About this FactMed analysis covering adverse side effect reports of DEPAS patients who developed ACANTHOLYSIS.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 2 individuals taking DEPAS reported ACANTHOLYSIS to the FDA. A total of 4954 DEPAS drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between DEPAS and ACANTHOLYSIS. In doing so, we compare DEPAS with other drugs that cause ACANTHOLYSIS, to help you evaluate whether or not DEPAS causes ACANTHOLYSIS. Likewise, this page shows the most highly-reported side effects of DEPAS, so you can see if ACANTHOLYSIS ranks among DEPAS's most well-known side effects.
Summary Statistics
Reports of DEPAS causing ACANTHOLYSIS: 2
Reports of any side effect of DEPAS : 4954
Percentage of DEPAS patients where ACANTHOLYSIS is a reported side effect: 0.0404%

FDA reports of any drug causing ACANTHOLYSIS : 33
Average percentage for all medicated patients where ACANTHOLYSIS is reported as a complication: 0.0002%

Physician opinion on DEPAS as adverse event culprit:

Overall opinion for all reports of this drug:
Most frequent diagnoses/indications for prescribing DEPAS:
INSOMNIA ( 736 patients )
DEPRESSION ( 242 patients )
ANXIETY ( 215 patients )
ANXIETY DISORDER ( 146 patients )
DRUG USE FOR UNKNOWN INDICATION ( 139 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 88 patients )
NEUROSIS ( 57 patients )
SLEEP DISORDER ( 35 patients )
PROPHYLAXIS ( 30 patients )
PSYCHOSOMATIC DISEASE ( 30 patients )
PANIC DISORDER ( 24 patients )
PAIN ( 23 patients )
SCHIZOPHRENIA ( 21 patients )
TENSION HEADACHE ( 21 patients )
ILL-DEFINED DISORDER ( 17 patients )
AUTONOMIC NERVOUS SYSTEM IMBALANCE ( 17 patients )
HEADACHE ( 16 patients )
RESTLESSNESS ( 15 patients )
SOMATOFORM DISORDER ( 10 patients )
ANXIOLYTIC THERAPY ( 10 patients )
HYPERTENSION ( 10 patients )
BIPOLAR DISORDER ( 9 patients )
MENTAL DISORDER ( 9 patients )
BIPOLAR I DISORDER ( 8 patients )
SPINAL OSTEOARTHRITIS ( 8 patients )
DEPRESSIVE SYMPTOM ( 7 patients )
CERVICOBRACHIAL SYNDROME ( 7 patients )
BACK PAIN ( 6 patients )
PARKINSON'S DISEASE ( 6 patients )
DIZZINESS ( 6 patients )
SUICIDE ATTEMPT ( 5 patients )
SLEEP DISORDER THERAPY ( 5 patients )
IRRITABILITY ( 5 patients )
METASTATIC RENAL CELL CARCINOMA ( 4 patients )
MULTIPLE MYELOMA ( 4 patients )
DRUG EXPOSURE DURING PREGNANCY ( 4 patients )
MUSCULOSKELETAL STIFFNESS ( 4 patients )
PSYCHOTIC DISORDER ( 4 patients )
MATERNAL EXPOSURE DURING PREGNANCY ( 4 patients )
DYSTHYMIC DISORDER ( 4 patients )
RENAL CELL CARCINOMA ( 4 patients )
LUMBAR SPINAL STENOSIS ( 4 patients )
MENOPAUSAL SYMPTOMS ( 3 patients )
GASTRITIS ( 3 patients )
BIPOLAR II DISORDER ( 3 patients )
THIRST ( 3 patients )
COMPRESSION FRACTURE ( 3 patients )
EATING DISORDER ( 3 patients )
TUMOUR EXCISION ( 3 patients )
FOETAL EXPOSURE DURING PREGNANCY ( 3 patients )
DEPRESSION POSTMENOPAUSAL ( 3 patients )
BALANCE DISORDER ( 3 patients )
HYPOAESTHESIA ( 3 patients )
ADJUSTMENT DISORDER ( 3 patients )
INITIAL INSOMNIA ( 3 patients )
