About this FactMed analysis covering adverse side effect reports of COMBIVENT patients who developed ACHLORHYDRIA.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 1 individuals taking COMBIVENT reported ACHLORHYDRIA to the FDA. A total of 12082 COMBIVENT drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between COMBIVENT and ACHLORHYDRIA. In doing so, we compare COMBIVENT with other drugs that cause ACHLORHYDRIA, to help you evaluate whether or not COMBIVENT causes ACHLORHYDRIA. Likewise, this page shows the most highly-reported side effects of COMBIVENT, so you can see if ACHLORHYDRIA ranks among COMBIVENT's most well-known side effects.
Summary Statistics
Reports of COMBIVENT causing ACHLORHYDRIA: 1
Reports of any side effect of COMBIVENT : 12082
Percentage of COMBIVENT patients where ACHLORHYDRIA is a reported side effect: 0.0083%

FDA reports of any drug causing ACHLORHYDRIA : 27
Average percentage for all medicated patients where ACHLORHYDRIA is reported as a complication: 0.0002%

Physician opinion on COMBIVENT as adverse event culprit:

Overall opinion for all reports of this drug:
Most frequent diagnoses/indications for prescribing COMBIVENT:
CHRONIC OBSTRUCTIVE PULMONARY DISEASE ( 1664 patients )
ASTHMA ( 798 patients )
DYSPNOEA ( 338 patients )
EMPHYSEMA ( 333 patients )
DRUG USE FOR UNKNOWN INDICATION ( 297 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 173 patients )
BRONCHITIS ( 80 patients )
CHRONIC OBSTRUCTIVE AIRWAYS DISEASE ( 57 patients )
BRONCHITIS CHRONIC ( 47 patients )
LUNG DISORDER ( 38 patients )
PNEUMONIA ( 30 patients )
WHEEZING ( 25 patients )
COUGH ( 22 patients )
RESPIRATORY DISORDER ( 18 patients )
HYPERSENSITIVITY ( 14 patients )
ILL-DEFINED DISORDER ( 14 patients )
BRONCHOSPASM ( 12 patients )
OXYGEN SATURATION DECREASED ( 11 patients )
PULMONARY FIBROSIS ( 9 patients )
MULTIPLE ALLERGIES ( 9 patients )
PULMONARY CONGESTION ( 9 patients )
BRONCHIECTASIS ( 7 patients )
ANTASTHMATIC DRUG LEVEL ( 7 patients )
SEASONAL ALLERGY ( 6 patients )
LOWER RESPIRATORY TRACT INFECTION ( 6 patients )
BRONCHIAL DISORDER ( 6 patients )
CARDIAC FAILURE CONGESTIVE ( 5 patients )
SARCOIDOSIS ( 5 patients )
INHALATION THERAPY ( 4 patients )
SLEEP APNOEA SYNDROME ( 4 patients )
FOETAL EXPOSURE DURING PREGNANCY ( 4 patients )
INFLUENZA ( 4 patients )
OBSTRUCTIVE AIRWAYS DISORDER ( 3 patients )
CHRONIC OBSTRUCTIVE AIRWAYS DISEASE EXACERBATED ( 3 patients )
PROPHYLAXIS AGAINST BRONCHOSPASM ( 3 patients )
OESOPHAGEAL CARCINOMA ( 3 patients )
BRONCHIAL HYPERREACTIVITY ( 3 patients )
LUNG NEOPLASM MALIGNANT ( 3 patients )
TOBACCO USER ( 2 patients )
FATIGUE ( 2 patients )
RESPIRATORY FAILURE ( 2 patients )
UNEVALUABLE EVENT ( 2 patients )
GLAUCOMA ( 2 patients )
RESPIRATORY TRACT CONGESTION ( 2 patients )
ADVERSE EVENT ( 2 patients )
HYPERTENSION ( 2 patients )
PNEUMONIA PRIMARY ATYPICAL ( 2 patients )
