About this FactMed analysis covering adverse side effect reports of ESTRADERM patients who developed ADHESION.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 4 individuals taking ESTRADERM reported ADHESION to the FDA. A total of 2511 ESTRADERM drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between ESTRADERM and ADHESION. In doing so, we compare ESTRADERM with other drugs that cause ADHESION, to help you evaluate whether or not ESTRADERM causes ADHESION. Likewise, this page shows the most highly-reported side effects of ESTRADERM, so you can see if ADHESION ranks among ESTRADERM's most well-known side effects.
Summary Statistics
Reports of ESTRADERM causing ADHESION: 4
Reports of any side effect of ESTRADERM : 2511
Percentage of ESTRADERM patients where ADHESION is a reported side effect: 0.1593%

FDA reports of any drug causing ADHESION : 955
Average percentage for all medicated patients where ADHESION is reported as a complication: 0.0060%

Physician opinion on ESTRADERM as adverse event culprit:

Overall opinion for all reports of this drug:
Most frequent diagnoses/indications for prescribing ESTRADERM:
HORMONE REPLACEMENT THERAPY ( 848 patients )
MENOPAUSE ( 214 patients )
MENOPAUSAL SYMPTOMS ( 199 patients )
DRUG USE FOR UNKNOWN INDICATION ( 26 patients )
HOT FLUSH ( 21 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 14 patients )
HORMONE THERAPY ( 13 patients )
OESTROGEN REPLACEMENT THERAPY ( 11 patients )
OSTEOPOROSIS PROPHYLAXIS ( 11 patients )
PROPHYLAXIS ( 9 patients )
VULVOVAGINAL DRYNESS ( 8 patients )
CARDIOVASCULAR EVENT PROPHYLAXIS ( 8 patients )
HYSTERECTOMY ( 8 patients )
POSTMENOPAUSE ( 5 patients )
BONE DISORDER ( 4 patients )
ARTIFICIAL MENOPAUSE ( 3 patients )
OSTEOPOROSIS ( 3 patients )
IN VITRO FERTILISATION ( 3 patients )
OVARIAN FAILURE ( 3 patients )
PREMENSTRUAL SYNDROME ( 3 patients )
NIGHT SWEATS ( 3 patients )
UTERINE CANCER ( 3 patients )
OESTROGEN DEFICIENCY ( 2 patients )
MALAISE ( 2 patients )
MOOD SWINGS ( 2 patients )
SURGERY ( 2 patients )
TRANSDERMAL CONTRACEPTION ( 2 patients )
OOPHORECTOMY ( 2 patients )
VULVOVAGINAL PAIN ( 2 patients )
NERVOUSNESS ( 1 patients )
TOTAL HYSTERECTOMY ( 1 patients )
TURNER'S SYNDROME ( 1 patients )
OESTROGEN THERAPY ( 1 patients )
HYPOGONADISM FEMALE ( 1 patients )
BLOOD FOLLICLE STIMULATING HORMONE DECREASED ( 1 patients )
BLOOD OESTROGEN ( 1 patients )
MENOPAUSAL DISORDER ( 1 patients )
RESTLESSNESS ( 1 patients )
ENDOMETRIOSIS ( 1 patients )
HYPERHIDROSIS ( 1 patients )
ACNE ( 1 patients )
ASSISTED FERTILISATION ( 1 patients )
INSOMNIA ( 1 patients )
BLOOD LUTEINISING HORMONE DECREASED ( 1 patients )
MENOPAUSAL DEPRESSION ( 1 patients )
DEPRESSION ( 1 patients )
REPRODUCTIVE TRACT DISORDER ( 1 patients )
MENORRHAGIA ( 1 patients )
ECZEMA ( 1 patients )
SLEEP DISORDER ( 1 patients )
( 0 patients )
Drugs with high FDA adverse event association with ADHESION:

FOSAMAX (219 patients)
VIOXX (200 patients)
