About this FactMed analysis covering adverse side effect reports of ACTIT patients who developed COMA.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 1 individuals taking ACTIT reported COMA to the FDA. A total of 67 ACTIT drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between ACTIT and COMA. In doing so, we compare ACTIT with other drugs that cause COMA, to help you evaluate whether or not ACTIT causes COMA. Likewise, this page shows the most highly-reported side effects of ACTIT, so you can see if COMA ranks among ACTIT's most well-known side effects.
Summary Statistics
Reports of ACTIT causing COMA: 1
Reports of any side effect of ACTIT : 67
Percentage of ACTIT patients where COMA is a reported side effect: 1.4925%

FDA reports of any drug causing COMA : 18306
Average percentage for all medicated patients where COMA is reported as a complication: 0.1147%

Physician opinion on ACTIT as adverse event culprit:

Overall opinion for all reports of this drug:
Most frequent diagnoses/indications for prescribing ACTIT:
PYREXIA ( 5 patients )
INFUSION ( 4 patients )
DECREASED APPETITE ( 3 patients )
FLUID REPLACEMENT ( 2 patients )
ASTHMA ( 1 patients )
DEHYDRATION ( 1 patients )
( 0 patients )
Drugs with high FDA adverse event association with COMA:

ASPIRIN (993 patients)
SEROQUEL (894 patients)
ACETAMINOPHEN (726 patients)
HEPARIN SODIUM INJECTION (627 patients)
AVONEX (584 patients)
OXYCONTIN (574 patients)
ZYPREXA (548 patients)
NEURONTIN (536 patients)
DURAGESIC-100 (535 patients)
VIOXX (525 patients)
LORAZEPAM (508 patients)
LASIX (507 patients)
RISPERDAL (416 patients)
OMEPRAZOLE (407 patients)
PREDNISONE (399 patients)
MORPHINE SULFATE (399 patients)
MORPHINE (382 patients)
BACLOFEN (381 patients)
LYRICA (381 patients)
IBUPROFEN (373 patients)
DIAZEPAM (365 patients)
NEXIUM (362 patients)
METHOTREXATE (352 patients)
FUROSEMIDE (342 patients)
PLAVIX (337 patients)
XANAX (330 patients)
CLONAZEPAM (318 patients)
COUMADIN (318 patients)
FENTANYL (311 patients)
HUMIRA (298 patients)
LEVOTHYROXINE SODIUM (296 patients)
DEPAKOTE (295 patients)
ATENOLOL (289 patients)
LIPITOR (285 patients)
ALPRAZOLAM (284 patients)
LISINOPRIL (280 patients)
STROMECTOL (280 patients)
LANTUS (279 patients)
CYMBALTA (269 patients)
OLANZAPINE (266 patients)
SYNTHROID (264 patients)
METFORMIN HCL (256 patients)
PREDNISOLONE (256 patients)
VALIUM (254 patients)
CITALOPRAM HYDROBROMIDE (254 patients)
TEGRETOL (249 patients)
INSULIN (248 patients)
HUMALOG (242 patients)
AMBIEN (242 patients)
HYDROCHLOROTHIAZIDE (241 patients)
GABAPENTIN (240 patients)
TRAMADOL HCL (233 patients)
OXYCODONE HCL (231 patients)
REMICADE (231 patients)
DIGOXIN (229 patients)
ALBUTEROL (229 patients)
AMITRIPTYLINE HCL (227 patients)
