Is EXTREMITY NECROSIS a side effect of CYCLOSPORINE ? ( FactMed.com )

About this FactMed analysis covering adverse side effect reports of CYCLOSPORINE patients who developed EXTREMITY NECROSIS.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 7 individuals taking CYCLOSPORINE reported EXTREMITY NECROSIS to the FDA. A total of 23141 CYCLOSPORINE drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between CYCLOSPORINE and EXTREMITY NECROSIS. In doing so, we compare CYCLOSPORINE with other drugs that cause EXTREMITY NECROSIS, to help you evaluate whether or not CYCLOSPORINE causes EXTREMITY NECROSIS. Likewise, this page shows the most highly-reported side effects of CYCLOSPORINE, so you can see if EXTREMITY NECROSIS ranks among CYCLOSPORINE's most well-known side effects.

Summary Statistics
Reports of CYCLOSPORINE causing EXTREMITY NECROSIS: 7
Reports of any side effect of CYCLOSPORINE : 23141
Percentage of CYCLOSPORINE patients where EXTREMITY NECROSIS is a reported side effect: 0.0302%

FDA reports of any drug causing EXTREMITY NECROSIS : 653
Average percentage for all medicated patients where EXTREMITY NECROSIS is reported as a complication: 0.0041%

Physician opinion on CYCLOSPORINE as adverse event culprit:

Overall opinion for all reports of this drug:

Most frequent diagnoses/indications for prescribing CYCLOSPORINE:

