Is TENDERNESS a side effect of SYNTHROID ? ( FactMed.com )

About this FactMed analysis covering adverse side effect reports of SYNTHROID patients who developed TENDERNESS.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 218 individuals taking SYNTHROID reported TENDERNESS to the FDA. A total of 65802 SYNTHROID drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between SYNTHROID and TENDERNESS. In doing so, we compare SYNTHROID with other drugs that cause TENDERNESS, to help you evaluate whether or not SYNTHROID causes TENDERNESS. Likewise, this page shows the most highly-reported side effects of SYNTHROID, so you can see if TENDERNESS ranks among SYNTHROID's most well-known side effects.

Summary Statistics
Reports of SYNTHROID causing TENDERNESS: 218
Reports of any side effect of SYNTHROID : 65802
Percentage of SYNTHROID patients where TENDERNESS is a reported side effect: 0.3313%

FDA reports of any drug causing TENDERNESS : 3193
Average percentage for all medicated patients where TENDERNESS is reported as a complication: 0.0200%

Physician opinion on SYNTHROID as adverse event culprit:

Overall opinion for all reports of this drug:

Most frequent diagnoses/indications for prescribing SYNTHROID:

HYPOTHYROIDISM ( 10056 patients )
THYROID DISORDER ( 3638 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 2522 patients )
DRUG USE FOR UNKNOWN INDICATION ( 2018 patients )
THYROIDECTOMY ( 468 patients )
AUTOIMMUNE THYROIDITIS ( 352 patients )
HYPERTHYROIDISM ( 312 patients )
BASEDOW'S DISEASE ( 107 patients )
HORMONE REPLACEMENT THERAPY ( 100 patients )
GOITRE ( 89 patients )
THYROID HORMONE REPLACEMENT THERAPY ( 87 patients )
THYROID CANCER ( 86 patients )
THYROID NEOPLASM ( 67 patients )
THYROID THERAPY ( 54 patients )
HYPOPITUITARISM ( 46 patients )
THYROID FUNCTION TEST ABNORMAL ( 41 patients )
BLOOD THYROID STIMULATING HORMONE INCREASED ( 34 patients )
SUPPLEMENTATION THERAPY ( 32 patients )
BLOOD THYROID STIMULATING HORMONE DECREASED ( 26 patients )
DRUG EXPOSURE DURING PREGNANCY ( 24 patients )
THYROIDITIS ( 21 patients )
POST PROCEDURAL HYPOTHYROIDISM ( 13 patients )
ILL-DEFINED DISORDER ( 11 patients )
THYROID OPERATION ( 11 patients )
CONGENITAL HYPOTHYROIDISM ( 10 patients )
DEPRESSION ( 10 patients )
PROPHYLAXIS ( 9 patients )
HYPERPARATHYROIDISM ( 9 patients )
FATIGUE ( 9 patients )
HYPOTENSION ( 9 patients )
BLOOD THYROID STIMULATING HORMONE ( 9 patients )
FOETAL EXPOSURE DURING PREGNANCY ( 8 patients )
BENIGN NEOPLASM OF THYROID GLAND ( 8 patients )
HORMONE THERAPY ( 7 patients )
CROHN'S DISEASE ( 7 patients )
BIPOLAR DISORDER ( 6 patients )
THYROXINE THERAPY ( 6 patients )
HYPOTHYROIDIC GOITRE ( 6 patients )
HYPERTENSION ( 6 patients )
RADIOTHERAPY TO THYROID ( 6 patients )
NODULE ( 5 patients )
PRIMARY HYPOTHYROIDISM ( 5 patients )
HYPOPARATHYROIDISM ( 5 patients )
BLOOD THYROID STIMULATING HORMONE ABNORMAL ( 5 patients )
HORMONE LEVEL ABNORMAL ( 5 patients )
PAIN ( 5 patients )
RADIOACTIVE IODINE THERAPY ( 5 patients )
ANTI-THYROID ANTIBODY POSITIVE ( 5 patients )
THYROID GLAND CANCER ( 5 patients )
NEOPLASM MALIGNANT ( 5 patients )
DIABETES MELLITUS ( 5 patients )
POSTOPERATIVE CARE ( 4 patients )
CARDIAC DISORDER ( 4 patients )
ADDISON'S DISEASE ( 4 patients )
THYROID ATROPHY ( 4 patients )
HYPERCHOLESTEROLAEMIA ( 4 patients )
PULMONARY EMBOLISM ( 4 patients )
SJOGREN'S SYNDROME ( 3 patients )
