Is LETHARGY a side effect of SORAFENIB (RAF KINASE INHIBITOR) ? ( FactMed.com )

About this FactMed analysis covering adverse side effect reports of SORAFENIB (RAF KINASE INHIBITOR) patients who developed LETHARGY.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 22 individuals taking SORAFENIB (RAF KINASE INHIBITOR) reported LETHARGY to the FDA. A total of 3329 SORAFENIB (RAF KINASE INHIBITOR) drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between SORAFENIB (RAF KINASE INHIBITOR) and LETHARGY. In doing so, we compare SORAFENIB (RAF KINASE INHIBITOR) with other drugs that cause LETHARGY, to help you evaluate whether or not SORAFENIB (RAF KINASE INHIBITOR) causes LETHARGY. Likewise, this page shows the most highly-reported side effects of SORAFENIB (RAF KINASE INHIBITOR), so you can see if LETHARGY ranks among SORAFENIB (RAF KINASE INHIBITOR)'s most well-known side effects.

Summary Statistics
Reports of SORAFENIB (RAF KINASE INHIBITOR) causing LETHARGY: 22
Reports of any side effect of SORAFENIB (RAF KINASE INHIBITOR) : 3329
Percentage of SORAFENIB (RAF KINASE INHIBITOR) patients where LETHARGY is a reported side effect: 0.6609%

FDA reports of any drug causing LETHARGY : 18507
Average percentage for all medicated patients where LETHARGY is reported as a complication: 0.1160%

Physician opinion on SORAFENIB (RAF KINASE INHIBITOR) as adverse event culprit:

Overall opinion for all reports of this drug:

Most frequent diagnoses/indications for prescribing SORAFENIB (RAF KINASE INHIBITOR):