RENAL TRANSPLANT ( 1844 patients )
PROPHYLAXIS AGAINST GRAFT VERSUS HOST DISEASE ( 1717 patients )
IMMUNOSUPPRESSION ( 1165 patients )
STEM CELL TRANSPLANT ( 793 patients )
PROPHYLAXIS AGAINST TRANSPLANT REJECTION ( 638 patients )
APLASTIC ANAEMIA ( 503 patients )
LIVER TRANSPLANT ( 494 patients )
DRUG USE FOR UNKNOWN INDICATION ( 395 patients )
BONE MARROW TRANSPLANT ( 379 patients )
HEART TRANSPLANT ( 370 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 350 patients )
IMMUNOSUPPRESSANT DRUG THERAPY ( 342 patients )
PSORIASIS ( 334 patients )
NEPHROTIC SYNDROME ( 274 patients )
CORD BLOOD TRANSPLANT THERAPY ( 254 patients )
GRAFT VERSUS HOST DISEASE ( 237 patients )
LUNG TRANSPLANT ( 233 patients )
RHEUMATOID ARTHRITIS ( 203 patients )
INTERSTITIAL LUNG DISEASE ( 123 patients )
PROPHYLAXIS ( 117 patients )
BEHCET'S SYNDROME ( 107 patients )
HISTIOCYTOSIS HAEMATOPHAGIC ( 90 patients )
SYSTEMIC LUPUS ERYTHEMATOSUS ( 85 patients )
COLITIS ULCERATIVE ( 85 patients )
PUSTULAR PSORIASIS ( 80 patients )
DERMATOMYOSITIS ( 67 patients )
ALLOGENIC BONE MARROW TRANSPLANTATION THERAPY ( 65 patients )
MYELODYSPLASTIC SYNDROME ( 64 patients )
PSORIATIC ARTHROPATHY ( 58 patients )
CHRONIC GRAFT VERSUS HOST DISEASE ( 53 patients )
APLASIA PURE RED CELL ( 49 patients )
GLOMERULONEPHRITIS MEMBRANOUS ( 45 patients )
TRANSPLANT ( 45 patients )
DERMATITIS ATOPIC ( 44 patients )
JUVENILE ARTHRITIS ( 43 patients )
PYODERMA GANGRENOSUM ( 41 patients )
ACUTE MYELOID LEUKAEMIA ( 40 patients )
ORGAN TRANSPLANT ( 39 patients )
DRY EYE ( 38 patients )
IDIOPATHIC THROMBOCYTOPENIC PURPURA ( 37 patients )
UVEITIS ( 35 patients )
EVANS SYNDROME ( 34 patients )
ACUTE GRAFT VERSUS HOST DISEASE ( 32 patients )
ILL-DEFINED DISORDER ( 31 patients )
TRANSPLANT REJECTION ( 30 patients )
POLYMYOSITIS ( 29 patients )
LYMPHOHISTIOCYTOSIS ( 28 patients )
HEART AND LUNG TRANSPLANT ( 27 patients )
WEGENER'S GRANULOMATOSIS ( 25 patients )
BONE MARROW FAILURE ( 25 patients )
CHRONIC LYMPHOCYTIC LEUKAEMIA ( 24 patients )
PEMPHIGUS ( 23 patients )
FOCAL SEGMENTAL GLOMERULOSCLEROSIS ( 23 patients )
MULTIPLE MYELOMA ( 22 patients )
SJOGREN'S SYNDROME ( 22 patients )
ECZEMA ( 21 patients )
PAROXYSMAL NOCTURNAL HAEMOGLOBINURIA ( 21 patients )
BONE MARROW CONDITIONING REGIMEN ( 21 patients )
LUPUS NEPHRITIS ( 21 patients )
MYASTHENIA GRAVIS ( 21 patients )
AUTOIMMUNE HEPATITIS ( 18 patients )
KIDNEY TRANSPLANT REJECTION ( 17 patients )
ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA ( 17 patients )
PEMPHIGOID ( 17 patients )
STILL'S DISEASE ADULT ONSET ( 16 patients )
UNRELATED DONOR BONE MARROW TRANSPLANTATION THERAPY ( 15 patients )
ANAEMIA HAEMOLYTIC AUTOIMMUNE ( 14 patients )
CROHN'S DISEASE ( 14 patients )
PROTEINURIA ( 14 patients )
EYE DISORDER ( 13 patients )
CONJUNCTIVITIS ( 10 patients )
ALOPECIA UNIVERSALIS ( 10 patients )
EPSTEIN-BARR VIRUS INFECTION ( 10 patients )
SKIN LESION ( 10 patients )
RETINOBLASTOMA BILATERAL ( 9 patients )
RENAL AND PANCREAS TRANSPLANT ( 9 patients )
CORNEAL TRANSPLANT ( 9 patients )
LEUKAEMIA ( 9 patients )
ERYTHRODERMIC PSORIASIS ( 9 patients )
LUPUS PNEUMONITIS ( 9 patients )
GLOMERULONEPHRITIS MEMBRANOPROLIFERATIVE ( 9 patients )
NEURODERMATITIS ( 8 patients )
FOCAL GLOMERULOSCLEROSIS ( 8 patients )
ACUTE LYMPHOCYTIC LEUKAEMIA ( 8 patients )
ARTHRITIS ( 8 patients )
RENAL AND LIVER TRANSPLANT ( 8 patients )
HEPATITIS B ( 7 patients )
TOXIC EPIDERMAL NECROLYSIS ( 7 patients )
ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY POSITIVE VASCULITIS ( 7 patients )
CONGENITAL APLASTIC ANAEMIA ( 7 patients )
GLOMERULONEPHRITIS MINIMAL LESION ( 7 patients )
THROMBOCYTOPENIA ( 6 patients )
VASCULITIS ( 6 patients )
IMPETIGO HERPETIFORMIS ( 6 patients )
PARANEOPLASTIC SYNDROME ( 6 patients )
SYMPATHETIC OPHTHALMIA ( 6 patients )
KERATOPLASTY ( 6 patients )
LANGERHANS' CELL GRANULOMATOSIS ( 6 patients )
RENAL DISORDER ( 6 patients )
LARGE GRANULAR LYMPHOCYTOSIS ( 6 patients )
LYMPHOMA ( 6 patients )
PARANEOPLASTIC PEMPHIGUS ( 6 patients )
