Is THROMBOCYTOPENIA a side effect of SORAFENIB (RAF KINASE INHIBITOR) ? ( FactMed.com )

About this FactMed analysis covering adverse side effect reports of SORAFENIB (RAF KINASE INHIBITOR) patients who developed THROMBOCYTOPENIA.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 41 individuals taking SORAFENIB (RAF KINASE INHIBITOR) reported THROMBOCYTOPENIA to the FDA. A total of 3329 SORAFENIB (RAF KINASE INHIBITOR) drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between SORAFENIB (RAF KINASE INHIBITOR) and THROMBOCYTOPENIA. In doing so, we compare SORAFENIB (RAF KINASE INHIBITOR) with other drugs that cause THROMBOCYTOPENIA, to help you evaluate whether or not SORAFENIB (RAF KINASE INHIBITOR) causes THROMBOCYTOPENIA. Likewise, this page shows the most highly-reported side effects of SORAFENIB (RAF KINASE INHIBITOR), so you can see if THROMBOCYTOPENIA ranks among SORAFENIB (RAF KINASE INHIBITOR)'s most well-known side effects.

Summary Statistics
Reports of SORAFENIB (RAF KINASE INHIBITOR) causing THROMBOCYTOPENIA: 41
Reports of any side effect of SORAFENIB (RAF KINASE INHIBITOR) : 3329
Percentage of SORAFENIB (RAF KINASE INHIBITOR) patients where THROMBOCYTOPENIA is a reported side effect: 1.2316%

FDA reports of any drug causing THROMBOCYTOPENIA : 37390
Average percentage for all medicated patients where THROMBOCYTOPENIA is reported as a complication: 0.2343%

Physician opinion on SORAFENIB (RAF KINASE INHIBITOR) as adverse event culprit:

Overall opinion for all reports of this drug:

Most frequent diagnoses/indications for prescribing SORAFENIB (RAF KINASE INHIBITOR):

