Study of possible correlation between WHITE BLOOD CELL COUNT INCREASED and SORAFENIB (RAF KINASE INHIBITOR)
Accompanying discussion about FactMed users Questions and Concerns
About this FactMed analysis covering adverse side effect reports of SORAFENIB (RAF KINASE INHIBITOR) patients who developed WHITE BLOOD CELL COUNT INCREASED.
FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 27 individuals taking SORAFENIB (RAF KINASE INHIBITOR) reported WHITE BLOOD CELL COUNT INCREASED to the FDA. A total of 3329 SORAFENIB (RAF KINASE INHIBITOR) drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.FDA Research Report
Introduction This page is designed to help you determine the relationship, if any, between SORAFENIB (RAF KINASE INHIBITOR) and WHITE BLOOD CELL COUNT INCREASED. In doing so, we compare SORAFENIB (RAF KINASE INHIBITOR) with other drugs that cause WHITE BLOOD CELL COUNT INCREASED, to help you evaluate whether or not SORAFENIB (RAF KINASE INHIBITOR) causes WHITE BLOOD CELL COUNT INCREASED. Likewise, this page shows the most highly-reported side effects of SORAFENIB (RAF KINASE INHIBITOR), so you can see if WHITE BLOOD CELL COUNT INCREASED ranks among SORAFENIB (RAF KINASE INHIBITOR)'s most well-known side effects.
Summary StatisticsReports of SORAFENIB (RAF KINASE INHIBITOR) causing WHITE BLOOD CELL COUNT INCREASED: 27
Reports of any side effect of SORAFENIB (RAF KINASE INHIBITOR) : 3329
Percentage of SORAFENIB (RAF KINASE INHIBITOR) patients where WHITE BLOOD CELL COUNT INCREASED is a reported side effect: 0.8111%
FDA reports of any drug causing WHITE BLOOD CELL COUNT INCREASED : 17106
Average percentage for all medicated patients where WHITE BLOOD CELL COUNT INCREASED is reported as a complication: 0.1072%
Physician opinion on SORAFENIB (RAF KINASE INHIBITOR) as adverse event culprit:
Overall opinion for all reports of this drug:
Most frequent diagnoses/indications for prescribing SORAFENIB (RAF KINASE INHIBITOR):
HEPATIC NEOPLASM MALIGNANT
( 770 patients )RENAL CELL CARCINOMA ( 114 patients )
THYROID CANCER ( 65 patients )
METASTATIC RENAL CELL CARCINOMA ( 44 patients )
THYROID CANCER METASTATIC ( 35 patients )
BREAST CANCER ( 31 patients )
BREAST CANCER METASTATIC ( 27 patients )
GASTRIC CANCER ( 25 patients )
NON-SMALL CELL LUNG CANCER ( 25 patients )
COLORECTAL CANCER METASTATIC ( 22 patients )
RENAL CANCER ( 17 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 14 patients )
BILE DUCT CANCER ( 14 patients )
SALIVARY GLAND CANCER ( 7 patients )
HEPATIC CANCER METASTATIC ( 7 patients )
COLORECTAL CANCER ( 7 patients )
SMALL CELL LUNG CANCER STAGE UNSPECIFIED ( 6 patients )
RECTAL CANCER ( 5 patients )
PANCREATIC CARCINOMA ( 4 patients )
PROSTATE CANCER ( 4 patients )
INTRAOCULAR MELANOMA ( 4 patients )
HEPATIC NEOPLASM MALIGNANT RECURRENT ( 3 patients )
NEOPLASM ( 3 patients )
LIVER DISORDER ( 3 patients )