DERMATITIS EXFOLIATIVE ( 5 patients )
CHRONIC LYMPHOCYTIC LEUKAEMIA REFRACTORY ( 5 patients )
PITYRIASIS RUBRA PILARIS ( 5 patients )
HISTOPLASMOSIS ( 5 patients )
LANGERHANS' CELL HISTIOCYTOSIS ( 5 patients )
LYMPHOCYTIC LEUKAEMIA ( 5 patients )
POLYCHONDRITIS ( 5 patients )
INFLAMMATORY BOWEL DISEASE ( 5 patients )
LICHEN SCLEROSUS ( 5 patients )
RETINOBLASTOMA ( 5 patients )
SYSTEMIC SCLEROSIS ( 5 patients )
SECONDARY IMMUNODEFICIENCY ( 5 patients )
MYOSITIS ( 5 patients )
THROMBOTIC THROMBOCYTOPENIC PURPURA ( 5 patients )
INFECTION PROPHYLAXIS ( 5 patients )
HEPATIC FUNCTION ABNORMAL ( 4 patients )
SARCOIDOSIS ( 4 patients )
FOETAL EXPOSURE DURING PREGNANCY ( 4 patients )
ACUTE GRAFT VERSUS HOST DISEASE IN LIVER ( 4 patients )
DRUG EXPOSURE DURING PREGNANCY ( 4 patients )
CHOROIDITIS ( 4 patients )
CONJUNCTIVOPLASTY ( 4 patients )
NODULAR VASCULITIS ( 4 patients )
ACUTE FEBRILE NEUTROPHILIC DERMATOSIS ( 4 patients )
HIDRADENITIS ( 4 patients )
MICROSCOPIC POLYANGIITIS ( 4 patients )
BREAST CANCER ( 4 patients )
HAEMATOLOGICAL MALIGNANCY ( 4 patients )
ACUTE GRAFT VERSUS HOST DISEASE IN INTESTINE ( 4 patients )
COLITIS ( 4 patients )
HAEMOLYTIC ANAEMIA ( 4 patients )
ACUTE GRAFT VERSUS HOST DISEASE IN SKIN ( 4 patients )
MUSCULAR WEAKNESS ( 4 patients )
CYSTIC FIBROSIS ( 4 patients )
TUBERCULOID LEPROSY ( 3 patients )
ANTIPHOSPHOLIPID SYNDROME ( 3 patients )
IDIOPATHIC PULMONARY FIBROSIS ( 3 patients )
APLASIA ( 3 patients )
TAKAYASU'S ARTERITIS ( 3 patients )
IMMUNE SYSTEM DISORDER ( 3 patients )
KERATOCONJUNCTIVITIS SICCA ( 3 patients )
EPSTEIN-BARR VIRUS ASSOCIATED LYMPHOPROLIFERATIVE DISORDER ( 3 patients )
ASTHMA ( 3 patients )
DIFFUSE LARGE B-CELL LYMPHOMA ( 3 patients )
THROMBOTIC MICROANGIOPATHY ( 3 patients )
BRONCHITIS ( 3 patients )
ANKYLOSING SPONDYLITIS ( 3 patients )
CARDIAC DISORDER ( 3 patients )
NEPHRITIS ( 3 patients )
MACULAR DEGENERATION ( 3 patients )
STEVENS-JOHNSON SYNDROME ( 3 patients )
IRON OVERLOAD ( 3 patients )
MALIGNANT HISTIOCYTOSIS ( 3 patients )
CHRONIC GRAFT VERSUS HOST DISEASE IN SKIN ( 3 patients )
DERMATITIS CONTACT ( 3 patients )
MATERNAL EXPOSURE TIMING UNSPECIFIED ( 3 patients )
RASH ( 3 patients )
ALPORT'S SYNDROME ( 3 patients )
OBLITERATIVE BRONCHIOLITIS ( 3 patients )
ANAEMIA ( 3 patients )
DIFFUSE ALVEOLAR DAMAGE ( 3 patients )
GASTROINTESTINAL INFLAMMATION ( 3 patients )
THROMBOCYTOPENIC PURPURA ( 3 patients )
IMMUNOMODULATORY THERAPY ( 3 patients )
DIFFUSE VASCULITIS ( 3 patients )
BRONCHOPULMONARY ASPERGILLOSIS ALLERGIC ( 3 patients )
PANCREAS TRANSPLANT ( 3 patients )
THYMOMA ( 3 patients )
ANGIOLYMPHOID HYPERPLASIA WITH EOSINOPHILIA ( 3 patients )
BURKITT'S LYMPHOMA ( 3 patients )
CRYOGLOBULINAEMIA ( 3 patients )
WISKOTT-ALDRICH SYNDROME ( 3 patients )
HYPER IGD SYNDROME ( 3 patients )
PANCYTOPENIA ( 3 patients )
HEART TRANSPLANT REJECTION ( 3 patients )
XANTHOGRANULOMA ( 3 patients )
RETINAL VASCULITIS ( 2 patients )
CYTOMEGALOVIRUS COLITIS ( 2 patients )
GLOMERULONEPHRITIS RAPIDLY PROGRESSIVE ( 2 patients )
BLASTOMYCOSIS ( 2 patients )
GLOMERULOSCLEROSIS ( 2 patients )
ILEUS ( 2 patients )
NON-HODGKIN'S LYMPHOMA ( 2 patients )
EPIDERMOLYSIS BULLOSA ( 2 patients )
SCLERODERMA ( 2 patients )
URTICARIA CHRONIC ( 2 patients )
HEPATITIS E ( 2 patients )
GLAUCOMA ( 2 patients )
MIXED CONNECTIVE TISSUE DISEASE ( 2 patients )
ERDHEIM-CHESTER DISEASE ( 2 patients )
GLOMERULONEPHRITIS ( 2 patients )
POEMS SYNDROME ( 2 patients )
RENAL FAILURE ( 2 patients )
NEOPLASM ( 2 patients )
COMBINED IMMUNODEFICIENCY ( 2 patients )
MULTIPLE-DRUG RESISTANCE ( 2 patients )
PANCREATIC CARCINOMA METASTATIC ( 2 patients )
CUTANEOUS SARCOIDOSIS ( 2 patients )
INFECTION ( 2 patients )
COMPLICATIONS OF TRANSPLANT SURGERY ( 2 patients )
PANNICULITIS ( 2 patients )
EYE INFECTION ( 2 patients )
CONGENITAL WHITE BLOOD CELL DISORDER ( 2 patients )
HYPERTENSION ( 2 patients )
HEPATIC CIRRHOSIS ( 2 patients )
MYELITIS ( 2 patients )
PREMEDICATION ( 2 patients )
HEPATIC NEOPLASM MALIGNANT ( 2 patients )

