Is NEUTROPENIA a side effect of SORAFENIB (RAF KINASE INHIBITOR) ? ( FactMed.com )

About this FactMed analysis covering adverse side effect reports of SORAFENIB (RAF KINASE INHIBITOR) patients who developed NEUTROPENIA.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 22 individuals taking SORAFENIB (RAF KINASE INHIBITOR) reported NEUTROPENIA to the FDA. A total of 3329 SORAFENIB (RAF KINASE INHIBITOR) drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between SORAFENIB (RAF KINASE INHIBITOR) and NEUTROPENIA. In doing so, we compare SORAFENIB (RAF KINASE INHIBITOR) with other drugs that cause NEUTROPENIA, to help you evaluate whether or not SORAFENIB (RAF KINASE INHIBITOR) causes NEUTROPENIA. Likewise, this page shows the most highly-reported side effects of SORAFENIB (RAF KINASE INHIBITOR), so you can see if NEUTROPENIA ranks among SORAFENIB (RAF KINASE INHIBITOR)'s most well-known side effects.

Summary Statistics
Reports of SORAFENIB (RAF KINASE INHIBITOR) causing NEUTROPENIA: 22
Reports of any side effect of SORAFENIB (RAF KINASE INHIBITOR) : 3329
Percentage of SORAFENIB (RAF KINASE INHIBITOR) patients where NEUTROPENIA is a reported side effect: 0.6609%

FDA reports of any drug causing NEUTROPENIA : 28973
Average percentage for all medicated patients where NEUTROPENIA is reported as a complication: 0.1816%

Physician opinion on SORAFENIB (RAF KINASE INHIBITOR) as adverse event culprit:

Overall opinion for all reports of this drug:

Most frequent diagnoses/indications for prescribing SORAFENIB (RAF KINASE INHIBITOR):