RESPIRATORY THERAPY ( 2 patients )
NASOPHARYNGITIS ( 2 patients )
ALLERGIC BRONCHITIS ( 2 patients )
ASPERGILLOSIS ( 2 patients )
ASTHMA EXERCISE INDUCED ( 2 patients )
PULMONARY FUNCTION TEST ( 1 patients )
MITRAL VALVE REPLACEMENT ( 1 patients )
MYASTHENIA GRAVIS ( 1 patients )
RHEUMATOID ARTHRITIS ( 1 patients )
CHEST DISCOMFORT ( 1 patients )
OXYGEN CONSUMPTION DECREASED ( 1 patients )
ANAPHYLACTIC REACTION ( 1 patients )
INCREASED UPPER AIRWAY SECRETION ( 1 patients )
RIB FRACTURE ( 1 patients )
OXYGEN SUPPLEMENTATION ( 1 patients )
ANTASTHMATIC DRUG LEVEL THERAPEUTIC ( 1 patients )
SINUS DISORDER ( 1 patients )
DRUG THERAPY ( 1 patients )
LUNG LOBECTOMY ( 1 patients )
LUNG OPERATION ( 1 patients )
SYSTEMIC LUPUS ERYTHEMATOSUS ( 1 patients )
FALL ( 1 patients )
BRONCHITIS ACUTE ( 1 patients )
TRICUSPID VALVE REPLACEMENT ( 1 patients )
BRONCHOPNEUMONIA ( 1 patients )
UPPER RESPIRATORY TRACT INFECTION ( 1 patients )
ACUTE PULMONARY OEDEMA ( 1 patients )
RESPIRATORY TRACT INFECTION ( 1 patients )
RHINORRHOEA ( 1 patients )
INTERSTITIAL LUNG DISEASE ( 1 patients )
SECRETION DISCHARGE ( 1 patients )
CYSTIC FIBROSIS ( 1 patients )
SINUSITIS ( 1 patients )
SMOKER ( 1 patients )
( 0 patients )
Drugs with high FDA adverse event association with ACHLORHYDRIA:

ASPIRIN (8 patients)
AMLODIPINE (7 patients)
COREG (6 patients)
COUMADIN (6 patients)
FLUCONAZOLE (6 patients)
GLUCOVANCE (6 patients)
GLYBURIDE (6 patients)
LASIX (6 patients)
LEVAQUIN (6 patients)
LIPITOR (6 patients)
PROMETHAZINE (6 patients)
SEROQUEL (6 patients)
AMOXICILLIN (5 patients)
CARVEDILOL (5 patients)
CIPROFLOXACIN (5 patients)
CYANOCOBALAMIN (5 patients)
DIGOXIN (5 patients)
DOXYCYCLINE (5 patients)
FOSINOPRIL SODIUM (5 patients)
GABAPENTIN (5 patients)
LISINOPRIL (5 patients)
LORCET-HD (5 patients)
MELOXICAM (5 patients)
METOLAZONE (5 patients)
NEXIUM (5 patients)
OMEPRAZOLE (5 patients)
OXYCODONE HCL AND ACETAMINOPHEN (5 patients)
ACULAR (4 patients)
GEMFIBROZIL (4 patients)
MUPIROCIN OINTMENT (4 patients)
NEORAL (4 patients)
POTASSIUM CHLORIDE (4 patients)
SILVASORB (4 patients)
TEMAZEPAM (4 patients)
TRIMETHO SULFAMETHOX (4 patients)
ACTOS (3 patients)
AGGRENOX (3 patients)
GLUCOPHAGE (3 patients)
KLOR-CON (3 patients)
LANSOPRAZOLE (3 patients)
SODIUM BICARBONATE (3 patients)
CODEINE (2 patients)
COZAAR (2 patients)
FUROSEMIDE (2 patients)
HYDROCODONE (2 patients)
MUPIROCIN (2 patients)
PANTOPRAZOLE SODIUM (2 patients)
PEG (2 patients)
POTASSIUM (2 patients)
PRILOSEC OTC (2 patients)
PROPO-K (2 patients)
RANITIDINE (2 patients)
SIMVASTATIN (2 patients)
SPIRIVA (2 patients)
SULFAMETHOXAZOLE AND TRIMETHOPRIM (2 patients)
WARFARIN SODIUM (2 patients)
ZANTAC (2 patients)
ACETYLSALICYLIC ACID SRT (1 patients)
ADVAIR HFA (1 patients)
ALBUTEROL SULFATE AUTOHALER (1 patients)
ALCOHOL (1 patients)
ALLEGRA (1 patients)
AMOXICILLIN+CLAVULANATE (1 patients)