HEPATIC NEOPLASM MALIGNANT ( 770 patients )
RENAL CELL CARCINOMA ( 114 patients )
THYROID CANCER ( 65 patients )
METASTATIC RENAL CELL CARCINOMA ( 44 patients )
THYROID CANCER METASTATIC ( 35 patients )
BREAST CANCER ( 31 patients )
BREAST CANCER METASTATIC ( 27 patients )
GASTRIC CANCER ( 25 patients )
NON-SMALL CELL LUNG CANCER ( 25 patients )
COLORECTAL CANCER METASTATIC ( 22 patients )
RENAL CANCER ( 17 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 14 patients )
BILE DUCT CANCER ( 14 patients )
SALIVARY GLAND CANCER ( 7 patients )
HEPATIC CANCER METASTATIC ( 7 patients )
COLORECTAL CANCER ( 7 patients )
SMALL CELL LUNG CANCER STAGE UNSPECIFIED ( 6 patients )
RECTAL CANCER ( 5 patients )
PANCREATIC CARCINOMA ( 4 patients )
PROSTATE CANCER ( 4 patients )
INTRAOCULAR MELANOMA ( 4 patients )
HEPATIC NEOPLASM MALIGNANT RECURRENT ( 3 patients )
NEOPLASM ( 3 patients )
LIVER DISORDER ( 3 patients )
ANGIOSARCOMA ( 3 patients )
NON-SMALL CELL LUNG CANCER STAGE IV ( 3 patients )
METASTASES TO LUNG ( 3 patients )
HEPATIC NEOPLASM MALIGNANT NON-RESECTABLE ( 3 patients )
COLORECTAL CANCER STAGE IV ( 3 patients )
NEOPLASM MALIGNANT ( 3 patients )
GALLBLADDER CANCER METASTATIC ( 3 patients )
BILIARY CANCER METASTATIC ( 3 patients )
METASTASIS ( 3 patients )
COLON CANCER METASTATIC ( 2 patients )
HYPOPHARYNGEAL CANCER ( 2 patients )
DESMOID TUMOUR ( 2 patients )
NEUROENDOCRINE CARCINOMA ( 2 patients )
ACUTE MYELOID LEUKAEMIA (IN REMISSION) ( 2 patients )
LUNG NEOPLASM MALIGNANT ( 2 patients )
OESOPHAGEAL CARCINOMA ( 2 patients )
METASTATIC MALIGNANT MELANOMA ( 2 patients )
TONGUE NEOPLASM MALIGNANT STAGE UNSPECIFIED ( 2 patients )
METASTATIC SQUAMOUS CELL CARCINOMA ( 2 patients )
ANGINA PECTORIS ( 2 patients )
RENAL CELL CARCINOMA STAGE IV ( 2 patients )
OSTEOSARCOMA METASTATIC ( 2 patients )
BONE SARCOMA ( 2 patients )
METASTATIC OCULAR MELANOMA ( 2 patients )
METASTATIC SALIVARY GLAND CANCER ( 2 patients )
TONSIL CANCER ( 2 patients )
MYELODYSPLASTIC SYNDROME ( 1 patients )
PROSTATE CANCER METASTATIC ( 1 patients )
GALLBLADDER CANCER ( 1 patients )
NEUROENDOCRINE TUMOUR ( 1 patients )
MALIGNANT NEOPLASM OF RENAL PELVIS ( 1 patients )
GLIOMA ( 1 patients )
BLADDER CANCER ( 1 patients )
OVARIAN CANCER METASTATIC ( 1 patients )
CAROTID ARTERY DISEASE ( 1 patients )
HEPATOBLASTOMA ( 1 patients )
NASOPHARYNGEAL CANCER ( 1 patients )
ACUTE MYELOID LEUKAEMIA ( 1 patients )
LUNG ADENOCARCINOMA ( 1 patients )
RENAL CANCER METASTATIC ( 1 patients )
DIFFUSE LARGE B-CELL LYMPHOMA ( 1 patients )
NEUROENDOCRINE CARCINOMA OF THE SKIN ( 1 patients )
MALIGNANT HISTIOCYTOSIS ( 1 patients )
ANTICOAGULANT THERAPY ( 1 patients )
MALIGNANT SOFT TISSUE NEOPLASM ( 1 patients )
SARCOMA ( 1 patients )
GERM CELL CANCER ( 1 patients )
OESOPHAGEAL ADENOCARCINOMA ( 1 patients )
SQUAMOUS CELL CARCINOMA ( 1 patients )
HEAD AND NECK CANCER ( 1 patients )
OVARIAN EPITHELIAL CANCER ( 1 patients )
( 0 patients )

Drugs with high FDA adverse event association with LETHARGY:

ASPIRIN (1678 patients)
HEPARIN SODIUM INJECTION (1263 patients)
SEROQUEL (1181 patients)
LASIX (686 patients)
PAXIL (683 patients)
LIPITOR (672 patients)
LYRICA (637 patients)
SYNTHROID (637 patients)
LISINOPRIL (624 patients)
ATENOLOL (613 patients)
DIGOXIN (606 patients)
SIMVASTATIN (574 patients)
FOSAMAX (537 patients)
FUROSEMIDE (519 patients)
NEURONTIN (518 patients)
OMEPRAZOLE (515 patients)
XANAX (508 patients)
COUMADIN (503 patients)
ACETAMINOPHEN (502 patients)
PREDNISONE (501 patients)
NEXIUM (497 patients)
ZOLOFT (479 patients)
ATIVAN (465 patients)
CYMBALTA (465 patients)
OXYCONTIN (464 patients)
LEXAPRO (461 patients)
AMBIEN (458 patients)
CHANTIX (456 patients)
LEVOTHYROXINE SODIUM (454 patients)
GABAPENTIN (417 patients)
METFORMIN HCL (412 patients)
SANDOSTATIN LAR (411 patients)
HYDROCHLOROTHIAZIDE (409 patients)
LORAZEPAM (397 patients)
FOLIC ACID (390 patients)
ALBUTEROL (389 patients)
VIOXX (388 patients)
NAMENDA (387 patients)
MORPHINE SULFATE (380 patients)
ZOCOR (372 patients)
DIAZEPAM (371 patients)
PLAVIX (367 patients)
POTASSIUM CHLORIDE (365 patients)
PREVACID (360 patients)
PRILOSEC (355 patients)
CLONAZEPAM (350 patients)
PROTONIX (342 patients)
NORVASC (342 patients)
TOPROL-XL (336 patients)
ZOMETA (333 patients)
MORPHINE (333 patients)
LOVENOX (331 patients)
FORTEO (330 patients)
AMLODIPINE (330 patients)
TYSABRI (326 patients)
KLONOPIN (317 patients)
HUMIRA (307 patients)
DEXAMETHASONE (305 patients)
IBUPROFEN (301 patients)
ZYPREXA (299 patients)
PAROXETINE HCL (298 patients)
EFFEXOR (295 patients)
PERCOCET (288 patients)
OXYCODONE HCL (288 patients)
WARFARIN SODIUM (283 patients)
DEPAKOTE (283 patients)
ALLOPURINOL (280 patients)
METHOTREXATE (278 patients)
DURAGESIC-100 (277 patients)
PROZAC (276 patients)
BYETTA (272 patients)
VICODIN (266 patients)
AVONEX (265 patients)
RISPERDAL (264 patients)
LEVAQUIN (264 patients)
CLOZARIL (261 patients)
CELEBREX (261 patients)
LANTUS (261 patients)
ZOFRAN (260 patients)
ENBREL (260 patients)
REMICADE (249 patients)
CRESTOR (249 patients)
KEPPRA (246 patients)
PREDNISOLONE (246 patients)
METOPROLOL TARTRATE (243 patients)
COREG (242 patients)
DIOVAN (233 patients)
DECADRON (231 patients)
TRAZODONE HCL (227 patients)
VITAMIN D (226 patients)
FENTANYL (224 patients)
CELEXA (223 patients)
CLOZAPINE (223 patients)
VALIUM (221 patients)
TYLENOL (217 patients)
KETEK (216 patients)
ALPRAZOLAM (215 patients)
STRATTERA (215 patients)
LANSOPRAZOLE (214 patients)
SINGULAIR (213 patients)
INSULIN (213 patients)
WELLBUTRIN (210 patients)
PREDNISONE TAB (209 patients)
AMITRIPTYLINE HCL (209 patients)
TYLENOL (CAPLET) (208 patients)
RANITIDINE (204 patients)
