About this FactMed analysis covering adverse side effect reports of LACIDIPINE patients who developed ACANTHOLYSIS.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 1 individuals taking LACIDIPINE reported ACANTHOLYSIS to the FDA. A total of 272 LACIDIPINE drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between LACIDIPINE and ACANTHOLYSIS. In doing so, we compare LACIDIPINE with other drugs that cause ACANTHOLYSIS, to help you evaluate whether or not LACIDIPINE causes ACANTHOLYSIS. Likewise, this page shows the most highly-reported side effects of LACIDIPINE, so you can see if ACANTHOLYSIS ranks among LACIDIPINE's most well-known side effects.
Summary Statistics
Reports of LACIDIPINE causing ACANTHOLYSIS: 1
Reports of any side effect of LACIDIPINE : 272
Percentage of LACIDIPINE patients where ACANTHOLYSIS is a reported side effect: 0.3676%

FDA reports of any drug causing ACANTHOLYSIS : 33
Average percentage for all medicated patients where ACANTHOLYSIS is reported as a complication: 0.0002%

Physician opinion on LACIDIPINE as adverse event culprit:

Overall opinion for all reports of this drug:
Most frequent diagnoses/indications for prescribing LACIDIPINE:
HYPERTENSION ( 52 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 17 patients )
DRUG USE FOR UNKNOWN INDICATION ( 15 patients )
OVERDOSE ( 10 patients )
BLOOD PRESSURE INCREASED ( 3 patients )
BLOOD PRESSURE ( 3 patients )
CEREBROVASCULAR DISORDER ( 2 patients )
CORONARY ARTERY DISEASE ( 1 patients )
DIABETES MELLITUS ( 1 patients )
ESSENTIAL HYPERTENSION ( 1 patients )
( 0 patients )
Drugs with high FDA adverse event association with ACANTHOLYSIS:

AMBIEN (10 patients)
ABRAXANE (9 patients)
ACIPHEX (9 patients)
AMPICILLIN (9 patients)
ASPIRIN (9 patients)
ATIVAN (9 patients)
AVASTIN (9 patients)
CYMBALTA (9 patients)
LEVOTHYROXINE SODIUM (9 patients)
NORCO (9 patients)
RADIATION (9 patients)
VICODIN (9 patients)
XELODA (9 patients)
ZOLOFT (9 patients)
ZOMETA (9 patients)
ZOFRAN (8 patients)
ARANESP (7 patients)
CAPECITABINE (7 patients)
CEFTRIAXONE (7 patients)
CEPHALEXIN (7 patients)
CIPROFLOXACIN (7 patients)
COLACE (7 patients)
DILAUDID (7 patients)
DOXIL (7 patients)
FEMARA (7 patients)
HYDROCODONE BITARTRATE AND ACETAMINOPHEN (7 patients)
KEFLEX (7 patients)
LASIX (7 patients)
LORAZEPAM (7 patients)
NAPROSYN (7 patients)
NEULASTA (7 patients)
NIACIN (7 patients)
PERCOCET (7 patients)
PROVIGIL (7 patients)
RITALIN (7 patients)
SYNTHROID (7 patients)
TAXOTERE (7 patients)
VANCOMYCIN (7 patients)
VANCOMYCIN HCL (7 patients)
DEXAMETHASONE (6 patients)
FENTANYL (6 patients)
CYCLOSPORINE (4 patients)
PLAVIX (4 patients)
RELAFEN (4 patients)
ACETYLSALICYLIC ACID SRT (3 patients)
ACYCLOVIR (3 patients)
AMITIZA (3 patients)
NABUMETONE (3 patients)
NEXIUM (3 patients)
NIFEDIPINE (3 patients)
XIFAXAN (3 patients)
ALDACTAZIDE (2 patients)
AMLOR (2 patients)
AZATHIOPRINE (2 patients)
CLINDAMYCIN (2 patients)
COZAAR (2 patients)