HEPATIC NEOPLASM MALIGNANT ( 770 patients )
RENAL CELL CARCINOMA ( 114 patients )
THYROID CANCER ( 65 patients )
METASTATIC RENAL CELL CARCINOMA ( 44 patients )
THYROID CANCER METASTATIC ( 35 patients )
BREAST CANCER ( 31 patients )
BREAST CANCER METASTATIC ( 27 patients )
GASTRIC CANCER ( 25 patients )
NON-SMALL CELL LUNG CANCER ( 25 patients )
COLORECTAL CANCER METASTATIC ( 22 patients )
RENAL CANCER ( 17 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 14 patients )
BILE DUCT CANCER ( 14 patients )
SALIVARY GLAND CANCER ( 7 patients )
HEPATIC CANCER METASTATIC ( 7 patients )
COLORECTAL CANCER ( 7 patients )
SMALL CELL LUNG CANCER STAGE UNSPECIFIED ( 6 patients )
RECTAL CANCER ( 5 patients )
PANCREATIC CARCINOMA ( 4 patients )
PROSTATE CANCER ( 4 patients )
INTRAOCULAR MELANOMA ( 4 patients )
HEPATIC NEOPLASM MALIGNANT RECURRENT ( 3 patients )
NEOPLASM ( 3 patients )
LIVER DISORDER ( 3 patients )
ANGIOSARCOMA ( 3 patients )
NON-SMALL CELL LUNG CANCER STAGE IV ( 3 patients )
METASTASES TO LUNG ( 3 patients )
HEPATIC NEOPLASM MALIGNANT NON-RESECTABLE ( 3 patients )
COLORECTAL CANCER STAGE IV ( 3 patients )
NEOPLASM MALIGNANT ( 3 patients )
GALLBLADDER CANCER METASTATIC ( 3 patients )
BILIARY CANCER METASTATIC ( 3 patients )
METASTASIS ( 3 patients )
COLON CANCER METASTATIC ( 2 patients )
HYPOPHARYNGEAL CANCER ( 2 patients )
DESMOID TUMOUR ( 2 patients )
NEUROENDOCRINE CARCINOMA ( 2 patients )
ACUTE MYELOID LEUKAEMIA (IN REMISSION) ( 2 patients )
LUNG NEOPLASM MALIGNANT ( 2 patients )
OESOPHAGEAL CARCINOMA ( 2 patients )
METASTATIC MALIGNANT MELANOMA ( 2 patients )
TONGUE NEOPLASM MALIGNANT STAGE UNSPECIFIED ( 2 patients )
METASTATIC SQUAMOUS CELL CARCINOMA ( 2 patients )
ANGINA PECTORIS ( 2 patients )
RENAL CELL CARCINOMA STAGE IV ( 2 patients )
OSTEOSARCOMA METASTATIC ( 2 patients )
BONE SARCOMA ( 2 patients )
METASTATIC OCULAR MELANOMA ( 2 patients )
METASTATIC SALIVARY GLAND CANCER ( 2 patients )
TONSIL CANCER ( 2 patients )
MYELODYSPLASTIC SYNDROME ( 1 patients )
PROSTATE CANCER METASTATIC ( 1 patients )
GALLBLADDER CANCER ( 1 patients )
NEUROENDOCRINE TUMOUR ( 1 patients )
MALIGNANT NEOPLASM OF RENAL PELVIS ( 1 patients )
GLIOMA ( 1 patients )
BLADDER CANCER ( 1 patients )
OVARIAN CANCER METASTATIC ( 1 patients )
CAROTID ARTERY DISEASE ( 1 patients )
HEPATOBLASTOMA ( 1 patients )
NASOPHARYNGEAL CANCER ( 1 patients )
ACUTE MYELOID LEUKAEMIA ( 1 patients )
LUNG ADENOCARCINOMA ( 1 patients )
RENAL CANCER METASTATIC ( 1 patients )
DIFFUSE LARGE B-CELL LYMPHOMA ( 1 patients )
NEUROENDOCRINE CARCINOMA OF THE SKIN ( 1 patients )
MALIGNANT HISTIOCYTOSIS ( 1 patients )
ANTICOAGULANT THERAPY ( 1 patients )
MALIGNANT SOFT TISSUE NEOPLASM ( 1 patients )
SARCOMA ( 1 patients )
GERM CELL CANCER ( 1 patients )
OESOPHAGEAL ADENOCARCINOMA ( 1 patients )
SQUAMOUS CELL CARCINOMA ( 1 patients )
HEAD AND NECK CANCER ( 1 patients )
OVARIAN EPITHELIAL CANCER ( 1 patients )
( 0 patients )

Drugs with high FDA adverse event association with THROMBOCYTOPENIA:

HEPARIN SODIUM INJECTION (4057 patients)
ASPIRIN (3010 patients)
REVLIMID (2931 patients)
DEXAMETHASONE (2402 patients)
LASIX (2000 patients)
PREDNISONE (1949 patients)
OMEPRAZOLE (1689 patients)
NPLATE (1653 patients)
CYCLOPHOSPHAMIDE (1515 patients)
VELCADE (1495 patients)
ACETAMINOPHEN (1483 patients)
ZOMETA (1451 patients)
CISPLATIN (1433 patients)
CARBOPLATIN (1423 patients)
FUROSEMIDE (1327 patients)
ALLOPURINOL (1293 patients)
METHOTREXATE (1215 patients)
HEPARIN (1202 patients)
FOLIC ACID (1184 patients)
PREDNISOLONE (1095 patients)
NEXIUM (1091 patients)
FLUOROURACIL (1068 patients)
POTASSIUM CHLORIDE (957 patients)
LOVENOX (939 patients)
COUMADIN (932 patients)
LISINOPRIL (931 patients)
SIMVASTATIN (918 patients)
PLAVIX (908 patients)
ZOFRAN (902 patients)
AREDIA (892 patients)
PROTONIX (889 patients)
DECADRON (880 patients)
VIOXX (877 patients)
LIPITOR (872 patients)
VANCOMYCIN (869 patients)
RITUXIMAB (857 patients)
PREDNISONE TAB (847 patients)
ETOPOSIDE (805 patients)
ACYCLOVIR (800 patients)
CYTARABINE (783 patients)
FOSAMAX (771 patients)
DIGOXIN (733 patients)
FLUCONAZOLE (730 patients)
VINCRISTINE (721 patients)
ATENOLOL (717 patients)
LEVOTHYROXINE SODIUM (717 patients)
KEPPRA (709 patients)
OXYCONTIN (703 patients)
PRILOSEC (689 patients)
HEPARIN SODIUM (674 patients)
AMBIEN (673 patients)
NEUPOGEN (672 patients)
ARANESP (660 patients)
DOXORUBICIN HCL (659 patients)
LORAZEPAM (658 patients)
MORPHINE (657 patients)
GLEEVEC (652 patients)
BACTRIM (650 patients)
OXALIPLATIN (643 patients)
SUTENT (642 patients)
ATIVAN (640 patients)
SYNTHROID (629 patients)
XANAX (619 patients)
NEURONTIN (611 patients)
NORVASC (611 patients)
GEMCITABINE (605 patients)
WARFARIN SODIUM (604 patients)
REMICADE (587 patients)
CYCLOSPORINE (586 patients)
THALIDOMIDE (585 patients)
LEVAQUIN (585 patients)
RIBAVIRIN (576 patients)
ALBUTEROL (573 patients)
PEGASYS (572 patients)
CIPROFLOXACIN (568 patients)
COMPAZINE (568 patients)
GEMZAR (554 patients)
EXJADE (554 patients)
IBUPROFEN (552 patients)
GABAPENTIN (549 patients)
HYDROCHLOROTHIAZIDE (542 patients)
SOLU-MEDROL (541 patients)
OXYCODONE HCL (532 patients)
SEROQUEL (531 patients)
METHYLPREDNISOLONE (524 patients)
METOPROLOL TARTRATE (520 patients)
INSULIN (519 patients)
ZOCOR (510 patients)
ONDANSETRON (496 patients)
VICODIN (492 patients)
LYRICA (488 patients)
PANTOPRAZOLE (488 patients)
AVASTIN (485 patients)
DIFLUCAN (482 patients)
LANSOPRAZOLE (479 patients)
AMLODIPINE (477 patients)
FAMOTIDINE (476 patients)
RAMIPRIL (473 patients)
VIDAZA (473 patients)
MULTI-VITAMINS (472 patients)
ZOLOFT (471 patients)
CORTICOSTEROIDS (468 patients)
PERCOCET (464 patients)
CLOZARIL (464 patients)
METFORMIN HCL (458 patients)
RISPERDAL (457 patients)