HEPATIC NEOPLASM MALIGNANT ( 770 patients )
RENAL CELL CARCINOMA ( 114 patients )
THYROID CANCER ( 65 patients )
METASTATIC RENAL CELL CARCINOMA ( 44 patients )
THYROID CANCER METASTATIC ( 35 patients )
BREAST CANCER ( 31 patients )
BREAST CANCER METASTATIC ( 27 patients )
GASTRIC CANCER ( 25 patients )
NON-SMALL CELL LUNG CANCER ( 25 patients )
COLORECTAL CANCER METASTATIC ( 22 patients )
RENAL CANCER ( 17 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 14 patients )
BILE DUCT CANCER ( 14 patients )
SALIVARY GLAND CANCER ( 7 patients )
HEPATIC CANCER METASTATIC ( 7 patients )
COLORECTAL CANCER ( 7 patients )
SMALL CELL LUNG CANCER STAGE UNSPECIFIED ( 6 patients )
RECTAL CANCER ( 5 patients )
PANCREATIC CARCINOMA ( 4 patients )
PROSTATE CANCER ( 4 patients )
INTRAOCULAR MELANOMA ( 4 patients )
HEPATIC NEOPLASM MALIGNANT RECURRENT ( 3 patients )
NEOPLASM ( 3 patients )
LIVER DISORDER ( 3 patients )
ANGIOSARCOMA ( 3 patients )
NON-SMALL CELL LUNG CANCER STAGE IV ( 3 patients )
METASTASES TO LUNG ( 3 patients )
HEPATIC NEOPLASM MALIGNANT NON-RESECTABLE ( 3 patients )
COLORECTAL CANCER STAGE IV ( 3 patients )
NEOPLASM MALIGNANT ( 3 patients )
GALLBLADDER CANCER METASTATIC ( 3 patients )
BILIARY CANCER METASTATIC ( 3 patients )
METASTASIS ( 3 patients )
COLON CANCER METASTATIC ( 2 patients )
HYPOPHARYNGEAL CANCER ( 2 patients )
DESMOID TUMOUR ( 2 patients )
NEUROENDOCRINE CARCINOMA ( 2 patients )
ACUTE MYELOID LEUKAEMIA (IN REMISSION) ( 2 patients )
LUNG NEOPLASM MALIGNANT ( 2 patients )
OESOPHAGEAL CARCINOMA ( 2 patients )
METASTATIC MALIGNANT MELANOMA ( 2 patients )
TONGUE NEOPLASM MALIGNANT STAGE UNSPECIFIED ( 2 patients )
METASTATIC SQUAMOUS CELL CARCINOMA ( 2 patients )
ANGINA PECTORIS ( 2 patients )
RENAL CELL CARCINOMA STAGE IV ( 2 patients )
OSTEOSARCOMA METASTATIC ( 2 patients )
BONE SARCOMA ( 2 patients )
METASTATIC OCULAR MELANOMA ( 2 patients )
METASTATIC SALIVARY GLAND CANCER ( 2 patients )
TONSIL CANCER ( 2 patients )
MYELODYSPLASTIC SYNDROME ( 1 patients )
PROSTATE CANCER METASTATIC ( 1 patients )
GALLBLADDER CANCER ( 1 patients )
NEUROENDOCRINE TUMOUR ( 1 patients )
MALIGNANT NEOPLASM OF RENAL PELVIS ( 1 patients )
GLIOMA ( 1 patients )
BLADDER CANCER ( 1 patients )
OVARIAN CANCER METASTATIC ( 1 patients )
CAROTID ARTERY DISEASE ( 1 patients )
HEPATOBLASTOMA ( 1 patients )
NASOPHARYNGEAL CANCER ( 1 patients )
ACUTE MYELOID LEUKAEMIA ( 1 patients )
LUNG ADENOCARCINOMA ( 1 patients )
RENAL CANCER METASTATIC ( 1 patients )
DIFFUSE LARGE B-CELL LYMPHOMA ( 1 patients )
NEUROENDOCRINE CARCINOMA OF THE SKIN ( 1 patients )
MALIGNANT HISTIOCYTOSIS ( 1 patients )
ANTICOAGULANT THERAPY ( 1 patients )
MALIGNANT SOFT TISSUE NEOPLASM ( 1 patients )
SARCOMA ( 1 patients )
GERM CELL CANCER ( 1 patients )
OESOPHAGEAL ADENOCARCINOMA ( 1 patients )
SQUAMOUS CELL CARCINOMA ( 1 patients )
HEAD AND NECK CANCER ( 1 patients )
OVARIAN EPITHELIAL CANCER ( 1 patients )
( 0 patients )

Drugs with high FDA adverse event association with NEUTROPENIA:

CYCLOPHOSPHAMIDE (2894 patients)
REVLIMID (2712 patients)
DEXAMETHASONE (2406 patients)
CISPLATIN (1972 patients)
FLUOROURACIL (1932 patients)
CARBOPLATIN (1786 patients)
DOXORUBICIN HCL (1583 patients)
ASPIRIN (1514 patients)
CLOZARIL (1458 patients)
PREDNISONE (1391 patients)
VINCRISTINE (1250 patients)
METHOTREXATE (1230 patients)
DOCETAXEL (1215 patients)
ETOPOSIDE (1209 patients)
OMEPRAZOLE (1199 patients)
NEUPOGEN (1178 patients)
PREDNISOLONE (1161 patients)
RITUXIMAB (1099 patients)
CYTARABINE (1031 patients)
ACETAMINOPHEN (1015 patients)
ZOMETA (1013 patients)
DECADRON (921 patients)
NEULASTA (888 patients)
ZOFRAN (881 patients)
CLOZAPINE (876 patients)
PACLITAXEL (849 patients)
OXALIPLATIN (848 patients)
ALLOPURINOL (845 patients)
LASIX (820 patients)
FOLIC ACID (815 patients)
ACYCLOVIR (807 patients)
PREDNISONE TAB (752 patients)
TAXOTERE (744 patients)
TAXOL (709 patients)
FLUCONAZOLE (707 patients)
LORAZEPAM (698 patients)
LEUCOVORIN CALCIUM (679 patients)
NEXIUM (652 patients)
SEROQUEL (629 patients)
PEGASYS (620 patients)
HEPARIN SODIUM INJECTION (618 patients)
FUROSEMIDE (611 patients)
RIBAVIRIN (606 patients)
CAPECITABINE (604 patients)
COMPAZINE (590 patients)
AREDIA (588 patients)
BACTRIM (578 patients)
VANCOMYCIN (566 patients)
VELCADE (566 patients)
POTASSIUM CHLORIDE (552 patients)
BEVACIZUMAB (551 patients)
LANSOPRAZOLE (536 patients)
IRINOTECAN HCL (536 patients)
ZYPREXA (530 patients)
GEMCITABINE (521 patients)
SIMVASTATIN (513 patients)
LEVOTHYROXINE SODIUM (505 patients)
ONDANSETRON (504 patients)
FOSAMAX (503 patients)
COUMADIN (503 patients)
MABTHERA (498 patients)
XELODA (497 patients)
ATIVAN (485 patients)
LISINOPRIL (481 patients)
AVASTIN (479 patients)
CETUXIMAB (473 patients)
GABAPENTIN (470 patients)
LAPATINIB (455 patients)
MORPHINE (452 patients)
CIPROFLOXACIN (448 patients)
GLEEVEC (443 patients)
AMBIEN (440 patients)
DEXAMETHASONE TAB (437 patients)
ATENOLOL (436 patients)
FLUDARABINE PHOSPHATE (435 patients)
VINCRISTINE SULFATE (434 patients)
LIPITOR (430 patients)
EPIRUBICIN (430 patients)
ARANESP (425 patients)
HYDROCHLOROTHIAZIDE (421 patients)
LOVENOX (418 patients)
RITUXAN (416 patients)
HERCEPTIN (415 patients)
PROTONIX (409 patients)
OXYCONTIN (395 patients)
VIDAZA (393 patients)
EXJADE (381 patients)
IBUPROFEN (380 patients)
OLANZAPINE (378 patients)
LEVAQUIN (376 patients)
TRASTUZUMAB (373 patients)
WARFARIN SODIUM (367 patients)
NEURONTIN (364 patients)
ADRIAMYCIN PFS (357 patients)
THALIDOMIDE (356 patients)
IFOSFAMIDE (355 patients)
METOCLOPRAMIDE (355 patients)
OXYCODONE HCL (355 patients)
LYRICA (353 patients)
DOXORUBICIN HYDROCHLORIDE (350 patients)
LEVOFLOXACIN (350 patients)
RISPERDAL (347 patients)
COPEGUS (347 patients)
CYTOXAN (342 patients)
CYCLOSPORINE (339 patients)