ANGIOSARCOMA ( 3 patients )
NON-SMALL CELL LUNG CANCER STAGE IV ( 3 patients )
METASTASES TO LUNG ( 3 patients )
HEPATIC NEOPLASM MALIGNANT NON-RESECTABLE ( 3 patients )
COLORECTAL CANCER STAGE IV ( 3 patients )
NEOPLASM MALIGNANT ( 3 patients )
GALLBLADDER CANCER METASTATIC ( 3 patients )
METASTASIS ( 3 patients )
BILIARY CANCER METASTATIC ( 3 patients )
COLON CANCER METASTATIC ( 2 patients )
HYPOPHARYNGEAL CANCER ( 2 patients )
DESMOID TUMOUR ( 2 patients )
NEUROENDOCRINE CARCINOMA ( 2 patients )
LUNG NEOPLASM MALIGNANT ( 2 patients )
ACUTE MYELOID LEUKAEMIA (IN REMISSION) ( 2 patients )
OESOPHAGEAL CARCINOMA ( 2 patients )
METASTATIC MALIGNANT MELANOMA ( 2 patients )
TONGUE NEOPLASM MALIGNANT STAGE UNSPECIFIED ( 2 patients )
METASTATIC SQUAMOUS CELL CARCINOMA ( 2 patients )
RENAL CELL CARCINOMA STAGE IV ( 2 patients )
ANGINA PECTORIS ( 2 patients )
OSTEOSARCOMA METASTATIC ( 2 patients )
METASTATIC OCULAR MELANOMA ( 2 patients )
BONE SARCOMA ( 2 patients )
METASTATIC SALIVARY GLAND CANCER ( 2 patients )
TONSIL CANCER ( 2 patients )
MYELODYSPLASTIC SYNDROME ( 1 patients )
PROSTATE CANCER METASTATIC ( 1 patients )
GALLBLADDER CANCER ( 1 patients )
NEUROENDOCRINE TUMOUR ( 1 patients )
MALIGNANT NEOPLASM OF RENAL PELVIS ( 1 patients )
GLIOMA ( 1 patients )
BLADDER CANCER ( 1 patients )
OVARIAN CANCER METASTATIC ( 1 patients )
CAROTID ARTERY DISEASE ( 1 patients )
HEPATOBLASTOMA ( 1 patients )
NASOPHARYNGEAL CANCER ( 1 patients )
LUNG ADENOCARCINOMA ( 1 patients )
RENAL CANCER METASTATIC ( 1 patients )
ACUTE MYELOID LEUKAEMIA ( 1 patients )
DIFFUSE LARGE B-CELL LYMPHOMA ( 1 patients )
NEUROENDOCRINE CARCINOMA OF THE SKIN ( 1 patients )
MALIGNANT HISTIOCYTOSIS ( 1 patients )
MALIGNANT SOFT TISSUE NEOPLASM ( 1 patients )
SARCOMA ( 1 patients )
ANTICOAGULANT THERAPY ( 1 patients )
GERM CELL CANCER ( 1 patients )
OESOPHAGEAL ADENOCARCINOMA ( 1 patients )
SQUAMOUS CELL CARCINOMA ( 1 patients )
HEAD AND NECK CANCER ( 1 patients )
OVARIAN EPITHELIAL CANCER ( 1 patients )
( 0 patients )
Drugs with high FDA adverse event association with WHITE BLOOD CELL COUNT INCREASED:
CLOZARIL (2636 patients)
ASPIRIN (1179 patients)
CLOZAPINE (836 patients)
PREDNISOLONE (743 patients)
LASIX (726 patients)
PREDNISONE (700 patients)
LIPITOR (676 patients)
HUMIRA (653 patients)
FOLIC ACID (631 patients)
GLEEVEC (621 patients)
TYSABRI (616 patients)
OMEPRAZOLE (603 patients)
FUROSEMIDE (527 patients)
FOSAMAX (518 patients)
EXJADE (499 patients)
VIOXX (481 patients)
ZYPREXA (470 patients)
SIMVASTATIN (468 patients)
ACETAMINOPHEN (468 patients)
LISINOPRIL (461 patients)
REMICADE (456 patients)
METHOTREXATE (427 patients)
SEROQUEL (400 patients)
AVONEX (394 patients)
ALLOPURINOL (379 patients)
NORVASC (372 patients)
LANSOPRAZOLE (371 patients)
ATENOLOL (368 patients)
ZOMETA (359 patients)
DIOVAN (339 patients)
LORAZEPAM (339 patients)
NEXIUM (336 patients)
