Is OEDEMA a side effect of SORAFENIB (RAF KINASE INHIBITOR) ? ( FactMed.com )

About this FactMed analysis covering adverse side effect reports of SORAFENIB (RAF KINASE INHIBITOR) patients who developed OEDEMA.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 19 individuals taking SORAFENIB (RAF KINASE INHIBITOR) reported OEDEMA to the FDA. A total of 3329 SORAFENIB (RAF KINASE INHIBITOR) drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between SORAFENIB (RAF KINASE INHIBITOR) and OEDEMA. In doing so, we compare SORAFENIB (RAF KINASE INHIBITOR) with other drugs that cause OEDEMA, to help you evaluate whether or not SORAFENIB (RAF KINASE INHIBITOR) causes OEDEMA. Likewise, this page shows the most highly-reported side effects of SORAFENIB (RAF KINASE INHIBITOR), so you can see if OEDEMA ranks among SORAFENIB (RAF KINASE INHIBITOR)'s most well-known side effects.

Summary Statistics
Reports of SORAFENIB (RAF KINASE INHIBITOR) causing OEDEMA: 19
Reports of any side effect of SORAFENIB (RAF KINASE INHIBITOR) : 3329
Percentage of SORAFENIB (RAF KINASE INHIBITOR) patients where OEDEMA is a reported side effect: 0.5707%

FDA reports of any drug causing OEDEMA : 18153
Average percentage for all medicated patients where OEDEMA is reported as a complication: 0.1138%

Physician opinion on SORAFENIB (RAF KINASE INHIBITOR) as adverse event culprit:

Overall opinion for all reports of this drug:

Most frequent diagnoses/indications for prescribing SORAFENIB (RAF KINASE INHIBITOR):

