Is ANHEDONIA a side effect of SORAFENIB (RAF KINASE INHIBITOR) ? ( FactMed.com )

About this FactMed analysis covering adverse side effect reports of SORAFENIB (RAF KINASE INHIBITOR) patients who developed ANHEDONIA.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 1 individuals taking SORAFENIB (RAF KINASE INHIBITOR) reported ANHEDONIA to the FDA. A total of 3329 SORAFENIB (RAF KINASE INHIBITOR) drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between SORAFENIB (RAF KINASE INHIBITOR) and ANHEDONIA. In doing so, we compare SORAFENIB (RAF KINASE INHIBITOR) with other drugs that cause ANHEDONIA, to help you evaluate whether or not SORAFENIB (RAF KINASE INHIBITOR) causes ANHEDONIA. Likewise, this page shows the most highly-reported side effects of SORAFENIB (RAF KINASE INHIBITOR), so you can see if ANHEDONIA ranks among SORAFENIB (RAF KINASE INHIBITOR)'s most well-known side effects.

Summary Statistics
Reports of SORAFENIB (RAF KINASE INHIBITOR) causing ANHEDONIA: 1
Reports of any side effect of SORAFENIB (RAF KINASE INHIBITOR) : 3329
Percentage of SORAFENIB (RAF KINASE INHIBITOR) patients where ANHEDONIA is a reported side effect: 0.0300%

FDA reports of any drug causing ANHEDONIA : 17054
Average percentage for all medicated patients where ANHEDONIA is reported as a complication: 0.1069%

Physician opinion on SORAFENIB (RAF KINASE INHIBITOR) as adverse event culprit:

Overall opinion for all reports of this drug:

Most frequent diagnoses/indications for prescribing SORAFENIB (RAF KINASE INHIBITOR):

