Is PLEURAL EFFUSION a side effect of SORAFENIB (RAF KINASE INHIBITOR) ? ( FactMed.com )

About this FactMed analysis covering adverse side effect reports of SORAFENIB (RAF KINASE INHIBITOR) patients who developed PLEURAL EFFUSION.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 97 individuals taking SORAFENIB (RAF KINASE INHIBITOR) reported PLEURAL EFFUSION to the FDA. A total of 3329 SORAFENIB (RAF KINASE INHIBITOR) drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between SORAFENIB (RAF KINASE INHIBITOR) and PLEURAL EFFUSION. In doing so, we compare SORAFENIB (RAF KINASE INHIBITOR) with other drugs that cause PLEURAL EFFUSION, to help you evaluate whether or not SORAFENIB (RAF KINASE INHIBITOR) causes PLEURAL EFFUSION. Likewise, this page shows the most highly-reported side effects of SORAFENIB (RAF KINASE INHIBITOR), so you can see if PLEURAL EFFUSION ranks among SORAFENIB (RAF KINASE INHIBITOR)'s most well-known side effects.

Summary Statistics
Reports of SORAFENIB (RAF KINASE INHIBITOR) causing PLEURAL EFFUSION: 97
Reports of any side effect of SORAFENIB (RAF KINASE INHIBITOR) : 3329
Percentage of SORAFENIB (RAF KINASE INHIBITOR) patients where PLEURAL EFFUSION is a reported side effect: 2.9138%

FDA reports of any drug causing PLEURAL EFFUSION : 26784
Average percentage for all medicated patients where PLEURAL EFFUSION is reported as a complication: 0.1679%

Physician opinion on SORAFENIB (RAF KINASE INHIBITOR) as adverse event culprit:

Overall opinion for all reports of this drug:

Most frequent diagnoses/indications for prescribing SORAFENIB (RAF KINASE INHIBITOR):