BACLOFEN (203 patients)
LAMICTAL (202 patients)
BENADRYL (201 patients)
RAMIPRIL (201 patients)
CITALOPRAM HYDROBROMIDE (199 patients)
FLUOXETINE (198 patients)
ARICEPT (198 patients)
RISPERIDONE (196 patients)
TRAMADOL HCL (194 patients)
CLONIDINE (193 patients)
ADVAIR DISKUS 100/50 (191 patients)
MULTI-VITAMINS (190 patients)
FLOMAX (189 patients)
METOPROLOL (186 patients)
TOPAMAX (186 patients)
NITROGLYCERIN (185 patients)
DILANTIN (185 patients)
SPIRONOLACTONE (183 patients)
AREDIA (181 patients)
GLYBURIDE (179 patients)
SERTRALINE HYDROCHLORIDE (179 patients)
CALCIUM (177 patients)
PROMETHAZINE (175 patients)
PREMARIN (175 patients)
MIRTAZAPINE (171 patients)
GLIPIZIDE (167 patients)
VANCOMYCIN (167 patients)
LOPRESSOR (167 patients)
ZANTAC (166 patients)
ABILIFY (165 patients)
VITAMIN B-12 (165 patients)
TEMAZEPAM (165 patients)
SPIRIVA (163 patients)
COLACE (162 patients)
REVLIMID (161 patients)
AMOXICILLIN (161 patients)
MULTI-VITAMIN (160 patients)
COMPAZINE (158 patients)
DILAUDID (158 patients)
LIORESAL (156 patients)
METOCLOPRAMIDE (156 patients)
REGLAN (156 patients)
LITHIUM CARBONATE (155 patients)
CARBAMAZEPINE (155 patients)
PROPRANOLOL (154 patients)
ULTRAM (153 patients)
EFFEXOR XR (153 patients)
ENALAPRIL MALEATE (153 patients)
PANTOPRAZOLE (151 patients)
PHENYTOIN (150 patients)
METFORMIN (147 patients)
ACCUTANE (147 patients)
NYSTATIN (147 patients)
CYCLOPHOSPHAMIDE (147 patients)
LACTULOSE (146 patients)
HEPARIN SODIUM (146 patients)
LEVOXYL (144 patients)
CARBOPLATIN (144 patients)
RIBAVIRIN (144 patients)
FLUCONAZOLE (143 patients)
COZAAR (143 patients)
DURAGESIC (143 patients)
SUTENT (143 patients)
LORTAB (143 patients)
FERROUS SULFATE TAB (143 patients)
METHADONE HCL (138 patients)
HEPARIN (137 patients)
GEODON (135 patients)
METOPROLOL SUCCINATE (134 patients)
CIPROFLOXACIN (134 patients)
CARVEDILOL (133 patients)
ACTOS (133 patients)
ARANESP (132 patients)
IRON (130 patients)
TEGRETOL (130 patients)
RESTORIL (129 patients)
ALLEGRA (129 patients)
MS CONTIN (128 patients)
ASCORBIC ACID (128 patients)
REBIF (127 patients)
ALTACE (127 patients)
ZYRTEC (126 patients)
FLEXERIL (125 patients)
VERAPAMIL (124 patients)
PRISTIQ (124 patients)
ALDACTONE (124 patients)
HALDOL (123 patients)
SEROQUEL XR (123 patients)
LAMOTRIGINE (123 patients)
SEROXAT (122 patients)
GLUCOPHAGE (122 patients)
MIRALAX (122 patients)
EPOGEN (121 patients)
VITAMIN E (121 patients)
NOVOLOG (120 patients)
ZITHROMAX (120 patients)
PEPCID (120 patients)
HUMALOG (119 patients)
ACYCLOVIR (118 patients)
HYDROCODONE (117 patients)
FLUOROURACIL (116 patients)
VELCADE (116 patients)
CALCIUM CARBONATE (115 patients)
CIPRO (114 patients)

