About this FactMed analysis covering adverse side effect reports of SAPHRIS patients who developed ANGER.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 39 individuals taking SAPHRIS reported ANGER to the FDA. A total of 3790 SAPHRIS drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between SAPHRIS and ANGER. In doing so, we compare SAPHRIS with other drugs that cause ANGER, to help you evaluate whether or not SAPHRIS causes ANGER. Likewise, this page shows the most highly-reported side effects of SAPHRIS, so you can see if ANGER ranks among SAPHRIS's most well-known side effects.
Summary Statistics
Reports of SAPHRIS causing ANGER: 39
Reports of any side effect of SAPHRIS : 3790
Percentage of SAPHRIS patients where ANGER is a reported side effect: 1.0290%

FDA reports of any drug causing ANGER : 12263
Average percentage for all medicated patients where ANGER is reported as a complication: 0.0769%

Physician opinion on SAPHRIS as adverse event culprit:

Overall opinion for all reports of this drug:
Most frequent diagnoses/indications for prescribing SAPHRIS:
BIPOLAR DISORDER ( 1106 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 950 patients )
DRUG USE FOR UNKNOWN INDICATION ( 706 patients )
SCHIZOPHRENIA ( 357 patients )
BIPOLAR I DISORDER ( 150 patients )
SCHIZOAFFECTIVE DISORDER ( 91 patients )
PSYCHOTIC DISORDER ( 80 patients )
DEPRESSION ( 56 patients )
MANIA ( 36 patients )
AFFECTIVE DISORDER ( 25 patients )
MAJOR DEPRESSION ( 18 patients )
ANXIETY ( 17 patients )
SCHIZOAFFECTIVE DISORDER BIPOLAR TYPE ( 17 patients )
BIPOLAR II DISORDER ( 12 patients )
MENTAL DISORDER ( 11 patients )
PARANOIA ( 10 patients )
HALLUCINATION ( 8 patients )
INSOMNIA ( 8 patients )
DELUSION ( 7 patients )
SCHIZOPHRENIFORM DISORDER ( 7 patients )
AGITATION ( 7 patients )
POST-TRAUMATIC STRESS DISORDER ( 7 patients )
SCHIZOPHRENIA, PARANOID TYPE ( 6 patients )
OBSESSIVE-COMPULSIVE DISORDER ( 6 patients )
SUICIDAL IDEATION ( 4 patients )
ASPERGER'S DISORDER ( 4 patients )
DELUSIONAL DISORDER, UNSPECIFIED TYPE ( 4 patients )
ANXIETY DISORDER ( 4 patients )
OFF LABEL USE ( 3 patients )
ANGER ( 3 patients )
GENERALISED ANXIETY DISORDER ( 3 patients )
HALLUCINATION, AUDITORY ( 3 patients )
AGGRESSION ( 2 patients )
SLEEP DISORDER ( 2 patients )
DEMENTIA ALZHEIMER'S TYPE ( 2 patients )
AUTISM ( 2 patients )
NERVOUS SYSTEM DISORDER ( 2 patients )
PANIC DISORDER ( 2 patients )
DEPRESSED MOOD ( 2 patients )
DEPRESSION SUICIDAL ( 2 patients )
ATTENTION DEFICIT/HYPERACTIVITY DISORDER ( 2 patients )
MOOD SWINGS ( 2 patients )
FATIGUE ( 1 patients )
SCHIZOPHRENIA, UNDIFFERENTIATED TYPE ( 1 patients )
OBSESSIVE THOUGHTS ( 1 patients )
SCHIZOTYPAL PERSONALITY DISORDER ( 1 patients )
BRAIN OPERATION ( 1 patients )
HALLUCINATION, VISUAL ( 1 patients )
AGORAPHOBIA ( 1 patients )
SOCIAL PHOBIA ( 1 patients )
INTERMITTENT EXPLOSIVE DISORDER ( 1 patients )
TOURETTE'S DISORDER ( 1 patients )