HEPATIC NEOPLASM MALIGNANT ( 770 patients )
RENAL CELL CARCINOMA ( 114 patients )
THYROID CANCER ( 65 patients )
METASTATIC RENAL CELL CARCINOMA ( 44 patients )
THYROID CANCER METASTATIC ( 35 patients )
BREAST CANCER ( 31 patients )
BREAST CANCER METASTATIC ( 27 patients )
GASTRIC CANCER ( 25 patients )
NON-SMALL CELL LUNG CANCER ( 25 patients )
COLORECTAL CANCER METASTATIC ( 22 patients )
RENAL CANCER ( 17 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 14 patients )
BILE DUCT CANCER ( 14 patients )
SALIVARY GLAND CANCER ( 7 patients )
HEPATIC CANCER METASTATIC ( 7 patients )
COLORECTAL CANCER ( 7 patients )
SMALL CELL LUNG CANCER STAGE UNSPECIFIED ( 6 patients )
RECTAL CANCER ( 5 patients )
PANCREATIC CARCINOMA ( 4 patients )
PROSTATE CANCER ( 4 patients )
INTRAOCULAR MELANOMA ( 4 patients )
HEPATIC NEOPLASM MALIGNANT RECURRENT ( 3 patients )
NEOPLASM ( 3 patients )
LIVER DISORDER ( 3 patients )
ANGIOSARCOMA ( 3 patients )
NON-SMALL CELL LUNG CANCER STAGE IV ( 3 patients )
METASTASES TO LUNG ( 3 patients )
HEPATIC NEOPLASM MALIGNANT NON-RESECTABLE ( 3 patients )
COLORECTAL CANCER STAGE IV ( 3 patients )
NEOPLASM MALIGNANT ( 3 patients )
GALLBLADDER CANCER METASTATIC ( 3 patients )
BILIARY CANCER METASTATIC ( 3 patients )
METASTASIS ( 3 patients )
COLON CANCER METASTATIC ( 2 patients )
HYPOPHARYNGEAL CANCER ( 2 patients )
DESMOID TUMOUR ( 2 patients )
NEUROENDOCRINE CARCINOMA ( 2 patients )
ACUTE MYELOID LEUKAEMIA (IN REMISSION) ( 2 patients )
LUNG NEOPLASM MALIGNANT ( 2 patients )
OESOPHAGEAL CARCINOMA ( 2 patients )
METASTATIC MALIGNANT MELANOMA ( 2 patients )
TONGUE NEOPLASM MALIGNANT STAGE UNSPECIFIED ( 2 patients )
METASTATIC SQUAMOUS CELL CARCINOMA ( 2 patients )
ANGINA PECTORIS ( 2 patients )
RENAL CELL CARCINOMA STAGE IV ( 2 patients )
OSTEOSARCOMA METASTATIC ( 2 patients )
BONE SARCOMA ( 2 patients )
METASTATIC OCULAR MELANOMA ( 2 patients )
METASTATIC SALIVARY GLAND CANCER ( 2 patients )
TONSIL CANCER ( 2 patients )
MYELODYSPLASTIC SYNDROME ( 1 patients )
PROSTATE CANCER METASTATIC ( 1 patients )
GALLBLADDER CANCER ( 1 patients )
NEUROENDOCRINE TUMOUR ( 1 patients )
MALIGNANT NEOPLASM OF RENAL PELVIS ( 1 patients )
GLIOMA ( 1 patients )
BLADDER CANCER ( 1 patients )
OVARIAN CANCER METASTATIC ( 1 patients )
CAROTID ARTERY DISEASE ( 1 patients )
HEPATOBLASTOMA ( 1 patients )
NASOPHARYNGEAL CANCER ( 1 patients )
ACUTE MYELOID LEUKAEMIA ( 1 patients )
LUNG ADENOCARCINOMA ( 1 patients )
RENAL CANCER METASTATIC ( 1 patients )
DIFFUSE LARGE B-CELL LYMPHOMA ( 1 patients )
NEUROENDOCRINE CARCINOMA OF THE SKIN ( 1 patients )
MALIGNANT HISTIOCYTOSIS ( 1 patients )
ANTICOAGULANT THERAPY ( 1 patients )
MALIGNANT SOFT TISSUE NEOPLASM ( 1 patients )
SARCOMA ( 1 patients )
GERM CELL CANCER ( 1 patients )
OESOPHAGEAL ADENOCARCINOMA ( 1 patients )
SQUAMOUS CELL CARCINOMA ( 1 patients )
HEAD AND NECK CANCER ( 1 patients )
OVARIAN EPITHELIAL CANCER ( 1 patients )
( 0 patients )

Drugs with high FDA adverse event association with PLEURAL EFFUSION:

HEPARIN SODIUM INJECTION (3283 patients)
ASPIRIN (3125 patients)
LASIX (2767 patients)
ZOMETA (2760 patients)
PREDNISONE (1725 patients)
AREDIA (1652 patients)
VIOXX (1555 patients)
FOSAMAX (1536 patients)
FUROSEMIDE (1462 patients)
REMICADE (1440 patients)
METHOTREXATE (1405 patients)
COUMADIN (1392 patients)
DIGOXIN (1334 patients)
LISINOPRIL (1293 patients)
PREDNISOLONE (1292 patients)
ACETAMINOPHEN (1179 patients)
DEXAMETHASONE (1166 patients)
POTASSIUM CHLORIDE (1114 patients)
NEXIUM (1113 patients)
ALLOPURINOL (1104 patients)
LIPITOR (1097 patients)
FOLIC ACID (1086 patients)
PROTONIX (1077 patients)
GLEEVEC (1028 patients)
OMEPRAZOLE (973 patients)
AMBIEN (965 patients)
ZOFRAN (936 patients)
DECADRON (899 patients)
SIMVASTATIN (888 patients)
ALBUTEROL (883 patients)
CYCLOPHOSPHAMIDE (872 patients)
SYNTHROID (856 patients)
OXYCONTIN (847 patients)
NORVASC (842 patients)
ATIVAN (832 patients)
TAXOTERE (808 patients)
PRILOSEC (793 patients)
LEVAQUIN (792 patients)
MORPHINE (780 patients)
PERCOCET (780 patients)
NEURONTIN (768 patients)
CARBOPLATIN (766 patients)
PLAVIX (749 patients)
HUMIRA (745 patients)
WARFARIN SODIUM (734 patients)
VELCADE (729 patients)
HYDROCHLOROTHIAZIDE (726 patients)
VICODIN (712 patients)
ZOCOR (705 patients)
ATENOLOL (702 patients)
PREDNISONE TAB (692 patients)
LEVOTHYROXINE SODIUM (679 patients)
LORAZEPAM (679 patients)
CELEBREX (678 patients)
XANAX (670 patients)
METOPROLOL TARTRATE (670 patients)
PAXIL (668 patients)
VANCOMYCIN (665 patients)
ARANESP (657 patients)
AMLODIPINE (657 patients)
OXYCODONE HCL (654 patients)
TOPROL-XL (644 patients)
PREVACID (632 patients)
LOVENOX (624 patients)
MULTI-VITAMINS (623 patients)
INSULIN (619 patients)
COREG (603 patients)
ZOLOFT (602 patients)
COMPAZINE (593 patients)
GEMZAR (589 patients)
AVASTIN (578 patients)
SPRYCEL (570 patients)
XELODA (570 patients)
TAXOL (569 patients)
IBUPROFEN (559 patients)
COLACE (556 patients)
REVLIMID (553 patients)
METFORMIN HCL (545 patients)
HEPARIN (544 patients)
ADVAIR DISKUS 100/50 (538 patients)
DIOVAN (530 patients)
ALDACTONE (516 patients)
ENBREL (514 patients)
NEXAVAR (507 patients)
LORTAB (506 patients)
VINCRISTINE (504 patients)
FEMARA (497 patients)
AVANDIA (496 patients)
FENTANYL (493 patients)
LANSOPRAZOLE (492 patients)
NITROGLYCERIN (487 patients)
AMOXICILLIN (485 patients)
VITAMIN D (482 patients)
SUTENT (480 patients)
LEXAPRO (479 patients)
SPIRONOLACTONE (475 patients)
LYRICA (473 patients)
DILAUDID (470 patients)
CYTARABINE (467 patients)
FLUOROURACIL (465 patients)
CIPROFLOXACIN (463 patients)
CISPLATIN (460 patients)
FLUCONAZOLE (459 patients)
GABAPENTIN (459 patients)
LOPRESSOR (454 patients)
HERCEPTIN (449 patients)
FERROUS SULFATE TAB (447 patients)