THERAPEUTIC PROCEDURE ( 3 patients )
THROAT CANCER ( 3 patients )
BLOOD CHOLESTEROL ABNORMAL ( 3 patients )
THYROXINE DECREASED ( 3 patients )
THYROID CYST ( 3 patients )
ANTI-THYROID ANTIBODY ( 3 patients )
GASTROOESOPHAGEAL REFLUX DISEASE ( 3 patients )
ASTHENIA ( 3 patients )
HORMONE SUPPRESSION THERAPY ( 3 patients )
ADENOMA BENIGN ( 3 patients )
HYPOMETABOLISM ( 3 patients )
PARATHYROID DISORDER ( 3 patients )
OEDEMA PERIPHERAL ( 2 patients )
DRUG EXPOSURE VIA BREAST MILK ( 2 patients )
BLOOD IRON DECREASED ( 2 patients )
ENDOCRINE DISORDER ( 2 patients )
RADIATION THYROIDITIS ( 2 patients )
PAPILLARY THYROID CANCER ( 2 patients )
BLOOD PRESSURE ( 2 patients )
EXPOSURE VIA SEMEN ( 2 patients )
PARATHYROIDECTOMY ( 2 patients )
BLOOD PRESSURE INCREASED ( 2 patients )
METABOLIC DISORDER ( 2 patients )
TRI-IODOTHYRONINE ABNORMAL ( 2 patients )
PITUITARY TUMOUR ( 2 patients )
HYPOTHALAMO-PITUITARY DISORDER ( 2 patients )
DIARRHOEA ( 2 patients )
LOCAL SWELLING ( 2 patients )
THYROXINE ABNORMAL ( 2 patients )
MATERNAL EXPOSURE TIMING UNSPECIFIED ( 2 patients )
BLOOD PRESSURE ABNORMAL ( 2 patients )
TRANSVERSE SINUS THROMBOSIS ( 2 patients )
THYROID MASS ( 2 patients )
POLYCYSTIC OVARIES ( 2 patients )
GOUT ( 1 patients )
DIVERTICULITIS ( 1 patients )
BODY TEMPERATURE INCREASED ( 1 patients )
OFF LABEL USE ( 1 patients )
JOINT CREPITATION ( 1 patients )
THYROTOXIC CRISIS ( 1 patients )
CHEMOTHERAPY ( 1 patients )
OVERDOSE ( 1 patients )
MATERNAL EXPOSURE DURING PREGNANCY ( 1 patients )
ADVERSE DRUG REACTION ( 1 patients )
CHRONIC OBSTRUCTIVE PULMONARY DISEASE ( 1 patients )
MENOPAUSE ( 1 patients )
RADIOTHERAPY ( 1 patients )
RASH GENERALISED ( 1 patients )
ANTIBODY TEST POSITIVE ( 1 patients )
CUSHING'S SYNDROME ( 1 patients )
BLOOD TEST ABNORMAL ( 1 patients )
METASTATIC RENAL CELL CARCINOMA ( 1 patients )
SCHIZOAFFECTIVE DISORDER ( 1 patients )
WEIGHT DECREASED ( 1 patients )
PITUITARY TUMOUR REMOVAL ( 1 patients )
NEOPLASM PROPHYLAXIS ( 1 patients )
SINUSITIS ( 1 patients )
OBESITY ( 1 patients )
IDIOPATHIC THROMBOCYTOPENIC PURPURA ( 1 patients )
POSTPARTUM DEPRESSION ( 1 patients )
CARCINOMA ( 1 patients )
OESOPHAGEAL DISORDER ( 1 patients )
THERAPY REGIMEN CHANGED ( 1 patients )
BLOOD CHOLESTEROL ( 1 patients )
DRUG TOLERANCE ( 1 patients )
IMPAIRED GASTRIC EMPTYING ( 1 patients )
THYROIDITIS CHRONIC ( 1 patients )
ACCIDENTAL EXPOSURE ( 1 patients )
CEREBROVASCULAR ACCIDENT PROPHYLAXIS ( 1 patients )
ORAL CONTRACEPTION ( 1 patients )
THYROID ADENOMA REMOVAL ( 1 patients )
BLOOD GLUCOSE ABNORMAL ( 1 patients )
ENDOCARDITIS ( 1 patients )
CHRONIC FATIGUE SYNDROME ( 1 patients )
BLOOD PARATHYROID HORMONE DECREASED ( 1 patients )
ENDOCRINE GLAND OPERATION ( 1 patients )
THYROXINE INCREASED ( 1 patients )
ALOPECIA ( 1 patients )
CONGENITAL ANOMALY ( 1 patients )
MENSTRUATION IRREGULAR ( 1 patients )
HYPOPHYSECTOMY ( 1 patients )
PHARYNGEAL OEDEMA ( 1 patients )
BLOOD PRESSURE MANAGEMENT ( 1 patients )
GASTRITIS ( 1 patients )
METABOLIC SYNDROME ( 1 patients )
RED BLOOD CELL SEDIMENTATION RATE INCREASED ( 1 patients )
TRI-IODOTHYRONINE DECREASED ( 1 patients )
ANXIETY ( 1 patients )
DEEP VEIN THROMBOSIS ( 1 patients )
PITUITARY TUMOUR BENIGN ( 1 patients )
GLAUCOMA ( 1 patients )
SECONDARY HYPOTHYROIDISM ( 1 patients )
ASTHMA ( 1 patients )
HYPOTHALAMO-PITUITARY DISORDERS ( 1 patients )
THYROID NODULE REMOVAL ( 1 patients )
( 0 patients )