Drugs with high FDA adverse event association with EXTREMITY NECROSIS:

HEPARIN SODIUM INJECTION (157 patients)
ASPIRIN (88 patients)
LASIX (56 patients)
HEPARIN SODIUM 5,000 UNITS IN DEXTROSE 5% (47 patients)
NITROGLYCERIN (42 patients)
DEPAKOTE (42 patients)
ZOMETA (39 patients)
SIMVASTATIN (39 patients)
PREDNISONE (38 patients)
POTASSIUM CHLORIDE (34 patients)
PLAVIX (34 patients)
AREDIA (34 patients)
HEPARIN SODIUM (33 patients)
DIANEAL (33 patients)
PAXIL (30 patients)
CARBOPLATIN (30 patients)
GEMZAR (29 patients)
COUMADIN (28 patients)
FOLIC ACID (27 patients)
GLEEVEC (27 patients)
INVEGA (26 patients)
AMLODIPINE (24 patients)
VIOXX (24 patients)
ATIVAN (24 patients)
HYDROCHLOROTHIAZIDE (24 patients)
INSULIN (24 patients)
TOCILIZUMAB (24 patients)
KETEK (23 patients)
WARFARIN SODIUM (23 patients)
LIPITOR (23 patients)
BETAFERON (23 patients)
FUROSEMIDE (23 patients)
OXYCONTIN (23 patients)
AVASTIN (22 patients)
K-DUR (22 patients)
ACETAMINOPHEN (21 patients)
DIGOXIN (21 patients)
PRESSORS (21 patients)
MULTI-VITAMINS (21 patients)
QUININE SULFATE (21 patients)
ALBUTEROL (20 patients)
VALIUM (20 patients)
CISPLATIN (20 patients)
DECADRON (20 patients)
CALCIUM WITH VITAMIN D (20 patients)
PREDNISONE TAB (19 patients)
PRILOSEC (18 patients)
MS CONTIN (18 patients)
SEVELAMER (18 patients)
VINCRISTINE (18 patients)
HYDROCORTISONE (17 patients)
PRIMIDONE (17 patients)
FLORINEF (17 patients)
TYLENOL W/ CODEINE NO. 3 (17 patients)
GENTEAL (17 patients)
HUMIRA (17 patients)
CATAPRES (17 patients)
CORTEF (17 patients)
PIRAMIDON (17 patients)
CYTOXAN (17 patients)
ENALAPRIL MALEATE (17 patients)
GENTEAL LUBRICANT (17 patients)
DIFLUCAN (17 patients)
DOXYCYCLINE (17 patients)
RESTASIS (17 patients)
AXID (17 patients)
KYTRIL (17 patients)
PIRAMIDONE (17 patients)
METFORMIN HCL (17 patients)
CARDIZEM (16 patients)
MAG-OX (16 patients)
ADRIAMYCIN PFS (16 patients)
PRIMODIAN (16 patients)
ROXICET (16 patients)
LEVAQUIN (16 patients)
PROAMATINE (16 patients)
KAYEXALATE (16 patients)
PROTONIX (16 patients)
PREDNISOLONE (16 patients)
DIPHENHYDRAMINE HCL (15 patients)
NEXIUM (15 patients)
METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA (15 patients)
NEORAL (15 patients)
FENTANYL (15 patients)
LISINOPRIL (14 patients)
ZYRTEC (14 patients)
ALIMTA (14 patients)
LANTUS (14 patients)
TRACLEER (14 patients)
METHOTREXATE (14 patients)
HUMALOG (14 patients)
AUGMENTIN '125' (14 patients)
CARBAMAZEPINE (14 patients)
SYNTHROID (13 patients)
LOXAPINE (13 patients)
PREVACID (13 patients)
OXYGEN THERAPY (13 patients)
FOSAMAX (13 patients)
DIOVAN (13 patients)
OSCAL (13 patients)
LOPID (13 patients)
LOPRESSOR (13 patients)
HEPARIN (13 patients)
PREMARIN /SCH/ (13 patients)
SINGULAIR (13 patients)
PEGASYS (13 patients)
