Is ARRHYTHMIA a side effect of SORAFENIB (RAF KINASE INHIBITOR) ? ( FactMed.com )

About this FactMed analysis covering adverse side effect reports of SORAFENIB (RAF KINASE INHIBITOR) patients who developed ARRHYTHMIA.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 2 individuals taking SORAFENIB (RAF KINASE INHIBITOR) reported ARRHYTHMIA to the FDA. A total of 3329 SORAFENIB (RAF KINASE INHIBITOR) drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between SORAFENIB (RAF KINASE INHIBITOR) and ARRHYTHMIA. In doing so, we compare SORAFENIB (RAF KINASE INHIBITOR) with other drugs that cause ARRHYTHMIA, to help you evaluate whether or not SORAFENIB (RAF KINASE INHIBITOR) causes ARRHYTHMIA. Likewise, this page shows the most highly-reported side effects of SORAFENIB (RAF KINASE INHIBITOR), so you can see if ARRHYTHMIA ranks among SORAFENIB (RAF KINASE INHIBITOR)'s most well-known side effects.

Summary Statistics
Reports of SORAFENIB (RAF KINASE INHIBITOR) causing ARRHYTHMIA: 2
Reports of any side effect of SORAFENIB (RAF KINASE INHIBITOR) : 3329
Percentage of SORAFENIB (RAF KINASE INHIBITOR) patients where ARRHYTHMIA is a reported side effect: 0.0601%

FDA reports of any drug causing ARRHYTHMIA : 20618
Average percentage for all medicated patients where ARRHYTHMIA is reported as a complication: 0.1292%

Physician opinion on SORAFENIB (RAF KINASE INHIBITOR) as adverse event culprit:

Overall opinion for all reports of this drug:

Most frequent diagnoses/indications for prescribing SORAFENIB (RAF KINASE INHIBITOR):