Drugs with high FDA adverse event association with TENDERNESS:

ZOMETA (808 patients)
AREDIA (596 patients)
ASPIRIN (435 patients)
FOSAMAX (362 patients)
COUMADIN (300 patients)
AMBIEN (295 patients)
LASIX (261 patients)
PREDNISONE (249 patients)
PRILOSEC (248 patients)
NEURONTIN (244 patients)
PROTONIX (241 patients)
OXYCONTIN (235 patients)
SYNTHROID (218 patients)
LEVAQUIN (215 patients)
CELEBREX (206 patients)
LIPITOR (205 patients)
HUMIRA (200 patients)
LORTAB (196 patients)
VIOXX (194 patients)
XANAX (188 patients)
DEXAMETHASONE (183 patients)
ATIVAN (182 patients)
FOLIC ACID (159 patients)
DECADRON (159 patients)
NEXIUM (154 patients)
PERCOCET (153 patients)
LISINOPRIL (152 patients)
ALLOPURINOL (150 patients)
ATENOLOL (147 patients)
HYDROCHLOROTHIAZIDE (145 patients)
TAMOXIFEN CITRATE (144 patients)
ENBREL (144 patients)
THALIDOMIDE (143 patients)
DIGOXIN (140 patients)
DURAGESIC-100 (137 patients)
CALCIUM (136 patients)
EFFEXOR (136 patients)
METHOTREXATE (135 patients)
FUROSEMIDE (134 patients)
ZOLOFT (130 patients)
VICODIN (128 patients)
MS CONTIN (128 patients)
SANDOSTATIN LAR (123 patients)
ALBUTEROL (123 patients)
ZOFRAN (121 patients)
CIPROFLOXACIN (119 patients)
FLEXERIL (119 patients)
PREVACID (118 patients)
ZANTAC (117 patients)
ALPRAZOLAM (114 patients)
SIMVASTATIN (114 patients)
MULTI-VITAMINS (113 patients)
FEMARA (113 patients)
RADIATION THERAPY (111 patients)
PAXIL (110 patients)
POTASSIUM CHLORIDE (108 patients)
AVELOX (106 patients)
CARBOPLATIN (106 patients)
OXYCODONE HCL (104 patients)
FLAGYL (103 patients)
LORAZEPAM (102 patients)
NORVASC (102 patients)
KLONOPIN (101 patients)
ADVAIR DISKUS 100/50 (101 patients)
VITAMIN D (101 patients)
OMEPRAZOLE (101 patients)
ELAVIL (99 patients)
MORPHINE (99 patients)
ACETAMINOPHEN (97 patients)
ZYRTEC (97 patients)
WARFARIN SODIUM (96 patients)
AROMASIN (95 patients)
CALCIUM CARBONATE (95 patients)
LYRICA (95 patients)
WELLBUTRIN (92 patients)
LEVOTHYROXINE SODIUM (92 patients)
PLAVIX (91 patients)
CRESTOR (91 patients)
ZOCOR (91 patients)
PERIDEX (89 patients)
LEXAPRO (89 patients)
VINCRISTINE (89 patients)
IBUPROFEN (87 patients)
COZAAR (87 patients)
SPIRONOLACTONE (87 patients)
REVLIMID (85 patients)
PROZAC (85 patients)
FERROUS SULFATE TAB (85 patients)
CLARITIN (85 patients)
REGLAN (84 patients)
PREDNISONE TAB (83 patients)
ARIMIDEX (83 patients)
TRAZODONE HCL (83 patients)
DIAZEPAM (83 patients)
COMPAZINE (82 patients)
AMOXICILLIN (82 patients)
TAXOTERE (81 patients)
DIFLUCAN (80 patients)
PREMARIN (79 patients)
SEROQUEL (77 patients)
COLACE (77 patients)
CYTOXAN (77 patients)
DOXYCYCLINE (76 patients)
MEGACE (76 patients)
FORTEO (76 patients)
VELCADE (74 patients)
DILAUDID (74 patients)
COREG (73 patients)
FLOMAX (73 patients)
MORPHINE SULFATE (73 patients)
CELEXA (73 patients)
ADRIAMYCIN PFS (71 patients)
NITROGLYCERIN (71 patients)
ACCUTANE (70 patients)
VITAMIN B-12 (70 patients)
DARVOCET-N 100 (70 patients)
METFORMIN HCL (70 patients)
TRAMADOL HCL (68 patients)
CYCLOPHOSPHAMIDE (68 patients)
FLONASE (67 patients)
HYDROCODONE BITARTRATE (66 patients)
TAXOL (65 patients)
ACYCLOVIR (65 patients)
PREDNISOLONE (65 patients)
METOPROLOL TARTRATE (65 patients)
VIAGRA (65 patients)
IRON (65 patients)
CYCLOBENZAPRINE (65 patients)
GABAPENTIN (64 patients)
ACIPHEX (64 patients)
TAGAMET (64 patients)
KLOR-CON (64 patients)
CYMBALTA (64 patients)
FENTANYL (64 patients)
CEPHALEXIN (63 patients)
NEUPOGEN (63 patients)
ACTONEL (62 patients)
TOPROL-XL (62 patients)
EPOGEN (62 patients)
BENADRYL (60 patients)
FASLODEX (60 patients)
LOVENOX (60 patients)
VANCOMYCIN (60 patients)
FISH OIL (60 patients)
ARANESP (59 patients)
INSULIN (59 patients)
ULTRACET (59 patients)
CHLORHEXIDINE GLUCONATE (59 patients)
OXYCODONE (58 patients)
ZITHROMAX (58 patients)
CLONAZEPAM (58 patients)
PEPCID (57 patients)
VITAMIN E (57 patients)
BEXTRA (57 patients)
GEMZAR (57 patients)
HEPARIN (57 patients)
LOPRESSOR (55 patients)
PROMETHAZINE (55 patients)
MELPHALAN (55 patients)
CASODEX (55 patients)
METRONIDAZOLE (54 patients)
LUPRON (53 patients)
VALIUM (53 patients)
NYSTATIN (53 patients)
LANSOPRAZOLE (52 patients)
TYLENOL (52 patients)
VASOTEC (52 patients)
ULTRAM (52 patients)
YASMIN (52 patients)
EFFEXOR XR (52 patients)
XELODA (52 patients)
MOTRIN (51 patients)
CLONIDINE (51 patients)
HYDROMORPHONE HCL (51 patients)
ZYPREXA (51 patients)
MIRALAX (51 patients)
K-DUR (50 patients)
FLUCONAZOLE (50 patients)
ZETIA (50 patients)
FLUOROURACIL (49 patients)
MELOXICAM (49 patients)
NAPROSYN (48 patients)
HYDROCODONE (48 patients)
BIAXIN (48 patients)
SKELAXIN (48 patients)
OXYCODONE HCL AND ACETAMINOPHEN (48 patients)
ASCORBIC ACID (48 patients)
PENICILLIN VK (48 patients)
RITALIN (47 patients)
LORCET-HD (47 patients)
SOMA (47 patients)
NAPROXEN (46 patients)
DARVOCET-N 50 (46 patients)
RECLAST (46 patients)
CHEMOTHERAPEUTICS NOS (46 patients)
YAZ (45 patients)
MIACALCIN (45 patients)
VYTORIN (45 patients)
RADIATION (45 patients)
DIOVAN (45 patients)
INFLUENZA VACCINE (45 patients)
AMLODIPINE (45 patients)
LEVOXYL (45 patients)
PREMPRO (44 patients)
LANTUS (44 patients)
ANZEMET (44 patients)
AUGMENTIN '125' (44 patients)
HYTRIN (44 patients)
ZOVIRAX (44 patients)
AMITRIPTYLINE HCL (44 patients)