MYCOPHENOLATE MOFETIL (446 patients)
ACYCLOVIR (442 patients)
TACROLIMUS (441 patients)
CALCIUM (441 patients)
ACCUTANE (440 patients)
ZANTAC (433 patients)
ACTOS (432 patients)
TAMOXIFEN CITRATE (430 patients)
CARVEDILOL (426 patients)
FAMOTIDINE (423 patients)
HEPARIN SODIUM (422 patients)
FLAGYL (422 patients)
LANTUS (420 patients)
THALIDOMIDE (419 patients)
METOPROLOL (418 patients)
MORPHINE SULFATE (414 patients)
TRAMADOL HCL (411 patients)
NEUPOGEN (410 patients)
DURAGESIC-100 (405 patients)
SPIRIVA (404 patients)
AMIODARONE HCL (402 patients)
AFINITOR (400 patients)
FASLODEX (398 patients)
CYCLOSPORINE (398 patients)
ARIMIDEX (396 patients)
ENALAPRIL MALEATE (389 patients)
REGLAN (386 patients)
BENADRYL (385 patients)
DOXORUBICIN HCL (383 patients)
PANTOPRAZOLE (381 patients)
CELEXA (380 patients)
ETOPOSIDE (375 patients)
RITUXIMAB (372 patients)
MULTI-VITAMIN (371 patients)
TYLENOL (371 patients)
PEPCID (368 patients)
SUNITINIB MALATE (367 patients)
ALPRAZOLAM (362 patients)
RADIATION THERAPY (361 patients)
DIFLUCAN (360 patients)
TASIGNA (359 patients)
RANITIDINE (359 patients)
PREMARIN (358 patients)
METOCLOPRAMIDE (355 patients)
DIANEAL (354 patients)
CYTOXAN (353 patients)
AMARYL (348 patients)
ONDANSETRON (345 patients)
NYSTATIN (344 patients)
MAGNESIUM OXIDE (343 patients)
AUGMENTIN '125' (342 patients)
ADRIAMYCIN PFS (339 patients)
VITAMIN B-12 (334 patients)
MS CONTIN (333 patients)
NAVELBINE (332 patients)
BACTRIM (330 patients)
CLINDAMYCIN (330 patients)
SEROQUEL (329 patients)
ASCORBIC ACID (326 patients)
CHEMOTHERAPEUTICS NOS (324 patients)
LACTULOSE (324 patients)
METHYLPREDNISOLONE (318 patients)
FLOMAX (317 patients)
ROCEPHIN (315 patients)
CALCIUM CARBONATE (312 patients)
BEVACIZUMAB (312 patients)
SOLU-MEDROL (311 patients)
AROMASIN (309 patients)
PACLITAXEL (309 patients)
EFFEXOR (309 patients)
CRESTOR (306 patients)
PROGRAF (305 patients)
ZITHROMAX (305 patients)
LEVOFLOXACIN (304 patients)
AVELOX (304 patients)
NUVARING (302 patients)
COZAAR (301 patients)
TRACLEER (301 patients)
GLYBURIDE (300 patients)
RAMIPRIL (296 patients)
SINGULAIR (295 patients)
VOLTAREN (295 patients)
INFLIXIMAB (293 patients)
PROCHLORPERAZINE (292 patients)
METRONIDAZOLE (289 patients)
DASATINIB (288 patients)
TYLENOL (CAPLET) (287 patients)
FLONASE (286 patients)
MEGACE (284 patients)
DOCETAXEL (284 patients)
GLUCOPHAGE (283 patients)
CEPHALEXIN (282 patients)
EPOGEN (282 patients)
PROCRIT /00909301/ (281 patients)
FLEXERIL (280 patients)
HEPARIN SODIUM 5,000 UNITS IN DEXTROSE 5% (278 patients)
ZYRTEC (277 patients)
TORSEMIDE (275 patients)
GLIPIZIDE (272 patients)
CAPECITABINE (269 patients)
SENOKOT (269 patients)
HYDROCORTISONE (268 patients)
ATROVENT (266 patients)

