About this FactMed analysis covering adverse side effect reports of REBETOL patients who developed ACANTHOLYSIS.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 1 individuals taking REBETOL reported ACANTHOLYSIS to the FDA. A total of 11331 REBETOL drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between REBETOL and ACANTHOLYSIS. In doing so, we compare REBETOL with other drugs that cause ACANTHOLYSIS, to help you evaluate whether or not REBETOL causes ACANTHOLYSIS. Likewise, this page shows the most highly-reported side effects of REBETOL, so you can see if ACANTHOLYSIS ranks among REBETOL's most well-known side effects.
Summary Statistics
Reports of REBETOL causing ACANTHOLYSIS: 1
Reports of any side effect of REBETOL : 11331
Percentage of REBETOL patients where ACANTHOLYSIS is a reported side effect: 0.0088%

FDA reports of any drug causing ACANTHOLYSIS : 33
Average percentage for all medicated patients where ACANTHOLYSIS is reported as a complication: 0.0002%

Physician opinion on REBETOL as adverse event culprit:

Overall opinion for all reports of this drug:
Most frequent diagnoses/indications for prescribing REBETOL:
HEPATITIS C ( 7312 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 132 patients )
DRUG USE FOR UNKNOWN INDICATION ( 124 patients )
HEPATITIS ( 64 patients )
CHRONIC HEPATITIS ( 49 patients )
HEPATIC CIRRHOSIS ( 29 patients )
HEPATITIS B ( 28 patients )
HEPATITIS CHRONIC ACTIVE ( 13 patients )
HEPATITIS C VIRUS ( 12 patients )
HEPATITIS VIRAL ( 12 patients )
DRUG EXPOSURE DURING PREGNANCY ( 11 patients )
HEPATITIS C VIRUS TEST POSITIVE ( 5 patients )
PREGNANCY ( 4 patients )
PROPHYLAXIS ( 4 patients )
VIRAEMIA ( 4 patients )
HEPATITIS C VIRUS TEST ( 4 patients )
HIV INFECTION ( 3 patients )
ANTIVIRAL PROPHYLAXIS ( 3 patients )
ADENOVIRUS INFECTION ( 3 patients )
DISEASE RECURRENCE ( 3 patients )
HEPATITIS ACUTE ( 2 patients )
CRYOGLOBULINAEMIA ( 2 patients )
ENCEPHALITIS ( 2 patients )
HEPATITIS C ANTIBODY POSITIVE ( 2 patients )
HEPATITIS CHOLESTATIC ( 2 patients )
H1N1 INFLUENZA ( 2 patients )
VIRAL HEPATITIS CARRIER ( 2 patients )
HEPATIC NEOPLASM MALIGNANT ( 1 patients )
MATERNAL EXPOSURE DURING PREGNANCY ( 1 patients )
ORGAN TRANSPLANT ( 1 patients )
PNEUMONIA PARAINFLUENZAE VIRAL ( 1 patients )
HEPATITIS C POSITIVE ( 1 patients )
CYTOLYTIC HEPATITIS ( 1 patients )
UNEVALUABLE EVENT ( 1 patients )
VIRAL INFECTION ( 1 patients )
LIVER DISORDER ( 1 patients )
OEDEMA PERIPHERAL ( 1 patients )
PATERNAL DRUGS AFFECTING FOETUS ( 1 patients )
POST PROCEDURAL COMPLICATION ( 1 patients )
HEPATITIS C RNA POSITIVE ( 1 patients )
CRYOGLOBULINS ( 1 patients )
RESPIRATORY SYNCYTIAL VIRUS INFECTION ( 1 patients )
VASCULITIS ( 1 patients )
HEPATITIS POST TRANSFUSION ( 1 patients )
( 0 patients )
Drugs with high FDA adverse event association with ACANTHOLYSIS:

AMBIEN (10 patients)
ABRAXANE (9 patients)
ACIPHEX (9 patients)
AMPICILLIN (9 patients)
ASPIRIN (9 patients)
ATIVAN (9 patients)
AVASTIN (9 patients)
CYMBALTA (9 patients)
LEVOTHYROXINE SODIUM (9 patients)
NORCO (9 patients)
RADIATION (9 patients)
VICODIN (9 patients)
XELODA (9 patients)
ZOLOFT (9 patients)
ZOMETA (9 patients)
ZOFRAN (8 patients)
ARANESP (7 patients)
CAPECITABINE (7 patients)