METHYLPREDNISOLONE (337 patients)
RANITIDINE (333 patients)
VALPROATE SODIUM (331 patients)
SYNTHROID (324 patients)
CLONAZEPAM (323 patients)
REMICADE (323 patients)
PRILOSEC (322 patients)
ALBUTEROL (320 patients)
ALIMTA (318 patients)
VITAMIN B-12 (317 patients)
NORVASC (314 patients)
METFORMIN HCL (312 patients)
DIFLUCAN (311 patients)
AMOXICILLIN (310 patients)
FAMOTIDINE (309 patients)
AMLODIPINE (309 patients)
RISPERIDONE (304 patients)
TACROLIMUS (302 patients)
ZIDOVUDINE (302 patients)
XANAX (298 patients)
KYTRIL (294 patients)
KEPPRA (291 patients)
AUGMENTIN '125' (288 patients)
GEMZAR (287 patients)
MORPHINE SULFATE (285 patients)
ZANTAC (281 patients)
PLAVIX (275 patients)
VICODIN (272 patients)
PERCOCET (271 patients)
CITALOPRAM HYDROBROMIDE (270 patients)
VITAMIN D (270 patients)
MYCOPHENOLATE MOFETIL (269 patients)
ZOLOFT (265 patients)
FENTANYL (265 patients)
THALOMID (263 patients)
MIRTAZAPINE (263 patients)
HYDROCORTISONE (261 patients)
RAMIPRIL (261 patients)
RETROVIR (259 patients)
MULTI-VITAMINS (254 patients)
RADIATION THERAPY (254 patients)
LACTULOSE (253 patients)
PANTOPRAZOLE (252 patients)
DIAZEPAM (251 patients)
NYSTATIN (251 patients)
HEPARIN (248 patients)
MEROPENEM (245 patients)
DEPAKOTE (245 patients)
PANTOPRAZOLE SODIUM (244 patients)
PROCRIT (243 patients)
ZOCOR (243 patients)
CALCIUM (241 patients)
FILGRASTIM (239 patients)
CELEBREX (236 patients)
LAMIVUDINE (235 patients)
CALCIUM CARBONATE (232 patients)
MAGNESIUM OXIDE (232 patients)
PROGRAF (230 patients)
NAVELBINE (229 patients)
SOLU-MEDROL (227 patients)
DAUNORUBICIN HCL (226 patients)
TRAMADOL HCL (226 patients)
PEG-INTRON (222 patients)
PARACETAMOL (222 patients)
SOLIRIS (222 patients)
CAMPTOSAR (222 patients)
PROCHLORPERAZINE (218 patients)
ENBREL (214 patients)
PAXIL (214 patients)
FLAGYL (213 patients)
MELPHALAN (212 patients)
SULFAMETHOXAZOLE AND TRIMETHOPRIM (212 patients)
DIGOXIN (212 patients)
MERCAPTOPURINE (210 patients)
LENALIDOMIDE (210 patients)
PANITUMUMAB (210 patients)
CIPRO (209 patients)
BENADRYL (209 patients)
MELPHALAN HYDROCHLORIDE (207 patients)
ERBITUX (205 patients)
COLACE (202 patients)
METOPROLOL TARTRATE (202 patients)
VINORELBINE (200 patients)
LEXAPRO (200 patients)
MESNA (199 patients)
TEMOZOLOMIDE (199 patients)
LORTAB (198 patients)
ITRACONAZOLE (198 patients)
VIOXX (198 patients)
VALPROIC ACID (197 patients)
HALAVEN (197 patients)
MULTI-VITAMIN (197 patients)
EMEND (196 patients)
SUTENT (195 patients)
VALTREX (195 patients)
PEGINTERFERON ALFA-2A (194 patients)
FERROUS SULFATE TAB (194 patients)
GEMCITABINE HCL (194 patients)
FLUDARA (194 patients)
DURAGESIC-100 (193 patients)
CAMPATH (193 patients)
DOXIL (193 patients)
ZOLPIDEM (193 patients)
CELEXA (193 patients)
SPIRIVA (193 patients)

