patients)
COUMADIN (462 patients)
LIPITOR (448 patients)
ZOMETA (427 patients)
LEVOTHYROXINE SODIUM (424 patients)
INSULIN (423 patients)
WARFARIN SODIUM (401 patients)
DIOVAN (400 patients)
CARVEDILOL (400 patients)
GLUCOPHAGE (393 patients)
FOLIC ACID (380 patients)
DEXAMETHASONE (371 patients)
PREDNISOLONE (367 patients)
NEXIUM (350 patients)
LANTUS (344 patients)
METOPROLOL TARTRATE (320 patients)
HYDROCHLOROTHIAZIDE (311 patients)
ZOCOR (308 patients)
NITROGLYCERIN (307 patients)
ALTACE (306 patients)
MICARDIS (298 patients)
ALBUTEROL (295 patients)
BISOPROLOL FUMARATE (293 patients)
AREDIA (281 patients)
COREG (280 patients)
PROTONIX (273 patients)
MORPHINE (272 patients)
CRESTOR (272 patients)
SEROQUEL (268 patients)
OXYCONTIN (268 patients)
NEURONTIN (267 patients)
OXYCODONE HCL (257 patients)
IBUPROFEN (247 patients)
BACTRIM (246 patients)
PREVISCAN (239 patients)
GABAPENTIN (238 patients)
PRILOSEC (238 patients)
PROGRAF (236 patients)
METOPROLOL (236 patients)
AMARYL (228 patients)
COZAAR (224 patients)
METFORMIN (224 patients)
CYCLOSPORINE (220 patients)
LYRICA (219 patients)
XANAX (218 patients)
LORAZEPAM (217 patients)
CORDARONE (216 patients)
GLYBURIDE (213 patients)
MORPHINE SULFATE (211 patients)
SYNTHROID (210 patients)
VALSARTAN (208 patients)
PREDNISONE TAB (205 patients)
LOPRESSOR (204 patients)
LANSOPRAZOLE (204 patients)
NEXAVAR (202 patients)
LEVAQUIN (200 patients)
LOVENOX (196 patients)
ARANESP (195 patients)
ATIVAN (193 patients)
VELCADE (192 patients)
TORSEMIDE (192 patients)
CIPROFLOXACIN (191 patients)
ATACAND (191 patients)
TOPROL-XL (189 patients)
GLIPIZIDE (188 patients)
CELEBREX (186 patients)
MAGNESIUM OXIDE (185 patients)
LACTULOSE (185 patients)
CISPLATIN (184 patients)
FAMOTIDINE (183 patients)
PREVACID (182 patients)
ATORVASTATIN CALCIUM (182 patients)
RANITIDINE (180 patients)
ZOFRAN (179 patients)
HUMALOG (178 patients)
AMIODARONE HCL (174 patients)
VANCOMYCIN (172 patients)
FENTANYL (172 patients)
RASILEZ (168 patients)
AMLODIPINE BESYLATE (168 patients)
VOLTAREN (168 patients)
DECADRON (168 patients)
SORAFENIB (167 patients)
MYCOPHENOLATE MOFETIL (166 patients)
SULFAMETHOXAZOLE AND TRIMETHOPRIM (165 patients)
FERROUS SULFATE TAB (164 patients)
ACTOS (163 patients)
EPOGEN (162 patients)
HEPARIN SODIUM 5,000 UNITS IN DEXTROSE 5% (159 patients)
REVLIMID (159 patients)
TRAMADOL HCL (155 patients)
PANTOPRAZOLE (154 patients)
ISOSORBIDE MONONITRATE (154 patients)
AMOXICILLIN (153 patients)
ZESTRIL (153 patients)
LASILIX (152 patients)
COMPAZINE (152 patients)
AMBIEN (151 patients)
PANTOPRAZOLE SODIUM (151 patients)
METOCLOPRAMIDE (151 patients)
HEPARIN (150 patients)
NIFEDIPINE (150 patients)
FLUCONAZOLE (150 patients)
AVANDIA (149 patients)
METOPROLOL SUCCINATE (148 patients)
OLMESARTAN MEDOXOMIL (147 patients)
RENAGEL (146 patients)
PERCOCET (146 patients)
CLOPIDOGREL (146 patients)
PROPOFOL (144 patients)
METFORMIN HYDROCHLORIDE (142 patients)
ATORVASTATIN (141 patients)