HEPATIC NEOPLASM MALIGNANT ( 770 patients )
RENAL CELL CARCINOMA ( 114 patients )
THYROID CANCER ( 65 patients )
METASTATIC RENAL CELL CARCINOMA ( 44 patients )
THYROID CANCER METASTATIC ( 35 patients )
BREAST CANCER ( 31 patients )
BREAST CANCER METASTATIC ( 27 patients )
GASTRIC CANCER ( 25 patients )
NON-SMALL CELL LUNG CANCER ( 25 patients )
COLORECTAL CANCER METASTATIC ( 22 patients )
RENAL CANCER ( 17 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 14 patients )
BILE DUCT CANCER ( 14 patients )
SALIVARY GLAND CANCER ( 7 patients )
HEPATIC CANCER METASTATIC ( 7 patients )
COLORECTAL CANCER ( 7 patients )
SMALL CELL LUNG CANCER STAGE UNSPECIFIED ( 6 patients )
RECTAL CANCER ( 5 patients )
PANCREATIC CARCINOMA ( 4 patients )
PROSTATE CANCER ( 4 patients )
INTRAOCULAR MELANOMA ( 4 patients )
HEPATIC NEOPLASM MALIGNANT RECURRENT ( 3 patients )
NEOPLASM ( 3 patients )
LIVER DISORDER ( 3 patients )
ANGIOSARCOMA ( 3 patients )
NON-SMALL CELL LUNG CANCER STAGE IV ( 3 patients )
METASTASES TO LUNG ( 3 patients )
HEPATIC NEOPLASM MALIGNANT NON-RESECTABLE ( 3 patients )
COLORECTAL CANCER STAGE IV ( 3 patients )
NEOPLASM MALIGNANT ( 3 patients )
GALLBLADDER CANCER METASTATIC ( 3 patients )
BILIARY CANCER METASTATIC ( 3 patients )
METASTASIS ( 3 patients )
COLON CANCER METASTATIC ( 2 patients )
HYPOPHARYNGEAL CANCER ( 2 patients )
DESMOID TUMOUR ( 2 patients )
NEUROENDOCRINE CARCINOMA ( 2 patients )
ACUTE MYELOID LEUKAEMIA (IN REMISSION) ( 2 patients )
LUNG NEOPLASM MALIGNANT ( 2 patients )
OESOPHAGEAL CARCINOMA ( 2 patients )
METASTATIC MALIGNANT MELANOMA ( 2 patients )
TONGUE NEOPLASM MALIGNANT STAGE UNSPECIFIED ( 2 patients )
METASTATIC SQUAMOUS CELL CARCINOMA ( 2 patients )
ANGINA PECTORIS ( 2 patients )
RENAL CELL CARCINOMA STAGE IV ( 2 patients )
OSTEOSARCOMA METASTATIC ( 2 patients )
BONE SARCOMA ( 2 patients )
METASTATIC OCULAR MELANOMA ( 2 patients )
METASTATIC SALIVARY GLAND CANCER ( 2 patients )
TONSIL CANCER ( 2 patients )
MYELODYSPLASTIC SYNDROME ( 1 patients )
PROSTATE CANCER METASTATIC ( 1 patients )
GALLBLADDER CANCER ( 1 patients )
NEUROENDOCRINE TUMOUR ( 1 patients )
MALIGNANT NEOPLASM OF RENAL PELVIS ( 1 patients )
GLIOMA ( 1 patients )
BLADDER CANCER ( 1 patients )
OVARIAN CANCER METASTATIC ( 1 patients )
CAROTID ARTERY DISEASE ( 1 patients )
HEPATOBLASTOMA ( 1 patients )
NASOPHARYNGEAL CANCER ( 1 patients )
ACUTE MYELOID LEUKAEMIA ( 1 patients )
LUNG ADENOCARCINOMA ( 1 patients )
RENAL CANCER METASTATIC ( 1 patients )
DIFFUSE LARGE B-CELL LYMPHOMA ( 1 patients )
NEUROENDOCRINE CARCINOMA OF THE SKIN ( 1 patients )
MALIGNANT HISTIOCYTOSIS ( 1 patients )
ANTICOAGULANT THERAPY ( 1 patients )
MALIGNANT SOFT TISSUE NEOPLASM ( 1 patients )
SARCOMA ( 1 patients )
GERM CELL CANCER ( 1 patients )
OESOPHAGEAL ADENOCARCINOMA ( 1 patients )
SQUAMOUS CELL CARCINOMA ( 1 patients )
HEAD AND NECK CANCER ( 1 patients )
OVARIAN EPITHELIAL CANCER ( 1 patients )
( 0 patients )

Drugs with high FDA adverse event association with OEDEMA:

ASPIRIN (1936 patients)
FOSAMAX (1632 patients)
LASIX (1619 patients)
VIOXX (1601 patients)
FUROSEMIDE (1162 patients)
HEPARIN SODIUM INJECTION (1069 patients)
LYRICA (1030 patients)
AVANDIA (968 patients)
ZOMETA (965 patients)
GLEEVEC (923 patients)
COUMADIN (878 patients)
PREDNISONE (853 patients)
LIPITOR (743 patients)
LISINOPRIL (729 patients)
MAGNEVIST (642 patients)
NORVASC (638 patients)
DIGOXIN (622 patients)
ATENOLOL (600 patients)
SYNTHROID (600 patients)
OMEPRAZOLE (595 patients)
POTASSIUM CHLORIDE (558 patients)
NEURONTIN (557 patients)
ACETAMINOPHEN (550 patients)
OMNISCAN (543 patients)
NEXIUM (533 patients)
DEXAMETHASONE (515 patients)
PREDNISOLONE (508 patients)
AREDIA (504 patients)
PLAVIX (495 patients)
TRACLEER (487 patients)
DIOVAN (482 patients)
ALLOPURINOL (472 patients)
PROTONIX (467 patients)
METHOTREXATE (464 patients)
SEROQUEL (452 patients)
HYDROCHLOROTHIAZIDE (446 patients)
LEVOTHYROXINE SODIUM (441 patients)
FOLIC ACID (431 patients)
ALBUTEROL (427 patients)
METFORMIN HCL (421 patients)
OXYCONTIN (420 patients)
LORAZEPAM (410 patients)
GABAPENTIN (405 patients)
XANAX (405 patients)
SIMVASTATIN (402 patients)
PRILOSEC (401 patients)
LETAIRIS (399 patients)
ZOLOFT (395 patients)
CELEBREX (394 patients)
SPIRONOLACTONE (389 patients)
IBUPROFEN (385 patients)
REMICADE (381 patients)
ZOCOR (379 patients)
ATIVAN (378 patients)
DECADRON (368 patients)
ACTOS (367 patients)
WARFARIN SODIUM (360 patients)
MORPHINE (360 patients)
INSULIN (359 patients)
VICODIN (357 patients)
PREVACID (353 patients)
LANTUS (351 patients)
HUMIRA (349 patients)
AMBIEN (349 patients)
CYCLOSPORINE (347 patients)
CYCLOPHOSPHAMIDE (347 patients)
LEVAQUIN (344 patients)
PERCOCET (334 patients)
EPOGEN (333 patients)
ALDACTONE (331 patients)
TOPROL-XL (326 patients)
COREG (325 patients)
PAXIL (325 patients)
CRESTOR (320 patients)
PREDNISONE TAB (316 patients)
AMLODIPINE (315 patients)
CYMBALTA (311 patients)
TAXOTERE (308 patients)
OXYCODONE HCL (302 patients)
LEXAPRO (297 patients)
VITAMIN D (293 patients)
METOPROLOL TARTRATE (293 patients)
DILAUDID (277 patients)
VELCADE (267 patients)
ACYCLOVIR (262 patients)
ZOFRAN (261 patients)
CALCIUM (261 patients)
REVLIMID (261 patients)
ZYPREXA (258 patients)
THALIDOMIDE (257 patients)
LORTAB (257 patients)
GLUCOPHAGE (254 patients)
NITROGLYCERIN (249 patients)
ALPRAZOLAM (248 patients)
ZANTAC (246 patients)
FENTANYL (245 patients)
COMPAZINE (244 patients)
ARANESP (244 patients)
VANCOMYCIN (241 patients)
REGLAN (232 patients)
TRAMADOL HCL (229 patients)
SANDOSTATIN LAR (228 patients)
LOVENOX (224 patients)
ADVAIR DISKUS 100/50 (220 patients)
PREMARIN (215 patients)
AMOXICILLIN (213 patients)
AMARYL (213 patients)