URTICARIA CHRONIC ( 3 patients )
DIARRHOEA ( 2 patients )
HYPERVENTILATION ( 2 patients )
POLLAKIURIA ( 2 patients )
ADENOCARCINOMA ( 2 patients )
DISSOCIATIVE DISORDER ( 2 patients )
PRURITUS ( 2 patients )
NECK PAIN ( 2 patients )
TONSILLITIS ( 2 patients )
INTERVERTEBRAL DISC PROTRUSION ( 2 patients )
RENAL FAILURE CHRONIC ( 2 patients )
PAIN IN EXTREMITY ( 2 patients )
DIABETIC NEUROPATHY ( 2 patients )
ABDOMINAL DISCOMFORT ( 2 patients )
DISEASE COMPLICATION ( 2 patients )
BLEPHAROSPASM ( 2 patients )
CEREBRAL PALSY ( 2 patients )
TINNITUS ( 2 patients )
FACIAL SPASM ( 2 patients )
DEAFNESS ( 2 patients )
ATAXIA ( 2 patients )
PALPITATIONS ( 1 patients )
SPINAL LIGAMENT OSSIFICATION ( 1 patients )
MUSCLE TIGHTNESS ( 1 patients )
CANCER PAIN ( 1 patients )
ADVERSE EVENT ( 1 patients )
ANALGESIC THERAPY ( 1 patients )
DYSPNOEA ( 1 patients )
NEURALGIA ( 1 patients )
COORDINATION ABNORMAL ( 1 patients )
LIVER DISORDER ( 1 patients )
FEELING ABNORMAL ( 1 patients )
WITHDRAWAL SYNDROME ( 1 patients )
DELIRIUM ( 1 patients )
GENERALISED ANXIETY DISORDER ( 1 patients )
PANIC ATTACK ( 1 patients )
MULTIPLE DRUG OVERDOSE INTENTIONAL ( 1 patients )
SPINAL CORD INJURY ( 1 patients )
MUSCLE DISORDER ( 1 patients )
POST HERPETIC NEURALGIA ( 1 patients )
MUSCULOSKELETAL PAIN ( 1 patients )
ALCOHOLIC LIVER DISEASE ( 1 patients )
MYALGIA ( 1 patients )
CHEMICAL POISONING ( 1 patients )
INTERMITTENT EXPLOSIVE DISORDER ( 1 patients )
ANTIEMETIC SUPPORTIVE CARE ( 1 patients )
NERVOUSNESS ( 1 patients )
TORTICOLLIS ( 1 patients )
CONTUSION ( 1 patients )
NEURILEMMOMA ( 1 patients )
FIBROMYALGIA ( 1 patients )
( 0 patients )
Drugs with high FDA adverse event association with ACANTHOLYSIS:

AMBIEN (10 patients)
ABRAXANE (9 patients)
ACIPHEX (9 patients)
AMPICILLIN (9 patients)
ASPIRIN (9 patients)
ATIVAN (9 patients)
AVASTIN (9 patients)
CYMBALTA (9 patients)
LEVOTHYROXINE SODIUM (9 patients)
NORCO (9 patients)
RADIATION (9 patients)
VICODIN (9 patients)
XELODA (9 patients)
ZOLOFT (9 patients)
ZOMETA (9 patients)
ZOFRAN (8 patients)
ARANESP (7 patients)
CAPECITABINE (7 patients)
CEFTRIAXONE (7 patients)
CEPHALEXIN (7 patients)
CIPROFLOXACIN (7 patients)
COLACE (7 patients)
DILAUDID (7 patients)
DOXIL (7 patients)
FEMARA (7 patients)
HYDROCODONE BITARTRATE AND ACETAMINOPHEN (7 patients)
KEFLEX (7 patients)
LASIX (7 patients)
LORAZEPAM (7 patients)
NAPROSYN (7 patients)
NEULASTA (7 patients)
NIACIN (7 patients)
PERCOCET (7 patients)
PROVIGIL (7 patients)
RITALIN (7 patients)
SYNTHROID (7 patients)
TAXOTERE (7 patients)
VANCOMYCIN (7 patients)
VANCOMYCIN HCL (7 patients)
DEXAMETHASONE (6 patients)
FENTANYL (6 patients)
CYCLOSPORINE (4 patients)
PLAVIX (4 patients)
RELAFEN (4 patients)
ACETYLSALICYLIC ACID SRT (3 patients)
ACYCLOVIR (3 patients)
AMITIZA (3 patients)
NABUMETONE (3 patients)
NEXIUM (3 patients)
NIFEDIPINE (3 patients)
XIFAXAN (3 patients)
ALDACTAZIDE (2 patients)
AMLOR (2 patients)
AZATHIOPRINE (2 patients)
CLINDAMYCIN (2 patients)
COZAAR (2 patients)
DEPAKENE (2 patients)
DEPAS (2 patients)