DISABILITY ( 1 patients )
SCHIZOAFFECTIVE DISORDER DEPRESSIVE TYPE ( 1 patients )
MOOD DISORDER DUE TO A GENERAL MEDICAL CONDITION ( 1 patients )
ENERGY INCREASED ( 1 patients )
BORDERLINE PERSONALITY DISORDER ( 1 patients )
SELF INJURIOUS BEHAVIOUR ( 1 patients )
CRYING ( 1 patients )
HYPOMANIA ( 1 patients )
SLEEP DISORDER THERAPY ( 1 patients )
AKATHISIA ( 1 patients )
INTENTIONAL DRUG MISUSE ( 1 patients )
SUBSTANCE ABUSE ( 1 patients )
PSYCHOTIC BEHAVIOUR ( 1 patients )
ANTISOCIAL PERSONALITY DISORDER ( 1 patients )
IRRITABILITY ( 1 patients )
TACHYPHRENIA ( 1 patients )
PULMONARY EMBOLISM ( 1 patients )
DRUG THERAPY ( 1 patients )
MOOD ALTERED ( 1 patients )
EATING DISORDER ( 1 patients )
( 0 patients )
Drugs with high FDA adverse event association with ANGER:

CHANTIX (2705 patients)
SEROQUEL (1332 patients)
PAXIL (804 patients)
CYMBALTA (670 patients)
ACCUTANE (646 patients)
XANAX (564 patients)
ZOLOFT (559 patients)
EFFEXOR XR (534 patients)
SINGULAIR (530 patients)
NEURONTIN (518 patients)
STRATTERA (481 patients)
KLONOPIN (435 patients)
LEXAPRO (413 patients)
PROZAC (398 patients)
EFFEXOR (371 patients)
WELLBUTRIN (346 patients)
ASPIRIN (320 patients)
LYRICA (318 patients)
AMBIEN (309 patients)
PAROXETINE HCL (302 patients)
PRISTIQ (301 patients)
LAMICTAL (299 patients)
CLONAZEPAM (295 patients)
RISPERDAL (292 patients)
OXYCONTIN (275 patients)
TRAZODONE HCL (272 patients)
ZYPREXA (270 patients)
NEXIUM (244 patients)
LIPITOR (242 patients)
SYNTHROID (242 patients)
LISINOPRIL (240 patients)
SIMVASTATIN (240 patients)
TYSABRI (232 patients)
DIAZEPAM (232 patients)
KEPPRA (221 patients)
DEPAKOTE (220 patients)
PEG-INTRON (217 patients)
ALBUTEROL (217 patients)
TOPAMAX (210 patients)
CELEXA (209 patients)
ATIVAN (204 patients)
VIOXX (203 patients)
ABILIFY (202 patients)
SEROQUEL XR (197 patients)
PEGASYS (193 patients)
RIBAVIRIN (193 patients)
GABAPENTIN (192 patients)
PRILOSEC (187 patients)
CELEBREX (184 patients)
ATENOLOL (179 patients)
LORAZEPAM (174 patients)
TOPROL-XL (173 patients)
IBUPROFEN (172 patients)
VALIUM (170 patients)
GEODON (165 patients)
MIRTAZAPINE (163 patients)
WELLBUTRIN XL (159 patients)
PERCOCET (159 patients)
LEVOTHYROXINE SODIUM (156 patients)
PAXIL CR (153 patients)
VYVANSE (152 patients)
ALPRAZOLAM (152 patients)
METFORMIN HCL (151 patients)
CITALOPRAM HYDROBROMIDE (150 patients)
OMEPRAZOLE (149 patients)
PREDNISONE (149 patients)
VICODIN (148 patients)
HYDROCHLOROTHIAZIDE (147 patients)
AVONEX (145 patients)
REBIF (141 patients)
FOSAMAX (140 patients)
ZOCOR (140 patients)
ADVAIR DISKUS 100/50 (136 patients)
ALL OTHER THERAPEUTIC PRODUCTS (132 patients)
LITHIUM CARBONATE (130 patients)
CONCERTA (125 patients)
CHAMPIX (124 patients)
COPEGUS (123 patients)
TRILEPTAL (122 patients)
SOMA (118 patients)
PLAVIX (116 patients)
RESTORIL (116 patients)
MOTRIN (116 patients)
PAROXETINE HYDROCHLORIDE (115 patients)
PREVACID (115 patients)