IBUPROFEN (331 patients)
RAMIPRIL (325 patients)
VOLTAREN (323 patients)
TEGRETOL (320 patients)
COUMADIN (315 patients)
DIGOXIN (315 patients)
NEURONTIN (312 patients)
METFORMIN HCL (312 patients)
DIAZEPAM (307 patients)
ACCUTANE (304 patients)
ENBREL (302 patients)
WARFARIN SODIUM (294 patients)
ALBUTEROL (293 patients)
NEORAL (293 patients)
PREDONINE (288 patients)
PREDNISONE TAB (286 patients)
SYNTHROID (285 patients)
LOVENOX (285 patients)
PROTONIX (285 patients)
LEVOTHYROXINE SODIUM (281 patients)
ATIVAN (280 patients)
PAXIL (278 patients)
OXYCONTIN (275 patients)
AMBIEN (273 patients)
LAMICTAL (272 patients)
HYDROCHLOROTHIAZIDE (266 patients)
PLAVIX (265 patients)
POTASSIUM CHLORIDE (263 patients)
RISPERDAL (260 patients)
XANAX (260 patients)
DEXAMETHASONE (257 patients)
VALPROATE SODIUM (255 patients)
ZOLOFT (249 patients)
HEPARIN SODIUM INJECTION (248 patients)
NEULASTA (247 patients)
LEXAPRO (241 patients)
FAMOTIDINE (241 patients)
VICODIN (232 patients)
VITAMIN D (229 patients)
CLONAZEPAM (228 patients)
PRILOSEC (225 patients)
CITALOPRAM HYDROBROMIDE (225 patients)
LYRICA (225 patients)
ZOCOR (220 patients)
LOXONIN (217 patients)
MORPHINE (215 patients)
DECADRON (213 patients)
GABAPENTIN (210 patients)
ZOFRAN (209 patients)
ZANTAC (207 patients)
OLANZAPINE (204 patients)
CELEBREX (202 patients)
ADVAIR DISKUS 100/50 (199 patients)
AMLODIPINE (198 patients)
TAXOTERE (197 patients)
NEUPOGEN (196 patients)
LITHIUM CARBONATE (194 patients)
LEVAQUIN (194 patients)
FERROUS SULFATE TAB (192 patients)
PREVACID (189 patients)
AMISULPRIDE (189 patients)
LAMOTRIGINE (189 patients)
LACTULOSE (188 patients)
OXYCODONE HCL (187 patients)
CALCIUM (186 patients)
CYCLOPHOSPHAMIDE (184 patients)
DEPAKENE (183 patients)
PERCOCET (183 patients)
CYCLOSPORINE (180 patients)
INSULIN (172 patients)
VANCOMYCIN (172 patients)
TRAMADOL HCL (172 patients)
FORTEO (171 patients)
TEMAZEPAM (171 patients)
EFFEXOR (171 patients)
FLUOROURACIL (169 patients)
CYMBALTA (167 patients)
TYLENOL (166 patients)
ALPRAZOLAM (165 patients)
SINGULAIR (164 patients)
CISPLATIN (163 patients)
ALDACTONE (162 patients)
MIRTAZAPINE (162 patients)
METOPROLOL TARTRATE (161 patients)
SOLU-MEDROL (161 patients)
SENNA (161 patients)
LANTUS (159 patients)
MORPHINE SULFATE (157 patients)
CRESTOR (155 patients)
MULTI-VITAMIN (155 patients)
PAROXETINE HCL (153 patients)
TOPROL-XL (151 patients)
DEPAKOTE (149 patients)
HALOPERIDOL (148 patients)
MULTI-VITAMINS (148 patients)
TOCILIZUMAB (146 patients)
RISPERIDONE (146 patients)
AMOXICILLIN (146 patients)
RANITIDINE (145 patients)
METHYLPREDNISOLONE (145 patients)
FENTANYL (145 patients)
PROZAC (144 patients)
MAGNESIUM OXIDE (144 patients)
COMPAZINE (144 patients)
KETEK (144 patients)
CARBOPLATIN (143 patients)
NIFEDIPINE (142 patients)
ZYRTEC (141 patients)
LEPONEX (141 patients)
AREDIA (140 patients)
ENALAPRIL MALEATE (140 patients)
