About this FactMed analysis covering adverse side effect reports of GLUCOVANCE patients who developed ACHLORHYDRIA.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 6 individuals taking GLUCOVANCE reported ACHLORHYDRIA to the FDA. A total of 4091 GLUCOVANCE drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between GLUCOVANCE and ACHLORHYDRIA. In doing so, we compare GLUCOVANCE with other drugs that cause ACHLORHYDRIA, to help you evaluate whether or not GLUCOVANCE causes ACHLORHYDRIA. Likewise, this page shows the most highly-reported side effects of GLUCOVANCE, so you can see if ACHLORHYDRIA ranks among GLUCOVANCE's most well-known side effects.
Summary Statistics
Reports of GLUCOVANCE causing ACHLORHYDRIA: 6
Reports of any side effect of GLUCOVANCE : 4091
Percentage of GLUCOVANCE patients where ACHLORHYDRIA is a reported side effect: 0.1467%

FDA reports of any drug causing ACHLORHYDRIA : 27
Average percentage for all medicated patients where ACHLORHYDRIA is reported as a complication: 0.0002%

Physician opinion on GLUCOVANCE as adverse event culprit:

Overall opinion for all reports of this drug:
Most frequent diagnoses/indications for prescribing GLUCOVANCE:
DIABETES MELLITUS ( 608 patients )
TYPE 2 DIABETES MELLITUS ( 125 patients )
DIABETES MELLITUS NON-INSULIN-DEPENDENT ( 111 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 37 patients )
DRUG USE FOR UNKNOWN INDICATION ( 35 patients )
BLOOD GLUCOSE INCREASED ( 10 patients )
DIABETES MELLITUS MANAGEMENT ( 8 patients )
HYPERGLYCAEMIA ( 3 patients )
TYPE 1 DIABETES MELLITUS ( 3 patients )
DIABETES MELLITUS INADEQUATE CONTROL ( 3 patients )
INSULIN-REQUIRING TYPE 2 DIABETES MELLITUS ( 2 patients )
GLUCOSE TOLERANCE IMPAIRED ( 1 patients )
BLOOD GLUCOSE ( 1 patients )
POLYCYSTIC OVARIES ( 1 patients )
ROUTINE HEALTH MAINTENANCE ( 1 patients )
DIABETES MELLITUS MALNUTRITION-RELATED ( 1 patients )
GLUCOSE URINE PRESENT ( 1 patients )
INSULIN RESISTANCE ( 1 patients )
ACCIDENTAL EXPOSURE ( 1 patients )
INSULIN-REQUIRING TYPE II DIABETES MELLITUS ( 1 patients )
BLOOD GLUCOSE ABNORMAL ( 1 patients )
CARDIOVASCULAR DISORDER ( 1 patients )
DRUG EXPOSURE DURING PREGNANCY ( 1 patients )
( 0 patients )
Drugs with high FDA adverse event association with ACHLORHYDRIA:

ASPIRIN (8 patients)
AMLODIPINE (7 patients)
COREG (6 patients)
COUMADIN (6 patients)
FLUCONAZOLE (6 patients)
GLUCOVANCE (6 patients)
GLYBURIDE (6 patients)
LASIX (6 patients)
LEVAQUIN (6 patients)
LIPITOR (6 patients)
PROMETHAZINE (6 patients)
SEROQUEL (6 patients)
AMOXICILLIN (5 patients)
CARVEDILOL (5 patients)
CIPROFLOXACIN (5 patients)
CYANOCOBALAMIN (5 patients)
DIGOXIN (5 patients)
DOXYCYCLINE (5 patients)
FOSINOPRIL SODIUM (5 patients)
GABAPENTIN (5 patients)
LISINOPRIL (5 patients)
LORCET-HD (5 patients)
MELOXICAM (5 patients)
METOLAZONE (5 patients)
NEXIUM (5 patients)
OMEPRAZOLE (5 patients)
OXYCODONE HCL AND ACETAMINOPHEN (5 patients)
ACULAR (4 patients)
GEMFIBROZIL (4 patients)
MUPIROCIN OINTMENT (4 patients)
NEORAL (4 patients)
POTASSIUM CHLORIDE (4 patients)
SILVASORB (4 patients)
TEMAZEPAM (4 patients)
TRIMETHO SULFAMETHOX (4 patients)
ACTOS (3 patients)
AGGRENOX (3 patients)
GLUCOPHAGE (3 patients)
KLOR-CON (3 patients)
LANSOPRAZOLE (3 patients)
SODIUM BICARBONATE (3 patients)
CODEINE (2 patients)
COZAAR (2 patients)
FUROSEMIDE (2 patients)
HYDROCODONE (2 patients)
MUPIROCIN (2 patients)
PANTOPRAZOLE SODIUM (2 patients)
PEG (2 patients)
POTASSIUM (2 patients)
PRILOSEC OTC (2 patients)
PROPO-K (2 patients)
RANITIDINE (2 patients)
SIMVASTATIN (2 patients)
SPIRIVA (2 patients)
SULFAMETHOXAZOLE AND TRIMETHOPRIM (2 patients)
WARFARIN SODIUM (2 patients)
ZANTAC (2 patients)
ACETYLSALICYLIC ACID SRT (1 patients)
ADVAIR HFA (1 patients)
ALBUTEROL SULFATE AUTOHALER (1 patients)
ALCOHOL (1 patients)
ALLEGRA (1 patients)
AMOXICILLIN+CLAVULANATE (1 patients)
ATENOLOL (1 patients)
AZITHROMYCIN (1 patients)
BUPROPION HCL (1 patients)
CALCIUM SUPPLEMENTS (1 patients)
CHLORTHALIDONE (1 patients)
CLOFAZIMINE (1 patients)
CLONAZEPAM (1 patients)
CLOTRIMAZOLE (1 patients)
COCAINE (1 patients)
COMBIVENT (1 patients)
CORTICOSTEROIDS (1 patients)
CYCLOBENZAPRINE (1 patients)
DARVOCET-N 100 (1 patients)
DEPO-MEDROL (1 patients)
DIET (NO INGREDIENTS/SUBSTANCES) (1 patients)
DIFLUCAN (1 patients)
DUONEB (1 patients)
EFFEXOR (1 patients)
ETHAMBUTOL HYDROCHLORIDE (1 patients)
FERROUS GLUCONATE (1 patients)
FLONASO (1 patients)
FLOR-CON (1 patients)
FLOVENT (1 patients)
INSULIN (1 patients)
LACTAID (1 patients)
LITHIUM CARBONATE (1 patients)
LOVASTATIN (1 patients)
MIRAPEX (1 patients)
MONTELUKAST SODIUM (1 patients)
NEOSTIGMINE BROMIDE (1 patients)
PAROXETINE HCL (1 patients)
PEPCID (1 patients)
POTASSIUM CHLORIDE CR (1 patients)
PRAVACHOL (1 patients)
PREDNISONE (1 patients)
PREMARIN (1 patients)
PREVACID (1 patients)
PRILOSEC (1 patients)
QUINIDINE GLUCONATE (1 patients)
RANITIDINE 150MG TABLETS, UNKNOWN MANUFACTURER (1 patients)
RANITIDINE HCL (1 patients)
RANITIDINE HYDROCHLORIDE (1 patients)
RECLAST (1 patients)
ROPINIROLE (1 patients)
SINGULAIR (1 patients)
SODIUM BICARBONATE IN PLASTIC CONTAINER (1 patients)
SYNTHROID (1 patients)
TOPROL-XL (1 patients)
TRAZODONE HCL (1 patients)
TRILEPTAL (1 patients)
TRIMEBUTINE (1 patients)
ZETIA (1 patients)
Most common side effects for patients taking GLUCOVANCE:
BLOOD GLUCOSE INCREASED (776 patients)
NAUSEA (652 patients)
WEIGHT DECREASED (462 patients)
BLOOD GLUCOSE DECREASED (366 patients)
DIZZINESS (324 patients)
MYOCARDIAL INFARCTION (306 patients)
DECREASED APPETITE (286 patients)