ATENOLOL (1 patients)
AZITHROMYCIN (1 patients)
BUPROPION HCL (1 patients)
CALCIUM SUPPLEMENTS (1 patients)
CHLORTHALIDONE (1 patients)
CLOFAZIMINE (1 patients)
CLONAZEPAM (1 patients)
CLOTRIMAZOLE (1 patients)
COCAINE (1 patients)
COMBIVENT (1 patients)
CORTICOSTEROIDS (1 patients)
CYCLOBENZAPRINE (1 patients)
DARVOCET-N 100 (1 patients)
DEPO-MEDROL (1 patients)
DIET (NO INGREDIENTS/SUBSTANCES) (1 patients)
DIFLUCAN (1 patients)
DUONEB (1 patients)
EFFEXOR (1 patients)
ETHAMBUTOL HYDROCHLORIDE (1 patients)
FERROUS GLUCONATE (1 patients)
FLONASO (1 patients)
FLOR-CON (1 patients)
FLOVENT (1 patients)
INSULIN (1 patients)
LACTAID (1 patients)
LITHIUM CARBONATE (1 patients)
LOVASTATIN (1 patients)
MIRAPEX (1 patients)
MONTELUKAST SODIUM (1 patients)
NEOSTIGMINE BROMIDE (1 patients)
PAROXETINE HCL (1 patients)
PEPCID (1 patients)
POTASSIUM CHLORIDE CR (1 patients)
PRAVACHOL (1 patients)
PREDNISONE (1 patients)
PREMARIN (1 patients)
PREVACID (1 patients)
PRILOSEC (1 patients)
QUINIDINE GLUCONATE (1 patients)
RANITIDINE 150MG TABLETS, UNKNOWN MANUFACTURER (1 patients)
RANITIDINE HCL (1 patients)
RANITIDINE HYDROCHLORIDE (1 patients)
RECLAST (1 patients)
ROPINIROLE (1 patients)
SINGULAIR (1 patients)
SODIUM BICARBONATE IN PLASTIC CONTAINER (1 patients)
SYNTHROID (1 patients)
TOPROL-XL (1 patients)
TRAZODONE HCL (1 patients)
TRILEPTAL (1 patients)
TRIMEBUTINE (1 patients)
ZETIA (1 patients)
Most common side effects for patients taking COMBIVENT:
DYSPNOEA (2044 patients)
DRUG INEFFECTIVE (1435 patients)
PNEUMONIA (965 patients)
NAUSEA (786 patients)
CHRONIC OBSTRUCTIVE PULMONARY DISEASE (756 patients)
COUGH (677 patients)
DIZZINESS (638 patients)
ANXIETY (623 patients)
PAIN (609 patients)
CHEST PAIN (545 patients)
FATIGUE (541 patients)
CARDIAC FAILURE CONGESTIVE (532 patients)
ASTHMA (530 patients)
ASTHENIA (528 patients)
DIARRHOEA (494 patients)
OEDEMA PERIPHERAL (462 patients)
VOMITING (456 patients)
HYPERTENSION (449 patients)
DEPRESSION (448 patients)
MYOCARDIAL INFARCTION (445 patients)
FALL (444 patients)
HEADACHE (443 patients)
ANAEMIA (389 patients)
DYSGEUSIA (382 patients)
BACK PAIN (376 patients)
BRONCHITIS (374 patients)
RESPIRATORY FAILURE (362 patients)
INSOMNIA (358 patients)
CONSTIPATION (356 patients)
PAIN IN EXTREMITY (326 patients)
HYPOTENSION (323 patients)
PHARMACEUTICAL PRODUCT COMPLAINT (323 patients)
ATRIAL FIBRILLATION (317 patients)
MALAISE (316 patients)
DEHYDRATION (308 patients)
ARTHRALGIA (304 patients)
DEATH (302 patients)
PYREXIA (301 patients)
WEIGHT DECREASED (298 patients)
CEREBROVASCULAR ACCIDENT (297 patients)
CHEST DISCOMFORT (284 patients)
CONDITION AGGRAVATED (281 patients)
URINARY TRACT INFECTION (277 patients)
TREMOR (271 patients)
RENAL FAILURE ACUTE (264 patients)
ABDOMINAL PAIN (260 patients)
WEIGHT INCREASED (257 patients)
RENAL FAILURE (257 patients)
WHEEZING (256 patients)
PLEURAL EFFUSION (256 patients)