HEPATIC NEOPLASM MALIGNANT ( 770 patients )
RENAL CELL CARCINOMA ( 114 patients )
THYROID CANCER ( 65 patients )
METASTATIC RENAL CELL CARCINOMA ( 44 patients )
THYROID CANCER METASTATIC ( 35 patients )
BREAST CANCER ( 31 patients )
BREAST CANCER METASTATIC ( 27 patients )
GASTRIC CANCER ( 25 patients )
NON-SMALL CELL LUNG CANCER ( 25 patients )
COLORECTAL CANCER METASTATIC ( 22 patients )
RENAL CANCER ( 17 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 14 patients )
BILE DUCT CANCER ( 14 patients )
SALIVARY GLAND CANCER ( 7 patients )
HEPATIC CANCER METASTATIC ( 7 patients )
COLORECTAL CANCER ( 7 patients )
SMALL CELL LUNG CANCER STAGE UNSPECIFIED ( 6 patients )
RECTAL CANCER ( 5 patients )
PANCREATIC CARCINOMA ( 4 patients )
PROSTATE CANCER ( 4 patients )
INTRAOCULAR MELANOMA ( 4 patients )
HEPATIC NEOPLASM MALIGNANT RECURRENT ( 3 patients )
NEOPLASM ( 3 patients )
LIVER DISORDER ( 3 patients )
ANGIOSARCOMA ( 3 patients )
NON-SMALL CELL LUNG CANCER STAGE IV ( 3 patients )
METASTASES TO LUNG ( 3 patients )
HEPATIC NEOPLASM MALIGNANT NON-RESECTABLE ( 3 patients )
COLORECTAL CANCER STAGE IV ( 3 patients )
NEOPLASM MALIGNANT ( 3 patients )
GALLBLADDER CANCER METASTATIC ( 3 patients )
BILIARY CANCER METASTATIC ( 3 patients )
METASTASIS ( 3 patients )
COLON CANCER METASTATIC ( 2 patients )
HYPOPHARYNGEAL CANCER ( 2 patients )
DESMOID TUMOUR ( 2 patients )
NEUROENDOCRINE CARCINOMA ( 2 patients )
ACUTE MYELOID LEUKAEMIA (IN REMISSION) ( 2 patients )
LUNG NEOPLASM MALIGNANT ( 2 patients )
OESOPHAGEAL CARCINOMA ( 2 patients )
METASTATIC MALIGNANT MELANOMA ( 2 patients )
TONGUE NEOPLASM MALIGNANT STAGE UNSPECIFIED ( 2 patients )
METASTATIC SQUAMOUS CELL CARCINOMA ( 2 patients )
ANGINA PECTORIS ( 2 patients )
RENAL CELL CARCINOMA STAGE IV ( 2 patients )
OSTEOSARCOMA METASTATIC ( 2 patients )
BONE SARCOMA ( 2 patients )
METASTATIC OCULAR MELANOMA ( 2 patients )
METASTATIC SALIVARY GLAND CANCER ( 2 patients )
TONSIL CANCER ( 2 patients )
MYELODYSPLASTIC SYNDROME ( 1 patients )
PROSTATE CANCER METASTATIC ( 1 patients )
GALLBLADDER CANCER ( 1 patients )
NEUROENDOCRINE TUMOUR ( 1 patients )
MALIGNANT NEOPLASM OF RENAL PELVIS ( 1 patients )
GLIOMA ( 1 patients )
BLADDER CANCER ( 1 patients )
OVARIAN CANCER METASTATIC ( 1 patients )
CAROTID ARTERY DISEASE ( 1 patients )
HEPATOBLASTOMA ( 1 patients )
NASOPHARYNGEAL CANCER ( 1 patients )
ACUTE MYELOID LEUKAEMIA ( 1 patients )
LUNG ADENOCARCINOMA ( 1 patients )
RENAL CANCER METASTATIC ( 1 patients )
DIFFUSE LARGE B-CELL LYMPHOMA ( 1 patients )
NEUROENDOCRINE CARCINOMA OF THE SKIN ( 1 patients )
MALIGNANT HISTIOCYTOSIS ( 1 patients )
ANTICOAGULANT THERAPY ( 1 patients )
MALIGNANT SOFT TISSUE NEOPLASM ( 1 patients )
SARCOMA ( 1 patients )
GERM CELL CANCER ( 1 patients )
OESOPHAGEAL ADENOCARCINOMA ( 1 patients )
SQUAMOUS CELL CARCINOMA ( 1 patients )
HEAD AND NECK CANCER ( 1 patients )
OVARIAN EPITHELIAL CANCER ( 1 patients )
( 0 patients )

Drugs with high FDA adverse event association with ARRHYTHMIA:

VIOXX (4118 patients)
ASPIRIN (1778 patients)
HEPARIN SODIUM INJECTION (1690 patients)
DIGOXIN (1060 patients)
FOSAMAX (952 patients)
AVANDIA (862 patients)
LASIX (862 patients)
LIPITOR (747 patients)
COUMADIN (687 patients)
FUROSEMIDE (682 patients)
LISINOPRIL (591 patients)
ATENOLOL (555 patients)
PLAVIX (554 patients)
CELEBREX (538 patients)
OMEPRAZOLE (520 patients)
FORTEO (514 patients)
SEROQUEL (487 patients)
SIMVASTATIN (473 patients)
BEXTRA (470 patients)
ZOMETA (467 patients)
PREDNISONE (463 patients)
SYNTHROID (455 patients)
NEXIUM (443 patients)
POTASSIUM CHLORIDE (436 patients)
DIOVAN (435 patients)
DARVOCET (425 patients)
ACETAMINOPHEN (413 patients)
WARFARIN SODIUM (410 patients)
HYDROCHLOROTHIAZIDE (401 patients)
PREDNISOLONE (398 patients)
NORVASC (394 patients)
PROPOXYPHENE HCL AND ACETAMINOPHEN (391 patients)
TOPROL-XL (389 patients)
ALLOPURINOL (380 patients)
DARVON (378 patients)
ZOCOR (378 patients)
LEVOTHYROXINE SODIUM (353 patients)
METFORMIN HCL (349 patients)
METOPROLOL TARTRATE (347 patients)
NEURONTIN (346 patients)
PROPOXYPHENE NAPSYLATE W/ ACETAMINOPHEN (342 patients)
INSULIN (333 patients)
COREG (330 patients)
REVLIMID (329 patients)
LYRICA (327 patients)
PRILOSEC (325 patients)
ZOLOFT (324 patients)
HUMIRA (322 patients)
ALBUTEROL (320 patients)
NITROGLYCERIN (316 patients)
METHOTREXATE (313 patients)
PROPOXYPHENE HCL (310 patients)
FOLIC ACID (302 patients)
PROPACET 100 (302 patients)
DEXAMETHASONE (293 patients)
AMIODARONE HCL (293 patients)
CRESTOR (282 patients)
RISPERDAL (273 patients)
PROTONIX (273 patients)
XANAX (272 patients)
CYMBALTA (271 patients)
AMBIEN (271 patients)
LANTUS (265 patients)
LEVAQUIN (261 patients)
ALDACTONE (261 patients)
SPIRONOLACTONE (257 patients)
ALPRAZOLAM (256 patients)
YASMIN (254 patients)
PREVACID (252 patients)
HEPARIN SODIUM (249 patients)
AVONEX (246 patients)
VICODIN (241 patients)
CARVEDILOL (241 patients)
YAZ (240 patients)
ENALAPRIL MALEATE (240 patients)
LORAZEPAM (237 patients)
IBUPROFEN (236 patients)
ZYPREXA (235 patients)
AREDIA (235 patients)
METOPROLOL (228 patients)
AMLODIPINE (226 patients)
PAXIL (225 patients)
LEXAPRO (220 patients)
REMICADE (220 patients)
DIAZEPAM (213 patients)
RAMIPRIL (212 patients)
VITAMIN D (207 patients)
ENBREL (204 patients)
PERCOCET (203 patients)
CLONAZEPAM (202 patients)
GLUCOPHAGE (199 patients)
ATIVAN (198 patients)
ZANTAC (197 patients)
SPIRIVA (195 patients)
MULTI-VITAMINS (192 patients)
CIPROFLOXACIN (191 patients)
CALCIUM (191 patients)
COZAAR (188 patients)
OXYCONTIN (187 patients)
DOXORUBICIN HCL (187 patients)
SINGULAIR (185 patients)
AMOXICILLIN (184 patients)
METOPROLOL SUCCINATE (184 patients)
PREDNISONE TAB (183 patients)