Most common side effects for patients taking SYNTHROID:

NAUSEA (5985 patients)
FATIGUE (4961 patients)
DYSPNOEA (4630 patients)
PAIN (4528 patients)
DIZZINESS (4476 patients)
HEADACHE (4182 patients)
ANXIETY (3803 patients)
DRUG INEFFECTIVE (3708 patients)
DIARRHOEA (3699 patients)
ASTHENIA (3682 patients)
FALL (3306 patients)
ARTHRALGIA (3116 patients)
VOMITING (3106 patients)
DEPRESSION (3026 patients)
PAIN IN EXTREMITY (2979 patients)
OEDEMA PERIPHERAL (2946 patients)
INSOMNIA (2761 patients)
CHEST PAIN (2743 patients)
WEIGHT DECREASED (2605 patients)
HYPERTENSION (2604 patients)
BACK PAIN (2501 patients)
WEIGHT INCREASED (2301 patients)
FEELING ABNORMAL (2109 patients)
MALAISE (2097 patients)
ABDOMINAL PAIN (2079 patients)
ANAEMIA (2017 patients)
PYREXIA (2005 patients)
RASH (1997 patients)
CONSTIPATION (1912 patients)
PNEUMONIA (1904 patients)
PALPITATIONS (1862 patients)
PRURITUS (1816 patients)
MYALGIA (1805 patients)
COUGH (1703 patients)
MUSCLE SPASMS (1703 patients)
MYOCARDIAL INFARCTION (1691 patients)
CEREBROVASCULAR ACCIDENT (1607 patients)
INJURY (1591 patients)
HYPOAESTHESIA (1590 patients)
BLOOD GLUCOSE INCREASED (1579 patients)
GASTROOESOPHAGEAL REFLUX DISEASE (1563 patients)
TREMOR (1560 patients)
URINARY TRACT INFECTION (1546 patients)
DEHYDRATION (1534 patients)
HYPOTENSION (1522 patients)
ABDOMINAL PAIN UPPER (1520 patients)
CARDIAC FAILURE CONGESTIVE (1504 patients)
BLOOD PRESSURE INCREASED (1502 patients)
PARAESTHESIA (1467 patients)
GAIT DISTURBANCE (1429 patients)
HYPOTHYROIDISM (1418 patients)
OSTEOARTHRITIS (1397 patients)
ALOPECIA (1366 patients)
SOMNOLENCE (1350 patients)
DECREASED APPETITE (1325 patients)
ATRIAL FIBRILLATION (1320 patients)
CONFUSIONAL STATE (1291 patients)
VISION BLURRED (1274 patients)
HYPERHIDROSIS (1258 patients)
RENAL FAILURE (1252 patients)
HEART RATE INCREASED (1178 patients)
MUSCULAR WEAKNESS (1165 patients)
LOSS OF CONSCIOUSNESS (1162 patients)
PULMONARY EMBOLISM (1161 patients)
DEEP VEIN THROMBOSIS (1159 patients)
DYSPEPSIA (1125 patients)
CONVULSION (1111 patients)
CONDITION AGGRAVATED (1069 patients)
ERYTHEMA (1065 patients)
DEATH (1056 patients)
FLUSHING (1044 patients)
BLOOD CHOLESTEROL INCREASED (1042 patients)
EMOTIONAL DISTRESS (1016 patients)
DIABETES MELLITUS (1009 patients)
SYNCOPE (1006 patients)
CONTUSION (995 patients)
CHEST DISCOMFORT (995 patients)
DYSPHAGIA (976 patients)
SINUSITIS (962 patients)
HYPERSENSITIVITY (953 patients)
OSTEONECROSIS (944 patients)
CHILLS (928 patients)
OSTEONECROSIS OF JAW (926 patients)
BRONCHITIS (915 patients)
RENAL FAILURE ACUTE (910 patients)
ABDOMINAL DISTENSION (907 patients)
DRY MOUTH (905 patients)
CORONARY ARTERY DISEASE (905 patients)
BONE DISORDER (893 patients)
ARTHRITIS (886 patients)
PLEURAL EFFUSION (856 patients)
NEUROPATHY PERIPHERAL (845 patients)
BALANCE DISORDER (842 patients)
URTICARIA (841 patients)
HAEMOGLOBIN DECREASED (839 patients)
DYSGEUSIA (833 patients)
PHARMACEUTICAL PRODUCT COMPLAINT (831 patients)
NERVOUSNESS (815 patients)
CHOLELITHIASIS (814 patients)
NECK PAIN (813 patients)
FEMUR FRACTURE (811 patients)
ASTHMA (799 patients)
OSTEOMYELITIS (798 patients)
CELLULITIS (796 patients)
MUSCULOSKELETAL PAIN (787 patients)
CATARACT (778 patients)
INFECTION (770 patients)
JOINT SWELLING (766 patients)
SWELLING (759 patients)