Most common side effects for patients taking SORAFENIB (RAF KINASE INHIBITOR):

DIARRHOEA (613 patients)
HEPATIC FAILURE (378 patients)
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME (342 patients)
HEPATIC ENCEPHALOPATHY (320 patients)
FATIGUE (300 patients)
RASH (276 patients)
ASCITES (253 patients)
ABDOMINAL PAIN (237 patients)
DECREASED APPETITE (226 patients)
UPPER GASTROINTESTINAL HAEMORRHAGE (198 patients)
PYREXIA (191 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (179 patients)
NAUSEA (165 patients)
HYPERTENSION (160 patients)
ASTHENIA (154 patients)
DEHYDRATION (140 patients)
HEPATIC FUNCTION ABNORMAL (133 patients)
DYSPNOEA (131 patients)
CONFUSIONAL STATE (131 patients)
HYPOKALAEMIA (125 patients)
ALOPECIA (124 patients)
VOMITING (118 patients)
CONSTIPATION (115 patients)
INTERSTITIAL LUNG DISEASE (114 patients)
LEFT VENTRICULAR DYSFUNCTION (113 patients)
DEATH (113 patients)
ENDOCARDITIS (112 patients)
ARTHRALGIA (111 patients)
STOMATITIS (111 patients)
ABDOMINAL PAIN UPPER (110 patients)
JAUNDICE (108 patients)
HEPATIC NEOPLASM MALIGNANT (106 patients)
GASTROINTESTINAL HAEMORRHAGE (106 patients)
RETINAL VASCULAR THROMBOSIS (103 patients)
LOWER GASTROINTESTINAL HAEMORRHAGE (103 patients)
LIVER CARCINOMA RUPTURED (101 patients)
OEDEMA PERIPHERAL (97 patients)
PLEURAL EFFUSION (97 patients)
STAPHYLOCOCCAL INFECTION (96 patients)
PNEUMONIA BACTERIAL (96 patients)
ENTEROBACTER INFECTION (96 patients)
MYOPATHY (95 patients)
DRY MOUTH (94 patients)
PAIN IN EXTREMITY (93 patients)
ANXIETY (90 patients)
MALAISE (89 patients)
PULMONARY EMBOLISM (85 patients)
ANAEMIA (84 patients)
PLATELET COUNT DECREASED (81 patients)
BACK PAIN (79 patients)
SEPSIS (78 patients)
PRURITUS (78 patients)
DUODENAL ULCER (77 patients)
MIGRAINE (76 patients)
MITRAL VALVE INCOMPETENCE (76 patients)
HYPOGLYCAEMIA (76 patients)
C-REACTIVE PROTEIN INCREASED (74 patients)
BLOOD PRESSURE INCREASED (73 patients)
VARICES OESOPHAGEAL (73 patients)
HEADACHE (72 patients)
RETINAL VEIN OCCLUSION (72 patients)
ABASIA (69 patients)
RENAL FAILURE ACUTE (69 patients)
WEIGHT DECREASED (67 patients)
DEEP VEIN THROMBOSIS (67 patients)
DIZZINESS (65 patients)
ERYTHEMA (65 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (64 patients)
CONVULSION (63 patients)
ALANINE AMINOTRANSFERASE INCREASED (62 patients)
DYSPHONIA (62 patients)
CEREBRAL HAEMORRHAGE (60 patients)
APHAGIA (58 patients)
COLITIS (58 patients)
PNEUMONIA (57 patients)
GASTRIC ULCER (56 patients)
HYPONATRAEMIA (55 patients)
HAEMOGLOBIN DECREASED (53 patients)
RESPIRATORY FAILURE (52 patients)
LUNG DISORDER (52 patients)
CEREBRAL ISCHAEMIA (49 patients)
PARAESTHESIA (49 patients)
BLOOD BILIRUBIN INCREASED (48 patients)
GAIT DISTURBANCE (48 patients)
THYROID CANCER METASTATIC (44 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (43 patients)
PERICARDIAL EFFUSION (41 patients)
THROMBOCYTOPENIA (41 patients)
BLISTER (41 patients)
FEBRILE NEUTROPENIA (40 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (40 patients)
HALLUCINATION (40 patients)
CHILLS (40 patients)
AMMONIA INCREASED (39 patients)
SKIN ULCER (39 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (38 patients)
PAIN (38 patients)
HYPOALBUMINAEMIA (38 patients)
HYPOCALCAEMIA (37 patients)
FALL (37 patients)
POLLAKIURIA (37 patients)
BLOOD PRESSURE DECREASED (37 patients)
SKIN EXFOLIATION (37 patients)
INSOMNIA (36 patients)
CARDIAC ARREST (36 patients)