HEPATIC NEOPLASM MALIGNANT ( 770 patients )
RENAL CELL CARCINOMA ( 114 patients )
THYROID CANCER ( 65 patients )
METASTATIC RENAL CELL CARCINOMA ( 44 patients )
THYROID CANCER METASTATIC ( 35 patients )
BREAST CANCER ( 31 patients )
BREAST CANCER METASTATIC ( 27 patients )
GASTRIC CANCER ( 25 patients )
NON-SMALL CELL LUNG CANCER ( 25 patients )
COLORECTAL CANCER METASTATIC ( 22 patients )
RENAL CANCER ( 17 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 14 patients )
BILE DUCT CANCER ( 14 patients )
SALIVARY GLAND CANCER ( 7 patients )
HEPATIC CANCER METASTATIC ( 7 patients )
COLORECTAL CANCER ( 7 patients )
SMALL CELL LUNG CANCER STAGE UNSPECIFIED ( 6 patients )
RECTAL CANCER ( 5 patients )
PANCREATIC CARCINOMA ( 4 patients )
PROSTATE CANCER ( 4 patients )
INTRAOCULAR MELANOMA ( 4 patients )
HEPATIC NEOPLASM MALIGNANT RECURRENT ( 3 patients )
NEOPLASM ( 3 patients )
LIVER DISORDER ( 3 patients )
ANGIOSARCOMA ( 3 patients )
NON-SMALL CELL LUNG CANCER STAGE IV ( 3 patients )
METASTASES TO LUNG ( 3 patients )
HEPATIC NEOPLASM MALIGNANT NON-RESECTABLE ( 3 patients )
COLORECTAL CANCER STAGE IV ( 3 patients )
NEOPLASM MALIGNANT ( 3 patients )
GALLBLADDER CANCER METASTATIC ( 3 patients )
METASTASIS ( 3 patients )
BILIARY CANCER METASTATIC ( 3 patients )
COLON CANCER METASTATIC ( 2 patients )
HYPOPHARYNGEAL CANCER ( 2 patients )
DESMOID TUMOUR ( 2 patients )
NEUROENDOCRINE CARCINOMA ( 2 patients )
LUNG NEOPLASM MALIGNANT ( 2 patients )
ACUTE MYELOID LEUKAEMIA (IN REMISSION) ( 2 patients )
OESOPHAGEAL CARCINOMA ( 2 patients )
METASTATIC MALIGNANT MELANOMA ( 2 patients )
TONGUE NEOPLASM MALIGNANT STAGE UNSPECIFIED ( 2 patients )
METASTATIC SQUAMOUS CELL CARCINOMA ( 2 patients )
RENAL CELL CARCINOMA STAGE IV ( 2 patients )
ANGINA PECTORIS ( 2 patients )
OSTEOSARCOMA METASTATIC ( 2 patients )
METASTATIC OCULAR MELANOMA ( 2 patients )
BONE SARCOMA ( 2 patients )
METASTATIC SALIVARY GLAND CANCER ( 2 patients )
TONSIL CANCER ( 2 patients )
MYELODYSPLASTIC SYNDROME ( 1 patients )
PROSTATE CANCER METASTATIC ( 1 patients )
GALLBLADDER CANCER ( 1 patients )
NEUROENDOCRINE TUMOUR ( 1 patients )
MALIGNANT NEOPLASM OF RENAL PELVIS ( 1 patients )
GLIOMA ( 1 patients )
BLADDER CANCER ( 1 patients )
OVARIAN CANCER METASTATIC ( 1 patients )
CAROTID ARTERY DISEASE ( 1 patients )
HEPATOBLASTOMA ( 1 patients )
NASOPHARYNGEAL CANCER ( 1 patients )
LUNG ADENOCARCINOMA ( 1 patients )
RENAL CANCER METASTATIC ( 1 patients )
ACUTE MYELOID LEUKAEMIA ( 1 patients )
DIFFUSE LARGE B-CELL LYMPHOMA ( 1 patients )
NEUROENDOCRINE CARCINOMA OF THE SKIN ( 1 patients )
MALIGNANT HISTIOCYTOSIS ( 1 patients )
MALIGNANT SOFT TISSUE NEOPLASM ( 1 patients )
SARCOMA ( 1 patients )
ANTICOAGULANT THERAPY ( 1 patients )
GERM CELL CANCER ( 1 patients )
OESOPHAGEAL ADENOCARCINOMA ( 1 patients )
SQUAMOUS CELL CARCINOMA ( 1 patients )
HEAD AND NECK CANCER ( 1 patients )
OVARIAN EPITHELIAL CANCER ( 1 patients )
( 0 patients )

Drugs with high FDA adverse event association with ANHEDONIA:

TRASYLOL (8239 patients)
ZOMETA (3155 patients)
YAZ (2621 patients)
YASMIN (2447 patients)
HEPARIN (2067 patients)
LASIX (2048 patients)
AREDIA (1868 patients)
METOCLOPRAMIDE (1634 patients)
ASPIRIN (1603 patients)
COUMADIN (1264 patients)
MAGNEVIST (1224 patients)
NITROGLYCERIN (1199 patients)
DIGOXIN (1127 patients)
VIOXX (1125 patients)
LIPITOR (1124 patients)
PROTAMINE SULFATE (1065 patients)
LISINOPRIL (1036 patients)
DROSPIRENONE AND ETHINYL ESTRADIOL (947 patients)
VERSED (891 patients)
ACETYLSALICYLIC ACID SRT (885 patients)
RED BLOOD CELLS (876 patients)
VANCOMYCIN (855 patients)
PROTONIX (840 patients)
FENTANYL (826 patients)
PREDNISONE (825 patients)
PLAVIX (785 patients)
AMBIEN (755 patients)
INSULIN (753 patients)
LEVAQUIN (718 patients)
OMNISCAN (712 patients)
PRILOSEC (702 patients)
ACCUTANE (686 patients)
ZOCOR (686 patients)
NEXIUM (685 patients)
PERCOCET (680 patients)
ATENOLOL (676 patients)
CELEBREX (674 patients)
NORVASC (669 patients)
OXYCONTIN (659 patients)
SYNTHROID (644 patients)
VICODIN (621 patients)
XANAX (621 patients)
TOPROL-XL (620 patients)
LEXAPRO (614 patients)
IBUPROFEN (602 patients)
DEXAMETHASONE (599 patients)
FUROSEMIDE (598 patients)
NEURONTIN (596 patients)
HYDROCHLOROTHIAZIDE (587 patients)
AMOXICILLIN (573 patients)
PREVACID (566 patients)
FOSAMAX (565 patients)
PLATELETS (561 patients)
ZOLOFT (558 patients)
MORPHINE (536 patients)
ALBUTEROL (522 patients)
LIDOCAINE (521 patients)
ATIVAN (514 patients)
COREG (513 patients)
DECADRON (512 patients)
REGLAN (503 patients)
LOPRESSOR (499 patients)
EPINEPHRINE (495 patients)
ANCEF (494 patients)
MANNITOL (487 patients)
POTASSIUM CHLORIDE (480 patients)
LOVENOX (474 patients)
PAXIL (459 patients)
OXYCODONE HCL (458 patients)
OPTIMARK (452 patients)
CHEMOTHERAPEUTICS NOS (446 patients)
WARFARIN SODIUM (433 patients)
AMIODARONE HCL (432 patients)
TAMOXIFEN CITRATE (429 patients)
SIMVASTATIN (425 patients)
DOPAMINE HCL (423 patients)
CLINDAMYCIN (422 patients)
ACETAMINOPHEN (417 patients)
METOPROLOL TARTRATE (413 patients)
CYMBALTA (411 patients)
LORAZEPAM (409 patients)
LORTAB (406 patients)
THALIDOMIDE (402 patients)
RADIATION THERAPY (392 patients)
CHLORHEXIDINE GLUCONATE (390 patients)
ZOFRAN (388 patients)
PERIDEX (386 patients)
EFFEXOR (384 patients)
ZANTAC (383 patients)
CEPHALEXIN (380 patients)
PROHANCE (375 patients)
MULTIHANCE (374 patients)
FRESH FROZEN PLASMA (358 patients)
COLACE (354 patients)
ADVAIR DISKUS 100/50 (350 patients)
CIPROFLOXACIN (349 patients)
FEMARA (347 patients)
FOLIC ACID (342 patients)
DILAUDID (340 patients)
CELEXA (339 patients)
ZITHROMAX (338 patients)
FLEXERIL (338 patients)
PROPOFOL (337 patients)
MULTI-VITAMINS (337 patients)