CEFTRIAXONE (7 patients)
CEPHALEXIN (7 patients)
CIPROFLOXACIN (7 patients)
COLACE (7 patients)
DILAUDID (7 patients)
DOXIL (7 patients)
FEMARA (7 patients)
HYDROCODONE BITARTRATE AND ACETAMINOPHEN (7 patients)
KEFLEX (7 patients)
LASIX (7 patients)
LORAZEPAM (7 patients)
NAPROSYN (7 patients)
NEULASTA (7 patients)
NIACIN (7 patients)
PERCOCET (7 patients)
PROVIGIL (7 patients)
RITALIN (7 patients)
SYNTHROID (7 patients)
TAXOTERE (7 patients)
VANCOMYCIN (7 patients)
VANCOMYCIN HCL (7 patients)
DEXAMETHASONE (6 patients)
FENTANYL (6 patients)
CYCLOSPORINE (4 patients)
PLAVIX (4 patients)
RELAFEN (4 patients)
ACETYLSALICYLIC ACID SRT (3 patients)
ACYCLOVIR (3 patients)
AMITIZA (3 patients)
NABUMETONE (3 patients)
NEXIUM (3 patients)
NIFEDIPINE (3 patients)
XIFAXAN (3 patients)
ALDACTAZIDE (2 patients)
AMLOR (2 patients)
AZATHIOPRINE (2 patients)
CLINDAMYCIN (2 patients)
COZAAR (2 patients)
DEPAKENE (2 patients)
DEPAS (2 patients)
DIGOXIN (2 patients)
DIPYRIDAMOL (2 patients)
EMPYNASE (2 patients)
ENALAPRIL MALEATE (2 patients)
ETRETINATE (2 patients)
FRACTAL (2 patients)
FUCIDIN CREAM (2 patients)
FUROSEMIDE (2 patients)
GAMUNEX (2 patients)
GLUCOR (2 patients)
HALCION (2 patients)
ISOSORBIDE MONONITRATE (2 patients)
LAMICTAL (2 patients)
LAXOBERON (2 patients)
LEVEMIR (2 patients)
MAGLAX (2 patients)
METHYLPREDNISOLONE (2 patients)
MINOCYCLIN (2 patients)
MOPRAL (2 patients)
MORPHINE (2 patients)
NITROGLYCERIN (2 patients)
PREDNISOLONE (2 patients)
PREDNISONE (2 patients)
SECTRAL (2 patients)
STILNOX (2 patients)
THEOPHYLLINE (2 patients)
TOPICAL ANTISEPTICS (2 patients)
ACENOCOUMAROL (1 patients)
ACENOCOUMAROL (ACENOCOUMAROL) (1 patients)
ACTIFED (1 patients)
AMILORIDE (1 patients)
AMILORIDE (AMILORIDE HYDROCHLORIDE) (1 patients)
ARNESP (1 patients)
ATENOLOL (1 patients)
ATORVASTATIN CALCIUM (1 patients)
BEMYLID (1 patients)
BETAMETHASONE DIPROPIIONATE (1 patients)
BETAMETHASONE DIPROPIONATE (1 patients)
CARBAMAZEPINE (1 patients)
CEFIXIME (1 patients)
CILAZAPRIL (1 patients)
CIPROFLOXACIN HCL (1 patients)
CIPROFLOXACIN IV (1 patients)
CISPLATIN (1 patients)
COPEGUS (1 patients)
DEXAMETHASONE ACETATE (1 patients)
DOXIUM (CALCIUM DOBESILATE) (1 patients)
ETHYOL (1 patients)
ETOPOSIDE (1 patients)
FENTANYL-100 (1 patients)
FILGRASTIM (FILGRASTIM) (1 patients)
FINASTERIDE (1 patients)
GEMZAR (1 patients)
GLIBENCLAMIDE (1 patients)
GLIMEPIRIDE (1 patients)
HEMERAN GEL (HEPARINOID) (1 patients)
HUMAN INSULIN (1 patients)
INSULIN ACTRAPID HUMAN (1 patients)
INTRON A (1 patients)
IRINOTECAN HCL (1 patients)
L-THYROXIN (1 patients)
LACIDIPINE (1 patients)
LACIDIPINE (LACIDIPINE) (1 patients)
MAGNESIUM OXIDE (MAGNESIUM OXIDE) (1 patients)
METHOTREXATE (1 patients)
MS CONTIN (1 patients)
OXYCODONE HCL (1 patients)
PEG-INTRON (1 patients)
PHENYTOIN (1 patients)
PRAVASTATIN (1 patients)
PRAVASTATIN SODIUM (1 patients)
PREDNISONE TAB (1 patients)
RADIATION THERAPY (1 patients)
REBETOL (1 patients)
RIBAVIRIN (1 patients)
TAREG (1 patients)
TOPICAL MEDICATIONS (FOR PSORIASIS) (1 patients)
ZETIA (1 patients)
Most common side effects for patients taking REBETOL:
ANAEMIA (1759 patients)
HAEMOGLOBIN DECREASED (1005 patients)
NAUSEA (850 patients)
RASH (802 patients)
WHITE BLOOD CELL COUNT DECREASED (774 patients)