VOMITING (261 patients)
PAIN (259 patients)
DIARRHOEA (251 patients)
FATIGUE (248 patients)
DYSPNOEA (244 patients)
HEADACHE (225 patients)
ANXIETY (219 patients)
CARDIAC FAILURE CONGESTIVE (215 patients)
ASTHENIA (210 patients)
DIABETES MELLITUS (197 patients)
OEDEMA PERIPHERAL (190 patients)
BACK PAIN (189 patients)
DRUG INEFFECTIVE (188 patients)
HYPOGLYCAEMIA (188 patients)
CEREBROVASCULAR ACCIDENT (172 patients)
HYPERTENSION (170 patients)
CORONARY ARTERY DISEASE (168 patients)
CHEST PAIN (165 patients)
INJURY (158 patients)
WEIGHT INCREASED (148 patients)
ARTHRALGIA (144 patients)
DEPRESSION (143 patients)
INSOMNIA (138 patients)
FALL (130 patients)
CONSTIPATION (129 patients)
DYSPEPSIA (124 patients)
TREMOR (121 patients)
ATRIAL FIBRILLATION (121 patients)
PAIN IN EXTREMITY (117 patients)
HYPERHIDROSIS (117 patients)
PARAESTHESIA (116 patients)
ANAEMIA (116 patients)
PNEUMONIA (111 patients)
COUGH (110 patients)
DEATH (106 patients)
RENAL FAILURE ACUTE (104 patients)
HYPOAESTHESIA (104 patients)
OSTEONECROSIS OF JAW (102 patients)
EMOTIONAL DISTRESS (99 patients)
VISION BLURRED (99 patients)
ABDOMINAL PAIN (98 patients)
GASTROOESOPHAGEAL REFLUX DISEASE (98 patients)
ABDOMINAL PAIN UPPER (92 patients)
HYPOTENSION (88 patients)
DIABETES MELLITUS INADEQUATE CONTROL (88 patients)
CARDIOMEGALY (88 patients)
PYREXIA (86 patients)
CARDIAC DISORDER (86 patients)
DRUG EFFECT DECREASED (85 patients)
CONFUSIONAL STATE (84 patients)
RASH (84 patients)
FEELING ABNORMAL (83 patients)
NERVOUSNESS (80 patients)
SOMNOLENCE (80 patients)
OSTEOMYELITIS (79 patients)
RENAL FAILURE (79 patients)
CELLULITIS (78 patients)
URINARY TRACT INFECTION (78 patients)
TRANSIENT ISCHAEMIC ATTACK (77 patients)
BLOOD PRESSURE INCREASED (76 patients)
ABDOMINAL DISTENSION (74 patients)
MALAISE (72 patients)
ERECTILE DYSFUNCTION (71 patients)
NEUROPATHY PERIPHERAL (71 patients)
MYALGIA (68 patients)
OSTEOARTHRITIS (67 patients)
MYOCARDIAL ISCHAEMIA (67 patients)
PALPITATIONS (66 patients)
PULMONARY EMBOLISM (66 patients)
PLEURAL EFFUSION (66 patients)
HYPERGLYCAEMIA (65 patients)
SYNCOPE (64 patients)
ACUTE MYOCARDIAL INFARCTION (62 patients)
TYPE 2 DIABETES MELLITUS (62 patients)
DEEP VEIN THROMBOSIS (61 patients)
INJECTION SITE PAIN (61 patients)
BLOOD CHOLESTEROL INCREASED (60 patients)
CHRONIC OBSTRUCTIVE PULMONARY DISEASE (59 patients)
BRONCHITIS (59 patients)
HYPONATRAEMIA (58 patients)
PAIN IN JAW (58 patients)
BLOOD GLUCOSE FLUCTUATION (57 patients)
MUSCLE SPASMS (57 patients)
MEMORY IMPAIRMENT (56 patients)
MUSCULOSKELETAL PAIN (55 patients)
INJECTION SITE BRUISING (55 patients)
CHOLELITHIASIS (55 patients)
VERTIGO (54 patients)
HEPATIC STEATOSIS (54 patients)
ARRHYTHMIA (54 patients)
PHARMACEUTICAL PRODUCT COMPLAINT (54 patients)
DEHYDRATION (53 patients)
CATARACT (53 patients)
DIABETIC NEUROPATHY (53 patients)
BONE DISORDER (52 patients)
ERUCTATION (52 patients)
FEELING JITTERY (52 patients)
INTERVERTEBRAL DISC PROTRUSION (51 patients)
SINUSITIS (51 patients)
UPPER RESPIRATORY TRACT INFECTION (51 patients)
NEPHROLITHIASIS (51 patients)
HOT FLUSH (50 patients)
OSTEOPOROSIS (50 patients)
DYSGEUSIA (50 patients)
HAEMATURIA (49 patients)
HYPOKALAEMIA (49 patients)
INJECTION SITE HAEMORRHAGE (49 patients)