GLIPIZIDE (213 patients)
LANSOPRAZOLE (213 patients)
OPTIMARK (211 patients)
PROCRIT (210 patients)
CELEXA (210 patients)
ASCORBIC ACID (208 patients)
COZAAR (206 patients)
ALENDRONATE SODIUM (206 patients)
WELLBUTRIN (205 patients)
NEORAL (205 patients)
LOPRESSOR (205 patients)
REVATIO (205 patients)
IRON (205 patients)
EFFEXOR (202 patients)
CIPROFLOXACIN (201 patients)
MYCOPHENOLATE MOFETIL (200 patients)
SPIRIVA (199 patients)
ZYRTEC (198 patients)
RENAGEL (196 patients)
CLONIDINE (194 patients)
KLOR-CON (194 patients)
ENBREL (194 patients)
GADOLINIUM IN UNSPECIFIED DRUG (193 patients)
ENALAPRIL MALEATE (192 patients)
CALCIUM CARBONATE (191 patients)
COLACE (189 patients)
LAMICTAL (188 patients)
ALTACE (187 patients)
AMIODARONE HCL (187 patients)
FERROUS SULFATE TAB (186 patients)
DURAGESIC-100 (185 patients)
JANUVIA (184 patients)
RISPERDAL (184 patients)
CARVEDILOL (184 patients)
CLONAZEPAM (183 patients)
AVANDAMET (183 patients)
FLUCONAZOLE (183 patients)
PROZAC (179 patients)
METOPROLOL (178 patients)
METHYLPREDNISOLONE (177 patients)
AUGMENTIN '125' (174 patients)
CLARITIN (172 patients)
FLONASE (171 patients)
FAMOTIDINE (170 patients)
ALLEGRA (169 patients)
BACTRIM (167 patients)
MULTI-VITAMINS (166 patients)
HUMALOG (166 patients)
[THERAPY UNSPECIFIED] (165 patients)
EXJADE (165 patients)
CARBOPLATIN (164 patients)
TYLENOL (CAPLET) (162 patients)
CHANTIX (162 patients)
HYDROCODONE (161 patients)
GLYBURIDE (161 patients)
FLAGYL (160 patients)
KLONOPIN (157 patients)
CLINDAMYCIN (156 patients)
HYDROCODONE BITARTRATE (156 patients)
PROGRAF (156 patients)
MORPHINE SULFATE (156 patients)
HEPARIN (155 patients)
BENADRYL (154 patients)
ARIMIDEX (153 patients)
CYTARABINE (153 patients)
SINGULAIR (151 patients)
DIAZEPAM (151 patients)
CEPHALEXIN (149 patients)
MAGNESIUM OXIDE (148 patients)
TAXOL (148 patients)
POTASSIUM (147 patients)
VITAMIN B-12 (147 patients)
LIDOCAINE (146 patients)
ZETIA (145 patients)
PEPCID (145 patients)
TORSEMIDE (145 patients)
FLEXERIL (145 patients)
FLUOROURACIL (144 patients)
RAMIPRIL (143 patients)
VERAPAMIL (142 patients)
HERCEPTIN (141 patients)
AMITRIPTYLINE HCL (141 patients)
THALOMID (141 patients)
TYLENOL (141 patients)
LACTULOSE (140 patients)
MULTIHANCE (139 patients)
XELODA (138 patients)
ZESTRIL (138 patients)
NOVOLOG (137 patients)
METRONIDAZOLE (137 patients)
MULTI-VITAMIN (137 patients)
PRAVACHOL (137 patients)
DIFLUCAN (136 patients)
AMLODIPINE BESYLATE (135 patients)
VYTORIN (135 patients)
ULTRAM (135 patients)
FLOMAX (135 patients)
METFORMIN (135 patients)
NAPROXEN (134 patients)
BISOPROLOL FUMARATE (134 patients)
TACROLIMUS (134 patients)
CHEMOTHERAPEUTICS NOS (133 patients)
NIFEDIPINE (133 patients)