PLATELET COUNT DECREASED (742 patients)
DECREASED APPETITE (742 patients)
PYREXIA (726 patients)
MALAISE (685 patients)
VOMITING (596 patients)
WEIGHT DECREASED (575 patients)
FATIGUE (559 patients)
DEPRESSION (557 patients)
ASTHENIA (551 patients)
DEHYDRATION (481 patients)
DIZZINESS (439 patients)
HEADACHE (428 patients)
DIARRHOEA (418 patients)
NEUTROPHIL COUNT DECREASED (399 patients)
RENAL IMPAIRMENT (389 patients)
INSOMNIA (359 patients)
HYPERURICAEMIA (348 patients)
DYSPNOEA (339 patients)
LOSS OF CONSCIOUSNESS (336 patients)
RENAL DISORDER (330 patients)
ERYTHEMA (325 patients)
BLOOD CREATININE INCREASED (318 patients)
ANOREXIA (293 patients)
PRURITUS (291 patients)
DRUG ERUPTION (281 patients)
PAIN (278 patients)
CONDITION AGGRAVATED (256 patients)
ALANINE AMINOTRANSFERASE INCREASED (254 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (253 patients)
FALL (239 patients)
ANXIETY (237 patients)
ARTHRALGIA (230 patients)
PNEUMONIA (230 patients)
INFLUENZA LIKE ILLNESS (208 patients)
CHEST PAIN (204 patients)
THROMBOCYTOPENIA (202 patients)
CONFUSIONAL STATE (197 patients)
ALOPECIA (190 patients)
MYALGIA (187 patients)
PANCYTOPENIA (184 patients)
SYNCOPE (184 patients)
FEELING ABNORMAL (184 patients)
NEUTROPENIA (181 patients)
OEDEMA PERIPHERAL (181 patients)
BLOOD URIC ACID INCREASED (178 patients)
MEMORY IMPAIRMENT (174 patients)
ABDOMINAL PAIN (170 patients)
BACK PAIN (170 patients)
HYPOAESTHESIA (170 patients)
PAIN IN EXTREMITY (167 patients)
DRUG INEFFECTIVE (166 patients)
RED BLOOD CELL COUNT DECREASED (163 patients)
DYSGEUSIA (161 patients)
SUICIDAL IDEATION (157 patients)
BLOOD BILIRUBIN INCREASED (151 patients)
ASCITES (151 patients)
ERYTHEMA MULTIFORME (148 patients)
RENAL FAILURE (148 patients)
CHILLS (147 patients)
LEUKOPENIA (140 patients)
COUGH (140 patients)
IRRITABILITY (137 patients)
ABDOMINAL PAIN UPPER (136 patients)
CONVULSION (134 patients)
VISION BLURRED (133 patients)
CEREBRAL HAEMORRHAGE (133 patients)
RENAL FAILURE ACUTE (132 patients)
TREMOR (128 patients)
DRY MOUTH (124 patients)
URINARY TRACT INFECTION (123 patients)
DEPRESSIVE SYMPTOM (122 patients)
SEPSIS (121 patients)
HYPERTENSION (120 patients)
HEPATIC FAILURE (119 patients)
AMNESIA (118 patients)
PANCREATITIS ACUTE (116 patients)
CARDIAC FAILURE (114 patients)
HYPERHIDROSIS (114 patients)
GAIT DISTURBANCE (111 patients)
JAUNDICE (110 patients)
AGGRESSION (106 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (106 patients)
HYPOTHYROIDISM (106 patients)
CONSTIPATION (104 patients)
INJECTION SITE ERYTHEMA (103 patients)
SOMNOLENCE (102 patients)
HEPATIC CIRRHOSIS (101 patients)
BRONCHITIS (101 patients)
RETINOPATHY (101 patients)
EPISTAXIS (101 patients)
HAEMATEMESIS (101 patients)
HEPATITIS C (100 patients)
STOMATITIS (100 patients)
PLEURAL EFFUSION (100 patients)
PANCREATITIS (98 patients)
MUSCLE SPASMS (97 patients)
DRUG EXPOSURE DURING PREGNANCY (97 patients)
HYPOTENSION (96 patients)
BLOOD PRESSURE INCREASED (95 patients)
INTERSTITIAL LUNG DISEASE (95 patients)
HEPATIC ENCEPHALOPATHY (94 patients)
CELLULITIS (94 patients)
STEVENS-JOHNSON SYNDROME (93 patients)
HAEMATOCRIT DECREASED (93 patients)
BLOOD PRESSURE DECREASED (93 patients)
CEREBRAL INFARCTION (92 patients)