TRAMADOL HCL (13 patients)
ACCOLATE (12 patients)
ACCUTANE (12 patients)
ADVAIR DISKUS 100/50 (12 patients)
CLARINEX (12 patients)
SOLU-MEDROL (12 patients)
MORPHINE SULFATE (12 patients)
AVONEX (12 patients)
HYDROCODONE/GUAIFENESIN COUGH SYRUP (12 patients)
FLUOROURACIL (12 patients)
OMEPRAZOLE (12 patients)
LOTENSIN /00909102/ (12 patients)
GEMCITABINE (12 patients)
MELPHALAN HYDROCHLORIDE (12 patients)
PREDONINE (12 patients)
VANCOMYCIN (11 patients)
ZOCOR (11 patients)
REBETOL (11 patients)
ATROVENT (11 patients)
CEFZIL (11 patients)
VITAMIN B-12 (10 patients)
CELLCEPT (10 patients)
DIPRIVAN (10 patients)
MORPHINE (10 patients)
NEPHROCAPS (10 patients)
NIFEDIPINE (10 patients)
RAMIPRIL (10 patients)
ZYPREXA (10 patients)
DEXAMETHASONE (10 patients)
HEPARIN SODIUM 1,000 UNITS AND SODIUM CHLORIDE 0.9% (10 patients)
MYSOLINE (10 patients)
PROVENTIL GENTLEHALER (10 patients)
CIPRO (10 patients)
RITUXIMAB (10 patients)
NEUTRA-PHOS (10 patients)
BENADRYL (10 patients)
SOLU-CORTEF (10 patients)
SURFAK (10 patients)
LITHIUM (10 patients)
TRAMADOL HYDROCHLORIDE (10 patients)
GLYCOPYRROLATE (9 patients)
ACETYLSALICYLIC ACID SRT (9 patients)
NOREPINEPHRINE BITARTRATE (9 patients)
LIDOCAINE (9 patients)
REMICADE (9 patients)
THELIN (9 patients)
EPINEPHRINE (9 patients)
AMPICILLIN W/SULBACTAM (9 patients)
GLUCOPHAGE (9 patients)
VERSED (9 patients)
MULTIVITAMIN (9 patients)
RENA-VITE (9 patients)
PANTOPRAZOLE (9 patients)
TORADOL (9 patients)
PHENERGAN (9 patients)
BUPIVACAINE HYDROCHLORIDE W/EPINEPHRINE (9 patients)
POTASSIUM ACETATE (9 patients)
PHOSEX (9 patients)
DARVOCET-N 100 (9 patients)
CALCIUM CARBONATE (9 patients)
NEXAVAR (9 patients)
LEUCOVORIN CALCIUM (8 patients)
COREG (8 patients)
HUMACART-N (8 patients)
CIPROFLOXACIN (8 patients)
REPAGLINIDE (8 patients)
PHENERGAN HCL (8 patients)
METOCLOPRAMIDE (8 patients)
PHENYTOIN (8 patients)
CENTRUM SILVER (8 patients)
LANSOPRAZOLE (8 patients)
CLEOCIN HYDROCHLORIDE (8 patients)
LEVEMIR (8 patients)
WELLBUTRIN (8 patients)
IRON (7 patients)
LOVENOX (7 patients)
[THERAPY UNSPECIFIED] (7 patients)
CYCLOSPORINE (7 patients)
EFFEXOR (7 patients)
NEOSTIGMINE (7 patients)
ZEMPLAR (7 patients)
NIFEDINE (7 patients)
IRBESARTAN (7 patients)
ZOFRAN (7 patients)
CORTANCYL (7 patients)
BISOPROLOL FUMARATE (7 patients)
COPEGUS (7 patients)
PANTOPRAZOLE SODIUM (6 patients)
PRADAXA (6 patients)
METOPROLOL (6 patients)
GABAPENTIN (6 patients)
ACTRAPID (6 patients)
HERCEPTIN (6 patients)
TRAZODONE HCL (6 patients)
LEVOTHYROXINE SODIUM (6 patients)
PRAVASTATIN (6 patients)
JANUVIA (6 patients)
OMNISCAN (6 patients)
OXALIPLATIN (6 patients)
PEG-INTRON (6 patients)
FTY720 VS MYCOPHENOLATE MOFETIL (6 patients)
GENTAMICIN SULFATE (6 patients)
TOPROL-XL (6 patients)
METHOTREXATE SODIUM (6 patients)

