About this FactMed analysis covering adverse side effect reports of L-THYROXIN patients who developed ACANTHOLYSIS.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 1 individuals taking L-THYROXIN reported ACANTHOLYSIS to the FDA. A total of 608 L-THYROXIN drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between L-THYROXIN and ACANTHOLYSIS. In doing so, we compare L-THYROXIN with other drugs that cause ACANTHOLYSIS, to help you evaluate whether or not L-THYROXIN causes ACANTHOLYSIS. Likewise, this page shows the most highly-reported side effects of L-THYROXIN, so you can see if ACANTHOLYSIS ranks among L-THYROXIN's most well-known side effects.
Summary Statistics
Reports of L-THYROXIN causing ACANTHOLYSIS: 1
Reports of any side effect of L-THYROXIN : 608
Percentage of L-THYROXIN patients where ACANTHOLYSIS is a reported side effect: 0.1645%

FDA reports of any drug causing ACANTHOLYSIS : 33
Average percentage for all medicated patients where ACANTHOLYSIS is reported as a complication: 0.0002%

Physician opinion on L-THYROXIN as adverse event culprit:

Overall opinion for all reports of this drug:
Most frequent diagnoses/indications for prescribing L-THYROXIN:
HYPOTHYROIDISM ( 94 patients )
DRUG USE FOR UNKNOWN INDICATION ( 54 patients )
THYROID DISORDER ( 14 patients )
GOITRE ( 8 patients )
AUTOIMMUNE THYROIDITIS ( 4 patients )
HYPERTHYROIDISM ( 3 patients )
THYROID HORMONE REPLACEMENT THERAPY ( 2 patients )
THYROIDECTOMY ( 2 patients )
ANKYLOSING SPONDYLITIS ( 2 patients )
THYROID OPERATION ( 1 patients )
DYSTONIA ( 1 patients )
ILL-DEFINED DISORDER ( 1 patients )
THYROID NEOPLASM ( 1 patients )
THYROID THERAPY ( 1 patients )
EMBOLISM ( 1 patients )
HYPERPARATHYROIDISM ( 1 patients )
PREMEDICATION ( 1 patients )
( 0 patients )
Drugs with high FDA adverse event association with ACANTHOLYSIS:

AMBIEN (10 patients)
ABRAXANE (9 patients)
ACIPHEX (9 patients)
AMPICILLIN (9 patients)
ASPIRIN (9 patients)
ATIVAN (9 patients)
AVASTIN (9 patients)
CYMBALTA (9 patients)
LEVOTHYROXINE SODIUM (9 patients)
NORCO (9 patients)
RADIATION (9 patients)
VICODIN (9 patients)
XELODA (9 patients)
ZOLOFT (9 patients)
ZOMETA (9 patients)
ZOFRAN (8 patients)
ARANESP (7 patients)
CAPECITABINE (7 patients)
CEFTRIAXONE (7 patients)
CEPHALEXIN (7 patients)
CIPROFLOXACIN (7 patients)
COLACE (7 patients)
DILAUDID (7 patients)
DOXIL (7 patients)
FEMARA (7 patients)
HYDROCODONE BITARTRATE AND ACETAMINOPHEN (7 patients)
KEFLEX (7 patients)
LASIX (7 patients)
LORAZEPAM (7 patients)
NAPROSYN (7 patients)
NEULASTA (7 patients)
NIACIN (7 patients)
PERCOCET (7 patients)
PROVIGIL (7 patients)
RITALIN (7 patients)
SYNTHROID (7 patients)
TAXOTERE (7 patients)
VANCOMYCIN (7 patients)
VANCOMYCIN HCL (7 patients)
DEXAMETHASONE (6 patients)
FENTANYL (6 patients)
CYCLOSPORINE (4 patients)
PLAVIX (4 patients)
RELAFEN (4 patients)
ACETYLSALICYLIC ACID SRT (3 patients)
ACYCLOVIR (3 patients)
AMITIZA (3 patients)
NABUMETONE (3 patients)
NEXIUM (3 patients)
NIFEDIPINE (3 patients)
XIFAXAN (3 patients)
ALDACTAZIDE (2 patients)
AMLOR (2 patients)
AZATHIOPRINE (2 patients)
CLINDAMYCIN (2 patients)
COZAAR (2 patients)
DEPAKENE (2 patients)
DEPAS (2 patients)
DIGOXIN (2 patients)
DIPYRIDAMOL (2 patients)
EMPYNASE (2 patients)
ENALAPRIL MALEATE (2 patients)
ETRETINATE (2 patients)
FRACTAL (2 patients)
FUCIDIN CREAM (2 patients)
FUROSEMIDE (2 patients)
GAMUNEX (2 patients)
GLUCOR (2 patients)
HALCION (2 patients)
ISOSORBIDE MONONITRATE (2 patients)
LAMICTAL (2 patients)
LAXOBERON (2 patients)
LEVEMIR (2 patients)
MAGLAX (2 patients)
METHYLPREDNISOLONE (2 patients)
MINOCYCLIN (2 patients)
MOPRAL (2 patients)
MORPHINE (2 patients)
NITROGLYCERIN (2 patients)
PREDNISOLONE (2 patients)
PREDNISONE (2 patients)
SECTRAL (2 patients)
STILNOX (2 patients)
THEOPHYLLINE (2 patients)
TOPICAL ANTISEPTICS (2 patients)
ACENOCOUMAROL (1 patients)
ACENOCOUMAROL (ACENOCOUMAROL) (1 patients)
ACTIFED (1 patients)
AMILORIDE (1 patients)
AMILORIDE (AMILORIDE HYDROCHLORIDE) (1 patients)
ARNESP (1 patients)
ATENOLOL (1 patients)
ATORVASTATIN CALCIUM (1 patients)
BEMYLID (1 patients)
BETAMETHASONE DIPROPIIONATE (1 patients)
BETAMETHASONE DIPROPIONATE (1 patients)
CARBAMAZEPINE (1 patients)
CEFIXIME (1 patients)
CILAZAPRIL (1 patients)
CIPROFLOXACIN HCL (1 patients)
CIPROFLOXACIN IV (1 patients)
CISPLATIN (1 patients)
COPEGUS (1 patients)
DEXAMETHASONE ACETATE (1 patients)
DOXIUM (CALCIUM DOBESILATE) (1 patients)
ETHYOL (1 patients)
ETOPOSIDE (1 patients)
FENTANYL-100 (1 patients)
FILGRASTIM (FILGRASTIM) (1 patients)
FINASTERIDE (1 patients)
GEMZAR (1 patients)
GLIBENCLAMIDE (1 patients)
GLIMEPIRIDE (1 patients)
HEMERAN GEL (HEPARINOID) (1 patients)
HUMAN INSULIN (1 patients)
INSULIN ACTRAPID HUMAN (1 patients)
INTRON A (1 patients)
IRINOTECAN HCL (1 patients)
L-THYROXIN (1 patients)
LACIDIPINE (1 patients)
LACIDIPINE (LACIDIPINE) (1 patients)
MAGNESIUM OXIDE (MAGNESIUM OXIDE) (1 patients)
METHOTREXATE (1 patients)
MS CONTIN (1 patients)
OXYCODONE HCL (1 patients)
PEG-INTRON (1 patients)
PHENYTOIN (1 patients)
PRAVASTATIN (1 patients)
PRAVASTATIN SODIUM (1 patients)
PREDNISONE TAB (1 patients)
RADIATION THERAPY (1 patients)
REBETOL (1 patients)
RIBAVIRIN (1 patients)
TAREG (1 patients)
TOPICAL MEDICATIONS (FOR PSORIASIS) (1 patients)
ZETIA (1 patients)
Most common side effects for patients taking L-THYROXIN:
DIZZINESS (39 patients)
DRUG INTERACTION (36 patients)
NAUSEA (34 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (26 patients)
DEPRESSION (25 patients)
FATIGUE (23 patients)
DYSPNOEA (23 patients)
ANAEMIA (22 patients)
VOMITING (22 patients)
PYREXIA (22 patients)
GASTRITIS (20 patients)
HYPERTENSION (20 patients)
RENAL FAILURE (19 patients)
THROMBOCYTOPENIA (18 patients)
DIARRHOEA (18 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (16 patients)
HYPERTENSIVE CRISIS (15 patients)
ERYTHEMA (15 patients)
LEUKOPENIA (15 patients)
ASTHENIA (15 patients)
ABDOMINAL PAIN (14 patients)
SYNCOPE (14 patients)
FALL (14 patients)
CONDITION AGGRAVATED (14 patients)
HEPATIC FAILURE (14 patients)
LOSS OF CONSCIOUSNESS (14 patients)
RESPIRATORY FAILURE (14 patients)
SOMNOLENCE (14 patients)
CHEST PAIN (14 patients)
HERPES ZOSTER (13 patients)
MITRAL VALVE INCOMPETENCE (13 patients)
CARDIAC FAILURE (13 patients)
HAEMATURIA (12 patients)
HYPOKALAEMIA (12 patients)
TACHYCARDIA (12 patients)
TRANSIENT ISCHAEMIC ATTACK (12 patients)
C-REACTIVE PROTEIN INCREASED (12 patients)
PNEUMONIA (12 patients)
RASH (12 patients)
BLOOD CREATININE INCREASED (11 patients)
HEADACHE (11 patients)
DRUG INEFFECTIVE (11 patients)
CEREBROVASCULAR ACCIDENT (11 patients)
CIRCULATORY COLLAPSE (11 patients)
LYMPHADENOPATHY (10 patients)
RENAL FAILURE ACUTE (10 patients)
HYPERHIDROSIS (10 patients)
ATRIAL FIBRILLATION (10 patients)
PAIN IN EXTREMITY (10 patients)
DUODENITIS (10 patients)
HYPOTENSION (10 patients)
CEREBRAL INFARCTION (10 patients)
SLEEP APNOEA SYNDROME (10 patients)
STAPHYLOCOCCAL INFECTION (10 patients)
GASTROOESOPHAGEAL REFLUX DISEASE (9 patients)
DEHYDRATION (9 patients)
CONSTIPATION (9 patients)
ANXIETY (9 patients)
AORTIC VALVE INCOMPETENCE (9 patients)
MALIGNANT NEOPLASM PROGRESSION (9 patients)
UPPER RESPIRATORY TRACT INFECTION (9 patients)
VERTIGO (9 patients)
CHILLS (9 patients)
SEPSIS (9 patients)
ILEUS (8 patients)
GENERALISED ANXIETY DISORDER (8 patients)
STOMATITIS (8 patients)
LEUKOCYTOSIS (8 patients)
AGGRESSION (8 patients)
AGITATION (8 patients)
ANGINA PECTORIS (8 patients)
ENDOCARDITIS (8 patients)
MIGRAINE WITH AURA (8 patients)
AORTIC VALVE SCLEROSIS (8 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (8 patients)
ASTHMA (8 patients)
PANIC DISORDER (8 patients)
RESTLESSNESS (8 patients)
STATUS EPILEPTICUS (8 patients)
LACUNAR INFARCTION (8 patients)
TENSION HEADACHE (8 patients)
THALAMUS HAEMORRHAGE (8 patients)
BLOOD GLUCOSE INCREASED (8 patients)
MITRAL VALVE CALCIFICATION (8 patients)
TREMOR (8 patients)
CORONARY ARTERY DISEASE (8 patients)
NON-CARDIAC CHEST PAIN (8 patients)
BRADYCARDIA (8 patients)
MYALGIA (8 patients)
GALLBLADDER DISORDER (8 patients)
BRONCHITIS (8 patients)
CATARACT (8 patients)
HYPOACUSIS (8 patients)
CHOLELITHIASIS (8 patients)
IRRITABLE BOWEL SYNDROME (8 patients)
CHRONIC FATIGUE SYNDROME (8 patients)
HYPOTHYROIDISM (7 patients)
PRURITUS (7 patients)
THYROIDECTOMY (7 patients)
ALANINE AMINOTRANSFERASE INCREASED (7 patients)
ALOPECIA (7 patients)
ARTHRALGIA (7 patients)
DYSPHAGIA (7 patients)
INFECTION (7 patients)
PAIN (7 patients)
BLOOD UREA INCREASED (7 patients)
CONFUSIONAL STATE (7 patients)
GRAND MAL CONVULSION (7 patients)
HYPONATRAEMIA (7 patients)
CEREBRAL HAEMORRHAGE (7 patients)
INSOMNIA (7 patients)
DISTURBANCE IN ATTENTION (6 patients)
INFLUENZA LIKE ILLNESS (6 patients)
PARKINSONISM (6 patients)
DECREASED APPETITE (6 patients)
LARYNGITIS (6 patients)
SPLENOMEGALY (6 patients)
VISUAL DISTURBANCE (6 patients)