VITAMIN B-12 (139 patients)
FLEXERIL (138 patients)
METRONIDAZOLE (138 patients)
ACTONEL (138 patients)
ABILIFY (137 patients)
SPIRONOLACTONE (136 patients)
PREMARIN (136 patients)
ALENDRONATE SODIUM (136 patients)
SPIRIVA (135 patients)
REVLIMID (135 patients)
ACTOS (134 patients)
CIPROFLOXACIN (134 patients)
CHANTIX (132 patients)
PROGRAF (131 patients)
METFORMIN (131 patients)
MYCOPHENOLATE MOFETIL (130 patients)
TYLENOL (CAPLET) (129 patients)
SOLIRIS (129 patients)
AVELOX (128 patients)
METOCLOPRAMIDE (127 patients)
HEPARIN (126 patients)
CELEXA (125 patients)
ARAVA (125 patients)
SANDOSTATIN LAR (124 patients)
FLUCONAZOLE (124 patients)
ZOPICLONE (123 patients)
TRAZODONE HCL (122 patients)
GEMZAR (122 patients)
TRIMETHOPRIM (122 patients)
METOPROLOL (121 patients)
CLARITHROMYCIN (121 patients)
ARIPIPRAZOLE (119 patients)
PEPCID (119 patients)
LEVOFLOXACIN (117 patients)
BACLOFEN (117 patients)
TACROLIMUS (116 patients)
TASIGNA (115 patients)
ALLEGRA (114 patients)
COREG (111 patients)
RAPTIVA (110 patients)
BYETTA (110 patients)
KLONOPIN (109 patients)
AMLODIPINE BESYLATE (108 patients)
CEPHALEXIN (108 patients)
ATORVASTATIN CALCIUM (107 patients)
COZAAR (107 patients)
ACETYLSALICYLIC ACID SRT (107 patients)
AMITRIPTYLINE HCL (106 patients)
SANDOSTATIN (105 patients)
REBIF (105 patients)
NAPROXEN (104 patients)
GLUCOPHAGE (104 patients)
DICLOFENAC SODIUM (102 patients)
WELLBUTRIN (102 patients)
LORTAB (101 patients)
MUCOSTA (101 patients)
ZELNORM (100 patients)
CALCIUM CARBONATE (100 patients)
DILAUDID (100 patients)
CLOMIPRAMINE (100 patients)
ZITHROMAX (99 patients)
ATORVASTATIN (99 patients)
COMBIVENT (99 patients)
ROCEPHIN (98 patients)
BENADRYL (98 patients)
VITAMIN E (98 patients)
DOXORUBICIN HCL (98 patients)
Most common side effects for patients taking SORAFENIB (RAF KINASE INHIBITOR):
DIARRHOEA (613 patients) HEPATIC FAILURE (378 patients)
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME (342 patients)
HEPATIC ENCEPHALOPATHY (320 patients)
FATIGUE (300 patients)
RASH (276 patients)
ASCITES (253 patients)
ABDOMINAL PAIN (237 patients)
DECREASED APPETITE (226 patients)
UPPER GASTROINTESTINAL HAEMORRHAGE (198 patients)
PYREXIA (191 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (179 patients)
NAUSEA (165 patients)
HYPERTENSION (160 patients)
ASTHENIA (154 patients)
DEHYDRATION (140 patients)
HEPATIC FUNCTION ABNORMAL (133 patients)
DYSPNOEA (131 patients)
CONFUSIONAL STATE (131 patients)
HYPOKALAEMIA (125 patients)
ALOPECIA (124 patients)
VOMITING (118 patients)
CONSTIPATION (115 patients)
INTERSTITIAL LUNG DISEASE (114 patients)
LEFT VENTRICULAR DYSFUNCTION (113 patients)
DEATH (113 patients)
ENDOCARDITIS (112 patients)
ARTHRALGIA (111 patients)
STOMATITIS (111 patients)
ABDOMINAL PAIN UPPER (110 patients)
JAUNDICE (108 patients)
HEPATIC NEOPLASM MALIGNANT (106 patients)
