About this FactMed analysis covering adverse side effect reports of AMITIZA patients who developed ACANTHOLYSIS.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 3 individuals taking AMITIZA reported ACANTHOLYSIS to the FDA. A total of 1556 AMITIZA drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between AMITIZA and ACANTHOLYSIS. In doing so, we compare AMITIZA with other drugs that cause ACANTHOLYSIS, to help you evaluate whether or not AMITIZA causes ACANTHOLYSIS. Likewise, this page shows the most highly-reported side effects of AMITIZA, so you can see if ACANTHOLYSIS ranks among AMITIZA's most well-known side effects.
Summary Statistics
Reports of AMITIZA causing ACANTHOLYSIS: 3
Reports of any side effect of AMITIZA : 1556
Percentage of AMITIZA patients where ACANTHOLYSIS is a reported side effect: 0.1928%

FDA reports of any drug causing ACANTHOLYSIS : 33
Average percentage for all medicated patients where ACANTHOLYSIS is reported as a complication: 0.0002%

Physician opinion on AMITIZA as adverse event culprit:

Overall opinion for all reports of this drug:
Most frequent diagnoses/indications for prescribing AMITIZA:
CONSTIPATION ( 495 patients )
IRRITABLE BOWEL SYNDROME ( 161 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 51 patients )
DRUG USE FOR UNKNOWN INDICATION ( 29 patients )
GASTROINTESTINAL DISORDER ( 14 patients )
DIVERTICULITIS ( 9 patients )
GASTRIC DISORDER ( 7 patients )
INTESTINAL FUNCTIONAL DISORDER ( 4 patients )
DYSPEPSIA ( 4 patients )
COLITIS ( 4 patients )
PREMEDICATION ( 3 patients )
BOWEL MOVEMENT IRREGULARITY ( 3 patients )
ABDOMINAL PAIN ( 3 patients )
GASTROINTESTINAL MOTILITY DISORDER ( 2 patients )
PAIN ( 2 patients )
FLATULENCE ( 2 patients )
GASTROINTESTINAL HYPOMOTILITY ( 2 patients )
CHANGE OF BOWEL HABIT ( 2 patients )
INTESTINAL OBSTRUCTION ( 2 patients )
MEGACOLON ( 1 patients )
FAECALOMA ( 1 patients )
PSYCHOSOMATIC DISEASE ( 1 patients )
FUNCTIONAL GASTROINTESTINAL DISORDER ( 1 patients )
ABDOMINAL DISTENSION ( 1 patients )
CLOSTRIDIAL INFECTION ( 1 patients )
IMPAIRED GASTRIC EMPTYING ( 1 patients )
COLONIC OBSTRUCTION ( 1 patients )
DIABETIC GASTROPARESIS ( 1 patients )
ABDOMINAL DISCOMFORT ( 1 patients )
UNEVALUABLE EVENT ( 1 patients )
GASTROINTESTINAL OBSTRUCTION ( 1 patients )
INFREQUENT BOWEL MOVEMENTS ( 1 patients )
DIARRHOEA ( 1 patients )
( 0 patients )
Drugs with high FDA adverse event association with ACANTHOLYSIS:

AMBIEN (10 patients)
ABRAXANE (9 patients)
ACIPHEX (9 patients)
AMPICILLIN (9 patients)
ASPIRIN (9 patients)
ATIVAN (9 patients)
AVASTIN (9 patients)
CYMBALTA (9 patients)
LEVOTHYROXINE SODIUM (9 patients)
NORCO (9 patients)
RADIATION (9 patients)
VICODIN (9 patients)
XELODA (9 patients)
ZOLOFT (9 patients)
ZOMETA (9 patients)
ZOFRAN (8 patients)
ARANESP (7 patients)
CAPECITABINE (7 patients)
CEFTRIAXONE (7 patients)
CEPHALEXIN (7 patients)
CIPROFLOXACIN (7 patients)
COLACE (7 patients)
DILAUDID (7 patients)
DOXIL (7 patients)
FEMARA (7 patients)
HYDROCODONE BITARTRATE AND ACETAMINOPHEN (7 patients)
KEFLEX (7 patients)
LASIX (7 patients)
LORAZEPAM (7 patients)
NAPROSYN (7 patients)
NEULASTA (7 patients)
NIACIN (7 patients)
PERCOCET (7 patients)
PROVIGIL (7 patients)
RITALIN (7 patients)
SYNTHROID (7 patients)
TAXOTERE (7 patients)
VANCOMYCIN (7 patients)
VANCOMYCIN HCL (7 patients)
DEXAMETHASONE (6 patients)
FENTANYL (6 patients)
CYCLOSPORINE (4 patients)
PLAVIX (4 patients)
RELAFEN (4 patients)
ACETYLSALICYLIC ACID SRT (3 patients)
ACYCLOVIR (3 patients)
AMITIZA (3 patients)
NABUMETONE (3 patients)
NEXIUM (3 patients)
NIFEDIPINE (3 patients)
XIFAXAN (3 patients)
ALDACTAZIDE (2 patients)
AMLOR (2 patients)
AZATHIOPRINE (2 patients)
CLINDAMYCIN (2 patients)
COZAAR (2 patients)
DEPAKENE (2 patients)
DEPAS (2 patients)
DIGOXIN (2 patients)
DIPYRIDAMOL (2 patients)
EMPYNASE (2 patients)
ENALAPRIL MALEATE (2 patients)
ETRETINATE (2 patients)
FRACTAL (2 patients)
FUCIDIN CREAM (2 patients)
FUROSEMIDE (2 patients)
GAMUNEX (2 patients)
GLUCOR (2 patients)
HALCION (2 patients)
ISOSORBIDE MONONITRATE (2 patients)
LAMICTAL (2 patients)
LAXOBERON (2 patients)
LEVEMIR (2 patients)
MAGLAX (2 patients)
METHYLPREDNISOLONE (2 patients)
MINOCYCLIN (2 patients)
MOPRAL (2 patients)
MORPHINE (2 patients)
NITROGLYCERIN (2 patients)
PREDNISOLONE (2 patients)
PREDNISONE (2 patients)
SECTRAL (2 patients)
STILNOX (2 patients)
THEOPHYLLINE (2 patients)
TOPICAL ANTISEPTICS (2 patients)
ACENOCOUMAROL (1 patients)
ACENOCOUMAROL (ACENOCOUMAROL) (1 patients)
ACTIFED (1 patients)
AMILORIDE (1 patients)
AMILORIDE (AMILORIDE HYDROCHLORIDE) (1 patients)
ARNESP (1 patients)
ATENOLOL (1 patients)
ATORVASTATIN CALCIUM (1 patients)
BEMYLID (1 patients)
BETAMETHASONE DIPROPIIONATE (1 patients)
BETAMETHASONE DIPROPIONATE (1 patients)
CARBAMAZEPINE (1 patients)
CEFIXIME (1 patients)
CILAZAPRIL (1 patients)
CIPROFLOXACIN HCL (1 patients)
CIPROFLOXACIN IV (1 patients)
CISPLATIN (1 patients)
COPEGUS (1 patients)
DEXAMETHASONE ACETATE (1 patients)
DOXIUM (CALCIUM DOBESILATE) (1 patients)
ETHYOL (1 patients)
ETOPOSIDE (1 patients)
FENTANYL-100 (1 patients)
FILGRASTIM (FILGRASTIM) (1 patients)
FINASTERIDE (1 patients)
GEMZAR (1 patients)
GLIBENCLAMIDE (1 patients)
GLIMEPIRIDE (1 patients)
HEMERAN GEL (HEPARINOID) (1 patients)
HUMAN INSULIN (1 patients)
INSULIN ACTRAPID HUMAN (1 patients)
INTRON A (1 patients)
IRINOTECAN HCL (1 patients)
L-THYROXIN (1 patients)
LACIDIPINE (1 patients)
LACIDIPINE (LACIDIPINE) (1 patients)
MAGNESIUM OXIDE (MAGNESIUM OXIDE) (1 patients)
METHOTREXATE (1 patients)
MS CONTIN (1 patients)
OXYCODONE HCL (1 patients)
PEG-INTRON (1 patients)
PHENYTOIN (1 patients)
PRAVASTATIN (1 patients)