DEPAKENE (2 patients)
DEPAS (2 patients)
DIGOXIN (2 patients)
DIPYRIDAMOL (2 patients)
EMPYNASE (2 patients)
ENALAPRIL MALEATE (2 patients)
ETRETINATE (2 patients)
FRACTAL (2 patients)
FUCIDIN CREAM (2 patients)
FUROSEMIDE (2 patients)
GAMUNEX (2 patients)
GLUCOR (2 patients)
HALCION (2 patients)
ISOSORBIDE MONONITRATE (2 patients)
LAMICTAL (2 patients)
LAXOBERON (2 patients)
LEVEMIR (2 patients)
MAGLAX (2 patients)
METHYLPREDNISOLONE (2 patients)
MINOCYCLIN (2 patients)
MOPRAL (2 patients)
MORPHINE (2 patients)
NITROGLYCERIN (2 patients)
PREDNISOLONE (2 patients)
PREDNISONE (2 patients)
SECTRAL (2 patients)
STILNOX (2 patients)
THEOPHYLLINE (2 patients)
TOPICAL ANTISEPTICS (2 patients)
ACENOCOUMAROL (1 patients)
ACENOCOUMAROL (ACENOCOUMAROL) (1 patients)
ACTIFED (1 patients)
AMILORIDE (1 patients)
AMILORIDE (AMILORIDE HYDROCHLORIDE) (1 patients)
ARNESP (1 patients)
ATENOLOL (1 patients)
ATORVASTATIN CALCIUM (1 patients)
BEMYLID (1 patients)
BETAMETHASONE DIPROPIIONATE (1 patients)
BETAMETHASONE DIPROPIONATE (1 patients)
CARBAMAZEPINE (1 patients)
CEFIXIME (1 patients)
CILAZAPRIL (1 patients)
CIPROFLOXACIN HCL (1 patients)
CIPROFLOXACIN IV (1 patients)
CISPLATIN (1 patients)
COPEGUS (1 patients)
DEXAMETHASONE ACETATE (1 patients)
DOXIUM (CALCIUM DOBESILATE) (1 patients)
ETHYOL (1 patients)
ETOPOSIDE (1 patients)
FENTANYL-100 (1 patients)
FILGRASTIM (FILGRASTIM) (1 patients)
FINASTERIDE (1 patients)
GEMZAR (1 patients)
GLIBENCLAMIDE (1 patients)
GLIMEPIRIDE (1 patients)
HEMERAN GEL (HEPARINOID) (1 patients)
HUMAN INSULIN (1 patients)
INSULIN ACTRAPID HUMAN (1 patients)
INTRON A (1 patients)
IRINOTECAN HCL (1 patients)
L-THYROXIN (1 patients)
LACIDIPINE (1 patients)
LACIDIPINE (LACIDIPINE) (1 patients)
MAGNESIUM OXIDE (MAGNESIUM OXIDE) (1 patients)
METHOTREXATE (1 patients)
MS CONTIN (1 patients)
OXYCODONE HCL (1 patients)
PEG-INTRON (1 patients)
PHENYTOIN (1 patients)
PRAVASTATIN (1 patients)
PRAVASTATIN SODIUM (1 patients)
PREDNISONE TAB (1 patients)
RADIATION THERAPY (1 patients)
REBETOL (1 patients)
RIBAVIRIN (1 patients)
TAREG (1 patients)
TOPICAL MEDICATIONS (FOR PSORIASIS) (1 patients)
ZETIA (1 patients)
Most common side effects for patients taking LACIDIPINE:
HYPOTENSION (40 patients)
CAROTID ARTERY STENOSIS (24 patients)
DRUG INTERACTION (23 patients)
PERIPHERAL ARTERIAL OCCLUSIVE DISEASE (22 patients)
ARTERIOVENOUS FISTULA THROMBOSIS (22 patients)
RHABDOMYOLYSIS (22 patients)
RENAL FAILURE (22 patients)
FEMORAL ARTERY OCCLUSION (22 patients)
ISCHAEMIC STROKE (22 patients)
DEVICE MALFUNCTION (20 patients)
DYSPNOEA (20 patients)
RENAL FAILURE ACUTE (19 patients)
CARDIAC ARREST (16 patients)
METABOLIC ACIDOSIS (14 patients)
SHOCK (14 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (13 patients)
OVERDOSE (13 patients)
HYPOXIA (13 patients)
TOXICITY TO VARIOUS AGENTS (12 patients)
BRADYCARDIA (11 patients)
ATRIAL FIBRILLATION (10 patients)
CEREBROVASCULAR ACCIDENT (10 patients)