INJURY (254 patients)
RASH (236 patients)
PALPITATIONS (231 patients)
CONFUSIONAL STATE (230 patients)
GASTROOESOPHAGEAL REFLUX DISEASE (229 patients)
DIABETES MELLITUS (229 patients)
CORONARY ARTERY DISEASE (226 patients)
HYPOAESTHESIA (225 patients)
VISION BLURRED (225 patients)
FEELING ABNORMAL (217 patients)
SOMNOLENCE (213 patients)
TACHYCARDIA (209 patients)
MUSCLE SPASMS (206 patients)
PULMONARY EMBOLISM (205 patients)
DECREASED APPETITE (199 patients)
DYSPHONIA (199 patients)
HYPOXIA (196 patients)
SYNCOPE (196 patients)
BLOOD GLUCOSE INCREASED (195 patients)
ATELECTASIS (194 patients)
ABDOMINAL PAIN UPPER (187 patients)
ECONOMIC PROBLEM (187 patients)
PRODUCT QUALITY ISSUE (183 patients)
EMOTIONAL DISTRESS (180 patients)
SINUSITIS (179 patients)
GAIT DISTURBANCE (179 patients)
HAEMOGLOBIN DECREASED (178 patients)
DYSPNOEA EXERTIONAL (178 patients)
LOSS OF CONSCIOUSNESS (177 patients)
CELLULITIS (175 patients)
EMPHYSEMA (174 patients)
THROMBOCYTOPENIA (174 patients)
PRURITUS (171 patients)
DRUG EFFECT DECREASED (171 patients)
MYALGIA (170 patients)
DRY MOUTH (170 patients)
HYPERSENSITIVITY (169 patients)
HEART RATE INCREASED (169 patients)
BLOOD PRESSURE INCREASED (168 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (166 patients)
CHOLELITHIASIS (165 patients)
SEPSIS (162 patients)
OSTEOARTHRITIS (161 patients)
DYSPHAGIA (158 patients)
CATARACT (157 patients)
DEEP VEIN THROMBOSIS (155 patients)
PRODUCTIVE COUGH (154 patients)
HYPOKALAEMIA (151 patients)
OSTEONECROSIS OF JAW (148 patients)
MENTAL STATUS CHANGES (148 patients)
BLOOD CHOLESTEROL INCREASED (147 patients)
CONVULSION (146 patients)
PULMONARY OEDEMA (146 patients)
HYPERHIDROSIS (146 patients)
UPPER RESPIRATORY TRACT INFECTION (142 patients)
CARDIAC DISORDER (141 patients)
OVERDOSE (140 patients)
MUSCULOSKELETAL PAIN (136 patients)
MITRAL VALVE INCOMPETENCE (133 patients)
CONTUSION (132 patients)
ERYTHEMA (132 patients)
LUNG DISORDER (131 patients)
SLEEP APNOEA SYNDROME (131 patients)
PULMONARY HYPERTENSION (129 patients)
LUNG NEOPLASM MALIGNANT (128 patients)
NERVOUSNESS (127 patients)
CARDIAC ARREST (127 patients)
ABDOMINAL DISTENSION (126 patients)
HYPERLIPIDAEMIA (126 patients)
THROAT IRRITATION (126 patients)
PARAESTHESIA (125 patients)
HYPONATRAEMIA (124 patients)
CARDIOMEGALY (124 patients)
EPISTAXIS (123 patients)
GASTROINTESTINAL HAEMORRHAGE (122 patients)
OSTEOPOROSIS (122 patients)
NECK PAIN (122 patients)
OROPHARYNGEAL PAIN (121 patients)
PULMONARY CONGESTION (120 patients)
RESPIRATORY DISTRESS (119 patients)
GASTRITIS (119 patients)
TYPE 2 DIABETES MELLITUS (115 patients)
STAPHYLOCOCCAL INFECTION (115 patients)
DRUG INTERACTION (114 patients)
ARTHRITIS (113 patients)
HYPERGLYCAEMIA (112 patients)
SPINAL OSTEOARTHRITIS (112 patients)
DYSPEPSIA (112 patients)
SUICIDAL IDEATION (111 patients)
CHILLS (109 patients)
LUNG INFECTION (108 patients)