GASTROINTESTINAL HAEMORRHAGE (106 patients)
RETINAL VASCULAR THROMBOSIS (103 patients)
LOWER GASTROINTESTINAL HAEMORRHAGE (103 patients)
LIVER CARCINOMA RUPTURED (101 patients)
OEDEMA PERIPHERAL (97 patients)
PLEURAL EFFUSION (97 patients)
STAPHYLOCOCCAL INFECTION (96 patients)
PNEUMONIA BACTERIAL (96 patients)
ENTEROBACTER INFECTION (96 patients)
MYOPATHY (95 patients)
DRY MOUTH (94 patients)
PAIN IN EXTREMITY (93 patients)
ANXIETY (90 patients)
MALAISE (89 patients)
PULMONARY EMBOLISM (85 patients)
ANAEMIA (84 patients)
PLATELET COUNT DECREASED (81 patients)
BACK PAIN (79 patients)
SEPSIS (78 patients)
PRURITUS (78 patients)
DUODENAL ULCER (77 patients)
MIGRAINE (76 patients)
MITRAL VALVE INCOMPETENCE (76 patients)
HYPOGLYCAEMIA (76 patients)
C-REACTIVE PROTEIN INCREASED (74 patients)
BLOOD PRESSURE INCREASED (73 patients)
VARICES OESOPHAGEAL (73 patients)
HEADACHE (72 patients)
RETINAL VEIN OCCLUSION (72 patients)
ABASIA (69 patients)
RENAL FAILURE ACUTE (69 patients)
WEIGHT DECREASED (67 patients)
DEEP VEIN THROMBOSIS (67 patients)
DIZZINESS (65 patients)
ERYTHEMA (65 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (64 patients)
CONVULSION (63 patients)
ALANINE AMINOTRANSFERASE INCREASED (62 patients)
DYSPHONIA (62 patients)
CEREBRAL HAEMORRHAGE (60 patients)
APHAGIA (58 patients)
COLITIS (58 patients)
PNEUMONIA (57 patients)
GASTRIC ULCER (56 patients)
HYPONATRAEMIA (55 patients)
HAEMOGLOBIN DECREASED (53 patients)
RESPIRATORY FAILURE (52 patients)
LUNG DISORDER (52 patients)
CEREBRAL ISCHAEMIA (49 patients)
PARAESTHESIA (49 patients)
BLOOD BILIRUBIN INCREASED (48 patients)
GAIT DISTURBANCE (48 patients)
THYROID CANCER METASTATIC (44 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (43 patients)
PERICARDIAL EFFUSION (41 patients)
THROMBOCYTOPENIA (41 patients)
BLISTER (41 patients)
FEBRILE NEUTROPENIA (40 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (40 patients)
HALLUCINATION (40 patients)
CHILLS (40 patients)
AMMONIA INCREASED (39 patients)
SKIN ULCER (39 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (38 patients)
PAIN (38 patients)
HYPOALBUMINAEMIA (38 patients)
HYPOCALCAEMIA (37 patients)
FALL (37 patients)
POLLAKIURIA (37 patients)
BLOOD PRESSURE DECREASED (37 patients)
SKIN EXFOLIATION (37 patients)
INSOMNIA (36 patients)
CARDIAC ARREST (36 patients)
HYPOAESTHESIA (35 patients)
INFECTIOUS PERITONITIS (35 patients)
MYOCARDIAL INFARCTION (35 patients)
RETINAL VASCULAR DISORDER (34 patients)
RENAL FAILURE (34 patients)
LIPASE INCREASED (34 patients)
HYPERKALAEMIA (33 patients)
HYPERGLYCAEMIA (33 patients)
HAEMOPTYSIS (31 patients)
ATRIAL FIBRILLATION (30 patients)
GENERALISED OEDEMA (30 patients)
FAECAL INCONTINENCE (30 patients)
WHITE BLOOD CELL COUNT DECREASED (30 patients)
CELLULITIS (29 patients)
CHEST PAIN (29 patients)
SOMNOLENCE (29 patients)
HYPERBILIRUBINAEMIA (28 patients)
HYPOTENSION (28 patients)