ABDOMINAL DISCOMFORT (734 patients)
AMNESIA (730 patients)
CHRONIC OBSTRUCTIVE PULMONARY DISEASE (721 patients)
OSTEOPOROSIS (720 patients)
MEMORY IMPAIRMENT (719 patients)
BREAST CANCER (719 patients)
SUICIDAL IDEATION (711 patients)
MIGRAINE (706 patients)
TRANSIENT ISCHAEMIC ATTACK (704 patients)
BONE PAIN (699 patients)
CARDIAC DISORDER (699 patients)
ARTHROPATHY (697 patients)
IMPAIRED HEALING (690 patients)
THROMBOSIS (686 patients)
DRUG INTERACTION (682 patients)
SPINAL OSTEOARTHRITIS (679 patients)
DRUG HYPERSENSITIVITY (671 patients)
INJECTION SITE PAIN (669 patients)
HOT FLUSH (660 patients)
HYPERLIPIDAEMIA (652 patients)
TACHYCARDIA (648 patients)
ANHEDONIA (644 patients)
LETHARGY (637 patients)
RESPIRATORY FAILURE (635 patients)
SEPSIS (634 patients)
THROMBOCYTOPENIA (629 patients)
BLOOD THYROID STIMULATING HORMONE INCREASED (618 patients)
PAIN IN JAW (618 patients)
BURNING SENSATION (613 patients)
OEDEMA (600 patients)
INTERVERTEBRAL DISC DEGENERATION (598 patients)
INTERVERTEBRAL DISC PROTRUSION (587 patients)
PRODUCT QUALITY ISSUE (573 patients)
OSTEOPENIA (573 patients)
TYPE 2 DIABETES MELLITUS (573 patients)
HAEMORRHOIDS (571 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (571 patients)
DRUG DOSE OMISSION (567 patients)
GASTROINTESTINAL HAEMORRHAGE (565 patients)
INFLUENZA LIKE ILLNESS (563 patients)
MUSCULOSKELETAL STIFFNESS (556 patients)
DYSPHONIA (556 patients)
SWELLING FACE (555 patients)
OVERDOSE (552 patients)
STRESS (548 patients)
MITRAL VALVE INCOMPETENCE (547 patients)
BLOOD GLUCOSE DECREASED (544 patients)
HYPOKALAEMIA (541 patients)
MENTAL STATUS CHANGES (541 patients)
BLOOD PRESSURE DECREASED (538 patients)
OROPHARYNGEAL PAIN (538 patients)
GASTRITIS (536 patients)
BLOOD CREATININE INCREASED (535 patients)
FEELING HOT (534 patients)
AGITATION (532 patients)
PANCREATITIS (530 patients)
VERTIGO (529 patients)
TOOTH DISORDER (529 patients)
PLATELET COUNT DECREASED (529 patients)
HALLUCINATION (525 patients)
DENTAL CARIES (523 patients)
DYSPNOEA EXERTIONAL (521 patients)
WHITE BLOOD CELL COUNT DECREASED (520 patients)
FEAR (519 patients)
HIATUS HERNIA (518 patients)
ABASIA (514 patients)
CARDIOMEGALY (511 patients)
HERPES ZOSTER (510 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (509 patients)
FLATULENCE (505 patients)
ALANINE AMINOTRANSFERASE INCREASED (505 patients)
HYPERGLYCAEMIA (502 patients)
THYROID DISORDER (500 patients)
ROAD TRAFFIC ACCIDENT (498 patients)
UPPER RESPIRATORY TRACT INFECTION (497 patients)
TINNITUS (496 patients)
ATELECTASIS (496 patients)
IRRITABILITY (494 patients)
VISUAL IMPAIRMENT (494 patients)
CARDIAC ARREST (494 patients)
SLEEP DISORDER (491 patients)
NASOPHARYNGITIS (488 patients)
HAEMORRHAGE (488 patients)
HYPOGLYCAEMIA (486 patients)
WRONG TECHNIQUE IN DRUG USAGE PROCESS (483 patients)
INCORRECT DOSE ADMINISTERED (482 patients)
EPISTAXIS (479 patients)
RECTAL HAEMORRHAGE (478 patients)
FOOT FRACTURE (466 patients)
LYMPHADENOPATHY (461 patients)
UNEVALUABLE EVENT (459 patients)
HEART RATE IRREGULAR (457 patients)
ARRHYTHMIA (455 patients)
DRUG EXPOSURE DURING PREGNANCY (448 patients)
OFF LABEL USE (447 patients)
POLLAKIURIA (444 patients)
HYPONATRAEMIA (441 patients)
BREAST CANCER FEMALE (441 patients)
RIB FRACTURE (438 patients)
MOBILITY DECREASED (438 patients)
SPEECH DISORDER (437 patients)

