Is MUSCLE SPASMS a side effect of SORAFENIB (RAF KINASE INHIBITOR) ? ( FactMed.com )

About this FactMed analysis covering adverse side effect reports of SORAFENIB (RAF KINASE INHIBITOR) patients who developed MUSCLE SPASMS.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 28 individuals taking SORAFENIB (RAF KINASE INHIBITOR) reported MUSCLE SPASMS to the FDA. A total of 3329 SORAFENIB (RAF KINASE INHIBITOR) drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between SORAFENIB (RAF KINASE INHIBITOR) and MUSCLE SPASMS. In doing so, we compare SORAFENIB (RAF KINASE INHIBITOR) with other drugs that cause MUSCLE SPASMS, to help you evaluate whether or not SORAFENIB (RAF KINASE INHIBITOR) causes MUSCLE SPASMS. Likewise, this page shows the most highly-reported side effects of SORAFENIB (RAF KINASE INHIBITOR), so you can see if MUSCLE SPASMS ranks among SORAFENIB (RAF KINASE INHIBITOR)'s most well-known side effects.

Summary Statistics
Reports of SORAFENIB (RAF KINASE INHIBITOR) causing MUSCLE SPASMS: 28
Reports of any side effect of SORAFENIB (RAF KINASE INHIBITOR) : 3329
Percentage of SORAFENIB (RAF KINASE INHIBITOR) patients where MUSCLE SPASMS is a reported side effect: 0.8411%

FDA reports of any drug causing MUSCLE SPASMS : 43893
Average percentage for all medicated patients where MUSCLE SPASMS is reported as a complication: 0.2751%

Physician opinion on SORAFENIB (RAF KINASE INHIBITOR) as adverse event culprit:

Overall opinion for all reports of this drug:

Most frequent diagnoses/indications for prescribing SORAFENIB (RAF KINASE INHIBITOR):