Most common side effects for patients taking SORAFENIB (RAF KINASE INHIBITOR):

DIARRHOEA (613 patients)
HEPATIC FAILURE (378 patients)
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME (342 patients)
HEPATIC ENCEPHALOPATHY (320 patients)
FATIGUE (300 patients)
RASH (276 patients)
ASCITES (253 patients)
ABDOMINAL PAIN (237 patients)
DECREASED APPETITE (226 patients)
UPPER GASTROINTESTINAL HAEMORRHAGE (198 patients)
PYREXIA (191 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (179 patients)
NAUSEA (165 patients)
HYPERTENSION (160 patients)
ASTHENIA (154 patients)
DEHYDRATION (140 patients)
HEPATIC FUNCTION ABNORMAL (133 patients)
DYSPNOEA (131 patients)
CONFUSIONAL STATE (131 patients)
HYPOKALAEMIA (125 patients)
ALOPECIA (124 patients)
VOMITING (118 patients)
CONSTIPATION (115 patients)
INTERSTITIAL LUNG DISEASE (114 patients)
LEFT VENTRICULAR DYSFUNCTION (113 patients)
DEATH (113 patients)
ENDOCARDITIS (112 patients)
ARTHRALGIA (111 patients)
STOMATITIS (111 patients)
ABDOMINAL PAIN UPPER (110 patients)
JAUNDICE (108 patients)
HEPATIC NEOPLASM MALIGNANT (106 patients)
GASTROINTESTINAL HAEMORRHAGE (106 patients)
RETINAL VASCULAR THROMBOSIS (103 patients)
LOWER GASTROINTESTINAL HAEMORRHAGE (103 patients)
LIVER CARCINOMA RUPTURED (101 patients)
OEDEMA PERIPHERAL (97 patients)
PLEURAL EFFUSION (97 patients)
STAPHYLOCOCCAL INFECTION (96 patients)
PNEUMONIA BACTERIAL (96 patients)
ENTEROBACTER INFECTION (96 patients)
MYOPATHY (95 patients)
DRY MOUTH (94 patients)
PAIN IN EXTREMITY (93 patients)
ANXIETY (90 patients)
MALAISE (89 patients)
PULMONARY EMBOLISM (85 patients)
ANAEMIA (84 patients)
PLATELET COUNT DECREASED (81 patients)
BACK PAIN (79 patients)
SEPSIS (78 patients)
PRURITUS (78 patients)
DUODENAL ULCER (77 patients)
MIGRAINE (76 patients)
MITRAL VALVE INCOMPETENCE (76 patients)
HYPOGLYCAEMIA (76 patients)
C-REACTIVE PROTEIN INCREASED (74 patients)
BLOOD PRESSURE INCREASED (73 patients)
VARICES OESOPHAGEAL (73 patients)
HEADACHE (72 patients)
RETINAL VEIN OCCLUSION (72 patients)
ABASIA (69 patients)
RENAL FAILURE ACUTE (69 patients)
WEIGHT DECREASED (67 patients)
DEEP VEIN THROMBOSIS (67 patients)
DIZZINESS (65 patients)
ERYTHEMA (65 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (64 patients)
CONVULSION (63 patients)
ALANINE AMINOTRANSFERASE INCREASED (62 patients)
DYSPHONIA (62 patients)
CEREBRAL HAEMORRHAGE (60 patients)
APHAGIA (58 patients)
COLITIS (58 patients)
PNEUMONIA (57 patients)
GASTRIC ULCER (56 patients)
HYPONATRAEMIA (55 patients)
HAEMOGLOBIN DECREASED (53 patients)
RESPIRATORY FAILURE (52 patients)
LUNG DISORDER (52 patients)
CEREBRAL ISCHAEMIA (49 patients)
PARAESTHESIA (49 patients)
BLOOD BILIRUBIN INCREASED (48 patients)
GAIT DISTURBANCE (48 patients)
THYROID CANCER METASTATIC (44 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (43 patients)
PERICARDIAL EFFUSION (41 patients)
THROMBOCYTOPENIA (41 patients)
BLISTER (41 patients)
FEBRILE NEUTROPENIA (40 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (40 patients)
HALLUCINATION (40 patients)
CHILLS (40 patients)
AMMONIA INCREASED (39 patients)
SKIN ULCER (39 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (38 patients)
PAIN (38 patients)
HYPOALBUMINAEMIA (38 patients)
HYPOCALCAEMIA (37 patients)
FALL (37 patients)
POLLAKIURIA (37 patients)
BLOOD PRESSURE DECREASED (37 patients)
SKIN EXFOLIATION (37 patients)
INSOMNIA (36 patients)
CARDIAC ARREST (36 patients)