TAXOTERE (336 patients)
ALPRAZOLAM (335 patients)
XELODA (334 patients)
GABAPENTIN (333 patients)
ARANESP (325 patients)
PEPCID (325 patients)
MILRINONE (324 patients)
ARIMIDEX (324 patients)
WELLBUTRIN (322 patients)
CALCIUM (321 patients)
FLAGYL (320 patients)
ALLOPURINOL (320 patients)
FLUCONAZOLE (318 patients)
OMEPRAZOLE (318 patients)
EPOGEN (316 patients)
DIOVAN (308 patients)
AROMASIN (306 patients)
VITAMIN D (306 patients)
PROZAC (302 patients)
ELAVIL (297 patients)
GLIPIZIDE (295 patients)
LANTUS (295 patients)
CLONIDINE (293 patients)
ZYRTEC (291 patients)
HYDROCODONE (289 patients)
DURAGESIC-100 (287 patients)
GADOLINIUM IN UNSPECIFIED DRUG (287 patients)
COZAAR (286 patients)
SODIUM BICARBONATE (282 patients)
LEVOPHED (280 patients)
CARDIZEM (280 patients)
PROMETHAZINE (279 patients)
DEPAKOTE (279 patients)
METOPROLOL (274 patients)
ALTACE (271 patients)
FASLODEX (271 patients)
ZESTRIL (268 patients)
SPIRONOLACTONE (267 patients)
ALBUMIN (HUMAN) (267 patients)
FLONASE (263 patients)
SEROQUEL (259 patients)
AZITHROMYCIN (256 patients)
AVANDIA (254 patients)
CYTOXAN (248 patients)
SOLU-MEDROL (246 patients)
LEVOTHYROXINE SODIUM (245 patients)
METFORMIN HCL (244 patients)
GLUCOPHAGE (244 patients)
CIPRO (243 patients)
LUPRON (243 patients)
FLOMAX (236 patients)
CEFAZOLIN (235 patients)
METRONIDAZOLE (234 patients)
LYRICA (233 patients)
KEFLEX (232 patients)
PREDNISONE TAB (231 patients)
PRAVACHOL (230 patients)
PROCRIT /00909301/ (227 patients)
TEMAZEPAM (224 patients)
KLONOPIN (222 patients)
BENADRYL (221 patients)
ACYCLOVIR (218 patients)
AVELOX (217 patients)
KLOR-CON (217 patients)
ZETIA (216 patients)
TAXOL (215 patients)
MORPHINE SULFATE (215 patients)
PLASMA (215 patients)
ALLEGRA (214 patients)
CONTRAST MEDIA (213 patients)
AUGMENTIN '125' (212 patients)
DARVOCET-N 100 (212 patients)
HERCEPTIN (208 patients)
NEUPOGEN (208 patients)
PHENYLEPHRINE HCL (207 patients)
GLYBURIDE (206 patients)
MS CONTIN (206 patients)
AMICAR (204 patients)
AVASTIN (203 patients)
POTASSIUM (202 patients)
CALCIUM CHLORIDE (202 patients)
ENALAPRIL MALEATE (202 patients)
SINGULAIR (201 patients)
MAGNESIUM SULFATE (200 patients)
ADRIAMYCIN PFS (200 patients)
CALCIUM CARBONATE (199 patients)
MOTRIN (199 patients)
ACTOS (198 patients)
DIFLUCAN (197 patients)
RENAGEL (196 patients)
IMDUR (195 patients)
PREMARIN (194 patients)
BACTRIM (194 patients)
DIAZEPAM (193 patients)
HYDROCODONE BITARTRATE (192 patients)
LANOXIN (192 patients)
MELPHALAN HYDROCHLORIDE (192 patients)
CRESTOR (191 patients)
CASODEX (191 patients)
ACCUPRIL (187 patients)
VELCADE (186 patients)
RESTORIL (185 patients)
ALDACTONE (184 patients)
NAPROXEN (183 patients)
OXYCODONE (183 patients)
VALIUM (180 patients)