HEPATIC NEOPLASM MALIGNANT ( 770 patients )
RENAL CELL CARCINOMA ( 114 patients )
THYROID CANCER ( 65 patients )
METASTATIC RENAL CELL CARCINOMA ( 44 patients )
THYROID CANCER METASTATIC ( 35 patients )
BREAST CANCER ( 31 patients )
BREAST CANCER METASTATIC ( 27 patients )
GASTRIC CANCER ( 25 patients )
NON-SMALL CELL LUNG CANCER ( 25 patients )
COLORECTAL CANCER METASTATIC ( 22 patients )
RENAL CANCER ( 17 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 14 patients )
BILE DUCT CANCER ( 14 patients )
SALIVARY GLAND CANCER ( 7 patients )
HEPATIC CANCER METASTATIC ( 7 patients )
COLORECTAL CANCER ( 7 patients )
SMALL CELL LUNG CANCER STAGE UNSPECIFIED ( 6 patients )
RECTAL CANCER ( 5 patients )
PANCREATIC CARCINOMA ( 4 patients )
PROSTATE CANCER ( 4 patients )
INTRAOCULAR MELANOMA ( 4 patients )
HEPATIC NEOPLASM MALIGNANT RECURRENT ( 3 patients )
NEOPLASM ( 3 patients )
LIVER DISORDER ( 3 patients )
ANGIOSARCOMA ( 3 patients )
NON-SMALL CELL LUNG CANCER STAGE IV ( 3 patients )
METASTASES TO LUNG ( 3 patients )
HEPATIC NEOPLASM MALIGNANT NON-RESECTABLE ( 3 patients )
COLORECTAL CANCER STAGE IV ( 3 patients )
NEOPLASM MALIGNANT ( 3 patients )
GALLBLADDER CANCER METASTATIC ( 3 patients )
BILIARY CANCER METASTATIC ( 3 patients )
METASTASIS ( 3 patients )
COLON CANCER METASTATIC ( 2 patients )
HYPOPHARYNGEAL CANCER ( 2 patients )
DESMOID TUMOUR ( 2 patients )
NEUROENDOCRINE CARCINOMA ( 2 patients )
ACUTE MYELOID LEUKAEMIA (IN REMISSION) ( 2 patients )
LUNG NEOPLASM MALIGNANT ( 2 patients )
OESOPHAGEAL CARCINOMA ( 2 patients )
METASTATIC MALIGNANT MELANOMA ( 2 patients )
TONGUE NEOPLASM MALIGNANT STAGE UNSPECIFIED ( 2 patients )
METASTATIC SQUAMOUS CELL CARCINOMA ( 2 patients )
ANGINA PECTORIS ( 2 patients )
RENAL CELL CARCINOMA STAGE IV ( 2 patients )
OSTEOSARCOMA METASTATIC ( 2 patients )
BONE SARCOMA ( 2 patients )
METASTATIC OCULAR MELANOMA ( 2 patients )
METASTATIC SALIVARY GLAND CANCER ( 2 patients )
TONSIL CANCER ( 2 patients )
MYELODYSPLASTIC SYNDROME ( 1 patients )
PROSTATE CANCER METASTATIC ( 1 patients )
GALLBLADDER CANCER ( 1 patients )
NEUROENDOCRINE TUMOUR ( 1 patients )
MALIGNANT NEOPLASM OF RENAL PELVIS ( 1 patients )
GLIOMA ( 1 patients )
BLADDER CANCER ( 1 patients )
OVARIAN CANCER METASTATIC ( 1 patients )
CAROTID ARTERY DISEASE ( 1 patients )
HEPATOBLASTOMA ( 1 patients )
NASOPHARYNGEAL CANCER ( 1 patients )
ACUTE MYELOID LEUKAEMIA ( 1 patients )
LUNG ADENOCARCINOMA ( 1 patients )
RENAL CANCER METASTATIC ( 1 patients )
DIFFUSE LARGE B-CELL LYMPHOMA ( 1 patients )
NEUROENDOCRINE CARCINOMA OF THE SKIN ( 1 patients )
MALIGNANT HISTIOCYTOSIS ( 1 patients )
ANTICOAGULANT THERAPY ( 1 patients )
MALIGNANT SOFT TISSUE NEOPLASM ( 1 patients )
SARCOMA ( 1 patients )
GERM CELL CANCER ( 1 patients )
OESOPHAGEAL ADENOCARCINOMA ( 1 patients )
SQUAMOUS CELL CARCINOMA ( 1 patients )
HEAD AND NECK CANCER ( 1 patients )
OVARIAN EPITHELIAL CANCER ( 1 patients )
( 0 patients )

Drugs with high FDA adverse event association with MUSCLE SPASMS:

FORTEO (4380 patients)
FOSAMAX (4274 patients)
LIPITOR (3384 patients)
ASPIRIN (3280 patients)
AVONEX (2583 patients)
TYSABRI (2520 patients)
VIOXX (2377 patients)
CRESTOR (2007 patients)
SYNTHROID (1703 patients)
NEXIUM (1569 patients)
SEROQUEL (1534 patients)
NEURONTIN (1504 patients)
LISINOPRIL (1488 patients)
LYRICA (1487 patients)
HUMIRA (1429 patients)
XANAX (1311 patients)
ZOCOR (1231 patients)
ATENOLOL (1173 patients)
VITAMIN D (1148 patients)
CYMBALTA (1111 patients)
LASIX (1110 patients)
SIMVASTATIN (1094 patients)
ZOMETA (1066 patients)
PRILOSEC (1065 patients)
OMEPRAZOLE (1063 patients)
HEPARIN SODIUM INJECTION (1058 patients)
HYDROCHLOROTHIAZIDE (1055 patients)
PREDNISONE (1049 patients)
CELEBREX (1001 patients)
ENBREL (1000 patients)
PLAVIX (998 patients)
ZOLOFT (988 patients)
COUMADIN (967 patients)
AMBIEN (943 patients)
CHANTIX (923 patients)
ALBUTEROL (919 patients)
CALCIUM (903 patients)
OXYCONTIN (894 patients)
LEVOTHYROXINE SODIUM (879 patients)
BACLOFEN (828 patients)
FUROSEMIDE (822 patients)
GLEEVEC (822 patients)
NORVASC (821 patients)
IBUPROFEN (809 patients)
PAXIL (809 patients)
GABAPENTIN (802 patients)
REBIF (787 patients)
DURAGESIC-100 (783 patients)
REVLIMID (782 patients)
TOPROL-XL (780 patients)
ADVAIR DISKUS 100/50 (777 patients)
PREVACID (770 patients)
AREDIA (767 patients)
VICODIN (762 patients)
LEXAPRO (755 patients)
PREMARIN (752 patients)
MIRENA (749 patients)
EFFEXOR (735 patients)
PROTONIX (731 patients)
SINGULAIR (711 patients)
FOLIC ACID (708 patients)
REMICADE (706 patients)
PERCOCET (700 patients)
DIOVAN (696 patients)
METFORMIN HCL (695 patients)
LEVAQUIN (684 patients)
NIASPAN (673 patients)
ATIVAN (669 patients)
ACETAMINOPHEN (643 patients)
METHOTREXATE (641 patients)
FLEXERIL (640 patients)
LORAZEPAM (639 patients)
CLONAZEPAM (635 patients)
VALIUM (623 patients)
PROZAC (619 patients)
KLONOPIN (613 patients)
LANTUS (585 patients)
POTASSIUM CHLORIDE (578 patients)
ZETIA (570 patients)
LORTAB (559 patients)
OXYCODONE HCL (559 patients)
SANDOSTATIN LAR (553 patients)
SPIRIVA (552 patients)
BYETTA (550 patients)
BONIVA (537 patients)
METOPROLOL TARTRATE (537 patients)
FISH OIL (532 patients)
DIAZEPAM (527 patients)
ALENDRONATE SODIUM (525 patients)
BETASERON (515 patients)
ZYRTEC (499 patients)
CELEXA (499 patients)
MULTI-VITAMIN (497 patients)
WELLBUTRIN (490 patients)
MULTI-VITAMINS (488 patients)
LIORESAL (485 patients)
ALLOPURINOL (475 patients)
TRAZODONE HCL (467 patients)
ALPRAZOLAM (466 patients)
ASCORBIC ACID (464 patients)
TRAMADOL HCL (463 patients)
AMLODIPINE (457 patients)
YAZ (451 patients)
DIGOXIN (447 patients)
PREDNISONE TAB (436 patients)