MITRAL VALVE INCOMPETENCE (49 patients)
JOINT SWELLING (48 patients)
LOSS OF CONSCIOUSNESS (48 patients)
DYSPHAGIA (48 patients)
CONVULSION (48 patients)
PANCREATITIS (48 patients)
PANCREATITIS ACUTE (47 patients)
ANHEDONIA (47 patients)
ANOREXIA (47 patients)
PULMONARY HYPERTENSION (46 patients)
RESPIRATORY FAILURE (46 patients)
SWELLING (46 patients)
ERYTHEMA (46 patients)
ECONOMIC PROBLEM (46 patients)
FACIAL PAIN (46 patients)
MUSCULAR WEAKNESS (46 patients)
GLYCOSYLATED HAEMOGLOBIN INCREASED (45 patients)
DENTAL CARIES (45 patients)
OBESITY (45 patients)
ARTHRITIS (45 patients)
MULTI-ORGAN FAILURE (44 patients)
ASTHMA (44 patients)
ALOPECIA (43 patients)
SLEEP APNOEA SYNDROME (43 patients)
ATELECTASIS (43 patients)
HIATUS HERNIA (42 patients)
DECREASED INTEREST (42 patients)
SEPSIS (42 patients)
BRADYCARDIA (42 patients)
INTERSTITIAL LUNG DISEASE (42 patients)
LEFT VENTRICULAR HYPERTROPHY (42 patients)
NECK PAIN (42 patients)
UNEVALUABLE EVENT (42 patients)
HYPERLIPIDAEMIA (41 patients)
GINGIVAL DISORDER (41 patients)
CONDITION AGGRAVATED (41 patients)
STRESS (41 patients)
HERPES ZOSTER (41 patients)
NASAL CONGESTION (40 patients)
ANGINA UNSTABLE (40 patients)
MEDICATION ERROR (40 patients)
HEART RATE INCREASED (39 patients)
HYPERSENSITIVITY (39 patients)
ORAL CANDIDIASIS (39 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (39 patients)
PRURITUS (39 patients)
ARTHROPATHY (39 patients)
PATHOLOGICAL FRACTURE (38 patients)
GAIT DISTURBANCE (38 patients)
CARDIAC ARREST (38 patients)
TOOTH DISORDER (38 patients)
EXCORIATION (38 patients)
TACHYCARDIA (38 patients)
THROMBOCYTOPENIA (38 patients)
BALANCE DISORDER (38 patients)
CHILLS (38 patients)
CONTUSION (37 patients)
OEDEMA (37 patients)
FLATULENCE (37 patients)
ANGINA PECTORIS (37 patients)
SINUS CONGESTION (37 patients)
MIGRAINE (37 patients)
FEELING HOT (36 patients)
TOOTH EXTRACTION (36 patients)
LETHARGY (36 patients)
IMPAIRED HEALING (36 patients)
TOOTH LOSS (36 patients)
STOMACH DISCOMFORT (36 patients)
SPINAL OSTEOARTHRITIS (36 patients)
DRY MOUTH (36 patients)
APHASIA (36 patients)
RENAL FAILURE CHRONIC (36 patients)
HYPERCHOLESTEROLAEMIA (36 patients)
OSTEONECROSIS (35 patients)
INCORRECT DOSE ADMINISTERED (35 patients)
POLLAKIURIA (35 patients)
HYPERKALAEMIA (35 patients)
METASTASES TO BONE (35 patients)
ARTERIOSCLEROSIS (35 patients)
CARDIOMYOPATHY (35 patients)
EARLY SATIETY (35 patients)
OESOPHAGITIS (34 patients)
DIPLOPIA (34 patients)
NIGHT SWEATS (34 patients)
DYSLIPIDAEMIA (34 patients)
RHINORRHOEA (34 patients)
SPEECH DISORDER (33 patients)
RENAL INJURY (33 patients)
RENAL IMPAIRMENT (33 patients)
DILATATION ATRIAL (33 patients)
BLOOD TRIGLYCERIDES INCREASED (33 patients)
THROMBOSIS (33 patients)
INFECTION (32 patients)
CHEST DISCOMFORT (32 patients)
DIVERTICULITIS (32 patients)
MULTIPLE INJURIES (32 patients)

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Recent FactMed Activity for GLUCOVANCE


Issue Description / Topic Timestamp
QUESTION
CHEST PAIN
chest pain as a result of glucovance solution 2016-09-23 16:40:44
CONCERN
CHEST PAIN
Im a 42 yr old male w/type 2 diabetes. Medication seem to be to strong. Glucose was dropping, along w/mild headaches and chest disconfort. 2016-11-06 12:24:37

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