Most common side effects for patients taking CYCLOSPORINE:

PYREXIA (2084 patients)
CYTOMEGALOVIRUS INFECTION (1799 patients)
BLOOD CREATININE INCREASED (1236 patients)
GRAFT VERSUS HOST DISEASE (1209 patients)
DIARRHOEA (1199 patients)
SEPSIS (1192 patients)
PNEUMONIA (905 patients)
RENAL FAILURE ACUTE (869 patients)
ANAEMIA (850 patients)
RENAL IMPAIRMENT (848 patients)
NAUSEA (811 patients)
RENAL FAILURE (792 patients)
ACUTE GRAFT VERSUS HOST DISEASE (753 patients)
DYSPNOEA (741 patients)
DRUG INTERACTION (740 patients)
HYPERTENSION (737 patients)
DRUG INEFFECTIVE (733 patients)
VOMITING (730 patients)
MULTI-ORGAN FAILURE (723 patients)
RESPIRATORY FAILURE (682 patients)
PANCYTOPENIA (624 patients)
KIDNEY TRANSPLANT REJECTION (622 patients)
ABDOMINAL PAIN (600 patients)
THROMBOCYTOPENIA (586 patients)
CHRONIC GRAFT VERSUS HOST DISEASE (574 patients)
INFECTION (571 patients)
FEBRILE NEUTROPENIA (570 patients)
LYMPHOCELE (568 patients)
URINARY TRACT INFECTION (560 patients)
ACUTE GRAFT VERSUS HOST DISEASE IN SKIN (556 patients)
LEUKOPENIA (519 patients)
HEADACHE (515 patients)
CONVULSION (513 patients)
HAEMOGLOBIN DECREASED (507 patients)
ASTHENIA (501 patients)
PROTEINURIA (449 patients)
OEDEMA PERIPHERAL (447 patients)
PLATELET COUNT DECREASED (443 patients)
EPSTEIN-BARR VIRUS INFECTION (441 patients)
HAEMODIALYSIS (433 patients)
DEATH (431 patients)
RHABDOMYOLYSIS (430 patients)
RASH (425 patients)
COMPLICATIONS OF TRANSPLANTED KIDNEY (424 patients)
THROMBOTIC MICROANGIOPATHY (423 patients)
HYPOTENSION (419 patients)
BLOOD BILIRUBIN INCREASED (418 patients)
TRANSPLANT REJECTION (418 patients)
ALANINE AMINOTRANSFERASE INCREASED (413 patients)
NEPHROPATHY TOXIC (413 patients)
DEHYDRATION (411 patients)
MUCOSAL INFLAMMATION (404 patients)
HAEMATOMA (398 patients)
PLEURAL EFFUSION (398 patients)
FATIGUE (395 patients)
COUGH (381 patients)
HERPES ZOSTER (372 patients)
DISEASE RECURRENCE (367 patients)
INTERSTITIAL LUNG DISEASE (364 patients)
PAIN (364 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (363 patients)
WEIGHT DECREASED (361 patients)
SEPTIC SHOCK (361 patients)
MALAISE (361 patients)
OEDEMA (347 patients)
ASPERGILLOSIS (344 patients)
CONDITION AGGRAVATED (344 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (341 patients)
NEUTROPENIA (339 patients)
LIVER FUNCTION TEST ABNORMAL (334 patients)
ARTHRALGIA (331 patients)
HEPATIC FUNCTION ABNORMAL (327 patients)
WHITE BLOOD CELL COUNT DECREASED (326 patients)
ACUTE GRAFT VERSUS HOST DISEASE IN INTESTINE (325 patients)
CARDIAC FAILURE (323 patients)
STAPHYLOCOCCAL INFECTION (311 patients)
CYSTITIS HAEMORRHAGIC (309 patients)
MYALGIA (308 patients)
EPSTEIN-BARR VIRUS ASSOCIATED LYMPHOPROLIFERATIVE DISORDER (308 patients)
CHOLELITHIASIS (306 patients)
DIABETES MELLITUS (301 patients)
HISTIOCYTOSIS HAEMATOPHAGIC (294 patients)
C-REACTIVE PROTEIN INCREASED (292 patients)
BONE MARROW FAILURE (290 patients)
ERYTHEMA (282 patients)
VENOOCCLUSIVE LIVER DISEASE (275 patients)
HAEMATURIA (274 patients)
DRUG EXPOSURE DURING PREGNANCY (273 patients)
CALCULUS URETERIC (272 patients)
CELLULITIS (270 patients)
LIVER DISORDER (261 patients)
TREMOR (260 patients)
STOMATITIS (257 patients)
WEIGHT INCREASED (256 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (255 patients)
HEPATIC FAILURE (253 patients)
CONFUSIONAL STATE (251 patients)
LYMPHADENOPATHY (251 patients)
PAIN IN EXTREMITY (247 patients)
DISEASE PROGRESSION (247 patients)
BLOOD TRIGLYCERIDES INCREASED (246 patients)
CHEST PAIN (246 patients)
BACK PAIN (243 patients)
BLOOD UREA INCREASED (242 patients)
CHOLESTASIS (238 patients)
DRUG LEVEL INCREASED (233 patients)
GASTROINTESTINAL HAEMORRHAGE (232 patients)