REGLAN (139 patients)
NEORAL (139 patients)
AMITRIPTYLINE HCL (138 patients)
JANUVIA (138 patients)
METHOTREXATE (137 patients)
DOXAZOSIN MESYLATE (137 patients)
ZOLOFT (136 patients)
PAXIL (136 patients)
KAYEXALATE (136 patients)
PEPCID (134 patients)
ACYCLOVIR (134 patients)
DIFLUCAN (132 patients)
SPIRIVA (131 patients)
CLONIDINE (130 patients)
IRBESARTAN (130 patients)
TACROLIMUS (130 patients)
PREDONINE (129 patients)
MULTI-VITAMINS (128 patients)
ZANTAC (128 patients)
SODIUM CHLORIDE (127 patients)
NAPROXEN (126 patients)
METHYLPREDNISOLONE (125 patients)
COLACE (125 patients)
VICODIN (124 patients)
ERLOTINIB HYDROCHLORIDE (123 patients)
PRINIVIL (122 patients)
CARBOPLATIN (121 patients)
CLONAZEPAM (120 patients)
FLUOROURACIL (120 patients)
CANDESARTAN CILEXETIL (119 patients)
DURAGESIC-100 (119 patients)
VERAPAMIL (119 patients)
HYDRALAZINE HCL (119 patients)
TAHOR (118 patients)
VITAMIN D (118 patients)
KALETRA (116 patients)
ACETYLSALICYLIC ACID SRT (116 patients)
VITAMIN B-12 (116 patients)
ZOLPIDEM (115 patients)
RABEPRAZOLE SODIUM (114 patients)
GLIMEPIRIDE (114 patients)
DILTIAZEM (113 patients)
TENORMIN (113 patients)
HYDROCORTISONE (113 patients)
HEPARIN SODIUM (112 patients)
LOSARTAN POTASSIUM (112 patients)
CAPTOPRIL (112 patients)
ALPRAZOLAM (111 patients)
CYCLOPHOSPHAMIDE (110 patients)
CALCIUM CARBONATE (110 patients)
VINCRISTINE (109 patients)
EFFEXOR (109 patients)
LANOXIN (108 patients)
GLICLAZIDE (106 patients)
PRAVASTATIN (105 patients)
ENALAPRIL (104 patients)
ADVAIR DISKUS 100/50 (103 patients)
IMDUR (103 patients)
ATROVENT (103 patients)
BUMETANIDE (103 patients)
ZYPREXA (103 patients)
TAXOTERE (103 patients)
KARDEGIC (103 patients)
SODIUM BICARBONATE (103 patients)
NEUPOGEN (103 patients)
BISOPROLOL (102 patients)
PROPRANOLOL (102 patients)
CITALOPRAM HYDROBROMIDE (102 patients)
TEMAZEPAM (101 patients)
CELLCEPT (100 patients)
PROMETHAZINE (100 patients)
NOVOLOG (100 patients)
SINTROM (100 patients)
ARICEPT (99 patients)
KLOR-CON (99 patients)
PARACETAMOL (99 patients)

Most common side effects for patients taking SORAFENIB (RAF KINASE INHIBITOR):

DIARRHOEA (613 patients)
HEPATIC FAILURE (378 patients)
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME (342 patients)
HEPATIC ENCEPHALOPATHY (320 patients)
FATIGUE (300 patients)
RASH (276 patients)
ASCITES (253 patients)
ABDOMINAL PAIN (237 patients)
DECREASED APPETITE (226 patients)
UPPER GASTROINTESTINAL HAEMORRHAGE (198 patients)
PYREXIA (191 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (179 patients)
NAUSEA (165 patients)
HYPERTENSION (160 patients)
ASTHENIA (154 patients)
DEHYDRATION (140 patients)
HEPATIC FUNCTION ABNORMAL (133 patients)
DYSPNOEA (131 patients)
CONFUSIONAL STATE (131 patients)
HYPOKALAEMIA (125 patients)
ALOPECIA (124 patients)
VOMITING (118 patients)
CONSTIPATION (115 patients)
INTERSTITIAL LUNG DISEASE (114 patients)
LEFT VENTRICULAR DYSFUNCTION (113 patients)
DEATH (113 patients)
ENDOCARDITIS (112 patients)