Most common side effects for patients taking SORAFENIB (RAF KINASE INHIBITOR):

DIARRHOEA (613 patients)
HEPATIC FAILURE (378 patients)
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME (342 patients)
HEPATIC ENCEPHALOPATHY (320 patients)
FATIGUE (300 patients)
RASH (276 patients)
ASCITES (253 patients)
ABDOMINAL PAIN (237 patients)
DECREASED APPETITE (226 patients)
UPPER GASTROINTESTINAL HAEMORRHAGE (198 patients)
PYREXIA (191 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (179 patients)
NAUSEA (165 patients)
HYPERTENSION (160 patients)
ASTHENIA (154 patients)
DEHYDRATION (140 patients)
HEPATIC FUNCTION ABNORMAL (133 patients)
DYSPNOEA (131 patients)
CONFUSIONAL STATE (131 patients)
HYPOKALAEMIA (125 patients)
ALOPECIA (124 patients)
VOMITING (118 patients)
CONSTIPATION (115 patients)
INTERSTITIAL LUNG DISEASE (114 patients)
LEFT VENTRICULAR DYSFUNCTION (113 patients)
DEATH (113 patients)
ENDOCARDITIS (112 patients)
ARTHRALGIA (111 patients)
STOMATITIS (111 patients)
ABDOMINAL PAIN UPPER (110 patients)
JAUNDICE (108 patients)
HEPATIC NEOPLASM MALIGNANT (106 patients)
GASTROINTESTINAL HAEMORRHAGE (106 patients)
RETINAL VASCULAR THROMBOSIS (103 patients)
LOWER GASTROINTESTINAL HAEMORRHAGE (103 patients)
LIVER CARCINOMA RUPTURED (101 patients)
OEDEMA PERIPHERAL (97 patients)
PLEURAL EFFUSION (97 patients)
STAPHYLOCOCCAL INFECTION (96 patients)
PNEUMONIA BACTERIAL (96 patients)
ENTEROBACTER INFECTION (96 patients)
MYOPATHY (95 patients)
DRY MOUTH (94 patients)
PAIN IN EXTREMITY (93 patients)
ANXIETY (90 patients)
MALAISE (89 patients)
PULMONARY EMBOLISM (85 patients)
ANAEMIA (84 patients)
PLATELET COUNT DECREASED (81 patients)
BACK PAIN (79 patients)
SEPSIS (78 patients)
PRURITUS (78 patients)
DUODENAL ULCER (77 patients)
MIGRAINE (76 patients)
MITRAL VALVE INCOMPETENCE (76 patients)
HYPOGLYCAEMIA (76 patients)
C-REACTIVE PROTEIN INCREASED (74 patients)
BLOOD PRESSURE INCREASED (73 patients)
VARICES OESOPHAGEAL (73 patients)
HEADACHE (72 patients)
RETINAL VEIN OCCLUSION (72 patients)
ABASIA (69 patients)
RENAL FAILURE ACUTE (69 patients)
WEIGHT DECREASED (67 patients)
DEEP VEIN THROMBOSIS (67 patients)
DIZZINESS (65 patients)
ERYTHEMA (65 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (64 patients)
CONVULSION (63 patients)
ALANINE AMINOTRANSFERASE INCREASED (62 patients)
DYSPHONIA (62 patients)
CEREBRAL HAEMORRHAGE (60 patients)
APHAGIA (58 patients)
COLITIS (58 patients)
PNEUMONIA (57 patients)
GASTRIC ULCER (56 patients)
HYPONATRAEMIA (55 patients)
HAEMOGLOBIN DECREASED (53 patients)
RESPIRATORY FAILURE (52 patients)
LUNG DISORDER (52 patients)
CEREBRAL ISCHAEMIA (49 patients)
PARAESTHESIA (49 patients)
BLOOD BILIRUBIN INCREASED (48 patients)
GAIT DISTURBANCE (48 patients)
THYROID CANCER METASTATIC (44 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (43 patients)
PERICARDIAL EFFUSION (41 patients)
THROMBOCYTOPENIA (41 patients)
BLISTER (41 patients)
FEBRILE NEUTROPENIA (40 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (40 patients)
HALLUCINATION (40 patients)
CHILLS (40 patients)
AMMONIA INCREASED (39 patients)
SKIN ULCER (39 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (38 patients)
PAIN (38 patients)
HYPOALBUMINAEMIA (38 patients)
HYPOCALCAEMIA (37 patients)
FALL (37 patients)
POLLAKIURIA (37 patients)
BLOOD PRESSURE DECREASED (37 patients)
SKIN EXFOLIATION (37 patients)
INSOMNIA (36 patients)
CARDIAC ARREST (36 patients)