DEXAMETHASONE (434 patients)
FOSAMAX PLUS D (433 patients)
BENADRYL (433 patients)
ZANTAC (431 patients)
ALLI (430 patients)
ACTONEL (427 patients)
SOMA (422 patients)
ALLEGRA (416 patients)
AMITRIPTYLINE HCL (413 patients)
TRICOR (409 patients)
WARFARIN SODIUM (408 patients)
EFFEXOR XR (394 patients)
CALCIUM CARBONATE (392 patients)
VITAMIN E (389 patients)
FENTANYL (389 patients)
VITAMIN B-12 (387 patients)
EVISTA (387 patients)
MORPHINE (386 patients)
LEVOXYL (374 patients)
GLUCOPHAGE (368 patients)
COZAAR (364 patients)
METOPROLOL (364 patients)
NITROGLYCERIN (364 patients)
RISPERDAL (364 patients)
YASMIN (363 patients)
VYTORIN (361 patients)
ZYPREXA (361 patients)
TOPAMAX (360 patients)
SYMBICORT (359 patients)
CLONIDINE (358 patients)
ACCUTANE (355 patients)
COREG (341 patients)
ACTOS (339 patients)
RECLAST (339 patients)
RANITIDINE (339 patients)
DECADRON (338 patients)
FLONASE (338 patients)
SKELAXIN (336 patients)
ELAVIL (335 patients)
ARIMIDEX (334 patients)
AMOXICILLIN (332 patients)
INSULIN (331 patients)
NUVARING (330 patients)
IRON (329 patients)
SIMCOR (327 patients)
TYLENOL (324 patients)
LAMICTAL (322 patients)
AVANDIA (322 patients)
TYLENOL (CAPLET) (319 patients)
ABILIFY (319 patients)
ULTRAM (318 patients)
RAMIPRIL (316 patients)
ZOFRAN (314 patients)
POTASSIUM (309 patients)
NEXAVAR (308 patients)
CIPROFLOXACIN (308 patients)
METFORMIN (306 patients)
ZITHROMAX (303 patients)
PANTOPRAZOLE (303 patients)
RIBAVIRIN (301 patients)
ZANAFLEX (301 patients)
AVELOX (299 patients)
HUMALOG (297 patients)
CLARITIN (296 patients)
NAPROXEN (292 patients)
PRAVACHOL (289 patients)
DILAUDID (289 patients)
ALTACE (289 patients)
COLACE (287 patients)
CALCIUM (UNSPECIFIED) (286 patients)
RISPERDAL CONSTA (285 patients)
PREMPRO (284 patients)
MOTRIN (283 patients)
DOXYCYCLINE (282 patients)
SPIRONOLACTONE (277 patients)
PROMETHAZINE (276 patients)
HYDROCODONE (273 patients)
GLIPIZIDE (272 patients)
PAROXETINE HCL (270 patients)
LOPRESSOR (269 patients)
FLOMAX (267 patients)
HYDROCODONE BITARTRATE (267 patients)
VERAPAMIL (266 patients)
PEPCID (266 patients)
GLYBURIDE (265 patients)
VITAMINS (264 patients)
REGLAN (262 patients)
REQUIP (262 patients)
BOTOX (262 patients)
PEGASYS (261 patients)
PRAVASTATIN (255 patients)
LOVENOX (253 patients)
MOBIC (251 patients)
CIPRO (249 patients)
MODOPAR (247 patients)
LOVASTATIN (247 patients)
ACYCLOVIR (246 patients)
XOLAIR (246 patients)
ATORVASTATIN CALCIUM (245 patients)
FEMARA (245 patients)
TEMAZEPAM (244 patients)
METOCLOPRAMIDE (244 patients)
CITALOPRAM HYDROBROMIDE (244 patients)
ACIPHEX (243 patients)
MIRALAX (243 patients)