HYPOAESTHESIA (35 patients)
INFECTIOUS PERITONITIS (35 patients)
MYOCARDIAL INFARCTION (35 patients)
RETINAL VASCULAR DISORDER (34 patients)
RENAL FAILURE (34 patients)
LIPASE INCREASED (34 patients)
HYPERKALAEMIA (33 patients)
HYPERGLYCAEMIA (33 patients)
HAEMOPTYSIS (31 patients)
ATRIAL FIBRILLATION (30 patients)
GENERALISED OEDEMA (30 patients)
FAECAL INCONTINENCE (30 patients)
WHITE BLOOD CELL COUNT DECREASED (30 patients)
CELLULITIS (29 patients)
CHEST PAIN (29 patients)
SOMNOLENCE (29 patients)
HYPERBILIRUBINAEMIA (28 patients)
HYPOTENSION (28 patients)
MUSCLE SPASMS (28 patients)
ABDOMINAL DISTENSION (27 patients)
WHITE BLOOD CELL COUNT INCREASED (27 patients)
VISION BLURRED (27 patients)
HEPATIC PAIN (26 patients)
BLOOD ALBUMIN DECREASED (26 patients)
DYSURIA (25 patients)
RASH GENERALISED (25 patients)
BLOOD SODIUM DECREASED (25 patients)
BLOOD URIC ACID INCREASED (25 patients)
COMA (25 patients)
COUGH (25 patients)
PANCYTOPENIA (25 patients)
ACUTE ABDOMEN (24 patients)
EOSINOPHIL COUNT INCREASED (24 patients)
CEREBROVASCULAR ACCIDENT (24 patients)
METASTASES TO CENTRAL NERVOUS SYSTEM (23 patients)
CEREBRAL INFARCTION (23 patients)
HYPOMAGNESAEMIA (23 patients)
RETINAL VEIN THROMBOSIS (23 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (23 patients)
TUMOUR LYSIS SYNDROME (22 patients)
HYPOPHOSPHATAEMIA (22 patients)
INFECTION (22 patients)
ORAL PAIN (22 patients)
BLOOD CREATININE INCREASED (22 patients)
NEUTROPENIA (22 patients)
RENAL IMPAIRMENT (22 patients)
LETHARGY (22 patients)
SKIN TOXICITY (21 patients)
TONGUE BLISTERING (21 patients)
LIVER ABSCESS (21 patients)
HAEMATEMESIS (21 patients)
OESOPHAGEAL VARICES HAEMORRHAGE (20 patients)
MENTAL IMPAIRMENT (20 patients)
NERVOUSNESS (20 patients)
NEPHROTIC SYNDROME (20 patients)
HYPOPHAGIA (20 patients)
ADRENAL INSUFFICIENCY (19 patients)
DRY SKIN (19 patients)
BLOOD AMYLASE INCREASED (19 patients)
OEDEMA (19 patients)
INFECTIOUS PLEURAL EFFUSION (19 patients)
DYSPEPSIA (19 patients)
COMA HEPATIC (19 patients)
HEART RATE INCREASED (18 patients)
HYPERTENSIVE CRISIS (18 patients)
MYALGIA (18 patients)
ECZEMA (18 patients)
URINARY TRACT INFECTION (18 patients)
NEUROMYOPATHY (18 patients)
MEDICAL DEVICE COMPLICATION (18 patients)
DIVERTICULITIS (18 patients)
OSTEOMYELITIS (18 patients)
CEREBRAL ATROPHY (18 patients)
CEREBRAL VENTRICLE DILATATION (18 patients)
DIABETIC FOOT INFECTION (18 patients)
NECK PAIN (18 patients)
OLIGURIA (17 patients)
GASTROINTESTINAL DISORDER (17 patients)
HAEMATOCHEZIA (17 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (17 patients)
HYPOTHYROIDISM (17 patients)
TRANSAMINASES INCREASED (17 patients)
OROPHARYNGEAL PAIN (17 patients)
CHRONIC MYELOID LEUKAEMIA (17 patients)
NEOPLASM PROGRESSION (17 patients)
METASTASES TO ADRENALS (16 patients)
LYMPHOCYTE COUNT DECREASED (16 patients)
INTERNATIONAL NORMALISED RATIO INCREASED (16 patients)
MULTI-ORGAN FAILURE (16 patients)
FEAR (16 patients)
PANCREATIC CARCINOMA (16 patients)
HYPERSOMNIA (16 patients)
EPILEPSY (16 patients)
SUBARACHNOID HAEMORRHAGE (16 patients)
METASTASES TO LUNG (16 patients)
TACHYCARDIA (16 patients)
MUSCULAR WEAKNESS (16 patients)
KLEBSIELLA SEPSIS (16 patients)
MYOCARDIAL ISCHAEMIA (16 patients)
DYSGEUSIA (16 patients)
LUNG INFECTION (16 patients)
FAECES DISCOLOURED (16 patients)
PAIN OF SKIN (16 patients)
SPINAL FRACTURE (16 patients)
PANIC REACTION (16 patients)

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