CARBAMAZEPINE (218 patients)
LAMICTAL (217 patients)
ZOLOFT (217 patients)
SIMVASTATIN (216 patients)
LEXAPRO (216 patients)
NORVASC (215 patients)
DURAGESIC (214 patients)
KEPPRA (214 patients)
DEXAMETHASONE (212 patients)
ABILIFY (212 patients)
ATIVAN (209 patients)
FOSAMAX (206 patients)
POTASSIUM CHLORIDE (204 patients)
HALDOL (203 patients)
ALLOPURINOL (201 patients)
PAXIL (201 patients)
AMLODIPINE (194 patients)
EFFEXOR (193 patients)
CELEBREX (192 patients)
VALPROATE SODIUM (191 patients)
ZOCOR (190 patients)
VICODIN (190 patients)
MIRTAZAPINE (187 patients)
FORTEO (185 patients)
CYCLOPHOSPHAMIDE (184 patients)
TRAZODONE HCL (182 patients)
PROZAC (181 patients)
FOLIC ACID (177 patients)
ALCOHOL (176 patients)
LIORESAL (176 patients)
LITHIUM CARBONATE (172 patients)
LOVENOX (170 patients)
ZOLPIDEM (170 patients)
VANCOMYCIN (169 patients)
TOPAMAX (168 patients)
FLUOROURACIL (167 patients)
RIVOTRIL (165 patients)
WARFARIN SODIUM (165 patients)
HEPARIN (164 patients)
RAMIPRIL (161 patients)
DEPAKENE (160 patients)
PERCOCET (158 patients)
METHADONE HCL (157 patients)
VALPROIC ACID (157 patients)
RISPERIDONE (153 patients)
TYSABRI (150 patients)
DIOVAN (148 patients)
CISPLATIN (145 patients)
GLUCOPHAGE (142 patients)
PROTONIX (141 patients)
ZOFRAN (141 patients)
PREDNISONE TAB (139 patients)
AVANDIA (137 patients)
PARACETAMOL (137 patients)
CLOZAPINE (136 patients)
TOPROL-XL (134 patients)
BACTRIM (134 patients)
PREVACID (130 patients)
REBIF (130 patients)
DILANTIN (129 patients)
BENADRYL (129 patients)
SOLU-MEDROL (128 patients)
METOPROLOL TARTRATE (128 patients)
CELEXA (127 patients)
BISOPROLOL FUMARATE (127 patients)
PAROXETINE HCL (127 patients)
ATARAX (127 patients)
MULTI-VITAMIN (126 patients)
DECADRON (125 patients)
KLONOPIN (125 patients)
PHENYTOIN (125 patients)
ZOLPIDEM TARTRATE (124 patients)
GLYBURIDE (123 patients)
ACETYLSALICYLIC ACID SRT (121 patients)
CRESTOR (120 patients)
MS CONTIN (119 patients)
OXAZEPAM (118 patients)
HUMULIN R (117 patients)
TRILEPTAL (117 patients)
CLONIDINE (117 patients)
CYTARABINE (117 patients)
GEODON (116 patients)
TEMAZEPAM (116 patients)
PROPRANOLOL (115 patients)
METOPROLOL (115 patients)
PROGRAF (113 patients)
LAMOTRIGINE (113 patients)
HUMULIN N (113 patients)
AMARYL (112 patients)
LANSOPRAZOLE (112 patients)
ALDACTONE (111 patients)
WELLBUTRIN (110 patients)
FLUOXETINE (109 patients)
NITROGLYCERIN (109 patients)
ARICEPT (108 patients)
ENALAPRIL MALEATE (108 patients)
FLUCONAZOLE (107 patients)
LEVOFLOXACIN (107 patients)
LEVAQUIN (107 patients)
ZOMETA (106 patients)
BETASERON (106 patients)
TYLENOL (102 patients)
SPIRONOLACTONE (102 patients)
PRILOSEC (101 patients)
AMIODARONE HCL (101 patients)
CYCLOSPORINE (101 patients)