HUMIRA (129 patients)
REMICADE (102 patients)
PEGASYS (82 patients)
ACCUTANE (70 patients)
LIPITOR (58 patients)
NEURONTIN (55 patients)
ASPIRIN (46 patients)
AVONEX (45 patients)
SYNTHROID (44 patients)
PRILOSEC (42 patients)
LORAZEPAM (41 patients)
COPEGUS (40 patients)
FOLIC ACID (40 patients)
VITAMIN E (39 patients)
PAXIL (38 patients)
METHOTREXATE (37 patients)
CELEBREX (37 patients)
DIANEAL (37 patients)
PREMARIN (37 patients)
LISINOPRIL (32 patients)
HYDROCHLOROTHIAZIDE (31 patients)
LYRICA (30 patients)
FLOVENT (30 patients)
XANAX (28 patients)
LIORESAL (28 patients)
NORVASC (27 patients)
PREDNISONE (27 patients)
IBUPROFEN (27 patients)
ACTONEL (26 patients)
ALBUTEROL (26 patients)
[THERAPY UNSPECIFIED] (26 patients)
CALCIUM (UNSPECIFIED) (26 patients)
DIGOXIN (25 patients)
AMBIEN (25 patients)
PROTONIX (25 patients)
FUROSEMIDE (24 patients)
ATENOLOL (24 patients)
LASIX (23 patients)
OXYCONTIN (23 patients)
NEXIUM (23 patients)
FLEXERIL (22 patients)
ACETAMINOPHEN (21 patients)
FOSAMAX PLUS D (21 patients)
ZANTAC (21 patients)
ZOLOFT (21 patients)
EVISTA (21 patients)
VITAMIN D (21 patients)
CIPRO (20 patients)
LEVOTHYROXINE SODIUM (20 patients)
FORTEO (19 patients)
PREDNISONE TAB (19 patients)
LANOXIN (19 patients)
LEXAPRO (18 patients)
ACIPHEX (18 patients)
LORTAB (18 patients)
COUMADIN (18 patients)
OMEPRAZOLE (18 patients)
FLUOROURACIL (18 patients)
VERAPAMIL (17 patients)
VITAMINS (UNSPECIFIED) (17 patients)
PERCOCET (17 patients)
HYDROCODONE BITARTRATE (17 patients)
TRAZODONE HYDROCHLORIDE (17 patients)
CLARITIN (17 patients)
CLONAZEPAM (17 patients)
MULTI-VITAMIN (17 patients)
MYCOPHENOLATE MOFETIL (16 patients)
DETROL LA (16 patients)
ACETAMINOPHEN AND HYDROCODONE BITARTRATE (16 patients)
SEROQUEL (16 patients)
AMITRIPTYLINE HYDROCHLORIDE (16 patients)
AMPICILLIN (16 patients)
ZOFRAN (16 patients)
VALIUM (15 patients)
CYANOCOBALAMIN (14 patients)
ALPRAZOLAM (14 patients)
WARFARIN SODIUM (14 patients)
VICODIN (14 patients)
ACYCLOVIR (13 patients)
LEVAQUIN (13 patients)
ROBAXIN (13 patients)
ALENDRONATE SODIUM (13 patients)
DECADRON (13 patients)
MORPHINE (13 patients)
VITAMIN B-12 (13 patients)
BACTRIM DS (13 patients)
ZELNORM (13 patients)
CIMZIA (13 patients)
ENTOCORT EC (13 patients)
ALTACE (12 patients)
VENTOLIN (12 patients)
K-DUR 10 (12 patients)
LEUCOVORIN CALCIUM (12 patients)
CYMBALTA (12 patients)
DEXAMETHASONE (12 patients)
MIRENA (12 patients)
GOLIMUMAB (12 patients)
HORMONES (UNSPECIFIED) (12 patients)
PREVACID (12 patients)
PRIMIDONE (12 patients)
CITALOPRAM HYDROBROMIDE (12 patients)
FENTANYL (12 patients)
VYTORIN (12 patients)
VITAMIN D (UNSPECIFIED) (11 patients)
ZOCOR (11 patients)
PREDNISOLONE (11 patients)
DOXORUBICIN HCL (11 patients)
POTASSIUM CHLORIDE (11 patients)
OYST CAL D (11 patients)
FAMOTIDINE (11 patients)
REGLAN (11 patients)
WELLBUTRIN (11 patients)
GABAPENTIN (11 patients)
OXYCODONE HCL (11 patients)
ZETIA (11 patients)