Most common side effects for patients taking SORAFENIB (RAF KINASE INHIBITOR):

DIARRHOEA (613 patients)
HEPATIC FAILURE (378 patients)
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME (342 patients)
HEPATIC ENCEPHALOPATHY (320 patients)
FATIGUE (300 patients)
RASH (276 patients)
ASCITES (253 patients)
ABDOMINAL PAIN (237 patients)
DECREASED APPETITE (226 patients)
UPPER GASTROINTESTINAL HAEMORRHAGE (198 patients)
PYREXIA (191 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (179 patients)
NAUSEA (165 patients)
HYPERTENSION (160 patients)
ASTHENIA (154 patients)
DEHYDRATION (140 patients)
HEPATIC FUNCTION ABNORMAL (133 patients)
DYSPNOEA (131 patients)
CONFUSIONAL STATE (131 patients)
HYPOKALAEMIA (125 patients)
ALOPECIA (124 patients)
VOMITING (118 patients)
CONSTIPATION (115 patients)
INTERSTITIAL LUNG DISEASE (114 patients)
LEFT VENTRICULAR DYSFUNCTION (113 patients)
DEATH (113 patients)
ENDOCARDITIS (112 patients)
ARTHRALGIA (111 patients)
STOMATITIS (111 patients)
ABDOMINAL PAIN UPPER (110 patients)
JAUNDICE (108 patients)
HEPATIC NEOPLASM MALIGNANT (106 patients)
GASTROINTESTINAL HAEMORRHAGE (106 patients)
RETINAL VASCULAR THROMBOSIS (103 patients)
LOWER GASTROINTESTINAL HAEMORRHAGE (103 patients)
LIVER CARCINOMA RUPTURED (101 patients)
OEDEMA PERIPHERAL (97 patients)
PLEURAL EFFUSION (97 patients)
STAPHYLOCOCCAL INFECTION (96 patients)
PNEUMONIA BACTERIAL (96 patients)
ENTEROBACTER INFECTION (96 patients)
MYOPATHY (95 patients)
DRY MOUTH (94 patients)
PAIN IN EXTREMITY (93 patients)
ANXIETY (90 patients)
MALAISE (89 patients)
PULMONARY EMBOLISM (85 patients)
ANAEMIA (84 patients)
PLATELET COUNT DECREASED (81 patients)
BACK PAIN (79 patients)
SEPSIS (78 patients)
PRURITUS (78 patients)
DUODENAL ULCER (77 patients)
MIGRAINE (76 patients)
MITRAL VALVE INCOMPETENCE (76 patients)
HYPOGLYCAEMIA (76 patients)
C-REACTIVE PROTEIN INCREASED (74 patients)
BLOOD PRESSURE INCREASED (73 patients)
VARICES OESOPHAGEAL (73 patients)
HEADACHE (72 patients)
RETINAL VEIN OCCLUSION (72 patients)
ABASIA (69 patients)
RENAL FAILURE ACUTE (69 patients)
WEIGHT DECREASED (67 patients)
DEEP VEIN THROMBOSIS (67 patients)
DIZZINESS (65 patients)
ERYTHEMA (65 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (64 patients)
CONVULSION (63 patients)
ALANINE AMINOTRANSFERASE INCREASED (62 patients)
DYSPHONIA (62 patients)
CEREBRAL HAEMORRHAGE (60 patients)
APHAGIA (58 patients)
COLITIS (58 patients)
PNEUMONIA (57 patients)
GASTRIC ULCER (56 patients)
HYPONATRAEMIA (55 patients)
HAEMOGLOBIN DECREASED (53 patients)
RESPIRATORY FAILURE (52 patients)
LUNG DISORDER (52 patients)
CEREBRAL ISCHAEMIA (49 patients)
PARAESTHESIA (49 patients)
BLOOD BILIRUBIN INCREASED (48 patients)
GAIT DISTURBANCE (48 patients)
THYROID CANCER METASTATIC (44 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (43 patients)
PERICARDIAL EFFUSION (41 patients)
THROMBOCYTOPENIA (41 patients)
BLISTER (41 patients)
FEBRILE NEUTROPENIA (40 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (40 patients)
HALLUCINATION (40 patients)
CHILLS (40 patients)
AMMONIA INCREASED (39 patients)
SKIN ULCER (39 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (38 patients)
PAIN (38 patients)
HYPOALBUMINAEMIA (38 patients)
HYPOCALCAEMIA (37 patients)
FALL (37 patients)
POLLAKIURIA (37 patients)
BLOOD PRESSURE DECREASED (37 patients)
SKIN EXFOLIATION (37 patients)
INSOMNIA (36 patients)
CARDIAC ARREST (36 patients)