HALDOL (115 patients)
NAMENDA (113 patients)
VITAMIN D (112 patients)
OXYCODONE HCL (112 patients)
RISPERIDONE (111 patients)
LORTAB (111 patients)
ZYRTEC (109 patients)
CRESTOR (108 patients)
PROTONIX (107 patients)
CLONIDINE (107 patients)
BETASERON (106 patients)
RITALIN (106 patients)
SEROXAT (105 patients)
FOLIC ACID (104 patients)
DURAGESIC-100 (102 patients)
SANDOSTATIN LAR (102 patients)
NICOTINE (101 patients)
FLUOXETINE (99 patients)
LAMOTRIGINE (97 patients)
LASIX (97 patients)
HYDROCODONE (94 patients)
COUMADIN (94 patients)
AMITRIPTYLINE HCL (93 patients)
MIRENA (92 patients)
FLEXERIL (90 patients)
NITROGLYCERIN (89 patients)
ACETAMINOPHEN (88 patients)
LEVAQUIN (88 patients)
POTASSIUM CHLORIDE (87 patients)
VISTARIL (87 patients)
BUSPAR (86 patients)
TRAZODONE (86 patients)
TRAMADOL HCL (85 patients)
FORTEO (84 patients)
FUROSEMIDE (84 patients)
COGENTIN (83 patients)
NAPROXEN (82 patients)
TEMAZEPAM (81 patients)
CLOZARIL (81 patients)
WELLBUTRIN SR (79 patients)
REMERON (79 patients)
TEGRETOL (79 patients)
PREMARIN (79 patients)
PROMETHAZINE (77 patients)
MULTI-VITAMINS (77 patients)
DARVOCET (77 patients)
ZANTAC (77 patients)
TRICOR (76 patients)
LANTUS (75 patients)
VARENICLINE TARTRATE (75 patients)
YAZ (74 patients)
PROVIGIL (73 patients)
REBETOL (73 patients)
ALCOHOL (72 patients)
TYLENOL (CAPLET) (72 patients)
LITHIUM (71 patients)
YASMIN (71 patients)
LUNESTA (71 patients)
FISH OIL (70 patients)
HYDROXYZINE (70 patients)
NORVASC (68 patients)
VITAMINS (68 patients)
ELAVIL (67 patients)
PROPRANOLOL (67 patients)
BUPROPION HYDROCHLORIDE (67 patients)
DILANTIN (67 patients)
CLARITIN (67 patients)
OXYCODONE (66 patients)
ZANAFLEX (65 patients)
SERTRALINE HYDROCHLORIDE (65 patients)
RANITIDINE (65 patients)
ENBREL (65 patients)
DIGOXIN (64 patients)
ZITHROMAX (64 patients)
HUMALOG (64 patients)
ACTIQ (64 patients)
RIBASPHERE (64 patients)
METOPROLOL TARTRATE (64 patients)
VENLAFAXINE HCL (63 patients)
ACETYLSALICYLIC ACID (63 patients)
VYTORIN (63 patients)
BENADRYL (62 patients)
INVEGA SUSTENNA (62 patients)
METFORMIN (62 patients)
CALCIUM (61 patients)
VITAMIN B-12 (61 patients)
LEVOXYL (61 patients)
TYLENOL (61 patients)
BUPROPION HCL (61 patients)
INSULIN (61 patients)
ZOMETA (60 patients)
ADDERALL 10 (59 patients)
SUBOXONE (59 patients)
AMLODIPINE (59 patients)
MIRAPEX (59 patients)
ARICEPT (58 patients)
HUMIRA (57 patients)
AZITHROMYCIN (57 patients)
RISPERDAL CONSTA (57 patients)
SAVELLA (57 patients)
CARISOPRODOL (56 patients)
AMNESTEEM (56 patients)
LANSOPRAZOLE (56 patients)
IMITREX (56 patients)
DAYTRANA (55 patients)
VITAMIN TAB (55 patients)
NO CONCURRENT MEDICATION (55 patients)
BACLOFEN (54 patients)
FLONASE (54 patients)
ZETIA (54 patients)
VALPROIC ACID (54 patients)
SKELAXIN (54 patients)
LARIAM (54 patients)
SYMBICORT (53 patients)
METOPROLOL (52 patients)
HYDROCODONE BITARTRATE (50 patients)
DEPAKOTE ER (50 patients)
ALLEGRA (50 patients)