DIGOXIN (2 patients)
DIPYRIDAMOL (2 patients)
EMPYNASE (2 patients)
ENALAPRIL MALEATE (2 patients)
ETRETINATE (2 patients)
FRACTAL (2 patients)
FUCIDIN CREAM (2 patients)
FUROSEMIDE (2 patients)
GAMUNEX (2 patients)
GLUCOR (2 patients)
HALCION (2 patients)
ISOSORBIDE MONONITRATE (2 patients)
LAMICTAL (2 patients)
LAXOBERON (2 patients)
LEVEMIR (2 patients)
MAGLAX (2 patients)
METHYLPREDNISOLONE (2 patients)
MINOCYCLIN (2 patients)
MOPRAL (2 patients)
MORPHINE (2 patients)
NITROGLYCERIN (2 patients)
PREDNISOLONE (2 patients)
PREDNISONE (2 patients)
SECTRAL (2 patients)
STILNOX (2 patients)
THEOPHYLLINE (2 patients)
TOPICAL ANTISEPTICS (2 patients)
ACENOCOUMAROL (1 patients)
ACENOCOUMAROL (ACENOCOUMAROL) (1 patients)
ACTIFED (1 patients)
AMILORIDE (1 patients)
AMILORIDE (AMILORIDE HYDROCHLORIDE) (1 patients)
ARNESP (1 patients)
ATENOLOL (1 patients)
ATORVASTATIN CALCIUM (1 patients)
BEMYLID (1 patients)
BETAMETHASONE DIPROPIIONATE (1 patients)
BETAMETHASONE DIPROPIONATE (1 patients)
CARBAMAZEPINE (1 patients)
CEFIXIME (1 patients)
CILAZAPRIL (1 patients)
CIPROFLOXACIN HCL (1 patients)
CIPROFLOXACIN IV (1 patients)
CISPLATIN (1 patients)
COPEGUS (1 patients)
DEXAMETHASONE ACETATE (1 patients)
DOXIUM (CALCIUM DOBESILATE) (1 patients)
ETHYOL (1 patients)
ETOPOSIDE (1 patients)
FENTANYL-100 (1 patients)
FILGRASTIM (FILGRASTIM) (1 patients)
FINASTERIDE (1 patients)
GEMZAR (1 patients)
GLIBENCLAMIDE (1 patients)
GLIMEPIRIDE (1 patients)
HEMERAN GEL (HEPARINOID) (1 patients)
HUMAN INSULIN (1 patients)
INSULIN ACTRAPID HUMAN (1 patients)
INTRON A (1 patients)
IRINOTECAN HCL (1 patients)
L-THYROXIN (1 patients)
LACIDIPINE (1 patients)
LACIDIPINE (LACIDIPINE) (1 patients)
MAGNESIUM OXIDE (MAGNESIUM OXIDE) (1 patients)
METHOTREXATE (1 patients)
MS CONTIN (1 patients)
OXYCODONE HCL (1 patients)
PEG-INTRON (1 patients)
PHENYTOIN (1 patients)
PRAVASTATIN (1 patients)
PRAVASTATIN SODIUM (1 patients)
PREDNISONE TAB (1 patients)
RADIATION THERAPY (1 patients)
REBETOL (1 patients)
RIBAVIRIN (1 patients)
TAREG (1 patients)
TOPICAL MEDICATIONS (FOR PSORIASIS) (1 patients)
ZETIA (1 patients)
Most common side effects for patients taking DEPAS:
PYREXIA (415 patients)
MALAISE (256 patients)
INTERSTITIAL LUNG DISEASE (237 patients)
HEPATIC FUNCTION ABNORMAL (227 patients)
ALANINE AMINOTRANSFERASE INCREASED (204 patients)
PLATELET COUNT DECREASED (199 patients)
NAUSEA (195 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (191 patients)
LIVER DISORDER (190 patients)
PNEUMONIA (189 patients)
ANAEMIA (187 patients)
DIZZINESS (181 patients)
DECREASED APPETITE (175 patients)
ALTERED STATE OF CONSCIOUSNESS (165 patients)
VOMITING (158 patients)
RHABDOMYOLYSIS (157 patients)
BLOOD CREATINE PHOSPHOKINASE INCREASED (150 patients)
DIARRHOEA (145 patients)
WHITE BLOOD CELL COUNT DECREASED (144 patients)
RASH (142 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (142 patients)
C-REACTIVE PROTEIN INCREASED (137 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (136 patients)