ARTHRALGIA (111 patients)
STOMATITIS (111 patients)
ABDOMINAL PAIN UPPER (110 patients)
JAUNDICE (108 patients)
HEPATIC NEOPLASM MALIGNANT (106 patients)
GASTROINTESTINAL HAEMORRHAGE (106 patients)
RETINAL VASCULAR THROMBOSIS (103 patients)
LOWER GASTROINTESTINAL HAEMORRHAGE (103 patients)
LIVER CARCINOMA RUPTURED (101 patients)
OEDEMA PERIPHERAL (97 patients)
PLEURAL EFFUSION (97 patients)
STAPHYLOCOCCAL INFECTION (96 patients)
PNEUMONIA BACTERIAL (96 patients)
ENTEROBACTER INFECTION (96 patients)
MYOPATHY (95 patients)
DRY MOUTH (94 patients)
PAIN IN EXTREMITY (93 patients)
ANXIETY (90 patients)
MALAISE (89 patients)
PULMONARY EMBOLISM (85 patients)
ANAEMIA (84 patients)
PLATELET COUNT DECREASED (81 patients)
BACK PAIN (79 patients)
SEPSIS (78 patients)
PRURITUS (78 patients)
DUODENAL ULCER (77 patients)
MIGRAINE (76 patients)
MITRAL VALVE INCOMPETENCE (76 patients)
HYPOGLYCAEMIA (76 patients)
C-REACTIVE PROTEIN INCREASED (74 patients)
BLOOD PRESSURE INCREASED (73 patients)
VARICES OESOPHAGEAL (73 patients)
HEADACHE (72 patients)
RETINAL VEIN OCCLUSION (72 patients)
ABASIA (69 patients)
RENAL FAILURE ACUTE (69 patients)
WEIGHT DECREASED (67 patients)
DEEP VEIN THROMBOSIS (67 patients)
DIZZINESS (65 patients)
ERYTHEMA (65 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (64 patients)
CONVULSION (63 patients)
ALANINE AMINOTRANSFERASE INCREASED (62 patients)
DYSPHONIA (62 patients)
CEREBRAL HAEMORRHAGE (60 patients)
APHAGIA (58 patients)
COLITIS (58 patients)
PNEUMONIA (57 patients)
GASTRIC ULCER (56 patients)
HYPONATRAEMIA (55 patients)
HAEMOGLOBIN DECREASED (53 patients)
RESPIRATORY FAILURE (52 patients)
LUNG DISORDER (52 patients)
CEREBRAL ISCHAEMIA (49 patients)
PARAESTHESIA (49 patients)
BLOOD BILIRUBIN INCREASED (48 patients)
GAIT DISTURBANCE (48 patients)
THYROID CANCER METASTATIC (44 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (43 patients)
PERICARDIAL EFFUSION (41 patients)
THROMBOCYTOPENIA (41 patients)
BLISTER (41 patients)
FEBRILE NEUTROPENIA (40 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (40 patients)
HALLUCINATION (40 patients)
CHILLS (40 patients)
AMMONIA INCREASED (39 patients)
SKIN ULCER (39 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (38 patients)
PAIN (38 patients)
HYPOALBUMINAEMIA (38 patients)
HYPOCALCAEMIA (37 patients)
FALL (37 patients)
POLLAKIURIA (37 patients)
BLOOD PRESSURE DECREASED (37 patients)
SKIN EXFOLIATION (37 patients)
INSOMNIA (36 patients)
CARDIAC ARREST (36 patients)
HYPOAESTHESIA (35 patients)
INFECTIOUS PERITONITIS (35 patients)
MYOCARDIAL INFARCTION (35 patients)
RETINAL VASCULAR DISORDER (34 patients)
RENAL FAILURE (34 patients)
LIPASE INCREASED (34 patients)
HYPERKALAEMIA (33 patients)
HYPERGLYCAEMIA (33 patients)
HAEMOPTYSIS (31 patients)
ATRIAL FIBRILLATION (30 patients)
GENERALISED OEDEMA (30 patients)
FAECAL INCONTINENCE (30 patients)
WHITE BLOOD CELL COUNT DECREASED (30 patients)
CELLULITIS (29 patients)
CHEST PAIN (29 patients)