PRAVASTATIN SODIUM (1 patients)
PREDNISONE TAB (1 patients)
RADIATION THERAPY (1 patients)
REBETOL (1 patients)
RIBAVIRIN (1 patients)
TAREG (1 patients)
TOPICAL MEDICATIONS (FOR PSORIASIS) (1 patients)
ZETIA (1 patients)
Most common side effects for patients taking AMITIZA:
DYSPNOEA (344 patients)
NAUSEA (285 patients)
PAIN (228 patients)
CONSTIPATION (200 patients)
DIARRHOEA (159 patients)
ABDOMINAL PAIN (153 patients)
CHEST PAIN (153 patients)
ANXIETY (153 patients)
VOMITING (142 patients)
CHEST DISCOMFORT (137 patients)
HEADACHE (125 patients)
BACK PAIN (123 patients)
DIZZINESS (121 patients)
FALL (112 patients)
OEDEMA PERIPHERAL (107 patients)
FATIGUE (107 patients)
ASTHENIA (106 patients)
DRUG INEFFECTIVE (100 patients)
WEIGHT DECREASED (97 patients)
PYREXIA (96 patients)
DEPRESSION (89 patients)
ABDOMINAL PAIN UPPER (84 patients)
COUGH (81 patients)
PAIN IN EXTREMITY (79 patients)
SWELLING (73 patients)
DEHYDRATION (69 patients)
PNEUMONIA (69 patients)
HYPERTENSION (68 patients)
ANAEMIA (67 patients)
ABDOMINAL DISTENSION (66 patients)
HYPOAESTHESIA (61 patients)
ARTHRALGIA (61 patients)
MUSCLE SPASMS (61 patients)
MUSCULAR WEAKNESS (60 patients)
HYPOTENSION (60 patients)
INSOMNIA (59 patients)
GASTROOESOPHAGEAL REFLUX DISEASE (58 patients)
INJURY (57 patients)
PARAESTHESIA (56 patients)
URINARY TRACT INFECTION (56 patients)
HYPERHIDROSIS (54 patients)
BONE DISORDER (54 patients)
MALAISE (53 patients)
PRURITUS (53 patients)
CONFUSIONAL STATE (53 patients)
RENAL FAILURE (52 patients)
SYNCOPE (51 patients)
FEELING ABNORMAL (50 patients)
DECREASED APPETITE (50 patients)
EMOTIONAL DISTRESS (48 patients)
TREMOR (48 patients)
ANHEDONIA (48 patients)
CEREBROVASCULAR ACCIDENT (46 patients)
CARDIAC FAILURE CONGESTIVE (46 patients)
TACHYCARDIA (45 patients)
DIVERTICULUM (45 patients)
GAIT DISTURBANCE (43 patients)
PAIN IN JAW (43 patients)
DYSPEPSIA (42 patients)
OSTEOMYELITIS (42 patients)
VISION BLURRED (41 patients)
BRONCHITIS (40 patients)
OSTEONECROSIS OF JAW (40 patients)
OROPHARYNGEAL PAIN (39 patients)
DYSPHAGIA (38 patients)
HYPOPHAGIA (38 patients)
SOMNOLENCE (37 patients)
CHILLS (37 patients)
CONVULSION (37 patients)
DEEP VEIN THROMBOSIS (37 patients)
WEIGHT INCREASED (37 patients)
IRRITABLE BOWEL SYNDROME (37 patients)
RASH (36 patients)
MEMORY IMPAIRMENT (36 patients)
TOOTH INFECTION (36 patients)
BLOOD PRESSURE INCREASED (36 patients)
LOSS OF CONSCIOUSNESS (35 patients)
HEART RATE INCREASED (34 patients)
OEDEMA (34 patients)
INJECTION SITE PAIN (33 patients)
SINUSITIS (32 patients)
JAW FRACTURE (32 patients)
CHRONIC OBSTRUCTIVE PULMONARY DISEASE (32 patients)
DRY MOUTH (32 patients)
PALPITATIONS (32 patients)
BONE PAIN (32 patients)
ECZEMA (32 patients)
CHOLECYSTITIS CHRONIC (31 patients)
ARTHRITIS (31 patients)
MYOCARDIAL INFARCTION (31 patients)
POSTMENOPAUSAL HAEMORRHAGE (31 patients)
VERTIGO (31 patients)
MULTIPLE MYELOMA (31 patients)
BONE LESION (31 patients)
RENAL FAILURE ACUTE (30 patients)
INFLUENZA LIKE ILLNESS (30 patients)
SLEEP APNOEA SYNDROME (30 patients)
MYALGIA (30 patients)
BLOOD GLUCOSE INCREASED (30 patients)
IMPAIRED GASTRIC EMPTYING (29 patients)
NEPHROLITHIASIS (29 patients)
OSTEOPOROSIS (29 patients)
DEATH (29 patients)