AMARYL (179 patients)
LOPRESSOR (177 patients)
AVELOX (176 patients)
PREMARIN (175 patients)
PANTOPRAZOLE (174 patients)
FORASEQ (174 patients)
VERAPAMIL (173 patients)
HEPARIN (173 patients)
DIOVAN HCT (173 patients)
DIANEAL (172 patients)
RANITIDINE (170 patients)
ZOFRAN (169 patients)
ADVAIR DISKUS 100/50 (169 patients)
[THERAPY UNSPECIFIED] (169 patients)
MORPHINE (166 patients)
ARICEPT (165 patients)
LOVENOX (165 patients)
SANDOSTATIN LAR (163 patients)
BYETTA (161 patients)
GLYBURIDE (160 patients)
LANSOPRAZOLE (159 patients)
LANOXIN (158 patients)
CORDARONE (157 patients)
KETEK (155 patients)
GLIPIZIDE (154 patients)
HUMALOG (154 patients)
CARDIZEM (153 patients)
FLUOROURACIL (153 patients)
ALLEGRA (153 patients)
CLOZARIL (151 patients)
DILTIAZEM (151 patients)
GABAPENTIN (150 patients)
ALTACE (150 patients)
FENTANYL (150 patients)
BENADRYL (148 patients)
VANCOMYCIN (148 patients)
CAPTOPRIL (146 patients)
TRAMADOL HCL (146 patients)
POTASSIUM (146 patients)
PEPCID (144 patients)
REGLAN (142 patients)
EFFEXOR (141 patients)
BISOPROLOL FUMARATE (141 patients)
ZYRTEC (141 patients)
FLOMAX (139 patients)
EXELON (138 patients)
TYLENOL (CAPLET) (138 patients)
ZETIA (137 patients)
ACTOS (137 patients)
NAPROXEN (135 patients)
EFFEXOR XR (135 patients)
CELEXA (134 patients)
CYCLOPHOSPHAMIDE (133 patients)
DECADRON (132 patients)
PROZAC (130 patients)
CLONIDINE (129 patients)
FERROUS SULFATE TAB (129 patients)
CLOPIDOGREL (129 patients)
METFORMIN (129 patients)
ACCUTANE (129 patients)
TIKOSYN (129 patients)
FLUCONAZOLE (129 patients)
ASCORBIC ACID (128 patients)
CITALOPRAM HYDROBROMIDE (127 patients)
TRAZODONE HCL (127 patients)
AVANDAMET (127 patients)
AMIODARONE (127 patients)
OXYCODONE HCL (126 patients)
VELCADE (126 patients)
IRON (126 patients)
TYLENOL (125 patients)
KLOR-CON (125 patients)
CALCIUM CARBONATE (125 patients)
PROPOFOL (125 patients)
ACCUPRIL (123 patients)
AMITRIPTYLINE HCL (123 patients)
METOCLOPRAMIDE (123 patients)
STRATTERA (123 patients)
SOTALOL HCL (122 patients)
COLACE (121 patients)
ALENDRONATE SODIUM (119 patients)
TAXOTERE (119 patients)
LORTAB (119 patients)
FEMARA (117 patients)
OXALIPLATIN (117 patients)
TRACLEER (115 patients)
GLEEVEC (114 patients)
ATACAND (114 patients)
ARANESP (113 patients)
METHADONE HCL (113 patients)
TEMAZEPAM (112 patients)
MAGNESIUM OXIDE (112 patients)
CLOZAPINE (111 patients)
PRAVACHOL (109 patients)
TEGRETOL (109 patients)
FLEXERIL (109 patients)
EXJADE (108 patients)
GEODON (108 patients)
ZITHROMAX (106 patients)
IMDUR (106 patients)
AMLODIPINE BESYLATE (106 patients)
LOSARTAN POTASSIUM (106 patients)
VALIUM (105 patients)
TENORMIN (105 patients)
PANTOPRAZOLE SODIUM (105 patients)
MULTI-VITAMIN (105 patients)