LOSS OF CONSCIOUSNESS (126 patients)
RENAL FAILURE ACUTE (124 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (123 patients)
SOMNOLENCE (121 patients)
HYPONATRAEMIA (119 patients)
INSOMNIA (117 patients)
DYSPNOEA (115 patients)
FALL (112 patients)
OVERDOSE (105 patients)
TREMOR (102 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (101 patients)
HAEMOGLOBIN DECREASED (100 patients)
DRUG ERUPTION (99 patients)
CONDITION AGGRAVATED (98 patients)
BLOOD CREATININE INCREASED (98 patients)
PLEURAL EFFUSION (96 patients)
HYPOGLYCAEMIA (94 patients)
DEHYDRATION (94 patients)
CARDIAC FAILURE (93 patients)
RENAL IMPAIRMENT (92 patients)
SUICIDE ATTEMPT (92 patients)
DRUG EXPOSURE DURING PREGNANCY (91 patients)
BLOOD PRESSURE DECREASED (89 patients)
BLOOD UREA INCREASED (87 patients)
PAIN (87 patients)
HEADACHE (86 patients)
DELIRIUM (85 patients)
WHITE BLOOD CELL COUNT INCREASED (83 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (82 patients)
ASTHENIA (81 patients)
FEELING ABNORMAL (80 patients)
ANOREXIA (79 patients)
RENAL FAILURE (77 patients)
NEUTROPHIL COUNT DECREASED (75 patients)
GAIT DISTURBANCE (75 patients)
RESTLESSNESS (73 patients)
IRRITABILITY (73 patients)
HYPOAESTHESIA (72 patients)
DEPRESSION (72 patients)
COUGH (71 patients)
CONSTIPATION (71 patients)
NEUROLEPTIC MALIGNANT SYNDROME (71 patients)
INFECTION (69 patients)
BACK PAIN (69 patients)
SHOCK (68 patients)
ASCITES (68 patients)
PANCYTOPENIA (68 patients)
MULTI-ORGAN FAILURE (68 patients)
PNEUMOCYSTIS JIROVECI PNEUMONIA (67 patients)
HYPERTENSION (66 patients)
STOMATITIS (66 patients)
ERYTHEMA (65 patients)
MYALGIA (64 patients)
CONVULSION (63 patients)
THROMBOCYTOPENIA (62 patients)
CEREBRAL INFARCTION (62 patients)
DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (62 patients)
DRUG INTERACTION (61 patients)
ANXIETY (61 patients)
HYPERKALAEMIA (61 patients)
RENAL DISORDER (60 patients)
PALPITATIONS (59 patients)
BRADYCARDIA (59 patients)
SEPSIS (59 patients)
HALLUCINATION (59 patients)
BLOOD PRESSURE INCREASED (59 patients)
NASOPHARYNGITIS (58 patients)
RESPIRATORY FAILURE (58 patients)
COMPLETED SUICIDE (57 patients)
INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION (57 patients)
RED BLOOD CELL COUNT DECREASED (57 patients)
MUSCULAR WEAKNESS (57 patients)
HYPOKALAEMIA (57 patients)
ABDOMINAL PAIN UPPER (56 patients)
BLOOD GLUCOSE INCREASED (55 patients)
OEDEMA PERIPHERAL (54 patients)
DEATH (54 patients)
ABNORMAL BEHAVIOUR (50 patients)
CELLULITIS (49 patients)
HYPERHIDROSIS (49 patients)
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME (48 patients)
PARKINSONISM (48 patients)
JAUNDICE (47 patients)
ATRIAL FIBRILLATION (47 patients)
AGGRESSION (46 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (46 patients)
PAIN IN EXTREMITY (46 patients)
URINARY TRACT INFECTION (46 patients)
PULMONARY OEDEMA (45 patients)
DYSARTHRIA (44 patients)
ARTHRALGIA (43 patients)
CHEST PAIN (42 patients)
FEBRILE NEUTROPENIA (42 patients)
HEPATITIS ACUTE (42 patients)
HEPATITIS FULMINANT (41 patients)