ROCEPHIN (100 patients)
CLOZARIL (99 patients)
ACYCLOVIR (99 patients)
DIPHENHYDRAMINE HCL (98 patients)
HALOPERIDOL (98 patients)
CARBOPLATIN (98 patients)
ATROVENT (97 patients)
ALL OTHER THERAPEUTIC PRODUCTS (97 patients)
VFEND (96 patients)
PANTOPRAZOLE (94 patients)
VELCADE (94 patients)
EFFEXOR XR (93 patients)
FAMOTIDINE (93 patients)
DIANEAL (93 patients)
RANITIDINE (93 patients)
RIBAVIRIN (92 patients)
VINCRISTINE (92 patients)
MIDAZOLAM HCL (91 patients)
ESCITALOPRAM (91 patients)
CORDARONE (91 patients)
EXELON (91 patients)
ARIXTRA (91 patients)
ETHANOL (91 patients)
METHYLPREDNISOLONE (90 patients)
ENBREL (90 patients)
TOPIRAMATE (89 patients)
VENLAFAXINE HCL (89 patients)
DILTIAZEM (88 patients)
CLOPIDOGREL BISULFATE (88 patients)
CIPROFLOXACIN (88 patients)
PROPOFOL (88 patients)
PROMETHAZINE (88 patients)
REMERON (86 patients)
CARVEDILOL (86 patients)
VITAMIN B-12 (86 patients)
LIDOCAINE (86 patients)
NAPROXEN (86 patients)
AVELOX (86 patients)
LEUCOVORIN CALCIUM (85 patients)
LOPRESSOR (85 patients)
AMLODIPINE BESYLATE (85 patients)
COZAAR (85 patients)
BENZODIAZEPINE DERIVATIVES (85 patients)
VERAPAMIL (85 patients)
ACETAMINOPHEN AND HYDROCODONE BITARTRATE (85 patients)
PANTOPRAZOLE SODIUM (84 patients)
METOCLOPRAMIDE (84 patients)
Most common side effects for patients taking ACTIT:
BLOOD POTASSIUM DECREASED (12 patients)
DIZZINESS POSTURAL (12 patients)
MULTIPLE SCLEROSIS RELAPSE (12 patients)
PALPITATIONS (12 patients)
LIVER DISORDER (7 patients)
NAUSEA (7 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (6 patients)
PYREXIA (6 patients)
ALANINE AMINOTRANSFERASE INCREASED (5 patients)
DYSPNOEA (5 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (5 patients)
HYPERTHERMIA (5 patients)
BLOOD PRESSURE DECREASED (4 patients)
HAEMOGLOBIN DECREASED (4 patients)
HEPATIC FUNCTION ABNORMAL (4 patients)
ILEUS (4 patients)
PNEUMONIA (4 patients)
PNEUMONIA ASPIRATION (4 patients)
STEVENS-JOHNSON SYNDROME (4 patients)
WHITE BLOOD CELL COUNT INCREASED (4 patients)
ANOREXIA NERVOSA (3 patients)
DECREASED APPETITE (3 patients)
DEPRESSION (3 patients)
DIARRHOEA (3 patients)
DRUG WITHDRAWAL SYNDROME (3 patients)
DYSPHORIA (3 patients)
GASTROINTESTINAL ULCER (3 patients)
HAEMATOCRIT DECREASED (3 patients)
MALAISE (3 patients)
PARKINSONISM (3 patients)
RENAL FAILURE (3 patients)
SHOCK HAEMORRHAGIC (3 patients)
SOMNOLENCE (3 patients)
UPPER GASTROINTESTINAL HAEMORRHAGE (3 patients)
VOMITING (3 patients)
ANORECTAL OPERATION (2 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (2 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (2 patients)
BLOOD UREA INCREASED (2 patients)
BRONCHIAL HAEMORRHAGE (2 patients)
CARDIAC FAILURE (2 patients)
COLD SWEAT (2 patients)