FENTANYL (452 patients)
ZYVOX (450 patients)
AUGMENTIN '125' (448 patients)
RANITIDINE (444 patients)
PACLITAXEL (439 patients)
PREVACID (436 patients)
XELODA (435 patients)
ENOXAPARIN SODIUM (431 patients)
TOPROL-XL (431 patients)
VITAMIN B-12 (431 patients)
DEXAMETHASONE TAB (430 patients)
ALDACTONE (429 patients)
PANTOPRAZOLE SODIUM (424 patients)
NEULASTA (423 patients)
NEORAL (419 patients)
LANTUS (419 patients)
DEPAKENE (416 patients)
PROCRIT (403 patients)
CELEBREX (400 patients)
ZANTAC (395 patients)
TAXOL (395 patients)
NITROGLYCERIN (392 patients)
VITAMIN D (390 patients)
CAPECITABINE (389 patients)
ROCEPHIN (388 patients)
ALIMTA (382 patients)
SPIRONOLACTONE (382 patients)
DURAGESIC-100 (380 patients)
ZYPREXA (378 patients)
MORPHINE SULFATE (378 patients)
BEVACIZUMAB (373 patients)
LEVOFLOXACIN (370 patients)
FERROUS SULFATE TAB (365 patients)
COREG (361 patients)
COLACE (361 patients)
LEXAPRO (361 patients)
HUMIRA (357 patients)
MYCOPHENOLATE MOFETIL (356 patients)
LEUCOVORIN CALCIUM (356 patients)
EPOGEN (355 patients)
AMOXICILLIN (353 patients)
COPEGUS (351 patients)
FLAGYL (350 patients)
LOPRESSOR (348 patients)
METOPROLOL (346 patients)
DILAUDID (345 patients)
CETUXIMAB (343 patients)
DIOVAN (338 patients)
METRONIDAZOLE (338 patients)
MAGNESIUM OXIDE (336 patients)
CALCIUM CARBONATE (336 patients)
ADRIAMYCIN PFS (333 patients)
REOPRO (332 patients)
MABTHERA (330 patients)
RADIATION THERAPY (328 patients)
CYTOXAN (327 patients)
DEPAKOTE (326 patients)
TRAMADOL HCL (325 patients)
METOCLOPRAMIDE (325 patients)
PROGRAF (324 patients)
LORTAB (324 patients)
TEMOZOLOMIDE (323 patients)
PEPCID (323 patients)
PAXIL (323 patients)
TASIGNA (321 patients)
LACTULOSE (319 patients)
ALPRAZOLAM (318 patients)
NYSTATIN (316 patients)
VALTREX (316 patients)
CLONAZEPAM (314 patients)
NEXAVAR (314 patients)
MELPHALAN HYDROCHLORIDE (313 patients)
CITALOPRAM HYDROBROMIDE (313 patients)
ENALAPRIL MALEATE (309 patients)
CLOPIDOGREL (308 patients)
CALCIUM (307 patients)
REGLAN (304 patients)
TAXOTERE (304 patients)
TEMODAL (301 patients)
DOCETAXEL (301 patients)
SUNITINIB MALATE (299 patients)
SODIUM CHLORIDE (296 patients)
VALPROATE SODIUM (295 patients)
PARACETAMOL (295 patients)
CRESTOR (294 patients)
RITUXAN (291 patients)
ACCUTANE (290 patients)
MS CONTIN (288 patients)
THALOMID (284 patients)
IRINOTECAN HCL (283 patients)
HYDROCORTISONE (282 patients)
KYTRIL (280 patients)
LAMICTAL (278 patients)
BISOPROLOL FUMARATE (278 patients)
ASCORBIC ACID (277 patients)
CARVEDILOL (277 patients)
TEGRETOL (274 patients)
XIGRIS (270 patients)
CLINDAMYCIN (268 patients)
COZAAR (268 patients)
GLUCOPHAGE (267 patients)
IFOSFAMIDE (266 patients)
EFFEXOR (266 patients)
MIRALAX (264 patients)