Most common side effects for patients taking SORAFENIB (RAF KINASE INHIBITOR):

DIARRHOEA (613 patients)
HEPATIC FAILURE (378 patients)
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME (342 patients)
HEPATIC ENCEPHALOPATHY (320 patients)
FATIGUE (300 patients)
RASH (276 patients)
ASCITES (253 patients)
ABDOMINAL PAIN (237 patients)
DECREASED APPETITE (226 patients)
UPPER GASTROINTESTINAL HAEMORRHAGE (198 patients)
PYREXIA (191 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (179 patients)
NAUSEA (165 patients)
HYPERTENSION (160 patients)
ASTHENIA (154 patients)
DEHYDRATION (140 patients)
HEPATIC FUNCTION ABNORMAL (133 patients)
DYSPNOEA (131 patients)
CONFUSIONAL STATE (131 patients)
HYPOKALAEMIA (125 patients)
ALOPECIA (124 patients)
VOMITING (118 patients)
CONSTIPATION (115 patients)
INTERSTITIAL LUNG DISEASE (114 patients)
LEFT VENTRICULAR DYSFUNCTION (113 patients)
DEATH (113 patients)
ENDOCARDITIS (112 patients)
ARTHRALGIA (111 patients)
STOMATITIS (111 patients)
ABDOMINAL PAIN UPPER (110 patients)
JAUNDICE (108 patients)
HEPATIC NEOPLASM MALIGNANT (106 patients)
GASTROINTESTINAL HAEMORRHAGE (106 patients)
RETINAL VASCULAR THROMBOSIS (103 patients)
LOWER GASTROINTESTINAL HAEMORRHAGE (103 patients)
LIVER CARCINOMA RUPTURED (101 patients)
OEDEMA PERIPHERAL (97 patients)
PLEURAL EFFUSION (97 patients)
STAPHYLOCOCCAL INFECTION (96 patients)
PNEUMONIA BACTERIAL (96 patients)
ENTEROBACTER INFECTION (96 patients)
MYOPATHY (95 patients)
DRY MOUTH (94 patients)
PAIN IN EXTREMITY (93 patients)
ANXIETY (90 patients)
MALAISE (89 patients)
PULMONARY EMBOLISM (85 patients)
ANAEMIA (84 patients)
PLATELET COUNT DECREASED (81 patients)
BACK PAIN (79 patients)
SEPSIS (78 patients)
PRURITUS (78 patients)
DUODENAL ULCER (77 patients)
MIGRAINE (76 patients)
MITRAL VALVE INCOMPETENCE (76 patients)
HYPOGLYCAEMIA (76 patients)
C-REACTIVE PROTEIN INCREASED (74 patients)
BLOOD PRESSURE INCREASED (73 patients)
VARICES OESOPHAGEAL (73 patients)
HEADACHE (72 patients)
RETINAL VEIN OCCLUSION (72 patients)
ABASIA (69 patients)
RENAL FAILURE ACUTE (69 patients)
WEIGHT DECREASED (67 patients)
DEEP VEIN THROMBOSIS (67 patients)
DIZZINESS (65 patients)
ERYTHEMA (65 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (64 patients)
CONVULSION (63 patients)
ALANINE AMINOTRANSFERASE INCREASED (62 patients)
DYSPHONIA (62 patients)
CEREBRAL HAEMORRHAGE (60 patients)
APHAGIA (58 patients)
COLITIS (58 patients)
PNEUMONIA (57 patients)
GASTRIC ULCER (56 patients)
HYPONATRAEMIA (55 patients)
HAEMOGLOBIN DECREASED (53 patients)
RESPIRATORY FAILURE (52 patients)
LUNG DISORDER (52 patients)
CEREBRAL ISCHAEMIA (49 patients)
PARAESTHESIA (49 patients)
BLOOD BILIRUBIN INCREASED (48 patients)
GAIT DISTURBANCE (48 patients)
THYROID CANCER METASTATIC (44 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (43 patients)
PERICARDIAL EFFUSION (41 patients)
THROMBOCYTOPENIA (41 patients)
BLISTER (41 patients)
FEBRILE NEUTROPENIA (40 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (40 patients)
HALLUCINATION (40 patients)
CHILLS (40 patients)
AMMONIA INCREASED (39 patients)
SKIN ULCER (39 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (38 patients)
PAIN (38 patients)
HYPOALBUMINAEMIA (38 patients)
HYPOCALCAEMIA (37 patients)
FALL (37 patients)
POLLAKIURIA (37 patients)
BLOOD PRESSURE DECREASED (37 patients)
SKIN EXFOLIATION (37 patients)
INSOMNIA (36 patients)
CARDIAC ARREST (36 patients)