DIABETES MELLITUS (92 patients)
VISUAL ACUITY REDUCED (92 patients)
SKIN DISORDER (87 patients)
STAPHYLOCOCCAL INFECTION (87 patients)
HYPOKALAEMIA (87 patients)
LIVER DISORDER (87 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (85 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (84 patients)
HEPATIC FUNCTION ABNORMAL (84 patients)
PALPITATIONS (83 patients)
HYPERTHYROIDISM (82 patients)
CEREBROVASCULAR ACCIDENT (82 patients)
DISEASE RECURRENCE (82 patients)
BLOOD GLUCOSE INCREASED (81 patients)
SPEECH DISORDER (81 patients)
INFECTION (80 patients)
ORAL INTAKE REDUCED (79 patients)
HAEMOLYTIC ANAEMIA (78 patients)
BLOOD POTASSIUM DECREASED (77 patients)
DELIRIUM (77 patients)
LYMPHADENOPATHY (77 patients)
DEATH (76 patients)
PULMONARY EMBOLISM (76 patients)
TOXIC SKIN ERUPTION (75 patients)
HEART RATE INCREASED (75 patients)
ANGER (73 patients)
DRY SKIN (71 patients)
RASH GENERALISED (71 patients)
DYSPHAGIA (71 patients)
ABNORMAL BEHAVIOUR (69 patients)
PARAESTHESIA (69 patients)
MULTI-ORGAN FAILURE (69 patients)
ECZEMA (68 patients)
DRUG HYPERSENSITIVITY (68 patients)
INFLUENZA (67 patients)
CONTUSION (67 patients)
PULMONARY OEDEMA (66 patients)
SUICIDE ATTEMPT (66 patients)
MUSCULAR WEAKNESS (66 patients)
DISTURBANCE IN ATTENTION (66 patients)
ABDOMINAL DISTENSION (65 patients)
RETINAL HAEMORRHAGE (65 patients)
DYSARTHRIA (65 patients)
PHARYNGOLARYNGEAL PAIN (63 patients)
BALANCE DISORDER (63 patients)
ATRIAL FIBRILLATION (63 patients)
NO THERAPEUTIC RESPONSE (62 patients)
HEPATIC NEOPLASM MALIGNANT (62 patients)
DYSPEPSIA (62 patients)
HAEMOPTYSIS (61 patients)
HAEMORRHAGE (61 patients)
WEIGHT INCREASED (61 patients)
TRANSMISSION OF DRUG VIA SEMEN (61 patients)
HEPATIC STEATOSIS (60 patients)
NASOPHARYNGITIS (60 patients)
DYSSTASIA (60 patients)
RASH PAPULAR (60 patients)
VISUAL DISTURBANCE (60 patients)
MYOCARDIAL INFARCTION (60 patients)
HEAD INJURY (60 patients)
AUTOIMMUNE DISORDER (60 patients)
CRYING (59 patients)
AGITATION (58 patients)
TACHYCARDIA (57 patients)
RESPIRATORY FAILURE (56 patients)
TREATMENT NONCOMPLIANCE (56 patients)
DISORIENTATION (56 patients)
ROAD TRAFFIC ACCIDENT (56 patients)
ABASIA (55 patients)
PSYCHOTIC DISORDER (55 patients)
ENCEPHALOPATHY (55 patients)
DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (55 patients)
ACUTE RESPIRATORY DISTRESS SYNDROME (55 patients)
OEDEMA (54 patients)
RECTAL HAEMORRHAGE (54 patients)
DRUG INTERACTION (54 patients)
SARCOIDOSIS (54 patients)
WHITE BLOOD CELL COUNT INCREASED (54 patients)
SUBARACHNOID HAEMORRHAGE (53 patients)
OVERDOSE (53 patients)
BLISTER (52 patients)
CARDIO-RESPIRATORY ARREST (52 patients)
DIABETIC KETOACIDOSIS (52 patients)
SLEEP DISORDER (51 patients)
BLOOD CREATINE PHOSPHOKINASE INCREASED (51 patients)
MUSCULOSKELETAL PAIN (51 patients)
AUTOIMMUNE HEPATITIS (50 patients)
COGNITIVE DISORDER (50 patients)
GASTROINTESTINAL HAEMORRHAGE (50 patients)
BLINDNESS (50 patients)
LUNG DISORDER (49 patients)
NERVOUSNESS (49 patients)
SWELLING (49 patients)
MIGRAINE (49 patients)
RASH PRURITIC (48 patients)
COMA (48 patients)
MENTAL DISORDER (48 patients)
CHEST DISCOMFORT (48 patients)
HAEMATOCHEZIA (48 patients)

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