HYPOAESTHESIA (35 patients)
INFECTIOUS PERITONITIS (35 patients)
MYOCARDIAL INFARCTION (35 patients)
RETINAL VASCULAR DISORDER (34 patients)
RENAL FAILURE (34 patients)
LIPASE INCREASED (34 patients)
HYPERKALAEMIA (33 patients)
HYPERGLYCAEMIA (33 patients)
HAEMOPTYSIS (31 patients)
ATRIAL FIBRILLATION (30 patients)
GENERALISED OEDEMA (30 patients)
FAECAL INCONTINENCE (30 patients)
WHITE BLOOD CELL COUNT DECREASED (30 patients)
CELLULITIS (29 patients)
CHEST PAIN (29 patients)
SOMNOLENCE (29 patients)
HYPERBILIRUBINAEMIA (28 patients)
HYPOTENSION (28 patients)
MUSCLE SPASMS (28 patients)
ABDOMINAL DISTENSION (27 patients)
WHITE BLOOD CELL COUNT INCREASED (27 patients)
VISION BLURRED (27 patients)
HEPATIC PAIN (26 patients)
BLOOD ALBUMIN DECREASED (26 patients)
DYSURIA (25 patients)
RASH GENERALISED (25 patients)
BLOOD SODIUM DECREASED (25 patients)
BLOOD URIC ACID INCREASED (25 patients)
COMA (25 patients)
COUGH (25 patients)
PANCYTOPENIA (25 patients)
ACUTE ABDOMEN (24 patients)
EOSINOPHIL COUNT INCREASED (24 patients)
CEREBROVASCULAR ACCIDENT (24 patients)
METASTASES TO CENTRAL NERVOUS SYSTEM (23 patients)
CEREBRAL INFARCTION (23 patients)
HYPOMAGNESAEMIA (23 patients)
RETINAL VEIN THROMBOSIS (23 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (23 patients)
TUMOUR LYSIS SYNDROME (22 patients)
HYPOPHOSPHATAEMIA (22 patients)
INFECTION (22 patients)
ORAL PAIN (22 patients)
BLOOD CREATININE INCREASED (22 patients)
NEUTROPENIA (22 patients)
RENAL IMPAIRMENT (22 patients)
LETHARGY (22 patients)
SKIN TOXICITY (21 patients)
TONGUE BLISTERING (21 patients)
LIVER ABSCESS (21 patients)
HAEMATEMESIS (21 patients)
OESOPHAGEAL VARICES HAEMORRHAGE (20 patients)
MENTAL IMPAIRMENT (20 patients)
NERVOUSNESS (20 patients)
NEPHROTIC SYNDROME (20 patients)
HYPOPHAGIA (20 patients)
ADRENAL INSUFFICIENCY (19 patients)
DRY SKIN (19 patients)
BLOOD AMYLASE INCREASED (19 patients)
OEDEMA (19 patients)
INFECTIOUS PLEURAL EFFUSION (19 patients)
DYSPEPSIA (19 patients)
COMA HEPATIC (19 patients)
HEART RATE INCREASED (18 patients)
HYPERTENSIVE CRISIS (18 patients)
MYALGIA (18 patients)
ECZEMA (18 patients)
URINARY TRACT INFECTION (18 patients)
NEUROMYOPATHY (18 patients)
MEDICAL DEVICE COMPLICATION (18 patients)
DIVERTICULITIS (18 patients)
OSTEOMYELITIS (18 patients)
CEREBRAL ATROPHY (18 patients)
CEREBRAL VENTRICLE DILATATION (18 patients)
DIABETIC FOOT INFECTION (18 patients)
NECK PAIN (18 patients)
OLIGURIA (17 patients)
GASTROINTESTINAL DISORDER (17 patients)
HAEMATOCHEZIA (17 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (17 patients)
HYPOTHYROIDISM (17 patients)
TRANSAMINASES INCREASED (17 patients)
OROPHARYNGEAL PAIN (17 patients)
CHRONIC MYELOID LEUKAEMIA (17 patients)
NEOPLASM PROGRESSION (17 patients)
METASTASES TO ADRENALS (16 patients)
LYMPHOCYTE COUNT DECREASED (16 patients)
INTERNATIONAL NORMALISED RATIO INCREASED (16 patients)
MULTI-ORGAN FAILURE (16 patients)
FEAR (16 patients)
PANCREATIC CARCINOMA (16 patients)
HYPERSOMNIA (16 patients)
EPILEPSY (16 patients)
SUBARACHNOID HAEMORRHAGE (16 patients)
METASTASES TO LUNG (16 patients)
TACHYCARDIA (16 patients)
MUSCULAR WEAKNESS (16 patients)
KLEBSIELLA SEPSIS (16 patients)
MYOCARDIAL ISCHAEMIA (16 patients)
DYSGEUSIA (16 patients)
LUNG INFECTION (16 patients)
FAECES DISCOLOURED (16 patients)
PAIN OF SKIN (16 patients)
SPINAL FRACTURE (16 patients)
PANIC REACTION (16 patients)

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