HYPOAESTHESIA (35 patients)
INFECTIOUS PERITONITIS (35 patients)
MYOCARDIAL INFARCTION (35 patients)
RETINAL VASCULAR DISORDER (34 patients)
RENAL FAILURE (34 patients)
LIPASE INCREASED (34 patients)
HYPERKALAEMIA (33 patients)
HYPERGLYCAEMIA (33 patients)
HAEMOPTYSIS (31 patients)
ATRIAL FIBRILLATION (30 patients)
GENERALISED OEDEMA (30 patients)
FAECAL INCONTINENCE (30 patients)
WHITE BLOOD CELL COUNT DECREASED (30 patients)
CELLULITIS (29 patients)
CHEST PAIN (29 patients)
SOMNOLENCE (29 patients)
HYPERBILIRUBINAEMIA (28 patients)
HYPOTENSION (28 patients)
MUSCLE SPASMS (28 patients)
ABDOMINAL DISTENSION (27 patients)
WHITE BLOOD CELL COUNT INCREASED (27 patients)
VISION BLURRED (27 patients)
HEPATIC PAIN (26 patients)
BLOOD ALBUMIN DECREASED (26 patients)
DYSURIA (25 patients)
RASH GENERALISED (25 patients)
BLOOD SODIUM DECREASED (25 patients)
BLOOD URIC ACID INCREASED (25 patients)
COMA (25 patients)
COUGH (25 patients)
PANCYTOPENIA (25 patients)
ACUTE ABDOMEN (24 patients)
EOSINOPHIL COUNT INCREASED (24 patients)
CEREBROVASCULAR ACCIDENT (24 patients)
METASTASES TO CENTRAL NERVOUS SYSTEM (23 patients)
CEREBRAL INFARCTION (23 patients)
HYPOMAGNESAEMIA (23 patients)
RETINAL VEIN THROMBOSIS (23 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (23 patients)
TUMOUR LYSIS SYNDROME (22 patients)
HYPOPHOSPHATAEMIA (22 patients)
INFECTION (22 patients)
ORAL PAIN (22 patients)
BLOOD CREATININE INCREASED (22 patients)
NEUTROPENIA (22 patients)
RENAL IMPAIRMENT (22 patients)
LETHARGY (22 patients)
SKIN TOXICITY (21 patients)
TONGUE BLISTERING (21 patients)
LIVER ABSCESS (21 patients)
HAEMATEMESIS (21 patients)
OESOPHAGEAL VARICES HAEMORRHAGE (20 patients)
MENTAL IMPAIRMENT (20 patients)
NERVOUSNESS (20 patients)
NEPHROTIC SYNDROME (20 patients)
HYPOPHAGIA (20 patients)
ADRENAL INSUFFICIENCY (19 patients)
DRY SKIN (19 patients)
BLOOD AMYLASE INCREASED (19 patients)
OEDEMA (19 patients)
INFECTIOUS PLEURAL EFFUSION (19 patients)
DYSPEPSIA (19 patients)
COMA HEPATIC (19 patients)
HEART RATE INCREASED (18 patients)
HYPERTENSIVE CRISIS (18 patients)
MYALGIA (18 patients)
ECZEMA (18 patients)
URINARY TRACT INFECTION (18 patients)
NEUROMYOPATHY (18 patients)
MEDICAL DEVICE COMPLICATION (18 patients)
DIVERTICULITIS (18 patients)
OSTEOMYELITIS (18 patients)
CEREBRAL ATROPHY (18 patients)
CEREBRAL VENTRICLE DILATATION (18 patients)
DIABETIC FOOT INFECTION (18 patients)
NECK PAIN (18 patients)
OLIGURIA (17 patients)
GASTROINTESTINAL DISORDER (17 patients)
HAEMATOCHEZIA (17 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (17 patients)
HYPOTHYROIDISM (17 patients)
TRANSAMINASES INCREASED (17 patients)
OROPHARYNGEAL PAIN (17 patients)
CHRONIC MYELOID LEUKAEMIA (17 patients)
NEOPLASM PROGRESSION (17 patients)
METASTASES TO ADRENALS (16 patients)
LYMPHOCYTE COUNT DECREASED (16 patients)
INTERNATIONAL NORMALISED RATIO INCREASED (16 patients)
MULTI-ORGAN FAILURE (16 patients)
FEAR (16 patients)
PANCREATIC CARCINOMA (16 patients)
HYPERSOMNIA (16 patients)
EPILEPSY (16 patients)
SUBARACHNOID HAEMORRHAGE (16 patients)
METASTASES TO LUNG (16 patients)
TACHYCARDIA (16 patients)
MUSCULAR WEAKNESS (16 patients)
KLEBSIELLA SEPSIS (16 patients)
MYOCARDIAL ISCHAEMIA (16 patients)
DYSGEUSIA (16 patients)
LUNG INFECTION (16 patients)
FAECES DISCOLOURED (16 patients)
PAIN OF SKIN (16 patients)
SPINAL FRACTURE (16 patients)
PANIC REACTION (16 patients)

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