DULCOLAX (11 patients)
URBASON (11 patients)
CLOZARIL (11 patients)
CLONIDINE (11 patients)
RANITIDINE (11 patients)
REBIF (10 patients)
PREMPRO (10 patients)
YAZ (10 patients)
CLONOPIN (10 patients)
ESTRATEST (10 patients)
VITAMINS (10 patients)
ASCORBIC ACID (10 patients)
TOCILIZUMAB (10 patients)
DEPAKOTE (10 patients)
MIACALCIN (10 patients)
DOSTINEX (10 patients)
BACLOFEN (10 patients)
CELEXA (10 patients)
NITROSTAT (10 patients)
LANTUS (10 patients)
CALCIUM (10 patients)
DIFLUCAN (9 patients)
ENBREL (9 patients)
ONDANSETRON (9 patients)
TEGRETOL (9 patients)
PROMETHAZINE (9 patients)
INDAPAMIDE (9 patients)
ADVAIR DISKUS 100/50 (9 patients)
PLAVIX (9 patients)
LANSOPRAZOLE (9 patients)
TACROLIMUS (9 patients)
AMOXICILLIN (9 patients)
IMURAN (9 patients)
MULTI-VITAMINS (9 patients)
DIOVAN (9 patients)
MORPHINE SULFATE (9 patients)
CENTRUM (9 patients)
BIRTH CONTROL PILLS (9 patients)
ESTRADIOL (9 patients)
CALCIUM GLUCONATE (9 patients)
LUPRON DEPOT (9 patients)
FISH OIL (9 patients)
DICLOFENAC (9 patients)
CALCIUM CARBONATE (9 patients)
LOVENOX (8 patients)
MIRALAX (8 patients)
SALAGEN (8 patients)
CELECOXIB (8 patients)
ULTRAM (8 patients)
DEPO-PROVERA (8 patients)
TRAZODONE HCL (8 patients)
SK-ERYTHROMYCIN (8 patients)
MIRAPEX (8 patients)
VALTREX (8 patients)
TYLENOL (CAPLET) (8 patients)
YASMIN (8 patients)
RENAGEL (8 patients)
SERTRALINE HYDROCHLORIDE (8 patients)
CRESTOR (8 patients)
CARTICEL (8 patients)
AUGMENTIN '125' (8 patients)
DICLOFENAC SODIUM (8 patients)
AVASTIN (8 patients)
PENTASA (8 patients)
VELCADE (8 patients)
VANCOMYCIN (8 patients)
VINCRISTINE (8 patients)
PROGRAF (8 patients)
FLAGYL (8 patients)
UNCODEABLE ^UNCLASSIFIABLE^ (7 patients)
ELIDEL (7 patients)
FLOXIN OTIC (7 patients)
ACTOS (7 patients)
CLINDAMYCIN (7 patients)
IMIPRAMINE (7 patients)
OXALIPLATIN (7 patients)
AMITRIPTYLINE HCL (7 patients)
CIPROFLOXACIN (7 patients)
NIFEDIPINE (7 patients)
LAMICTAL (7 patients)
COZAAR (7 patients)
WARFARIN (7 patients)
FLORINEF (7 patients)
METOPROLOL (7 patients)
HUMALOG (7 patients)
BEVACIZUMAB (7 patients)
ISONIAZID (7 patients)
KLONOPIN (7 patients)
PROZAC (7 patients)
CALCICHEW (7 patients)
PYRIDIUM (7 patients)
RAMIPRIL (7 patients)
NUVARING (7 patients)
Most common side effects for patients taking ESTRADERM:
BREAST CANCER (847 patients)
BREAST CANCER FEMALE (414 patients)
ANXIETY (295 patients)
DEPRESSION (285 patients)
BREAST MASS (262 patients)
HOT FLUSH (227 patients)
HYPERTENSION (212 patients)
OESTROGEN RECEPTOR ASSAY POSITIVE (205 patients)
PAIN (194 patients)
MASTECTOMY (189 patients)
PAIN IN EXTREMITY (181 patients)
OSTEOPENIA (170 patients)
DYSPNOEA (166 patients)
HEADACHE (162 patients)
CHEST PAIN (160 patients)
RADIOTHERAPY (153 patients)
PROGESTERONE RECEPTOR ASSAY POSITIVE (150 patients)
BREAST CANCER IN SITU (146 patients)
NAUSEA (145 patients)
MALIGNANT BREAST LUMP REMOVAL (141 patients)
FIBROCYSTIC BREAST DISEASE (135 patients)
BACK PAIN (131 patients)