IMMUNOSUPPRESSANT DRUG LEVEL INCREASED (232 patients)
HYPOXIA (231 patients)
ASCITES (231 patients)
NEPHROTIC SYNDROME (230 patients)
MUSCULAR WEAKNESS (230 patients)
LUNG INFILTRATION (230 patients)
HYPERBILIRUBINAEMIA (229 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (228 patients)
ACUTE RESPIRATORY DISTRESS SYNDROME (226 patients)
BRONCHOPULMONARY ASPERGILLOSIS (225 patients)
HYPERKALAEMIA (220 patients)
PSORIASIS (218 patients)
BLOOD CREATINE PHOSPHOKINASE INCREASED (216 patients)
NEUROTOXICITY (212 patients)
PNEUMOCYSTIS JIROVECI PNEUMONIA (211 patients)
OLIGURIA (209 patients)
LYMPHOPROLIFERATIVE DISORDER (209 patients)
BK VIRUS INFECTION (209 patients)
BLOOD CHOLESTEROL INCREASED (208 patients)
RENAL FAILURE CHRONIC (203 patients)
CEREBRAL HAEMORRHAGE (201 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (200 patients)
CHILLS (200 patients)
BLOOD PRESSURE INCREASED (200 patients)
ENCEPHALOPATHY (199 patients)
BASAL CELL CARCINOMA (194 patients)
HEPATOTOXICITY (194 patients)
STEM CELL TRANSPLANT (193 patients)
FALL (193 patients)
MYOCARDIAL INFARCTION (193 patients)
GAIT DISTURBANCE (193 patients)
TACHYCARDIA (192 patients)
SOMNOLENCE (192 patients)
DIZZINESS (191 patients)
THERAPEUTIC RESPONSE DECREASED (191 patients)
DRUG TOXICITY (191 patients)
FUNGAL INFECTION (190 patients)
ADENOVIRUS INFECTION (189 patients)
PRURITUS (186 patients)
ANXIETY (184 patients)
RENAL TUBULAR NECROSIS (184 patients)
CHRONIC ALLOGRAFT NEPHROPATHY (184 patients)
POST PROCEDURAL COMPLICATION (183 patients)
HYPERGLYCAEMIA (182 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (182 patients)
BACTERIAL INFECTION (181 patients)
PULMONARY OEDEMA (181 patients)
PSEUDOMONAS INFECTION (181 patients)
WHITE BLOOD CELL COUNT INCREASED (180 patients)
THERAPEUTIC AGENT TOXICITY (179 patients)
ATRIAL FIBRILLATION (176 patients)
JAUNDICE (174 patients)
CYTOMEGALOVIRUS VIRAEMIA (173 patients)
SKIN LESION (169 patients)
TRANSAMINASES INCREASED (168 patients)
VENOOCCLUSIVE DISEASE (168 patients)
GRAND MAL CONVULSION (166 patients)
DIALYSIS (166 patients)
RESPIRATORY DISTRESS (166 patients)
INFLAMMATION (165 patients)
DECREASED APPETITE (165 patients)
ANOREXIA (164 patients)
RENAL DISORDER (163 patients)
REVERSIBLE POSTERIOR LEUKOENCEPHALOPATHY SYNDROME (163 patients)
STAPHYLOCOCCAL SEPSIS (161 patients)
ACUTE MYELOID LEUKAEMIA (160 patients)
ENTEROCOCCAL INFECTION (157 patients)
TRANSPLANT FAILURE (157 patients)
HEPATIC ENZYME INCREASED (157 patients)
CARDIAC FAILURE CONGESTIVE (154 patients)
PNEUMONIA CYTOMEGALOVIRAL (154 patients)
LIVER TRANSPLANT REJECTION (151 patients)
PERICARDIAL EFFUSION (151 patients)
CANDIDIASIS (151 patients)
KAPOSI'S SARCOMA (150 patients)
ABDOMINAL PAIN UPPER (149 patients)
LOW DENSITY LIPOPROTEIN INCREASED (148 patients)
PARAESTHESIA (147 patients)
CYTOMEGALOVIRUS TEST POSITIVE (145 patients)
ANURIA (145 patients)
OSTEOPOROSIS (144 patients)
CHOLECYSTITIS (144 patients)
BACTERIAL SEPSIS (144 patients)
GRAFT DYSFUNCTION (143 patients)
GASTROENTERITIS (142 patients)
APLASTIC ANAEMIA (142 patients)
DEPRESSION (141 patients)
CARDIAC ARREST (139 patients)
BRONCHIECTASIS (138 patients)
CYTOMEGALOVIRUS ANTIGEN POSITIVE (136 patients)
DEEP VEIN THROMBOSIS (136 patients)
MOUTH ULCERATION (135 patients)
OSTEONECROSIS (135 patients)
HAEMATOCRIT DECREASED (133 patients)
LUNG DISORDER (133 patients)
HYPOAESTHESIA (133 patients)
HYPERCHOLESTEROLAEMIA (132 patients)
HYPONATRAEMIA (131 patients)
NO THERAPEUTIC RESPONSE (130 patients)
PULMONARY EMBOLISM (130 patients)
ACUTE GRAFT VERSUS HOST DISEASE IN LIVER (130 patients)
URINARY TRACT INFECTION ENTEROCOCCAL (130 patients)
ABDOMINAL DISTENSION (129 patients)