In addition to reviewing our up-to-date FDA research, users may interact with the FactMed community - currently one million members and growing! FactMed online research and discussions are read by patients, scientists, physicians, and other interested health care parties. Post follow up Questions to learn from our diverse readership. Likewise, patients who have experienced unwanted effects are encouraged to share their Concerns to help educate and inform our members.

Recent FactMed Activity for SYNTHROID

Issue	Description / Topic	Timestamp
CONCERN PRESBYOPIA	I believe Synthroid and other thyroid supplements such as Levothyroxine (Levoxyl) have caused me to develop Presbyopia. I also notice that everyone (of any age including children / teens) who take Thyroid supplements need glasses or reading glasses and I think the link between Thyroid and poor vision or the inability to focus on objects close up should be studied in more detail. In my opinion, wIth my body, Synthroid has caused poor eyesight and the inability to focus on close objects ( Presbyopia ).	2014-12-04 11:01:25
CONCERN LIFE EXPECTANCY SHORTENED	The following was posted on 12-4-2014. I have the exact same symptoms. I have been on thryoid replacement therapy with Synthroid since 1995. "I believe Synthroid and other thyroid supplements such as Levothyroxine (Levoxyl) have caused me to develop Presbyopia. I also notice that everyone (of any age including children / teens) who take Thyroid supplements need glasses or reading glasses and I think the link between Thyroid and poor vision or the inability to focus on objects close up should be studied in more detail. In my opinion, wIth my body, Synthroid has caused poor eyesight and the inability to focus on close objects ( Presbyopia ). "	2014-12-28 13:54:15
QUESTION VAGINAL DISCHARGE	does synthroid cause vaginal discharge and smell	2015-01-03 17:13:16
QUESTION DEMENTIA	I have thyroidectomy and I am WO.dering whether I should take synthroid or armour	2015-01-15 08:31:00
QUESTION THROMBOCYTOPENIA	I am thrombocytopaenic after initiated synthroid. what's causing it?	2015-01-25 08:34:53
QUESTION BURNING MOUTH SYNDROME	I've had bms for about 8 years. I have been to many doctors, etc. now I'm wondering if levithyroxine is the culprit. I've been told that Armour is a natural drug used to treat thyroid problems, but my doc wont prescribe it. Any suggestions?	2015-01-31 22:49:56
QUESTION NERVOUSNESS	Why am I getting dizzy spells?	2015-02-11 09:13:47
QUESTION LIFE EXPECTANCY SHORTENED	Causes of synthroid in humans and life expectancy.	2015-02-22 08:38:18
QUESTION LIFE EXPECTANCY SHORTENED	Causes of synthroid in humans and life expectancy.	2015-02-22 08:41:24
QUESTION LIFE EXPECTANCY SHORTENED	Causes of synthroid in humans and life expectancy.mmanning4117@comcast.net	2015-02-22 08:42:40
QUESTION GRANULOMA ANNULARE	I take synthroid, 75 mcg daily and began over a year ago to have lesions on my arms. A dermatologist did a biopsy and found these lesions to be granuloma annular. I'm lost 70 pounds +, and now figured out that my synthroid should be adjusted. A TSH test was normal, but an endo suggested a free T 4 test. I'm now awaiting the results from this test. I'm sensitive to hearing, eyesight; have to wear sunglasses indoors, even, and am quite anxious. So, my question is, "Can an larger dose of synthroid cause the symptoms I have just mentioned?" Any help on this matter is appreciated. Oh, my regular doctor suggested I see a psychiatrist. Used to it was lose weight and you will be better. Are these the only two suggestions a dr. can come up with if they just don't know what is going on? Come on, be a professional and just say, "I don't know", already?	2015-03-05 16:44:37
QUESTION BLADDER IRRITATION	I have intersistial cystitis of the bladder and urethra. Mu Dr. increased my synthroid from 50 to 75 abt. 8 weeks ago. Just before 7 wks on the increased dose, I started to experience bladder problems, after being fine for the previous 2 mos. I'm wondering if it could be any thing added to the synthroid (ie, dyes , etc)	2015-03-23 12:57:38
QUESTION SEBACEOUS HYPERPLASIA	I have been taking synthroid for many years. I am now having problems with Sebaceous hyperplasia! I will be seeing a dermatologist but appointments are scheduled 8 months out! My lesions are mostly on my nose some are a reddish bump and also some are donut like. What should I do to control them? And what treatments work the best! I can't go without my synthroid.	2015-04-10 01:46:58
CONCERN VAGINAL BURNING SENSATION	Vaginal burning after only a few days of taking Synthroid. Thought it was a yeast infection. Still burning. Use Estrace cream daily. Ready to come off Synthroid. Awful feeling.	2015-04-26 16:53:10
QUESTION CENTRAL NERVOUS SYSTEM MASS	Does long term use of Synthroid have an effect on the small fiber nerves and cause Neuropathy in both feet? Would a change in a natural product like Amour help the situation?	2015-05-08 13:32:56
QUESTION IRON DEFICIENCY ANAEMIA	Ive been on synthroid for 9 years........and since then I have been unable to mantain my iron levels.......they were brought to normal with iron infusions and since the past year have depleted again...........do you think synthroid could be doing this?	2015-05-24 20:11:20
QUESTION DEEP VEIN THROMBOSIS	There is any relation between Dvt and tsh and is there any effect on tsh level when diagnosis of deep vein thrombosis	2015-05-27 10:56:17
QUESTION OSTEONECROSIS	I have been on levothyroxine for 25 years. In August 2014 I developed Osteonecrosis and have been trying to find a link with Hashimotos. And a large number of the people I have met online have both conditions. I also have problems with blurred vision. As well as this I have also started to get acid reflux, tingling and numbness in my fingers and suffer wirh incontinence. NDT is supposedly not available in the uk. What can I do to protect my health from a drug that should be helping me live but may be causing damage to other parts of my body? Is it the drug or the disease?	2015-06-04 02:59:47
QUESTION OSTEONECROSIS	I have been on levothyroxine for 25 years. In August 2014 I developed Osteonecrosis and have been trying to find a link with Hashimotos. And a large number of the people I have met online have both conditions. I also have problems with blurred vision. As well as this I have also started to get acid reflux, tingling and numbness in my fingers and suffer wirh incontinence. NDT is supposedly not available in the uk. What can I do to protect my health from a drug that should be helping me live but may be causing damage to other parts of my body? Is it the drug or the disease?	2015-06-04 03:17:14
QUESTION CHOLELITHIASIS	You're on top of the game. Thanks for shaginr.	2015-07-12 02:10:58