SUICIDAL IDEATION (41 patients)
HISTIOCYTOSIS HAEMATOPHAGIC (41 patients)
INTENTIONAL OVERDOSE (41 patients)
STEVENS-JOHNSON SYNDROME (41 patients)
CARDIO-RESPIRATORY ARREST (41 patients)
CHILLS (40 patients)
DRUG INEFFECTIVE (40 patients)
HAEMATOCRIT DECREASED (40 patients)
DRUG WITHDRAWAL SYNDROME (40 patients)
DIABETES MELLITUS (40 patients)
BLOOD BILIRUBIN INCREASED (40 patients)
OEDEMA (39 patients)
ILEUS (39 patients)
DYSKINESIA (39 patients)
MALIGNANT NEOPLASM PROGRESSION (39 patients)
NEOPLASM MALIGNANT (39 patients)
RASH GENERALISED (38 patients)
ENCEPHALOPATHY (38 patients)
WEIGHT INCREASED (38 patients)
DYSPHAGIA (38 patients)
HYPOXIA (37 patients)
GASTRIC ULCER (37 patients)
PRURITUS (37 patients)
PNEUMONIA ASPIRATION (37 patients)
ABDOMINAL PAIN (36 patients)
URINARY RETENTION (36 patients)
RESPIRATORY ARREST (36 patients)
RESPIRATORY DEPRESSION (35 patients)
THIRST (35 patients)
LYMPHOCYTE COUNT DECREASED (35 patients)
GENERALISED OEDEMA (35 patients)
CEREBRAL HAEMORRHAGE (35 patients)
HEPATITIS (35 patients)
CONFUSIONAL STATE (35 patients)
DRUG WITHDRAWAL SYNDROME NEONATAL (34 patients)
AGITATION (34 patients)
COMA (34 patients)
URTICARIA (34 patients)
BLOOD POTASSIUM DECREASED (34 patients)
EOSINOPHIL COUNT INCREASED (34 patients)
ELECTROCARDIOGRAM QT PROLONGED (33 patients)
SEROTONIN SYNDROME (33 patients)
MUSCULOSKELETAL STIFFNESS (33 patients)
PERITONITIS (33 patients)
HALLUCINATION, AUDITORY (32 patients)
BLOOD SODIUM DECREASED (32 patients)
HYPOTENSION (32 patients)
DISEASE PROGRESSION (32 patients)
NEONATAL ASPHYXIA (32 patients)
FATIGUE (32 patients)
SPEECH DISORDER (32 patients)
CARDIAC FAILURE ACUTE (31 patients)
ANAPHYLACTIC SHOCK (31 patients)
DYSURIA (31 patients)
HAEMORRHAGIC DIATHESIS (31 patients)
BONE MARROW FAILURE (30 patients)
GASTROINTESTINAL HAEMORRHAGE (30 patients)
HAEMORRHAGE SUBCUTANEOUS (30 patients)
DISORIENTATION (30 patients)
ACUTE RESPIRATORY DISTRESS SYNDROME (29 patients)
ERYTHEMA MULTIFORME (29 patients)
HAEMORRHAGE (29 patients)
GASTRIC CANCER (29 patients)
MULTIPLE SCLEROSIS RELAPSE (29 patients)
OXYGEN SATURATION DECREASED (28 patients)
ROAD TRAFFIC ACCIDENT (28 patients)
TACHYCARDIA (28 patients)
WEIGHT DECREASED (28 patients)
LYMPHOCYTE STIMULATION TEST POSITIVE (28 patients)
HEPATIC ENZYME INCREASED (28 patients)
ABDOMINAL DISTENSION (27 patients)
OFF LABEL USE (27 patients)
VENTRICULAR TACHYCARDIA (27 patients)
OROPHARYNGEAL PAIN (26 patients)
MYOCARDIAL INFARCTION (26 patients)
HAEMOPTYSIS (26 patients)
SUDDEN DEATH (26 patients)
POLLAKIURIA (25 patients)
LUNG DISORDER (25 patients)
PULMONARY EMBOLISM (25 patients)
EYE PAIN (25 patients)
DRUG TOXICITY (25 patients)
CHEST DISCOMFORT (25 patients)
SKIN ULCER (25 patients)
SEPTIC SHOCK (25 patients)
HAEMOLYTIC ANAEMIA (25 patients)
BURSITIS (25 patients)
FIBRIN D DIMER INCREASED (24 patients)
CARDIAC ARREST (24 patients)
CATARACT (24 patients)
VENTRICULAR FIBRILLATION (24 patients)
HEPATITIS C (24 patients)

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