UTERINE LEIOMYOMA (124 patients)
INJURY (123 patients)
OSTEOPOROSIS (118 patients)
FATIGUE (117 patients)
FALL (117 patients)
DIZZINESS (115 patients)
ARTHRALGIA (114 patients)
BLOOD CHOLESTEROL INCREASED (114 patients)
BREAST CYST (114 patients)
OSTEOARTHRITIS (113 patients)
DRUG INEFFECTIVE (113 patients)
MAMMOGRAM ABNORMAL (112 patients)
GASTROOESOPHAGEAL REFLUX DISEASE (112 patients)
INSOMNIA (111 patients)
SPINAL OSTEOARTHRITIS (99 patients)
ABDOMINAL PAIN (98 patients)
OEDEMA PERIPHERAL (96 patients)
LYMPHADENECTOMY (95 patients)
BREAST CALCIFICATIONS (95 patients)
DIARRHOEA (93 patients)
MALAISE (92 patients)
BREAST CANCER METASTATIC (91 patients)
ASTHENIA (88 patients)
HYPOAESTHESIA (86 patients)
PNEUMONIA (81 patients)
SCAR (81 patients)
PALPITATIONS (80 patients)
PYREXIA (79 patients)
CEREBROVASCULAR ACCIDENT (79 patients)
ARTHRITIS (78 patients)
MIGRAINE (71 patients)
VOMITING (70 patients)
COUGH (69 patients)
COLONIC POLYP (69 patients)
POSTMENOPAUSAL HAEMORRHAGE (69 patients)
BIOPSY BREAST ABNORMAL (67 patients)
BREAST RECONSTRUCTION (66 patients)
HYPERHIDROSIS (66 patients)
VAGINAL HAEMORRHAGE (66 patients)
HYPOTHYROIDISM (64 patients)
BREAST DISORDER (63 patients)
PLEURAL EFFUSION (62 patients)
CHRONIC OBSTRUCTIVE PULMONARY DISEASE (61 patients)
ABDOMINAL PAIN UPPER (60 patients)
MUSCLE SPASMS (59 patients)
BREAST LUMP REMOVAL (59 patients)
BLOOD TRIGLYCERIDES INCREASED (58 patients)
RASH (58 patients)
CHOLECYSTECTOMY (58 patients)
DEEP VEIN THROMBOSIS (58 patients)
NERVOUSNESS (57 patients)
INTERVERTEBRAL DISC DEGENERATION (57 patients)
IRRITABLE BOWEL SYNDROME (56 patients)
EMOTIONAL DISTRESS (55 patients)
DIVERTICULUM (55 patients)
UTERINE DILATION AND CURETTAGE (55 patients)
ASTHMA (55 patients)
HYSTERECTOMY (53 patients)
LYMPHOEDEMA (53 patients)
CHILLS (53 patients)
AMNESIA (52 patients)
DEFORMITY (52 patients)
URINARY TRACT INFECTION (52 patients)
BREAST HYPERPLASIA (52 patients)
ABDOMINAL DISTENSION (51 patients)
MODIFIED RADICAL MASTECTOMY (51 patients)
WEIGHT INCREASED (50 patients)
CHEMOTHERAPY (50 patients)
FEELING ABNORMAL (50 patients)
DIABETES MELLITUS (49 patients)
TRANSIENT ISCHAEMIC ATTACK (48 patients)
BREAST MICROCALCIFICATION (48 patients)
CHOLELITHIASIS (48 patients)
ARTERIOSCLEROSIS (48 patients)
ATRIAL FIBRILLATION (48 patients)
HAEMORRHOIDS (47 patients)
CATARACT (47 patients)
MYOCARDIAL INFARCTION (47 patients)
CONSTIPATION (47 patients)
FIBROMYALGIA (47 patients)
CATARACT OPERATION (46 patients)
VISION BLURRED (46 patients)
GAIT DISTURBANCE (46 patients)
ARRHYTHMIA (46 patients)
CARDIAC DISORDER (46 patients)
SINUSITIS (45 patients)
BONE DENSITY DECREASED (45 patients)
INTERVERTEBRAL DISC PROTRUSION (45 patients)
BREAST PAIN (45 patients)
WEIGHT DECREASED (45 patients)
UTERINE POLYP (45 patients)
BONE PAIN (43 patients)
DYSPNOEA EXERTIONAL (42 patients)
OVARIAN CYST (42 patients)
BREAST TENDERNESS (42 patients)
GASTRITIS (42 patients)