QUESTION FLUSHING	I am 74 yrs. old, am 5'2 and weigh 180 + or which is up or down 2-3 lbs. never really going down. I am autaclly pretty healthy having been working with a functional doctor for a year and a half taking scads of tests, trying to find out why I can't lose weight when 10-15 years ago the high protein diet always worked for me.He exhausted all the supplements etc. that he had and agreed with me that maybe the missing part of the puzzle was thryoid.(He also lectures about thryoid every month or so and is well versed in this.However, he has never really thought the T3 therapy was valid but encouraged me to try it.)I went to an endo who also doesn't use T3 but did put me on Armour thryoid 30 mg. per day. I have taken this along with your Thryocare and see no difference (oh my thryoid tests all show normal ) after almost 2 months.I am not fatigued like some people but feel slightly sluggish at times and wish I had more motivation. I have taken my temperature like you suggest all this time and it has only gone to 98.6 six times. It varies from a couple of days 96.4 and the majority of time is in the 97 exact or plus area with some 98.0 to 98.4. Is this still considered low temp and do you have any advice for me. My eyebrows have always seemed to be short by 1/3,altho my skin is oily not dry. I would love to go to a doctor who you suggest in your newsletter, but none of them are on Medicare and that is why I went to a regular endo. I could not afford their fees. Thank you.	2015-07-13 11:19:26
QUESTION LICHEN PLANUS	I have lichen planus. I have lost the right part of the thyroid gland. I am told it could because I have used thyroid medicine for so long (maybe 35 years). I have always had low temps but doctors refused to believe that I was not normal. I itch all day and night. I begin itching after taking my Thyroid medication. I tell the doctors that I have have thyroid poisoning. They tell me no. I tell them I am allergic to thyroid medication. They tell me no one is allergic to thyroid medicine. I have an aortic valve insufficiency, high blood pressure and sometime low blood pressure. My thyroid levels are never the same from visit to visit. I had a lumpectomy on my left breast but have not taken any anti cancer medication because of the lichen planus. I need a doctor who can address some of these issues. What can I do and who can I talk to?	2015-07-29 12:48:00
QUESTION AORTIC VALVE STENOSIS	Did sythorid cause any one to have aortic Valve Stenosis	2015-08-30 22:51:51
QUESTION ANION GAP	I visit my doctor today and my anion gap was 6. Does this have something to do with my potassium or synthroid medicine? How can you increase your anion gap to normal.	2015-09-14 23:27:00
QUESTION CEREBROVASCULAR ACCIDENT	My 74 y/o mother suffered a massive right-sided CVA exactly 6 weeks after her gynecologist started her on synthroid 50mcg/day. The doctor ran a single TSH level to make this decision, and never even discussed the thyroid screen with her before handing her a prescription saying, "you need to take this for your thyroid and you'll take it for the rest of your life." My mother was in perfect health and had only gone to this doctor for an annual well-woman checkup. Her TSH was 4.92. After her stroke, a cardiologist determined since my mother had zero risk factors for a stroke, and there had been a single recorded episode of atrial fibrillation while in the ICU, that this had likely been the cause of the stroke. By the time I started putting the puzzle together and asked the rehab physician to check her thyroid function, her TSH was 0.011. After this, they took her off the synthroid, and will follow up with a cardiologist to evaluate for any episodes of atrial fibrillation after enough time has passed for the synthroid to be eliminated from her body. What recommendations are prompting a physician to prescribe this drug to patients who have no complaints related to hypothyroidism, after only a single TSH level that was essentially normal for a 74 year old???	2015-09-29 18:47:06
QUESTION VASCULITIS	I had my thyroid removed in May of 2014 and it has been down hill since then. In and out of hosp. rapid pvcs etc. I am 71 and normally a very active person ex. I do an59x70 ft. Garden and can the majority of the veg. Or make meals from them and freeze them. I weighed 165 @ surgery andnam up to 200. Ihave been diagnosed with vasculitis via bopsy and no one knows why, im dead tired most of the time falling asleep sitting up during the day. Joint and muscle aches and pains much worse than in the past. My endo dr. wouldnt do a T3. Wanted it done as they havent been able to regulate tsh level at allit can go from low to high. So i paid on my own for a private org. To order it. It came as 2.4 my t4 has always been pretty close around 1.3 while tsh off the wall. Tsh with this test 1.25 in may 3.1 o 88mcg of levothyroxine, in July it was4.0 inc. To 100, in Sept. it was 1.74 still on 100, Oct. it was 2.7 and Nov. 4th, 1.25 still on 100. The yrs. before I had to have thyroid removal range for tsh was 0.629 and I had no fatigue and no pvcs. Any input you have I would greatly appreciate	2015-11-05 10:24:19
QUESTION DIURETIC EFFECT	Could Levothyroxin 50mcg once daily become a diuretic? Some nights I'm urinating 3 or 4 times in one night. The dose is taken in the evening on an empty stomach,	2015-11-23 01:04:07
QUESTION GRANULOMA ANNULARE	I was diagnosed with Granuloma Annulare in March. It has gotten progressively worse. Topical steroids did not work and neither did antibiotics. I have been on a heavy dose of Synthroid for 30 years after having Graves Disease and treated with Radioactive Iodine. I would love to hear from anyone who has been diagnosed with Granuloma Annulare and taking synthroid.	2015-12-02 15:54:32
CONCERN PROSTATE CANCER	PSA started going up the same month that I started Synthoroid. Does it make tumors grow and does it make prostate cancer become more aggressive?	2015-12-22 22:49:00
QUESTION VASCULITIS	CAN SYNTHROID CAUSE VASCULITIS?	2016-01-05 00:13:21
QUESTION POSTNASAL DRIP	I HAVE BEEN SUFFERING TERRIBLE POST NASAL DRIP FOR LAST TWO YEARS.I HAVE BEEN TREATED FOR ALLERGIES AND EVEN HAD SINUS SURGERY BUT NOTHING HAS HELPED. i HAVE BEEN TAKING SYNTHROID FOR OVER 15 YEARS AND WAS WONDERING IF THERE IS ANY CONNECTION. tHANKS BARBARA	2016-03-22 17:14:46
QUESTION BREAST ENLARGEMENT	Is it possible that my breast became bigger from Synthroid? I always had little breast, and could go without bra, now I have much bigger breast, even I lost 30lb in weight. I'm taking Synthroid for 15 years.	2016-07-09 21:14:01
QUESTION HOARSENESS	I am taking Synthroid and have become hoarse to the point I can hardly talk. I am also experiencing blurreness. Is it possible to get off this medication?	2016-07-10 20:20:22
QUESTION DYSFUNCTIONAL UTERINE BLEEDING	can use of .50 synthroid cause the lining of the uterus to thicken	2016-07-24 14:15:47