COFFEE (50 patients)
ASCORBIC ACID (49 patients)
NUVARING (49 patients)
DEPAKENE (49 patients)
ADVIL (48 patients)
MORPHINE SULFATE (48 patients)
BECLAMIDE (47 patients)
Most common side effects for patients taking SAPHRIS:
INAPPROPRIATE SCHEDULE OF DRUG ADMINISTRATION (414 patients)
DYSGEUSIA (282 patients)
UNDERDOSE (241 patients)
HYPOAESTHESIA ORAL (218 patients)
INCORRECT ROUTE OF DRUG ADMINISTRATION (190 patients)
WEIGHT INCREASED (184 patients)
DIZZINESS (164 patients)
NAUSEA (162 patients)
SOMNOLENCE (140 patients)
SEDATION (118 patients)
VOMITING (116 patients)
SWOLLEN TONGUE (115 patients)
AKATHISIA (114 patients)
INSOMNIA (101 patients)
AGITATION (99 patients)
OEDEMA PERIPHERAL (97 patients)
FEELING ABNORMAL (87 patients)
TREMOR (81 patients)
DYSPNOEA (81 patients)
ANXIETY (80 patients)
DYSTONIA (73 patients)
RASH (72 patients)
MANIA (71 patients)
FATIGUE (70 patients)
HYPOAESTHESIA (69 patients)
SUICIDAL IDEATION (66 patients)
EXTRAPYRAMIDAL DISORDER (66 patients)
HEADACHE (59 patients)
CONVULSION (59 patients)
DEPRESSION (59 patients)
DYSPHAGIA (56 patients)
RESTLESS LEGS SYNDROME (56 patients)
GLOSSODYNIA (50 patients)
OFF LABEL USE (49 patients)
DYSKINESIA (47 patients)
DEATH (46 patients)
TARDIVE DYSKINESIA (45 patients)
WRONG TECHNIQUE IN DRUG USAGE PROCESS (43 patients)
DRUG INEFFECTIVE (43 patients)
DRUG HYPERSENSITIVITY (43 patients)
PSYCHOTIC DISORDER (41 patients)
BLOOD GLUCOSE INCREASED (40 patients)
RESTLESSNESS (40 patients)
ANGER (39 patients)
GAIT DISTURBANCE (39 patients)
CONDITION AGGRAVATED (39 patients)
PARANOIA (39 patients)
SYNCOPE (38 patients)
ORAL DISCOMFORT (37 patients)
CONFUSIONAL STATE (36 patients)
AGGRESSION (35 patients)
FALL (34 patients)
SWELLING FACE (33 patients)
OVERDOSE (33 patients)
MUSCLE SPASMS (32 patients)
HALLUCINATION (32 patients)
COMPLETED SUICIDE (32 patients)
VISION BLURRED (31 patients)
MUSCULOSKELETAL STIFFNESS (31 patients)
DYSARTHRIA (31 patients)
HYPERHIDROSIS (30 patients)
SPEECH DISORDER (30 patients)
ANGIOEDEMA (29 patients)
PHARYNGEAL OEDEMA (29 patients)
LOSS OF CONSCIOUSNESS (28 patients)
HYPERSENSITIVITY (27 patients)
DRUG DOSE OMISSION (27 patients)
DROOLING (27 patients)
STOMATITIS (27 patients)
CHEST PAIN (27 patients)
PAIN IN EXTREMITY (27 patients)
PARAESTHESIA (26 patients)
JOINT SWELLING (25 patients)
ARTHRALGIA (25 patients)
INCREASED APPETITE (25 patients)
DISORIENTATION (25 patients)
OEDEMA (25 patients)
TOOTH DISCOLOURATION (24 patients)
HYPOTENSION (24 patients)
ANAPHYLACTIC REACTION (24 patients)
NIGHTMARE (24 patients)
OROPHARYNGEAL BLISTERING (24 patients)
TONGUE BLISTERING (22 patients)
MUSCLE TWITCHING (22 patients)
HEART RATE INCREASED (22 patients)
MOUTH ULCERATION (22 patients)
HYPERTENSION (22 patients)
PAIN (22 patients)
PANIC ATTACK (22 patients)
DIARRHOEA (22 patients)
THROAT TIGHTNESS (21 patients)
TONGUE DISORDER (21 patients)
SALIVARY HYPERSECRETION (21 patients)