Most common side effects for patients taking SORAFENIB (RAF KINASE INHIBITOR):

DIARRHOEA (613 patients)
HEPATIC FAILURE (378 patients)
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME (342 patients)
HEPATIC ENCEPHALOPATHY (320 patients)
FATIGUE (300 patients)
RASH (276 patients)
ASCITES (253 patients)
ABDOMINAL PAIN (237 patients)
DECREASED APPETITE (226 patients)
UPPER GASTROINTESTINAL HAEMORRHAGE (198 patients)
PYREXIA (191 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (179 patients)
NAUSEA (165 patients)
HYPERTENSION (160 patients)
ASTHENIA (154 patients)
DEHYDRATION (140 patients)
HEPATIC FUNCTION ABNORMAL (133 patients)
DYSPNOEA (131 patients)
CONFUSIONAL STATE (131 patients)
HYPOKALAEMIA (125 patients)
ALOPECIA (124 patients)
VOMITING (118 patients)
CONSTIPATION (115 patients)
INTERSTITIAL LUNG DISEASE (114 patients)
LEFT VENTRICULAR DYSFUNCTION (113 patients)
DEATH (113 patients)
ENDOCARDITIS (112 patients)
ARTHRALGIA (111 patients)
STOMATITIS (111 patients)
ABDOMINAL PAIN UPPER (110 patients)
JAUNDICE (108 patients)
HEPATIC NEOPLASM MALIGNANT (106 patients)
GASTROINTESTINAL HAEMORRHAGE (106 patients)
RETINAL VASCULAR THROMBOSIS (103 patients)
LOWER GASTROINTESTINAL HAEMORRHAGE (103 patients)
LIVER CARCINOMA RUPTURED (101 patients)
OEDEMA PERIPHERAL (97 patients)
PLEURAL EFFUSION (97 patients)
STAPHYLOCOCCAL INFECTION (96 patients)
PNEUMONIA BACTERIAL (96 patients)
ENTEROBACTER INFECTION (96 patients)
MYOPATHY (95 patients)
DRY MOUTH (94 patients)
PAIN IN EXTREMITY (93 patients)
ANXIETY (90 patients)
MALAISE (89 patients)
PULMONARY EMBOLISM (85 patients)
ANAEMIA (84 patients)
PLATELET COUNT DECREASED (81 patients)
BACK PAIN (79 patients)
SEPSIS (78 patients)
PRURITUS (78 patients)
DUODENAL ULCER (77 patients)
MIGRAINE (76 patients)
MITRAL VALVE INCOMPETENCE (76 patients)
HYPOGLYCAEMIA (76 patients)
C-REACTIVE PROTEIN INCREASED (74 patients)
BLOOD PRESSURE INCREASED (73 patients)
VARICES OESOPHAGEAL (73 patients)
HEADACHE (72 patients)
RETINAL VEIN OCCLUSION (72 patients)
ABASIA (69 patients)
RENAL FAILURE ACUTE (69 patients)
WEIGHT DECREASED (67 patients)
DEEP VEIN THROMBOSIS (67 patients)
DIZZINESS (65 patients)
ERYTHEMA (65 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (64 patients)
CONVULSION (63 patients)
ALANINE AMINOTRANSFERASE INCREASED (62 patients)
DYSPHONIA (62 patients)
CEREBRAL HAEMORRHAGE (60 patients)
APHAGIA (58 patients)
COLITIS (58 patients)
PNEUMONIA (57 patients)
GASTRIC ULCER (56 patients)
HYPONATRAEMIA (55 patients)
HAEMOGLOBIN DECREASED (53 patients)
RESPIRATORY FAILURE (52 patients)
LUNG DISORDER (52 patients)
CEREBRAL ISCHAEMIA (49 patients)
PARAESTHESIA (49 patients)
BLOOD BILIRUBIN INCREASED (48 patients)
GAIT DISTURBANCE (48 patients)
THYROID CANCER METASTATIC (44 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (43 patients)
PERICARDIAL EFFUSION (41 patients)
THROMBOCYTOPENIA (41 patients)
BLISTER (41 patients)
FEBRILE NEUTROPENIA (40 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (40 patients)
HALLUCINATION (40 patients)
CHILLS (40 patients)
AMMONIA INCREASED (39 patients)
SKIN ULCER (39 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (38 patients)
PAIN (38 patients)
HYPOALBUMINAEMIA (38 patients)
HYPOCALCAEMIA (37 patients)
FALL (37 patients)
POLLAKIURIA (37 patients)
BLOOD PRESSURE DECREASED (37 patients)
SKIN EXFOLIATION (37 patients)
INSOMNIA (36 patients)
CARDIAC ARREST (36 patients)