QUESTION VAGINAL DISCHARGE	vaginal odor, taking synthroid.	2016-08-18 18:35:41
QUESTION COLITIS MICROSCOPIC	I was just diagnosed with colitis, discovered by bleeding from the rectum and a CAT scan. Reading the above comments, I have extreme hoarseness, had to begin taking iron supplements and I have numbness in my pinky during the night. Can Synthroid .125 be contributing to any of these problems. I have been taking synthroid since 1995 (about 20 years)	2016-10-04 21:19:07
QUESTION VAGINAL DISCHARGE	I have a milky discharge where pubic hair is cluttered like glue no real odor re Indy's me of my youth In puberty! I'm 60 years old and done with meanopose! Thanks	2016-10-11 23:59:56
QUESTION IRON DEFICIENCY ANAEMIA	I take synthroid. Have for 15 years because of thyroid cancer. Twice now in the last four years I have become severly anemic. My Dr. Says its my diet. I dont believe my diet is that bad.I think its a medication thing. Does synthroid cause anemia?	2016-10-21 12:57:08
CONCERN LYMPHOMA	I have had my thyroid removed many years ago due to hashimoto's syndrome. I've been on rather a high dose (225mcg per day) of synthroid since then (over 20 years). In that time I've had lymphoma twice. Once NHL and once Hodgkin's Lymphoma. My oncologist was puzzled how it was possible for me to get it twice especially different types after it had been in remission for more than 10 years. I never considered there was a possible link to synthroid but now it makes sense.	2017-01-01 16:16:19
QUESTION IRON DEFICIENCY ANAEMIA	I just started on Synthroid, 2 months now and have some pretty difficult issues with anemia. My bones hurt from the inside out. Initially I thought it was the synthroid making me so sore, but my sonogram & blood check was good. My doctor is happy with my thyroid Numbers- not with my iron levels. I'm 45 & this is my first health issue. Any guidance here would be helpful. Does it ever level off? Any one iron supplement better than another? Should I be doing B12 shots?	2017-01-03 10:57:50
QUESTION URETHRAL CARUNCLE	Have suddenly developed urethral carbuncle, TSH also suddenly Low, 0.016 any connection to having been on synthroid for years!	2017-01-03 18:44:50
QUESTION PRURITUS	Should I not take synthroid at the same time as taking Tums for calcium I would like to take TUms at night rather than Omeprozole for treatment of minor acid reflux	2017-01-04 10:58:01
QUESTION PANCREATIC CYST	My thyroidectomy was in 2014 and have been taking Synthroid ever since. I had endoscopic ultrasound of my pancreas and have 4 cyst. Can the pancreatic cysts be related to taking Synthroid?	2017-01-06 02:03:55
QUESTION URINARY TRACT INFECTION	Can synthroid cause urinary tract infections?	2017-02-07 10:23:14
QUESTION NASAL CONGESTION	I take Synthroid 150 mcg three mornings a week and 137 mcg four mornings a week. I've noticed on the mornings I take the 150, I have a lot of nasal discharge and have to blow my nose a lot for the first 2 hours after taking it. This is not the case when I take the 137. I'm wondering if anyone else has experienced this symptom.	2017-03-08 07:10:34
QUESTION URINE OUTPUT INCREASED	Thanks so much for the article.Much thanks again. Great. ckkkbakckegk	2017-03-28 16:04:22
QUESTION PAIN IN EXTREMITY	I take synthrhoid 100mcg and my legs burn and feel like a bad sun burn and after that break out in sores and i was blaming it on generics	2017-04-09 07:58:23
QUESTION MESENTERIC PANNICULITIS	I have been on Synthroid for about 7 years. I have developed Mesenteric Panniculitis. The symptoms of this disease became very obvious roughly 5 years ago. Could there be a relationship between Synthroid and Mesenteric Panniculitis?	2017-04-16 04:18:44
CONCERN BLOOD TRIGLYCERIDES INCREASED	Started on 25mcg Levothyroxine about 6 months ago. 50 years old, generally excellent health, triglyceride levels throughout my life have always been 95-105. Level was 101 6 mos ago. Went in for labs last week to check thyroid levels and suddenly my triglycerides have spiked to 417. I have had no changes to diet, and have been more physically active. Also have had weight gain which is out of the ordinary for me - I fluctuate within a 10lb range since I was 40 and I've bumped above that.	2017-06-05 12:34:27
QUESTION alter immune system	After being on 200mcg synthroid for 40 yrs, my dr. left me on that dosage even though TSH was .07, .18,.24,..36 over next year. Besides osteoporosis and aggressive arthritis, and massive inflammation, I think it altered my immune system and opened the door for autoimmune diseases and many more problems. Has anyone lived this nightmare?	2017-06-16 16:43:37
QUESTION HERPES SIMPLEX DNA TEST POSITIVE	Does taking synthroid cause positive hsv testing	2017-06-24 10:09:49
QUESTION VAGINAL BURNING SENSATION	I took Synthroid during my pregnancy with my daughter and generally attributed the vaginal burning sensation with pregnancy, not ever really considering synthroid because nobody ever listed it as a probable side effect and I was having a difficult pregnancy swelling-wise. I stopped taking the synthroid after giving birth because I believed my pregnancy was the culprit of my awry thyroid horomone levels. Therefore, when my vagina returned to normal function after birth, I once again contributed this to being relative to pregnancy. However, the day of taking synthroid because my levels are off once more (and I'm not pregnant at all), that vaginal burning sensation has returned!	2017-06-26 00:35:10
QUESTION LIVEDO RETICULARIS	I have been on tyroxine medication for 34 years high doseage . I have over the last few years developed pains in my knees and livedo reticularis in my arms and legs , it's very distressing ! Has anyone else experienced the same ?	2017-07-01 11:51:21

My Patient Resources

Get your questions answered! Over one million patients, researchers, and health care providers have visited FactMed. If you have a question about TENDERNESS and SYNTHROID, post it here. You may receive a response from a fellow patient - or a leading expert in the field.

Your Question:

Share your experience: Over one million patients, researchers, and health care providers have visited FactMed. If you have a noteworthy experience as a patient taking SYNTHROID, post it here. Your story could help a fellow patient - or provide insight to a leading expert in the field.

Your Experience or Concern:

Telemedicine Expert Consults FactMed newest feature allows patients to consult - via realtime videoconferencing - experts in SYNTHROID. This premium feature connects patients to experts, regardless of geography. FactMed experts charge reasonable rates that may be reimbursable by your insurance as a second-opinion.

We are currently accepting registration for SYNTHROID experts. If you are a healthcare provider experienced in prescribing SYNTHROID, please register here.