INCORRECT DOSE ADMINISTERED (20 patients)
ASTHENIA (20 patients)
BALANCE DISORDER (20 patients)
BLOOD PRESSURE INCREASED (20 patients)
NERVOUSNESS (20 patients)
PSYCHOMOTOR HYPERACTIVITY (20 patients)
HALLUCINATION, AUDITORY (20 patients)
MIGRAINE (20 patients)
URTICARIA (19 patients)
PALPITATIONS (19 patients)
IRRITABILITY (19 patients)
THERAPEUTIC PRODUCT INEFFECTIVE (19 patients)
CONSTIPATION (18 patients)
WEIGHT DECREASED (18 patients)
MYALGIA (18 patients)
HYPERSOMNIA (17 patients)
TACHYCARDIA (16 patients)
MYOCARDIAL INFARCTION (16 patients)
TONGUE ULCERATION (16 patients)
GALACTORRHOEA (16 patients)
PRURITUS (16 patients)
RASH GENERALISED (16 patients)
SUICIDE ATTEMPT (16 patients)
CONTUSION (16 patients)
MUSCLE TIGHTNESS (15 patients)
ALOPECIA (15 patients)
AMNESIA (15 patients)
PYREXIA (15 patients)
ABNORMAL BEHAVIOUR (14 patients)
AGEUSIA (14 patients)
MALAISE (14 patients)
ANAPHYLACTIC SHOCK (14 patients)
MEMORY IMPAIRMENT (14 patients)
PHARYNGEAL HYPOAESTHESIA (14 patients)
LIP SWELLING (14 patients)
ERYTHEMA (14 patients)
SCHIZOPHRENIA (14 patients)
SOMNAMBULISM (14 patients)
HEAD INJURY (14 patients)
CHOKING (14 patients)
COUGH (14 patients)
HUNGER (13 patients)
STEVENS-JOHNSON SYNDROME (13 patients)
INJURY (13 patients)
CEREBROVASCULAR ACCIDENT (13 patients)
CHEST DISCOMFORT (13 patients)
SWELLING (13 patients)
ENURESIS (13 patients)
DECREASED APPETITE (13 patients)
WHITE BLOOD CELL COUNT DECREASED (13 patients)
ABDOMINAL PAIN (12 patients)
TREATMENT NONCOMPLIANCE (12 patients)
LACERATION (12 patients)
BIPOLAR DISORDER (12 patients)
BLOOD PROLACTIN INCREASED (12 patients)
PRODUCT TASTE ABNORMAL (12 patients)
UNEVALUABLE EVENT (12 patients)
DELUSION (12 patients)
PALLOR (12 patients)
FEELING DRUNK (12 patients)
DRUG ADMINISTERED TO PATIENT OF INAPPROPRIATE AGE (11 patients)
MOVEMENT DISORDER (11 patients)
HYPOMANIA (11 patients)
BACK PAIN (11 patients)
THINKING ABNORMAL (11 patients)
ORTHOSTATIC HYPOTENSION (11 patients)
DRUG INTOLERANCE (11 patients)
PULMONARY EMBOLISM (11 patients)
DRY MOUTH (11 patients)
LETHARGY (11 patients)
DYSSTASIA (11 patients)
TACHYPHRENIA (11 patients)
ADVERSE EVENT (10 patients)
FEELING JITTERY (10 patients)
UNRESPONSIVE TO STIMULI (10 patients)
ATAXIA (10 patients)
BLOOD CHOLESTEROL INCREASED (10 patients)
BLOOD PRESSURE DECREASED (10 patients)
DRUG INTERACTION (10 patients)
EYE MOVEMENT DISORDER (10 patients)
PNEUMONIA (10 patients)
MENTAL DISORDER (10 patients)
ABASIA (9 patients)
ABDOMINAL DISCOMFORT (9 patients)
ABDOMINAL DISTENSION (9 patients)
GUN SHOT WOUND (9 patients)
DISTURBANCE IN ATTENTION (9 patients)
APATHY (9 patients)
MUSCLE RIGIDITY (9 patients)
ARRHYTHMIA (9 patients)
INTENTIONAL SELF-INJURY (9 patients)
EMOTIONAL DISORDER (9 patients)
FLUID RETENTION (9 patients)
HOSPITALISATION (9 patients)
ABDOMINAL PAIN UPPER (8 patients)
LIVER FUNCTION TEST ABNORMAL (8 patients)
FLUSHING (8 patients)
MUSCULAR WEAKNESS (8 patients)