OVERDOSE (28 patients)
SEPSIS (28 patients)
EXCESSIVE GRANULATION TISSUE (28 patients)
DEFORMITY (28 patients)
BLOOD POTASSIUM DECREASED (28 patients)
NIGHT SWEATS (27 patients)
MIGRAINE (27 patients)
IMPAIRED HEALING (27 patients)
SPINAL OSTEOARTHRITIS (27 patients)
JAW OPERATION (27 patients)
RESPIRATORY FAILURE (26 patients)
PARAESTHESIA ORAL (26 patients)
TOOTH FRACTURE (26 patients)
DRUG DOSE OMISSION (26 patients)
CHOLELITHIASIS (26 patients)
FLATULENCE (26 patients)
PULMONARY EMBOLISM (26 patients)
TOOTH DISORDER (26 patients)
RENAL IMPAIRMENT (26 patients)
SKIN DISORDER (25 patients)
FLUSHING (25 patients)
CONDITION AGGRAVATED (25 patients)
NECK PAIN (25 patients)
ERYTHEMA (25 patients)
METASTASES TO BONE (25 patients)
TOOTH EXTRACTION (25 patients)
LYMPHADENOPATHY (24 patients)
HYPERKERATOSIS (24 patients)
SWELLING FACE (24 patients)
OSTEONECROSIS (24 patients)
INTERVERTEBRAL DISC PROTRUSION (24 patients)
ASTHMA (24 patients)
BACTERAEMIA (24 patients)
LOOSE TOOTH (24 patients)
DYSURIA (24 patients)
INFECTION (24 patients)
ABDOMINAL DISCOMFORT (23 patients)
UTERINE LEIOMYOMA (23 patients)
ICHTHYOSIS (23 patients)
FIBROUS HISTIOCYTOMA (23 patients)
PURULENT DISCHARGE (23 patients)
ANGIOPATHY (23 patients)
ORAL CAVITY FISTULA (23 patients)
HYPERLIPIDAEMIA (23 patients)
ENDODONTIC PROCEDURE (23 patients)
ECZEMA ASTEATOTIC (23 patients)
ORAL MUCOSA ATROPHY (23 patients)
DERMATITIS (23 patients)
TOOTH LOSS (23 patients)
MITRAL VALVE PROLAPSE (23 patients)
ECONOMIC PROBLEM (23 patients)
BONE EROSION (23 patients)
BONE FRAGMENTATION (23 patients)
CONTUSION (22 patients)
NEUROPATHY PERIPHERAL (22 patients)
CYSTITIS (22 patients)
NECK INJURY (22 patients)
RECTAL HAEMORRHAGE (21 patients)
ORTHODONTIC APPLIANCE USER (21 patients)
HALLUCINATION (21 patients)
DYSPNOEA EXERTIONAL (21 patients)
GASTROINTESTINAL DISORDER (21 patients)
LUNG NEOPLASM (21 patients)
RENAL DISORDER (21 patients)
BONE DENSITY DECREASED (21 patients)
HAEMATOCHEZIA (20 patients)
ACTINOMYCOSIS (20 patients)
THYROID CANCER (20 patients)
TOOTH ABSCESS (20 patients)
DYSKINESIA (20 patients)
MUCOSAL INFLAMMATION (20 patients)
THROAT TIGHTNESS (20 patients)
INFLAMMATION (20 patients)
FLUID OVERLOAD (20 patients)
HAEMATURIA (20 patients)
HYPERSENSITIVITY (20 patients)
SKIN NEOPLASM EXCISION (20 patients)
STEM CELL TRANSPLANT (20 patients)
GASTRIC DISORDER (20 patients)
HYPONATRAEMIA (19 patients)
JAW DISORDER (19 patients)
DRUG HYPERSENSITIVITY (19 patients)
THYROID NEOPLASM (19 patients)
THROMBOSIS (19 patients)
AMNESIA (19 patients)
CARDIOMYOPATHY (19 patients)
CEREBRAL ATROPHY (19 patients)
DRUG EFFECT DECREASED (19 patients)
FISTULA (19 patients)
SUICIDE ATTEMPT (19 patients)
NERVOUSNESS (19 patients)
HALLUCINATION, AUDITORY (19 patients)
COLITIS ISCHAEMIC (19 patients)
BLOOD PRESSURE DECREASED (19 patients)
HYPOVOLAEMIA (19 patients)
RETCHING (19 patients)
HAEMATEMESIS (18 patients)
ORAL PAIN (18 patients)
JOINT EFFUSION (18 patients)
MALNUTRITION (18 patients)
THROMBOCYTOPENIA (18 patients)
RESORPTION BONE INCREASED (18 patients)
DRUG EXPOSURE DURING PREGNANCY (18 patients)
PRIMARY SEQUESTRUM (18 patients)
NEURALGIA (18 patients)
CARDIOMEGALY (18 patients)
CANDIDIASIS (18 patients)