MUSCLE SPASMS (28 patients)
ABDOMINAL DISTENSION (27 patients)
WHITE BLOOD CELL COUNT INCREASED (27 patients)
VISION BLURRED (27 patients)
HEPATIC PAIN (26 patients)
BLOOD ALBUMIN DECREASED (26 patients)
DYSURIA (25 patients)
RASH GENERALISED (25 patients)
BLOOD SODIUM DECREASED (25 patients)
BLOOD URIC ACID INCREASED (25 patients)
COMA (25 patients)
COUGH (25 patients)
PANCYTOPENIA (25 patients)
ACUTE ABDOMEN (24 patients)
EOSINOPHIL COUNT INCREASED (24 patients)
CEREBROVASCULAR ACCIDENT (24 patients)
METASTASES TO CENTRAL NERVOUS SYSTEM (23 patients)
CEREBRAL INFARCTION (23 patients)
HYPOMAGNESAEMIA (23 patients)
RETINAL VEIN THROMBOSIS (23 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (23 patients)
TUMOUR LYSIS SYNDROME (22 patients)
HYPOPHOSPHATAEMIA (22 patients)
INFECTION (22 patients)
ORAL PAIN (22 patients)
BLOOD CREATININE INCREASED (22 patients)
NEUTROPENIA (22 patients)
RENAL IMPAIRMENT (22 patients)
LETHARGY (22 patients)
SKIN TOXICITY (21 patients)
TONGUE BLISTERING (21 patients)
LIVER ABSCESS (21 patients)
HAEMATEMESIS (21 patients)
OESOPHAGEAL VARICES HAEMORRHAGE (20 patients)
MENTAL IMPAIRMENT (20 patients)
NERVOUSNESS (20 patients)
NEPHROTIC SYNDROME (20 patients)
HYPOPHAGIA (20 patients)
ADRENAL INSUFFICIENCY (19 patients)
DRY SKIN (19 patients)
BLOOD AMYLASE INCREASED (19 patients)
OEDEMA (19 patients)
INFECTIOUS PLEURAL EFFUSION (19 patients)
DYSPEPSIA (19 patients)
COMA HEPATIC (19 patients)
HEART RATE INCREASED (18 patients)
HYPERTENSIVE CRISIS (18 patients)
MYALGIA (18 patients)
ECZEMA (18 patients)
URINARY TRACT INFECTION (18 patients)
NEUROMYOPATHY (18 patients)
MEDICAL DEVICE COMPLICATION (18 patients)
DIVERTICULITIS (18 patients)
OSTEOMYELITIS (18 patients)
CEREBRAL ATROPHY (18 patients)
CEREBRAL VENTRICLE DILATATION (18 patients)
DIABETIC FOOT INFECTION (18 patients)
NECK PAIN (18 patients)
OLIGURIA (17 patients)
GASTROINTESTINAL DISORDER (17 patients)
HAEMATOCHEZIA (17 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (17 patients)
HYPOTHYROIDISM (17 patients)
TRANSAMINASES INCREASED (17 patients)
OROPHARYNGEAL PAIN (17 patients)
CHRONIC MYELOID LEUKAEMIA (17 patients)
NEOPLASM PROGRESSION (17 patients)
METASTASES TO ADRENALS (16 patients)
LYMPHOCYTE COUNT DECREASED (16 patients)
INTERNATIONAL NORMALISED RATIO INCREASED (16 patients)
MULTI-ORGAN FAILURE (16 patients)
FEAR (16 patients)
PANCREATIC CARCINOMA (16 patients)
HYPERSOMNIA (16 patients)
EPILEPSY (16 patients)
SUBARACHNOID HAEMORRHAGE (16 patients)
METASTASES TO LUNG (16 patients)
TACHYCARDIA (16 patients)
MUSCULAR WEAKNESS (16 patients)
KLEBSIELLA SEPSIS (16 patients)
MYOCARDIAL ISCHAEMIA (16 patients)
DYSGEUSIA (16 patients)
LUNG INFECTION (16 patients)
FAECES DISCOLOURED (16 patients)
PAIN OF SKIN (16 patients)
SPINAL FRACTURE (16 patients)
PANIC REACTION (16 patients)
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