HYPOAESTHESIA (35 patients)
INFECTIOUS PERITONITIS (35 patients)
MYOCARDIAL INFARCTION (35 patients)
RETINAL VASCULAR DISORDER (34 patients)
RENAL FAILURE (34 patients)
LIPASE INCREASED (34 patients)
HYPERKALAEMIA (33 patients)
HYPERGLYCAEMIA (33 patients)
HAEMOPTYSIS (31 patients)
ATRIAL FIBRILLATION (30 patients)
GENERALISED OEDEMA (30 patients)
FAECAL INCONTINENCE (30 patients)
WHITE BLOOD CELL COUNT DECREASED (30 patients)
CELLULITIS (29 patients)
CHEST PAIN (29 patients)
SOMNOLENCE (29 patients)
HYPERBILIRUBINAEMIA (28 patients)
HYPOTENSION (28 patients)
MUSCLE SPASMS (28 patients)
ABDOMINAL DISTENSION (27 patients)
WHITE BLOOD CELL COUNT INCREASED (27 patients)
VISION BLURRED (27 patients)
HEPATIC PAIN (26 patients)
BLOOD ALBUMIN DECREASED (26 patients)
DYSURIA (25 patients)
RASH GENERALISED (25 patients)
BLOOD SODIUM DECREASED (25 patients)
BLOOD URIC ACID INCREASED (25 patients)
COMA (25 patients)
COUGH (25 patients)
PANCYTOPENIA (25 patients)
ACUTE ABDOMEN (24 patients)
EOSINOPHIL COUNT INCREASED (24 patients)
CEREBROVASCULAR ACCIDENT (24 patients)
METASTASES TO CENTRAL NERVOUS SYSTEM (23 patients)
CEREBRAL INFARCTION (23 patients)
HYPOMAGNESAEMIA (23 patients)
RETINAL VEIN THROMBOSIS (23 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (23 patients)
TUMOUR LYSIS SYNDROME (22 patients)
HYPOPHOSPHATAEMIA (22 patients)
INFECTION (22 patients)
ORAL PAIN (22 patients)
BLOOD CREATININE INCREASED (22 patients)
NEUTROPENIA (22 patients)
RENAL IMPAIRMENT (22 patients)
LETHARGY (22 patients)
SKIN TOXICITY (21 patients)
TONGUE BLISTERING (21 patients)
LIVER ABSCESS (21 patients)
HAEMATEMESIS (21 patients)
OESOPHAGEAL VARICES HAEMORRHAGE (20 patients)
MENTAL IMPAIRMENT (20 patients)
NERVOUSNESS (20 patients)
NEPHROTIC SYNDROME (20 patients)
HYPOPHAGIA (20 patients)
ADRENAL INSUFFICIENCY (19 patients)
DRY SKIN (19 patients)
BLOOD AMYLASE INCREASED (19 patients)
OEDEMA (19 patients)
INFECTIOUS PLEURAL EFFUSION (19 patients)
DYSPEPSIA (19 patients)
COMA HEPATIC (19 patients)
HEART RATE INCREASED (18 patients)
HYPERTENSIVE CRISIS (18 patients)
MYALGIA (18 patients)
ECZEMA (18 patients)
URINARY TRACT INFECTION (18 patients)
NEUROMYOPATHY (18 patients)
MEDICAL DEVICE COMPLICATION (18 patients)
DIVERTICULITIS (18 patients)
OSTEOMYELITIS (18 patients)
CEREBRAL ATROPHY (18 patients)
CEREBRAL VENTRICLE DILATATION (18 patients)
DIABETIC FOOT INFECTION (18 patients)
NECK PAIN (18 patients)
OLIGURIA (17 patients)
GASTROINTESTINAL DISORDER (17 patients)
HAEMATOCHEZIA (17 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (17 patients)
HYPOTHYROIDISM (17 patients)
TRANSAMINASES INCREASED (17 patients)
OROPHARYNGEAL PAIN (17 patients)
CHRONIC MYELOID LEUKAEMIA (17 patients)
NEOPLASM PROGRESSION (17 patients)
METASTASES TO ADRENALS (16 patients)
LYMPHOCYTE COUNT DECREASED (16 patients)
INTERNATIONAL NORMALISED RATIO INCREASED (16 patients)
MULTI-ORGAN FAILURE (16 patients)
FEAR (16 patients)
PANCREATIC CARCINOMA (16 patients)
HYPERSOMNIA (16 patients)
EPILEPSY (16 patients)
SUBARACHNOID HAEMORRHAGE (16 patients)
METASTASES TO LUNG (16 patients)
TACHYCARDIA (16 patients)
MUSCULAR WEAKNESS (16 patients)
KLEBSIELLA SEPSIS (16 patients)
MYOCARDIAL ISCHAEMIA (16 patients)
DYSGEUSIA (16 patients)
LUNG INFECTION (16 patients)
FAECES DISCOLOURED (16 patients)
PAIN OF SKIN (16 patients)
SPINAL FRACTURE (16 patients)
PANIC REACTION (16 patients)

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