ANAPHYLACTIC REACTION (6 patients)
ARRHYTHMIA (6 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (6 patients)
DRUG TOXICITY (6 patients)
PULMONARY EMBOLISM (6 patients)
CONVULSION (6 patients)
BALANCE DISORDER (6 patients)
BLOOD BILIRUBIN INCREASED (6 patients)
BLOOD CREATINE PHOSPHOKINASE INCREASED (6 patients)
BLOOD CREATINE PHOSPHOKINASE MB INCREASED (6 patients)
MEDULLARY THYROID CANCER (6 patients)
MUCOSAL INFLAMMATION (6 patients)
BLOOD THYROID STIMULATING HORMONE INCREASED (6 patients)
URINARY TRACT INFECTION (6 patients)
BUNDLE BRANCH BLOCK LEFT (6 patients)
RESPIRATORY DEPRESSION (6 patients)
SLEEP DISORDER (6 patients)
SUICIDE ATTEMPT (6 patients)
TRANSAMINASES INCREASED (5 patients)
MALAISE (5 patients)
JAUNDICE (5 patients)
EXOSTOSIS (5 patients)
APPETITE DISORDER (5 patients)
NEUTROPENIA (5 patients)
HAEMOGLOBIN DECREASED (5 patients)
TUBO-OVARIAN ABSCESS (5 patients)
MYOCARDIAL INFARCTION (5 patients)
ATRIOVENTRICULAR BLOCK SECOND DEGREE (5 patients)
HYPERSENSITIVITY (5 patients)
BACK PAIN (5 patients)
IMPAIRED HEALING (5 patients)
INJURY (5 patients)
BLOOD CHOLESTEROL INCREASED (5 patients)
BLOOD POTASSIUM DECREASED (5 patients)
BLOOD PRESSURE INCREASED (5 patients)
TOXIC EPIDERMAL NECROLYSIS (5 patients)
GAIT DISTURBANCE (5 patients)
OSTEONECROSIS (5 patients)
NERVOUSNESS (5 patients)
WEIGHT DECREASED (5 patients)
OSTEOARTHRITIS (5 patients)
VENTRICULAR HYPERTROPHY (5 patients)
DERMATITIS ALLERGIC (5 patients)
BRAIN OEDEMA (5 patients)
URTICARIA (5 patients)
WEIGHT INCREASED (5 patients)
DRUG EXPOSURE DURING PREGNANCY (5 patients)
BRONCHITIS CHRONIC (5 patients)
PLEURAL EFFUSION (5 patients)
PLATELET COUNT DECREASED (5 patients)
DYSARTHRIA (5 patients)
HYPERTHYROIDISM (5 patients)
RASH MACULO-PAPULAR (5 patients)
HYPOKINESIA (5 patients)
DRUG HYPERSENSITIVITY (5 patients)
HYPERGLYCAEMIA (5 patients)
WOUND DEHISCENCE (5 patients)
SUDDEN DEATH (5 patients)
COGNITIVE DISORDER (5 patients)
PAPILLARY THYROID CANCER (4 patients)
ACTIVITIES OF DAILY LIVING IMPAIRED (4 patients)
POLYNEUROPATHY (4 patients)
ANGER (4 patients)
ANOREXIA (4 patients)
LABILE HYPERTENSION (4 patients)
APHASIA (4 patients)
APLASIA PURE RED CELL (4 patients)
WRONG TECHNIQUE IN DRUG USAGE PROCESS (4 patients)
ERYSIPELAS (4 patients)
ENCEPHALOPATHY (4 patients)
INJECTION SITE REACTION (4 patients)
BINOCULAR EYE MOVEMENT DISORDER (4 patients)
FEBRILE NEUTROPENIA (4 patients)
STRABISMUS (4 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (4 patients)
LARGE INTESTINE PERFORATION (4 patients)
RHEUMATOID ARTHRITIS (4 patients)
LIVER FUNCTION TEST ABNORMAL (4 patients)
RHINITIS SEASONAL (4 patients)
BLOOD PRESSURE INADEQUATELY CONTROLLED (4 patients)
DIABETES MELLITUS (4 patients)
DIFFICULTY IN WALKING (4 patients)
PARAESTHESIA (4 patients)
PANCREATITIS ACUTE (4 patients)
DRUG ABUSE (4 patients)
CARDIAC ARREST (4 patients)
PULMONARY HYPERTENSION (4 patients)
INFLAMMATION (4 patients)
SUPRAVENTRICULAR EXTRASYSTOLES (4 patients)
STEVENS-JOHNSON SYNDROME (4 patients)
ELECTROCARDIOGRAM ST SEGMENT ELEVATION (4 patients)
SEROTONIN SYNDROME (4 patients)

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Recent FactMed Activity for L-THYROXIN


Issue Description / Topic Timestamp
QUESTION
SEROTONIN SYNDROME
Your calculation of 5.5556% for L-Thyroxine having seratonin syndrome as a side effect seems incorrect. 2015-11-24 10:26:55
QUESTION
THROMBOCYTOPENIA
Can thyroxine cause thrombocytopenia 2016-09-11 01:22:24

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