ALANINE AMINOTRANSFERASE INCREASED (9 patients)
MULTI-ORGAN FAILURE (9 patients)
MALAISE (9 patients)
GUILLAIN-BARRE SYNDROME (9 patients)
SYNCOPE (9 patients)
APHASIA (8 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (8 patients)
ASTHENIA (8 patients)
ATRIOVENTRICULAR BLOCK COMPLETE (8 patients)
BLOOD CREATINE PHOSPHOKINASE INCREASED (8 patients)
FALL (8 patients)
MUSCULAR WEAKNESS (8 patients)
HYPERTENSION (8 patients)
LOSS OF CONSCIOUSNESS (7 patients)
RASH GENERALISED (7 patients)
DIZZINESS (7 patients)
CARDIAC FAILURE (6 patients)
EAR HAEMORRHAGE (6 patients)
HAEMODYNAMIC INSTABILITY (6 patients)
HEADACHE (6 patients)
HEMIPARESIS (6 patients)
BLOOD GLUCOSE INCREASED (5 patients)
VENTRICULAR HYPOKINESIA (5 patients)
BONE DISORDER (5 patients)
BREAST CANCER (5 patients)
CONFUSIONAL STATE (5 patients)
DEATH (5 patients)
DIABETES MELLITUS (5 patients)
EYE PAIN (5 patients)
HAEMORRHAGE (5 patients)
JAW DISORDER (5 patients)
IMPAIRED HEALING (5 patients)
VISUAL IMPAIRMENT (4 patients)
ALOPECIA (4 patients)
ANAEMIA HAEMOLYTIC AUTOIMMUNE (4 patients)
NAUSEA (4 patients)
MYOCARDIAL INFARCTION (4 patients)
ATAXIA (4 patients)
BACK PAIN (4 patients)
BLOOD CREATININE INCREASED (4 patients)
CARDIOMEGALY (4 patients)
SOMNOLENCE (4 patients)
TRANSIENT ISCHAEMIC ATTACK (4 patients)
CYTOMEGALOVIRUS INFECTION (4 patients)
DRUG INEFFECTIVE (4 patients)
VITAMIN D DEFICIENCY (4 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (4 patients)
OSTEONECROSIS (4 patients)
PRURITUS (4 patients)
PNEUMONIA (4 patients)
HYPERCALCAEMIA (4 patients)
HYPOKALAEMIA (4 patients)
HYPOPHOSPHATAEMIA (4 patients)
AGGRESSION (3 patients)
PYREXIA (3 patients)
ARTHROPATHY (3 patients)
OEDEMA PERIPHERAL (3 patients)
TREMOR (3 patients)
BURNING SENSATION (3 patients)
CARDIAC FAILURE CONGESTIVE (3 patients)
CARDIOGENIC SHOCK (3 patients)
POLYURIA (3 patients)
CEREBRAL HAEMORRHAGE (3 patients)
THROMBOCYTOPENIA (3 patients)
CORONARY ARTERY STENOSIS (3 patients)
SUBDURAL HAEMATOMA (3 patients)
URTICARIA (3 patients)
SKULL FRACTURE (3 patients)
NASAL SEPTUM DISORDER (3 patients)
JOINT SWELLING (3 patients)
NEUROLOGICAL SYMPTOM (3 patients)
HAEMORRHAGE INTRACRANIAL (3 patients)
HEAD INJURY (3 patients)
HEPATOCELLULAR DAMAGE (3 patients)
HYPERKALAEMIA (3 patients)
HYPOCALCIURIA (3 patients)
HYPONATRAEMIA (3 patients)
SKIN LESION (3 patients)
INCLUSION BODY MYOSITIS (3 patients)
JAUNDICE (3 patients)
INTERSTITIAL LUNG DISEASE (3 patients)
ORAL CANDIDIASIS (2 patients)
ACIDOSIS (2 patients)
PROTHROMBIN TIME PROLONGED (2 patients)
SPLENITIS (2 patients)
PARAPSORIASIS (2 patients)
ACUTE PULMONARY OEDEMA (2 patients)
ACUTE RESPIRATORY FAILURE (2 patients)
LEUKOPENIA (2 patients)
SUDDEN DEATH (2 patients)
ORAL HERPES (2 patients)
AGITATION (2 patients)
ANAEMIA (2 patients)
URINARY TRACT INFECTION (2 patients)
ARTERIOSCLEROSIS (2 patients)
ARTHRALGIA (2 patients)
ASPHYXIA (2 patients)
MASTICATION DISORDER (2 patients)