Most common side effects for patients taking SORAFENIB (RAF KINASE INHIBITOR):

DIARRHOEA (613 patients)
HEPATIC FAILURE (378 patients)
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME (342 patients)
HEPATIC ENCEPHALOPATHY (320 patients)
FATIGUE (300 patients)
RASH (276 patients)
ASCITES (253 patients)
ABDOMINAL PAIN (237 patients)
DECREASED APPETITE (226 patients)
UPPER GASTROINTESTINAL HAEMORRHAGE (198 patients)
PYREXIA (191 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (179 patients)
NAUSEA (165 patients)
HYPERTENSION (160 patients)
ASTHENIA (154 patients)
DEHYDRATION (140 patients)
HEPATIC FUNCTION ABNORMAL (133 patients)
DYSPNOEA (131 patients)
CONFUSIONAL STATE (131 patients)
HYPOKALAEMIA (125 patients)
ALOPECIA (124 patients)
VOMITING (118 patients)
CONSTIPATION (115 patients)
INTERSTITIAL LUNG DISEASE (114 patients)
LEFT VENTRICULAR DYSFUNCTION (113 patients)
DEATH (113 patients)
ENDOCARDITIS (112 patients)
ARTHRALGIA (111 patients)
STOMATITIS (111 patients)
ABDOMINAL PAIN UPPER (110 patients)
JAUNDICE (108 patients)
HEPATIC NEOPLASM MALIGNANT (106 patients)
GASTROINTESTINAL HAEMORRHAGE (106 patients)
RETINAL VASCULAR THROMBOSIS (103 patients)
LOWER GASTROINTESTINAL HAEMORRHAGE (103 patients)
LIVER CARCINOMA RUPTURED (101 patients)
OEDEMA PERIPHERAL (97 patients)
PLEURAL EFFUSION (97 patients)
STAPHYLOCOCCAL INFECTION (96 patients)
PNEUMONIA BACTERIAL (96 patients)
ENTEROBACTER INFECTION (96 patients)
MYOPATHY (95 patients)
DRY MOUTH (94 patients)
PAIN IN EXTREMITY (93 patients)
ANXIETY (90 patients)
MALAISE (89 patients)
PULMONARY EMBOLISM (85 patients)
ANAEMIA (84 patients)
PLATELET COUNT DECREASED (81 patients)
BACK PAIN (79 patients)
SEPSIS (78 patients)
PRURITUS (78 patients)
DUODENAL ULCER (77 patients)
MIGRAINE (76 patients)
MITRAL VALVE INCOMPETENCE (76 patients)
HYPOGLYCAEMIA (76 patients)
C-REACTIVE PROTEIN INCREASED (74 patients)
BLOOD PRESSURE INCREASED (73 patients)
VARICES OESOPHAGEAL (73 patients)
HEADACHE (72 patients)
RETINAL VEIN OCCLUSION (72 patients)
ABASIA (69 patients)
RENAL FAILURE ACUTE (69 patients)
WEIGHT DECREASED (67 patients)
DEEP VEIN THROMBOSIS (67 patients)
DIZZINESS (65 patients)
ERYTHEMA (65 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (64 patients)
CONVULSION (63 patients)
ALANINE AMINOTRANSFERASE INCREASED (62 patients)
DYSPHONIA (62 patients)
CEREBRAL HAEMORRHAGE (60 patients)
APHAGIA (58 patients)
COLITIS (58 patients)
PNEUMONIA (57 patients)
GASTRIC ULCER (56 patients)
HYPONATRAEMIA (55 patients)
HAEMOGLOBIN DECREASED (53 patients)
RESPIRATORY FAILURE (52 patients)
LUNG DISORDER (52 patients)
CEREBRAL ISCHAEMIA (49 patients)
PARAESTHESIA (49 patients)
BLOOD BILIRUBIN INCREASED (48 patients)
GAIT DISTURBANCE (48 patients)
THYROID CANCER METASTATIC (44 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (43 patients)
PERICARDIAL EFFUSION (41 patients)
THROMBOCYTOPENIA (41 patients)
BLISTER (41 patients)
FEBRILE NEUTROPENIA (40 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (40 patients)
HALLUCINATION (40 patients)
CHILLS (40 patients)
AMMONIA INCREASED (39 patients)
SKIN ULCER (39 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (38 patients)
PAIN (38 patients)
HYPOALBUMINAEMIA (38 patients)
HYPOCALCAEMIA (37 patients)
FALL (37 patients)
POLLAKIURIA (37 patients)
BLOOD PRESSURE DECREASED (37 patients)
SKIN EXFOLIATION (37 patients)
INSOMNIA (36 patients)
CARDIAC ARREST (36 patients)