SOMNOLENCE (29 patients)
HYPERBILIRUBINAEMIA (28 patients)
HYPOTENSION (28 patients)
MUSCLE SPASMS (28 patients)
ABDOMINAL DISTENSION (27 patients)
WHITE BLOOD CELL COUNT INCREASED (27 patients)
VISION BLURRED (27 patients)
HEPATIC PAIN (26 patients)
BLOOD ALBUMIN DECREASED (26 patients)
DYSURIA (25 patients)
RASH GENERALISED (25 patients)
BLOOD SODIUM DECREASED (25 patients)
BLOOD URIC ACID INCREASED (25 patients)
COMA (25 patients)
COUGH (25 patients)
PANCYTOPENIA (25 patients)
ACUTE ABDOMEN (24 patients)
EOSINOPHIL COUNT INCREASED (24 patients)
CEREBROVASCULAR ACCIDENT (24 patients)
METASTASES TO CENTRAL NERVOUS SYSTEM (23 patients)
CEREBRAL INFARCTION (23 patients)
HYPOMAGNESAEMIA (23 patients)
RETINAL VEIN THROMBOSIS (23 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (23 patients)
TUMOUR LYSIS SYNDROME (22 patients)
HYPOPHOSPHATAEMIA (22 patients)
INFECTION (22 patients)
ORAL PAIN (22 patients)
BLOOD CREATININE INCREASED (22 patients)
NEUTROPENIA (22 patients)
RENAL IMPAIRMENT (22 patients)
LETHARGY (22 patients)
SKIN TOXICITY (21 patients)
TONGUE BLISTERING (21 patients)
LIVER ABSCESS (21 patients)
HAEMATEMESIS (21 patients)
OESOPHAGEAL VARICES HAEMORRHAGE (20 patients)
MENTAL IMPAIRMENT (20 patients)
NERVOUSNESS (20 patients)
NEPHROTIC SYNDROME (20 patients)
HYPOPHAGIA (20 patients)
ADRENAL INSUFFICIENCY (19 patients)
DRY SKIN (19 patients)
BLOOD AMYLASE INCREASED (19 patients)
OEDEMA (19 patients)
INFECTIOUS PLEURAL EFFUSION (19 patients)
DYSPEPSIA (19 patients)
COMA HEPATIC (19 patients)
HEART RATE INCREASED (18 patients)
HYPERTENSIVE CRISIS (18 patients)
MYALGIA (18 patients)
ECZEMA (18 patients)
URINARY TRACT INFECTION (18 patients)
NEUROMYOPATHY (18 patients)
MEDICAL DEVICE COMPLICATION (18 patients)
DIVERTICULITIS (18 patients)
OSTEOMYELITIS (18 patients)
CEREBRAL ATROPHY (18 patients)
CEREBRAL VENTRICLE DILATATION (18 patients)
DIABETIC FOOT INFECTION (18 patients)
NECK PAIN (18 patients)
OLIGURIA (17 patients)
GASTROINTESTINAL DISORDER (17 patients)
HAEMATOCHEZIA (17 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (17 patients)
HYPOTHYROIDISM (17 patients)
TRANSAMINASES INCREASED (17 patients)
OROPHARYNGEAL PAIN (17 patients)
CHRONIC MYELOID LEUKAEMIA (17 patients)
NEOPLASM PROGRESSION (17 patients)
METASTASES TO ADRENALS (16 patients)
LYMPHOCYTE COUNT DECREASED (16 patients)
INTERNATIONAL NORMALISED RATIO INCREASED (16 patients)
MULTI-ORGAN FAILURE (16 patients)
FEAR (16 patients)
PANCREATIC CARCINOMA (16 patients)
HYPERSOMNIA (16 patients)
EPILEPSY (16 patients)
SUBARACHNOID HAEMORRHAGE (16 patients)
METASTASES TO LUNG (16 patients)
TACHYCARDIA (16 patients)
MUSCULAR WEAKNESS (16 patients)
KLEBSIELLA SEPSIS (16 patients)
MYOCARDIAL ISCHAEMIA (16 patients)
DYSGEUSIA (16 patients)
LUNG INFECTION (16 patients)
FAECES DISCOLOURED (16 patients)
PAIN OF SKIN (16 patients)
SPINAL FRACTURE (16 patients)
PANIC REACTION (16 patients)

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