PAIN IN EXTREMITY (2 patients)
ONYCHOLYSIS (2 patients)
PROTEINURIA (2 patients)
RENAL IMPAIRMENT (2 patients)
LIVER FUNCTION TEST ABNORMAL (2 patients)
STOMATITIS (2 patients)
BLOOD GLUCAGON ABNORMAL (2 patients)
VENTRICULAR TACHYCARDIA (2 patients)
BLOOD POTASSIUM DECREASED (2 patients)
BLOOD PRESSURE DECREASED (2 patients)
WHEEZING (2 patients)
BLOOD PRESSURE INCREASED (2 patients)
TACHYCARDIA (2 patients)
KIDNEY TRANSPLANT REJECTION (2 patients)
BRADYARRHYTHMIA (2 patients)
BRAIN STEM ISCHAEMIA (2 patients)
MYOPATHY (2 patients)
LARYNGEAL OEDEMA (2 patients)
PARAESTHESIA (2 patients)
CARDIAC HYPERTROPHY (2 patients)
NEUROTOXICITY (2 patients)
CARDIO-RESPIRATORY ARREST (2 patients)
RESPIRATORY DISTRESS (2 patients)
CEREBRAL DISORDER (2 patients)
CHEST PAIN (2 patients)
PULMONARY HAEMORRHAGE (2 patients)
OESOPHAGITIS (2 patients)
COLON CANCER (2 patients)
LUNG NEOPLASM MALIGNANT (2 patients)
CONDITION AGGRAVATED (2 patients)
TRANSAMINASES INCREASED (2 patients)
COORDINATION ABNORMAL (2 patients)
URINARY RETENTION (2 patients)
CYSTITIS NONINFECTIVE (2 patients)
DEHYDRATION (2 patients)
VISION BLURRED (2 patients)
DERMATITIS ALLERGIC (2 patients)
VENOUS THROMBOSIS LIMB (2 patients)
DISABILITY (2 patients)
VOMITING (2 patients)
LOWER RESPIRATORY TRACT INFECTION (2 patients)
DYSPHAGIA (2 patients)
EJECTION FRACTION DECREASED (2 patients)
LIVER INJURY (2 patients)
ELECTROCARDIOGRAM QT PROLONGED (2 patients)
EMPHYSEMA (2 patients)
EPISTAXIS (2 patients)
ERYTHROPENIA (2 patients)
KNEE OPERATION (2 patients)
EXTRAPYRAMIDAL DISORDER (2 patients)
KETOACIDOSIS (2 patients)
MUSCLE SPASMS (2 patients)
MULTIPLE DRUG OVERDOSE (2 patients)
MOVEMENT DISORDER (2 patients)
FATIGUE (2 patients)
MYOCARDIAL FIBROSIS (2 patients)
NEPHRITIS INTERSTITIAL (2 patients)
NASAL SEPTAL OPERATION (2 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (2 patients)
LYMPHOPENIA (2 patients)
GASTROENTERITIS (2 patients)
PEMPHIGUS (2 patients)
GOITRE (2 patients)
NEUROLOGICAL INFECTION (2 patients)
HAEMOGLOBIN DECREASED (2 patients)
RED BLOOD CELL SEDIMENTATION RATE INCREASED (2 patients)
HEPATIC FAILURE (2 patients)
HEPATITIS ACUTE (2 patients)
RETINAL VEIN OCCLUSION (2 patients)
HIATUS HERNIA (2 patients)
RENAL INJURY (2 patients)
RENAL DISORDER (2 patients)
PERIPHERAL SENSORY NEUROPATHY (2 patients)
HYPERHIDROSIS (2 patients)
NERVOUS SYSTEM DISORDER (2 patients)
HYPERTHERMIA MALIGNANT (2 patients)
SYSTEMIC LUPUS ERYTHEMATOSUS (2 patients)
TONGUE OEDEMA (2 patients)
SEPSIS (2 patients)
INSOMNIA (2 patients)
INTENTIONAL OVERDOSE (2 patients)
INTERNATIONAL NORMALISED RATIO INCREASED (2 patients)
ISCHAEMIC CARDIOMYOPATHY (2 patients)
BLOOD POTASSIUM INCREASED (1 patients)
BLOOD PRESSURE DIASTOLIC DECREASED (1 patients)
DIABETES MELLITUS INADEQUATE CONTROL (1 patients)
DISEASE PROGRESSION (1 patients)
DRUG WITHDRAWAL SYNDROME (1 patients)
DRY MOUTH (1 patients)
DRY THROAT (1 patients)

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