Most common side effects for patients taking SORAFENIB (RAF KINASE INHIBITOR):

DIARRHOEA (613 patients)
HEPATIC FAILURE (378 patients)
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME (342 patients)
HEPATIC ENCEPHALOPATHY (320 patients)
FATIGUE (300 patients)
RASH (276 patients)
ASCITES (253 patients)
ABDOMINAL PAIN (237 patients)
DECREASED APPETITE (226 patients)
UPPER GASTROINTESTINAL HAEMORRHAGE (198 patients)
PYREXIA (191 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (179 patients)
NAUSEA (165 patients)
HYPERTENSION (160 patients)
ASTHENIA (154 patients)
DEHYDRATION (140 patients)
HEPATIC FUNCTION ABNORMAL (133 patients)
DYSPNOEA (131 patients)
CONFUSIONAL STATE (131 patients)
HYPOKALAEMIA (125 patients)
ALOPECIA (124 patients)
VOMITING (118 patients)
CONSTIPATION (115 patients)
INTERSTITIAL LUNG DISEASE (114 patients)
LEFT VENTRICULAR DYSFUNCTION (113 patients)
DEATH (113 patients)
ENDOCARDITIS (112 patients)
ARTHRALGIA (111 patients)
STOMATITIS (111 patients)
ABDOMINAL PAIN UPPER (110 patients)
JAUNDICE (108 patients)
HEPATIC NEOPLASM MALIGNANT (106 patients)
GASTROINTESTINAL HAEMORRHAGE (106 patients)
RETINAL VASCULAR THROMBOSIS (103 patients)
LOWER GASTROINTESTINAL HAEMORRHAGE (103 patients)
LIVER CARCINOMA RUPTURED (101 patients)
OEDEMA PERIPHERAL (97 patients)
PLEURAL EFFUSION (97 patients)
STAPHYLOCOCCAL INFECTION (96 patients)
PNEUMONIA BACTERIAL (96 patients)
ENTEROBACTER INFECTION (96 patients)
MYOPATHY (95 patients)
DRY MOUTH (94 patients)
PAIN IN EXTREMITY (93 patients)
ANXIETY (90 patients)
MALAISE (89 patients)
PULMONARY EMBOLISM (85 patients)
ANAEMIA (84 patients)
PLATELET COUNT DECREASED (81 patients)
BACK PAIN (79 patients)
SEPSIS (78 patients)
PRURITUS (78 patients)
DUODENAL ULCER (77 patients)
MIGRAINE (76 patients)
MITRAL VALVE INCOMPETENCE (76 patients)
HYPOGLYCAEMIA (76 patients)
C-REACTIVE PROTEIN INCREASED (74 patients)
BLOOD PRESSURE INCREASED (73 patients)
VARICES OESOPHAGEAL (73 patients)
HEADACHE (72 patients)
RETINAL VEIN OCCLUSION (72 patients)
ABASIA (69 patients)
RENAL FAILURE ACUTE (69 patients)
WEIGHT DECREASED (67 patients)
DEEP VEIN THROMBOSIS (67 patients)
DIZZINESS (65 patients)
ERYTHEMA (65 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (64 patients)
CONVULSION (63 patients)
ALANINE AMINOTRANSFERASE INCREASED (62 patients)
DYSPHONIA (62 patients)
CEREBRAL HAEMORRHAGE (60 patients)
APHAGIA (58 patients)
COLITIS (58 patients)
PNEUMONIA (57 patients)
GASTRIC ULCER (56 patients)
HYPONATRAEMIA (55 patients)
HAEMOGLOBIN DECREASED (53 patients)
RESPIRATORY FAILURE (52 patients)
LUNG DISORDER (52 patients)
CEREBRAL ISCHAEMIA (49 patients)
PARAESTHESIA (49 patients)
BLOOD BILIRUBIN INCREASED (48 patients)
GAIT DISTURBANCE (48 patients)
THYROID CANCER METASTATIC (44 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (43 patients)
PERICARDIAL EFFUSION (41 patients)
THROMBOCYTOPENIA (41 patients)
BLISTER (41 patients)
FEBRILE NEUTROPENIA (40 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (40 patients)
HALLUCINATION (40 patients)
CHILLS (40 patients)
AMMONIA INCREASED (39 patients)
SKIN ULCER (39 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (38 patients)
PAIN (38 patients)
HYPOALBUMINAEMIA (38 patients)
HYPOCALCAEMIA (37 patients)
FALL (37 patients)
POLLAKIURIA (37 patients)
BLOOD PRESSURE DECREASED (37 patients)
SKIN EXFOLIATION (37 patients)
INSOMNIA (36 patients)
CARDIAC ARREST (36 patients)