COUGH (2 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (2 patients)
DRUG ERUPTION (2 patients)
DYSKINESIA (2 patients)
DYSURIA (2 patients)
FIBRINOLYSIS INCREASED (2 patients)
GENERALISED ERYTHEMA (2 patients)
HAEMODIALYSIS (2 patients)
HAEMORRHAGE SUBCUTANEOUS (2 patients)
HEPARIN-INDUCED THROMBOCYTOPENIA (2 patients)
HEPATITIS ACUTE (2 patients)
HEPATITIS FULMINANT (2 patients)
MELAENA (2 patients)
PAIN (2 patients)
PLATELET COUNT DECREASED (2 patients)
PLATELET COUNT INCREASED (2 patients)
PNEUMONIA BACTERIAL (2 patients)
PRODUCTIVE COUGH (2 patients)
PROTEIN TOTAL DECREASED (2 patients)
RED BLOOD CELL COUNT DECREASED (2 patients)
RENAL FAILURE ACUTE (2 patients)
RESPIRATORY ARREST (2 patients)
THROMBOCYTOPENIA (2 patients)
URINARY TRACT INFECTION (2 patients)
WHEEZING (2 patients)
WHITE BLOOD CELL COUNT DECREASED (2 patients)
ABNORMAL BEHAVIOUR (1 patients)
ANOREXIA (1 patients)
BACK PAIN (1 patients)
BLOOD GLUCOSE INCREASED (1 patients)
BLOOD PRESSURE INCREASED (1 patients)
BLOOD URINE PRESENT (1 patients)
BRADYCARDIA (1 patients)
C-REACTIVE PROTEIN INCREASED (1 patients)
CACHEXIA (1 patients)
CAESAREAN SECTION (1 patients)
CHILLS (1 patients)
CHOLANGITIS SCLEROSING (1 patients)
COAGULATION TEST ABNORMAL (1 patients)
COAGULOPATHY (1 patients)
COMA (1 patients)
CONJUNCTIVAL HYPERAEMIA (1 patients)
CONSTIPATION (1 patients)
CONVULSION (1 patients)
DEATH (1 patients)
DIZZINESS (1 patients)
DRUG EXPOSURE DURING PREGNANCY (1 patients)
DRUG HYPERSENSITIVITY (1 patients)
DRUG INTERACTION (1 patients)
FALL (1 patients)
FEELING ABNORMAL (1 patients)
FOETAL GROWTH RETARDATION (1 patients)
FUNGAL TEST POSITIVE (1 patients)
GASTROINTESTINAL DISORDER (1 patients)
GASTROINTESTINAL HAEMORRHAGE (1 patients)
HEADACHE (1 patients)
HEPATIC NEOPLASM MALIGNANT (1 patients)
HYPERCALCAEMIA (1 patients)
HYPERKALAEMIA (1 patients)
HYPOMANIA (1 patients)
INJURY ASPHYXIATION (1 patients)
INTERSTITIAL LUNG DISEASE (1 patients)
IRRITABILITY (1 patients)
LIVER FUNCTION TEST ABNORMAL (1 patients)
LYMPHADENOPATHY (1 patients)
LYMPHOCYTE STIMULATION TEST POSITIVE (1 patients)
MALNUTRITION (1 patients)
MUSCLE RIGIDITY (1 patients)
MYDRIASIS (1 patients)
OCULOMUCOCUTANEOUS SYNDROME (1 patients)
ORGANISING PNEUMONIA (1 patients)
PLEURAL EFFUSION (1 patients)
POST PROCEDURAL COMPLICATION (1 patients)
PRE-ECLAMPSIA (1 patients)
PROCTALGIA (1 patients)
PULMONARY TUBERCULOSIS (1 patients)
RASH GENERALISED (1 patients)
RED BLOOD CELL ANISOCYTES PRESENT (1 patients)
RENAL CELL CARCINOMA (1 patients)
RESPIRATORY DISORDER (1 patients)
SEPSIS (1 patients)
SPEECH DISORDER (1 patients)
STUPOR (1 patients)
SUDDEN DEATH (1 patients)
TACHYCARDIA (1 patients)
WHITE BLOOD CELLS URINE POSITIVE (1 patients)

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