HYPOAESTHESIA (35 patients)
INFECTIOUS PERITONITIS (35 patients)
MYOCARDIAL INFARCTION (35 patients)
RETINAL VASCULAR DISORDER (34 patients)
RENAL FAILURE (34 patients)
LIPASE INCREASED (34 patients)
HYPERKALAEMIA (33 patients)
HYPERGLYCAEMIA (33 patients)
HAEMOPTYSIS (31 patients)
ATRIAL FIBRILLATION (30 patients)
GENERALISED OEDEMA (30 patients)
FAECAL INCONTINENCE (30 patients)
WHITE BLOOD CELL COUNT DECREASED (30 patients)
CELLULITIS (29 patients)
CHEST PAIN (29 patients)
SOMNOLENCE (29 patients)
HYPERBILIRUBINAEMIA (28 patients)
HYPOTENSION (28 patients)
MUSCLE SPASMS (28 patients)
ABDOMINAL DISTENSION (27 patients)
WHITE BLOOD CELL COUNT INCREASED (27 patients)
VISION BLURRED (27 patients)
HEPATIC PAIN (26 patients)
BLOOD ALBUMIN DECREASED (26 patients)
DYSURIA (25 patients)
RASH GENERALISED (25 patients)
BLOOD SODIUM DECREASED (25 patients)
BLOOD URIC ACID INCREASED (25 patients)
COMA (25 patients)
COUGH (25 patients)
PANCYTOPENIA (25 patients)
ACUTE ABDOMEN (24 patients)
EOSINOPHIL COUNT INCREASED (24 patients)
CEREBROVASCULAR ACCIDENT (24 patients)
METASTASES TO CENTRAL NERVOUS SYSTEM (23 patients)
CEREBRAL INFARCTION (23 patients)
HYPOMAGNESAEMIA (23 patients)
RETINAL VEIN THROMBOSIS (23 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (23 patients)
TUMOUR LYSIS SYNDROME (22 patients)
HYPOPHOSPHATAEMIA (22 patients)
INFECTION (22 patients)
ORAL PAIN (22 patients)
BLOOD CREATININE INCREASED (22 patients)
NEUTROPENIA (22 patients)
RENAL IMPAIRMENT (22 patients)
LETHARGY (22 patients)
SKIN TOXICITY (21 patients)
TONGUE BLISTERING (21 patients)
LIVER ABSCESS (21 patients)
HAEMATEMESIS (21 patients)
OESOPHAGEAL VARICES HAEMORRHAGE (20 patients)
MENTAL IMPAIRMENT (20 patients)
NERVOUSNESS (20 patients)
NEPHROTIC SYNDROME (20 patients)
HYPOPHAGIA (20 patients)
ADRENAL INSUFFICIENCY (19 patients)
DRY SKIN (19 patients)
BLOOD AMYLASE INCREASED (19 patients)
OEDEMA (19 patients)
INFECTIOUS PLEURAL EFFUSION (19 patients)
DYSPEPSIA (19 patients)
COMA HEPATIC (19 patients)
HEART RATE INCREASED (18 patients)
HYPERTENSIVE CRISIS (18 patients)
MYALGIA (18 patients)
ECZEMA (18 patients)
URINARY TRACT INFECTION (18 patients)
NEUROMYOPATHY (18 patients)
MEDICAL DEVICE COMPLICATION (18 patients)
DIVERTICULITIS (18 patients)
OSTEOMYELITIS (18 patients)
CEREBRAL ATROPHY (18 patients)
CEREBRAL VENTRICLE DILATATION (18 patients)
DIABETIC FOOT INFECTION (18 patients)
NECK PAIN (18 patients)
OLIGURIA (17 patients)
GASTROINTESTINAL DISORDER (17 patients)
HAEMATOCHEZIA (17 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (17 patients)
HYPOTHYROIDISM (17 patients)
TRANSAMINASES INCREASED (17 patients)
OROPHARYNGEAL PAIN (17 patients)
CHRONIC MYELOID LEUKAEMIA (17 patients)
NEOPLASM PROGRESSION (17 patients)
METASTASES TO ADRENALS (16 patients)
LYMPHOCYTE COUNT DECREASED (16 patients)
INTERNATIONAL NORMALISED RATIO INCREASED (16 patients)
MULTI-ORGAN FAILURE (16 patients)
FEAR (16 patients)
PANCREATIC CARCINOMA (16 patients)
HYPERSOMNIA (16 patients)
EPILEPSY (16 patients)
SUBARACHNOID HAEMORRHAGE (16 patients)
METASTASES TO LUNG (16 patients)
TACHYCARDIA (16 patients)
MUSCULAR WEAKNESS (16 patients)
KLEBSIELLA SEPSIS (16 patients)
MYOCARDIAL ISCHAEMIA (16 patients)
DYSGEUSIA (16 patients)
LUNG INFECTION (16 patients)
FAECES DISCOLOURED (16 patients)
PAIN OF SKIN (16 patients)
SPINAL FRACTURE (16 patients)
PANIC REACTION (16 patients)

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