HYPOAESTHESIA (35 patients)
INFECTIOUS PERITONITIS (35 patients)
MYOCARDIAL INFARCTION (35 patients)
RETINAL VASCULAR DISORDER (34 patients)
RENAL FAILURE (34 patients)
LIPASE INCREASED (34 patients)
HYPERKALAEMIA (33 patients)
HYPERGLYCAEMIA (33 patients)
HAEMOPTYSIS (31 patients)
ATRIAL FIBRILLATION (30 patients)
GENERALISED OEDEMA (30 patients)
FAECAL INCONTINENCE (30 patients)
WHITE BLOOD CELL COUNT DECREASED (30 patients)
CELLULITIS (29 patients)
CHEST PAIN (29 patients)
SOMNOLENCE (29 patients)
HYPERBILIRUBINAEMIA (28 patients)
HYPOTENSION (28 patients)
MUSCLE SPASMS (28 patients)
ABDOMINAL DISTENSION (27 patients)
WHITE BLOOD CELL COUNT INCREASED (27 patients)
VISION BLURRED (27 patients)
HEPATIC PAIN (26 patients)
BLOOD ALBUMIN DECREASED (26 patients)
DYSURIA (25 patients)
RASH GENERALISED (25 patients)
BLOOD SODIUM DECREASED (25 patients)
BLOOD URIC ACID INCREASED (25 patients)
COMA (25 patients)
COUGH (25 patients)
PANCYTOPENIA (25 patients)
ACUTE ABDOMEN (24 patients)
EOSINOPHIL COUNT INCREASED (24 patients)
CEREBROVASCULAR ACCIDENT (24 patients)
METASTASES TO CENTRAL NERVOUS SYSTEM (23 patients)
CEREBRAL INFARCTION (23 patients)
HYPOMAGNESAEMIA (23 patients)
RETINAL VEIN THROMBOSIS (23 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (23 patients)
TUMOUR LYSIS SYNDROME (22 patients)
HYPOPHOSPHATAEMIA (22 patients)
INFECTION (22 patients)
ORAL PAIN (22 patients)
BLOOD CREATININE INCREASED (22 patients)
NEUTROPENIA (22 patients)
RENAL IMPAIRMENT (22 patients)
LETHARGY (22 patients)
SKIN TOXICITY (21 patients)
TONGUE BLISTERING (21 patients)
LIVER ABSCESS (21 patients)
HAEMATEMESIS (21 patients)
OESOPHAGEAL VARICES HAEMORRHAGE (20 patients)
MENTAL IMPAIRMENT (20 patients)
NERVOUSNESS (20 patients)
NEPHROTIC SYNDROME (20 patients)
HYPOPHAGIA (20 patients)
ADRENAL INSUFFICIENCY (19 patients)
DRY SKIN (19 patients)
BLOOD AMYLASE INCREASED (19 patients)
OEDEMA (19 patients)
INFECTIOUS PLEURAL EFFUSION (19 patients)
DYSPEPSIA (19 patients)
COMA HEPATIC (19 patients)
HEART RATE INCREASED (18 patients)
HYPERTENSIVE CRISIS (18 patients)
MYALGIA (18 patients)
ECZEMA (18 patients)
URINARY TRACT INFECTION (18 patients)
NEUROMYOPATHY (18 patients)
MEDICAL DEVICE COMPLICATION (18 patients)
DIVERTICULITIS (18 patients)
OSTEOMYELITIS (18 patients)
CEREBRAL ATROPHY (18 patients)
CEREBRAL VENTRICLE DILATATION (18 patients)
DIABETIC FOOT INFECTION (18 patients)
NECK PAIN (18 patients)
OLIGURIA (17 patients)
GASTROINTESTINAL DISORDER (17 patients)
HAEMATOCHEZIA (17 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (17 patients)
HYPOTHYROIDISM (17 patients)
TRANSAMINASES INCREASED (17 patients)
OROPHARYNGEAL PAIN (17 patients)
CHRONIC MYELOID LEUKAEMIA (17 patients)
NEOPLASM PROGRESSION (17 patients)
METASTASES TO ADRENALS (16 patients)
LYMPHOCYTE COUNT DECREASED (16 patients)
INTERNATIONAL NORMALISED RATIO INCREASED (16 patients)
MULTI-ORGAN FAILURE (16 patients)
FEAR (16 patients)
PANCREATIC CARCINOMA (16 patients)
HYPERSOMNIA (16 patients)
EPILEPSY (16 patients)
SUBARACHNOID HAEMORRHAGE (16 patients)
METASTASES TO LUNG (16 patients)
TACHYCARDIA (16 patients)
MUSCULAR WEAKNESS (16 patients)
KLEBSIELLA SEPSIS (16 patients)
MYOCARDIAL ISCHAEMIA (16 patients)
DYSGEUSIA (16 patients)
LUNG INFECTION (16 patients)
FAECES DISCOLOURED (16 patients)
PAIN OF SKIN (16 patients)
SPINAL FRACTURE (16 patients)
PANIC REACTION (16 patients)

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