HYPOAESTHESIA (35 patients)
INFECTIOUS PERITONITIS (35 patients)
MYOCARDIAL INFARCTION (35 patients)
RETINAL VASCULAR DISORDER (34 patients)
RENAL FAILURE (34 patients)
LIPASE INCREASED (34 patients)
HYPERKALAEMIA (33 patients)
HYPERGLYCAEMIA (33 patients)
HAEMOPTYSIS (31 patients)
ATRIAL FIBRILLATION (30 patients)
GENERALISED OEDEMA (30 patients)
FAECAL INCONTINENCE (30 patients)
WHITE BLOOD CELL COUNT DECREASED (30 patients)
CELLULITIS (29 patients)
CHEST PAIN (29 patients)
SOMNOLENCE (29 patients)
HYPERBILIRUBINAEMIA (28 patients)
HYPOTENSION (28 patients)
MUSCLE SPASMS (28 patients)
ABDOMINAL DISTENSION (27 patients)
WHITE BLOOD CELL COUNT INCREASED (27 patients)
VISION BLURRED (27 patients)
HEPATIC PAIN (26 patients)
BLOOD ALBUMIN DECREASED (26 patients)
DYSURIA (25 patients)
RASH GENERALISED (25 patients)
BLOOD SODIUM DECREASED (25 patients)
BLOOD URIC ACID INCREASED (25 patients)
COMA (25 patients)
COUGH (25 patients)
PANCYTOPENIA (25 patients)
ACUTE ABDOMEN (24 patients)
EOSINOPHIL COUNT INCREASED (24 patients)
CEREBROVASCULAR ACCIDENT (24 patients)
METASTASES TO CENTRAL NERVOUS SYSTEM (23 patients)
CEREBRAL INFARCTION (23 patients)
HYPOMAGNESAEMIA (23 patients)
RETINAL VEIN THROMBOSIS (23 patients)
GAMMA-GLUTAMYLTRANSFERASE INCREASED (23 patients)
TUMOUR LYSIS SYNDROME (22 patients)
HYPOPHOSPHATAEMIA (22 patients)
INFECTION (22 patients)
ORAL PAIN (22 patients)
BLOOD CREATININE INCREASED (22 patients)
NEUTROPENIA (22 patients)
RENAL IMPAIRMENT (22 patients)
LETHARGY (22 patients)
SKIN TOXICITY (21 patients)
TONGUE BLISTERING (21 patients)
LIVER ABSCESS (21 patients)
HAEMATEMESIS (21 patients)
OESOPHAGEAL VARICES HAEMORRHAGE (20 patients)
MENTAL IMPAIRMENT (20 patients)
NERVOUSNESS (20 patients)
NEPHROTIC SYNDROME (20 patients)
HYPOPHAGIA (20 patients)
ADRENAL INSUFFICIENCY (19 patients)
DRY SKIN (19 patients)
BLOOD AMYLASE INCREASED (19 patients)
OEDEMA (19 patients)
INFECTIOUS PLEURAL EFFUSION (19 patients)
DYSPEPSIA (19 patients)
COMA HEPATIC (19 patients)
HEART RATE INCREASED (18 patients)
HYPERTENSIVE CRISIS (18 patients)
MYALGIA (18 patients)
ECZEMA (18 patients)
URINARY TRACT INFECTION (18 patients)
NEUROMYOPATHY (18 patients)
MEDICAL DEVICE COMPLICATION (18 patients)
DIVERTICULITIS (18 patients)
OSTEOMYELITIS (18 patients)
CEREBRAL ATROPHY (18 patients)
CEREBRAL VENTRICLE DILATATION (18 patients)
DIABETIC FOOT INFECTION (18 patients)
NECK PAIN (18 patients)
OLIGURIA (17 patients)
GASTROINTESTINAL DISORDER (17 patients)
HAEMATOCHEZIA (17 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (17 patients)
HYPOTHYROIDISM (17 patients)
TRANSAMINASES INCREASED (17 patients)
OROPHARYNGEAL PAIN (17 patients)
CHRONIC MYELOID LEUKAEMIA (17 patients)
NEOPLASM PROGRESSION (17 patients)
METASTASES TO ADRENALS (16 patients)
LYMPHOCYTE COUNT DECREASED (16 patients)
INTERNATIONAL NORMALISED RATIO INCREASED (16 patients)
MULTI-ORGAN FAILURE (16 patients)
FEAR (16 patients)
PANCREATIC CARCINOMA (16 patients)
HYPERSOMNIA (16 patients)
EPILEPSY (16 patients)
SUBARACHNOID HAEMORRHAGE (16 patients)
METASTASES TO LUNG (16 patients)
TACHYCARDIA (16 patients)
MUSCULAR WEAKNESS (16 patients)
KLEBSIELLA SEPSIS (16 patients)
MYOCARDIAL ISCHAEMIA (16 patients)
DYSGEUSIA (16 patients)
LUNG INFECTION (16 patients)
FAECES DISCOLOURED (16 patients)
PAIN OF SKIN (16 patients)
SPINAL FRACTURE (16 patients)
PANIC REACTION (16 patients)

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