MITRAL VALVE INCOMPETENCE (42 patients)
SMEAR CERVIX ABNORMAL (41 patients)
TREMOR (41 patients)
BIOPSY (41 patients)
IRRITABILITY (41 patients)
SWELLING (41 patients)
MENOPAUSAL SYMPTOMS (41 patients)
ORAL PAIN (41 patients)
ATROPHIC VULVOVAGINITIS (41 patients)
PARAESTHESIA (41 patients)
SUICIDAL IDEATION (40 patients)
MUSCULAR WEAKNESS (40 patients)
VERTIGO (39 patients)
SURGERY (39 patients)
RENAL CYST (38 patients)
DYSPHAGIA (38 patients)
HYPOKALAEMIA (38 patients)
NECK PAIN (38 patients)
CONDITION AGGRAVATED (38 patients)
NEUROPATHY PERIPHERAL (38 patients)
CARDIOMEGALY (37 patients)
ANAEMIA (37 patients)
OVARIAN CANCER (37 patients)
LUMBAR SPINAL STENOSIS (37 patients)
HEPATITIS (37 patients)
DYSPEPSIA (37 patients)
URINARY INCONTINENCE (37 patients)
HEPATIC ENZYME INCREASED (36 patients)
HYPERLIPIDAEMIA (36 patients)
THROMBOSIS (36 patients)
PANIC ATTACK (36 patients)
HEART RATE IRREGULAR (36 patients)
LOSS OF CONSCIOUSNESS (35 patients)
EMOTIONAL DISORDER (35 patients)
BREAST CANCER RECURRENT (34 patients)
UTERINE HAEMORRHAGE (34 patients)
ERYTHEMA (34 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (34 patients)
TEMPOROMANDIBULAR JOINT SYNDROME (33 patients)
CORONARY ARTERY DISEASE (33 patients)
BLOOD PRESSURE INCREASED (32 patients)
LYMPHADENOPATHY (32 patients)
MYALGIA (32 patients)
HIATUS HERNIA (32 patients)
HEPATIC STEATOSIS (32 patients)
TRICUSPID VALVE INCOMPETENCE (32 patients)
DIVERTICULUM INTESTINAL (32 patients)
METRORRHAGIA (32 patients)
BASAL CELL CARCINOMA (32 patients)
HAEMATURIA (31 patients)
BLOOD THYROID STIMULATING HORMONE INCREASED (30 patients)
MUSCULOSKELETAL PAIN (30 patients)
BIOPSY BREAST (30 patients)
ANGER (30 patients)
TACHYCARDIA (30 patients)
HYPOXIA (30 patients)
BALANCE DISORDER (30 patients)
PLATELET COUNT DECREASED (29 patients)
BRONCHITIS (29 patients)
DIVERTICULITIS (29 patients)
METASTASES TO LYMPH NODES (29 patients)
VULVOVAGINAL DRYNESS (29 patients)
GASTRIC POLYPS (29 patients)
IMPAIRED HEALING (29 patients)
BREAST NECROSIS (29 patients)
EPIGASTRIC DISCOMFORT (28 patients)
OBESITY (28 patients)
VAGINAL DISCHARGE (28 patients)
VENTRICULAR EXTRASYSTOLES (28 patients)
HYSTEROSCOPY (28 patients)
TEMPERATURE INTOLERANCE (28 patients)
ENDOMETRIAL DISORDER (28 patients)
FOOT FRACTURE (27 patients)
ROAD TRAFFIC ACCIDENT (27 patients)
CARDIAC FAILURE CONGESTIVE (27 patients)
RENAL FAILURE ACUTE (27 patients)
LIVER DISORDER (27 patients)
PRURITUS (27 patients)
LUNG NEOPLASM (27 patients)
NEPHROLITHIASIS (27 patients)
VISUAL IMPAIRMENT (27 patients)
PSYCHIATRIC SYMPTOM (27 patients)
HEPATIC CYST (27 patients)
STRESS (27 patients)
NUCLEAR MAGNETIC RESONANCE IMAGING ABNORMAL (26 patients)
CERVICAL DYSPLASIA (26 patients)
ENDOMETRIAL HYPERTROPHY (26 patients)
CONFUSIONAL STATE (26 patients)
EMPHYSEMA (26 patients)
SCIATICA (26 patients)
MENIERE'S DISEASE (26 patients)
PELVIC PAIN (26 patients)

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