HALLUCINATION (108 patients)
RENAL FAILURE CHRONIC (107 patients)
LUNG NEOPLASM (105 patients)
AGITATION (105 patients)
BALANCE DISORDER (105 patients)
MUSCULAR WEAKNESS (105 patients)
THERAPEUTIC RESPONSE DECREASED (104 patients)
RIB FRACTURE (102 patients)
OEDEMA (101 patients)
TRANSIENT ISCHAEMIC ATTACK (101 patients)
MEMORY IMPAIRMENT (101 patients)
ALOPECIA (101 patients)
CARDIAC FAILURE (101 patients)
STRESS (100 patients)
ARRHYTHMIA (100 patients)
DYSURIA (100 patients)
ABDOMINAL DISCOMFORT (99 patients)
WHITE BLOOD CELL COUNT INCREASED (99 patients)
CANDIDIASIS (99 patients)
LEUKOCYTOSIS (98 patients)
NASOPHARYNGITIS (98 patients)
INFECTION (97 patients)
HAEMORRHOIDS (96 patients)
LUNG INFILTRATION (95 patients)
HIATUS HERNIA (94 patients)
OXYGEN SATURATION DECREASED (94 patients)
TREATMENT NONCOMPLIANCE (93 patients)
URTICARIA (93 patients)
URINARY RETENTION (92 patients)
AMNESIA (92 patients)
NEUROPATHY PERIPHERAL (91 patients)
BURNING SENSATION (91 patients)
MULTIPLE INJURIES (90 patients)
CARDIO-RESPIRATORY ARREST (89 patients)
HAEMATOCRIT DECREASED (89 patients)
ANHEDONIA (89 patients)
INTERVERTEBRAL DISC PROTRUSION (88 patients)
CARDIOMYOPATHY (88 patients)
NASAL CONGESTION (88 patients)
THROMBOSIS (88 patients)
LETHARGY (88 patients)
INCREASED UPPER AIRWAY SECRETION (87 patients)
OSTEOMYELITIS (87 patients)
MEDICATION ERROR (87 patients)
SINUS TACHYCARDIA (86 patients)
RECTAL HAEMORRHAGE (86 patients)
HAEMOPTYSIS (86 patients)
INTERNATIONAL NORMALISED RATIO INCREASED (86 patients)
UNEVALUABLE EVENT (86 patients)
ABNORMAL DREAMS (85 patients)
ANGINA PECTORIS (85 patients)
BRADYCARDIA (85 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (84 patients)
ACUTE MYOCARDIAL INFARCTION (84 patients)
HEPATIC STEATOSIS (84 patients)
FLATULENCE (84 patients)
BRONCHOSPASM (84 patients)
DRUG WITHDRAWAL SYNDROME (84 patients)
DISEASE PROGRESSION (83 patients)
MIGRAINE (81 patients)
COLONIC POLYP (81 patients)
PANCREATITIS (81 patients)
HERPES ZOSTER (80 patients)
SWELLING (80 patients)
ANOREXIA (80 patients)
LYMPHADENOPATHY (79 patients)
BURSITIS (79 patients)
SWELLING FACE (79 patients)
DEFORMITY (79 patients)

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Recent FactMed Activity for COMBIVENT


Issue Description / Topic Timestamp
QUESTION
CORONARY ARTERY DISEASE
Where is this supposed to be set? Just curious. For some reason I auaoiatmctlly associate 90th street with upper Manhattan, but it seemed pretty clear this was not set in NYC.I'm from California, so I guess most Japanese kids I know are third or fourth generation. Are there currently many second generation Japanese Americans? Are they clustered in any particular regions? 2017-03-20 08:49:08
QUESTION
MYASTHENIA GRAVIS CRISIS
Levoflaxin causing myasthenia gravis crisis 2017-05-19 22:22:57

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