AMENORRHOEA (8 patients)
BIPOLAR I DISORDER (8 patients)
FEELING HOT (8 patients)
PARAESTHESIA ORAL (8 patients)
MOOD ALTERED (8 patients)
PARKINSONISM (8 patients)
SLEEP DISORDER (8 patients)
TONGUE DISCOLOURATION (8 patients)
NO THERAPEUTIC RESPONSE (8 patients)
HEPATIC ENZYME INCREASED (8 patients)
EUPHORIC MOOD (8 patients)
LOCAL SWELLING (8 patients)
LOSS OF LIBIDO (8 patients)
MEDICATION ERROR (8 patients)
PAIN IN JAW (8 patients)
SELF-MEDICATION (7 patients)
THROMBOCYTOPENIA (7 patients)
HOT FLUSH (7 patients)
BLOOD POTASSIUM DECREASED (7 patients)

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Recent FactMed Activity for SAPHRIS


Issue Description / Topic Timestamp
QUESTION
NEUROLOGICAL SYMPTOM
I have been taking saphris for 7 minths. And recently have been having problems driving. I forget which petal is which and my legs won't move. Whats going on? 2015-04-09 01:10:18
QUESTION
SPONTANEOUS PENILE ERECTION
Ive been on saphris 5mg. For 21 days Ive not had an erection yet. 2015-04-14 11:06:34
QUESTION
THYROID DISORDER
I have been on saphris for over a year now. I was already obese, but I have gained a lot more weight since being on it. Lately I have had two periods a month, fatigue, and some shortness of breath. I know I need to lose weight, but could the saphris make this harder? Could it cause any of this? 2015-09-13 15:55:14
QUESTION
PANCREATITIS
Can saphris cause pancreatitis after stopping 2015-09-20 23:54:31
QUESTION
URINARY INCONTINENCE
I have swelling of face feet and hands also urinary incontinence that all started about the third week of taking saphris. I am 41 yr old female with severe maj depressive disorder. The med made me feel wonderful for once in my life.. But had to stop taking it because of these side effects. Anyone else relate? 2016-02-17 16:02:23
QUESTION
DRUG SCREEN FALSE POSITIVE
Can saphris give a false postive for benzodiazepines on a drug test I keep testing positive for Benzodiazepines but the only thing different is the saphris 2016-03-04 13:52:11
QUESTION
CRYING
Dose Saphris cause crying and why? 2016-03-20 19:18:07
QUESTION
CRYING
Dose Saphris cause crying and why? 2016-03-20 20:55:17
QUESTION
CRYING
Does saphris cause crying and why? 2016-03-21 05:02:55
QUESTION
DRUG SCREEN FALSE POSITIVE
I'm on probation and if I take saphris 10mg will it show up a false positive for a benzo or uppers and downers on my drug screen ??? 2016-03-29 13:28:20
QUESTION
DRUG SCREEN FALSE POSITIVE
I'm on probation and if I take saphris 10mg will it show up a false positive for a benzo or uppers and downers on my drug screen ??? 2016-03-29 13:29:29
QUESTION
SYNCOPE
I am on 5mg of Saphris and am also on 50mg of endep. I've been fainting every 4-6 weeks since being on the combination (and fractured my spine). Is Saphris likely to lead to syncope and abnormal ecg's? 2016-04-08 20:58:49

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