In addition to reviewing our up-to-date FDA research, users may interact with the FactMed community - currently one million members and growing! FactMed online research and discussions are read by patients, scientists, physicians, and other interested health care parties. Post follow up Questions to learn from our diverse readership. Likewise, patients who have experienced unwanted effects are encouraged to share their Concerns to help educate and inform our members.

Recent FactMed Activity for CYCLOSPORINE

Issue	Description / Topic	Timestamp
QUESTION VISUAL DISTURBANCE	I've been on cyclosporine 50mg for 4 weeks, then my dose was increased to 75mg per day. It has been prescribed for SLE/lupus. It has been extremely useful for lupus but I experienced blurry vision in my left eye and also my left eye's lid is difficult to open in the night. With my rheumatologist's agreement I've stopped the drug for a week to see if these side effects disappear. Do you have any experience of these side effects and if so, did they resolve with a decrease or ceasing the drug?	2014-11-22 16:21:56
QUESTION EXPIRED DRUG ADMINISTERED	I just realized today I was taking 100 mg 2 x a day that expired on April 2015. My prescription was filled 5-22-15. I have taken 11 of them and threw one away today when I realized they were expired.	2015-05-30 13:01:08
CONCERN SNEEZING	150 MG CYCLOSPORINE FOR RENAL TRANSPLANT. THIS MEDICINE CAUSE S ME TO COUGH AND SNEEZE.	2015-10-06 17:03:53
QUESTION DRUG INTERACTION	Is it OK with Phenytoin,SImvastatin and Thyroxine?	2015-11-18 15:39:24
QUESTION EXPIRED DRUG ADMINISTERED	I have a box of cyclosporine that has been expired last oct 2015. Its already dec now. Can I still take the meds eventhough its outdated? Will it cause me any side effects?	2015-12-16 09:19:30
QUESTION FOLLICULITIS	i have been taking 200mg of cyclosporine per day prescribed for severe eczema for about 12 months now. Over the last 4 months I have developed strange spots allover my back and the sides of my face I saw my dermatologist last week and she was unsure what it is and did 2 biopsies, and stopped the cyclosporin what's terrifying me is she did mention the possibility of lymphoma anyone else had a similar thing	2016-03-07 15:48:54
QUESTION THIRST	Anyone get extremely thirsty on this medication?	2016-09-04 14:20:44
QUESTION THIRST	Anyone get extremely thirsty on this medication?	2016-09-04 14:22:34
QUESTION EXPIRED DRUG ADMINISTERED	Im taken ciclosporine but arealised They expires since 2014 is ok to keep taken them no money to doctor	2016-10-08 23:43:30
QUESTION PREGNANCY TEST FALSE POSITIVE	I have been taking cyclosporine for two weeks now,I am a week late on my period and I'm normally like clock work.ive done pregnancy tests which are negative.could this have effect on the reading	2016-10-10 15:53:00
QUESTION BLADDER CANCER	Can cyclosporine cause urinary bladder cancer. I am taking 25 mg in the morning and 50 mg at night for my kidney transplant for several years now? I will appreciate your reply. Thanks.	2016-11-03 13:58:10
QUESTION EXPIRED DRUG ADMINISTERED	What will happen if I take expired ciclsplorin for psoriasis.	2016-11-23 17:55:56
QUESTION EXPIRED DRUG ADMINISTERED	I see my question but don't see an answer. Will taking expired cyclosporine be harmful? Does expired cyclosporine still work enough to prevent rejection?	2017-02-01 14:12:13
QUESTION NEUTROPENIA	I have been on cyclosporine for 31 years (liver transplant). For a number of years my white cell count has been just out of the normal range (every now and then it will be just in the normal range). This last blood test also showed my neutrophils to be out of the normal range. Could there be a relationship between my taking cyclosporine and these tests. I have normal blood pressure and aren't on any other immune suppressants.	2017-06-16 05:24:06

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