In addition to reviewing our up-to-date FDA research, users may interact with the FactMed community - currently one million members and growing! FactMed online research and discussions are read by patients, scientists, physicians, and other interested health care parties. Post follow up Questions to learn from our diverse readership. Likewise, patients who have experienced unwanted effects are encouraged to share their Concerns to help educate and inform our members.


Recent FactMed Activity for AMITIZA


Issue Description / Topic Timestamp
QUESTION
SEROTONIN SYNDROME
I take Amitza, I have started in shaking along with tightness in my chest( right side) along with bloating in my stomach. could the amitiza cause this ? 2015-04-22 11:40:13
QUESTION
METASTASES TO LYMPH NODES
I started Amitiza 2 1/2 weeks ago. For the past 3 days, I have had stuffy nose and slight sore throat. But I have also had what feels like slightly swollen lymph nodes on both sides of my neck, and it is very tender and sore to touch. At first, I thought it was allergies, but I have never had swollen lymph nodes with allergies before. Could swollen lymph nodes be a side effect from the Amitiza? 2015-04-23 10:32:29
QUESTION
TYPE 2 DIABETES MELLITUS
I have type 2 diabetes is it safe for me to take amitiza 8mg or 24mg please let me no something please 2015-05-16 18:39:30
QUESTION
EXPIRED DRUG ADMINISTERED
Is it bad to take AMITIZA if it's expired? 2016-04-28 11:19:02
QUESTION
CARCINOID TUMOUR
I have been recently diagnosed with Carcinoid Syndrome-I am also on Amitiza.....I have atonic bowel and struggle every day to go to the bathroom. I don't want to become obstructed nor do I want to increase the problems with the carcinoid. Is Amitiza safe to take with my medical issues? 2016-04-29 09:58:48
QUESTION
CHILLS
12 yo on Amitiza c/o feeling very shakey inside and chills. Is this a side effect? 2016-05-17 07:59:21
QUESTION
DEMENTIA
I have been on amitiza 24 mcg for almost 2 years. I feel like i have some dementia going on. Please some advice?? 2016-06-02 12:40:53
QUESTION
MUCOUS MEMBRANE DISORDER
I started taking amitiza one week ago and my bloating and constipation are both gone. However, I am feeling very congested and im coughing like I have a cold but I don't feel sick. Is this a side effect of taking amitiza and is this temporary or will I always feel like this when taking this medication? 2016-07-28 09:45:50
QUESTION
HEARING IMPAIRED
can Amitiza cause sudden deafness 2016-10-19 23:31:04
QUESTION
CARDIAC FAILURE
My MD put me on Amitiza and I feel change in heart rhythm. Possible? I also take several heart drugs including Lisinopril, Norvasc and Sectral. 2017-02-06 14:28:04
QUESTION
HYPERTENSION
Could Amitiza cause heart rhythm and blood pressure Spikes? 2017-03-28 10:49:56
QUESTION
LYMPHOEDEMA
Does anyone have any experience with Amitiza causing pre-existing secondary lymphedema to get worse? 2017-06-08 16:25:24
QUESTION
TARDIVE DYSKINESIA
Can Amitiza cause tardive dyskinesia? 2017-11-11 08:20:29

My Patient Resources

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Your Question:

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Your Experience or Concern:

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