HYPOAESTHESIA (35 patients)
INFECTIOUS PERITONITIS (35 patients)
MYOCARDIAL INFARCTION (35 patients)
RETINAL VASCULAR DISORDER (34 patients)
RENAL FAILURE (34 patients)
LIPASE INCREASED (34 patients)
HYPERKALAEMIA (33 patients)
HYPERGLYCAEMIA (33 patients)
HAEMOPTYSIS (31 patients)
ATRIAL FIBRILLATION (30 patients)
GENERALISED OEDEMA (30 patients)
FAECAL INCONTINENCE (30 patients)
WHITE BLOOD CELL COUNT DECREASED (30 patients)
CELLULITIS (29 patients)
CHEST PAIN (29 patients)
SOMNOLENCE (29 patients)
HYPERBILIRUBINAEMIA (28 patients)
HYPOTENSION (28 patients)
MUSCLE SPASMS (28 patients)
ABDOMINAL DISTENSION (27 patients)
WHITE BLOOD CELL COUNT INCREASED (27 patients)
VISION BLURRED (27 patients)
HEPATIC PAIN (26 patients)
BLOOD ALBUMIN DECREASED (26 patients)
DYSURIA (25 patients)
RASH GENERALISED (25 patients)
BLOOD SODIUM DECREASED (25 patients)
BLOOD URIC ACID INCREASED (25 patients)
COMA (25 patients)
COUGH (25 patients)
PANCYTOPENIA (25 patients)
ACUTE ABDOMEN (24 patients)
EOSINOPHIL COUNT INCREASED (24 patients)
CEREBROVASCULAR ACCIDENT (24 patients)
METASTASES TO CENTRAL NERVOUS SYSTEM (23 patients)
CEREBRAL INFARCTION (23 patients)
HYPOMAGNESAEMIA (23 patients)
RETINAL VEIN THROMBOSIS (23 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (23 patients)
TUMOUR LYSIS SYNDROME (22 patients)
HYPOPHOSPHATAEMIA (22 patients)
INFECTION (22 patients)
ORAL PAIN (22 patients)
BLOOD CREATININE INCREASED (22 patients)
NEUTROPENIA (22 patients)
RENAL IMPAIRMENT (22 patients)
LETHARGY (22 patients)
SKIN TOXICITY (21 patients)
TONGUE BLISTERING (21 patients)
LIVER ABSCESS (21 patients)
HAEMATEMESIS (21 patients)
OESOPHAGEAL VARICES HAEMORRHAGE (20 patients)
MENTAL IMPAIRMENT (20 patients)
NERVOUSNESS (20 patients)
NEPHROTIC SYNDROME (20 patients)
HYPOPHAGIA (20 patients)
ADRENAL INSUFFICIENCY (19 patients)
DRY SKIN (19 patients)
BLOOD AMYLASE INCREASED (19 patients)
OEDEMA (19 patients)
INFECTIOUS PLEURAL EFFUSION (19 patients)
DYSPEPSIA (19 patients)
COMA HEPATIC (19 patients)
HEART RATE INCREASED (18 patients)
HYPERTENSIVE CRISIS (18 patients)
MYALGIA (18 patients)
ECZEMA (18 patients)
URINARY TRACT INFECTION (18 patients)
NEUROMYOPATHY (18 patients)
MEDICAL DEVICE COMPLICATION (18 patients)
DIVERTICULITIS (18 patients)
OSTEOMYELITIS (18 patients)
CEREBRAL ATROPHY (18 patients)
CEREBRAL VENTRICLE DILATATION (18 patients)
DIABETIC FOOT INFECTION (18 patients)
NECK PAIN (18 patients)
OLIGURIA (17 patients)
GASTROINTESTINAL DISORDER (17 patients)
HAEMATOCHEZIA (17 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (17 patients)
HYPOTHYROIDISM (17 patients)
TRANSAMINASES INCREASED (17 patients)
OROPHARYNGEAL PAIN (17 patients)
CHRONIC MYELOID LEUKAEMIA (17 patients)
NEOPLASM PROGRESSION (17 patients)
METASTASES TO ADRENALS (16 patients)
LYMPHOCYTE COUNT DECREASED (16 patients)
INTERNATIONAL NORMALISED RATIO INCREASED (16 patients)
MULTI-ORGAN FAILURE (16 patients)
FEAR (16 patients)
PANCREATIC CARCINOMA (16 patients)
HYPERSOMNIA (16 patients)
EPILEPSY (16 patients)
SUBARACHNOID HAEMORRHAGE (16 patients)
METASTASES TO LUNG (16 patients)
TACHYCARDIA (16 patients)
MUSCULAR WEAKNESS (16 patients)
KLEBSIELLA SEPSIS (16 patients)
MYOCARDIAL ISCHAEMIA (16 patients)
DYSGEUSIA (16 patients)
LUNG INFECTION (16 patients)
FAECES DISCOLOURED (16 patients)
PAIN OF SKIN (16 patients)
SPINAL FRACTURE (16 patients)
PANIC REACTION (16 patients)

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