About this FactMed analysis covering adverse side effect reports of TPN patients who developed ADHESION.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 1 individuals taking TPN reported ADHESION to the FDA. A total of 1509 TPN drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between TPN and ADHESION. In doing so, we compare TPN with other drugs that cause ADHESION, to help you evaluate whether or not TPN causes ADHESION. Likewise, this page shows the most highly-reported side effects of TPN, so you can see if ADHESION ranks among TPN's most well-known side effects.
Summary Statistics
Reports of TPN causing ADHESION: 1
Reports of any side effect of TPN : 1509
Percentage of TPN patients where ADHESION is a reported side effect: 0.0663%

FDA reports of any drug causing ADHESION : 955
Average percentage for all medicated patients where ADHESION is reported as a complication: 0.0060%

Physician opinion on TPN as adverse event culprit:

Overall opinion for all reports of this drug:
Most frequent diagnoses/indications for prescribing TPN:
CROHN'S DISEASE ( 102 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 84 patients )
DRUG USE FOR UNKNOWN INDICATION ( 60 patients )
NUTRITIONAL SUPPORT ( 31 patients )
PARENTERAL NUTRITION ( 25 patients )
MEDICAL DIET ( 22 patients )
MALNUTRITION ( 13 patients )
MUCOSAL INFLAMMATION ( 12 patients )
SUPPLEMENTATION THERAPY ( 10 patients )
WEIGHT DECREASED ( 10 patients )
DECREASED APPETITE ( 10 patients )
DIARRHOEA ( 8 patients )
SHORT-BOWEL SYNDROME ( 8 patients )
VITAMIN SUPPLEMENTATION ( 6 patients )
PAIN MANAGEMENT ( 5 patients )
COLITIS ULCERATIVE ( 5 patients )
DEHYDRATION ( 5 patients )
UNDERWEIGHT ( 4 patients )
CACHEXIA ( 4 patients )
INTESTINAL OBSTRUCTION ( 3 patients )
ENTERAL NUTRITION ( 3 patients )
HYPOPHAGIA ( 3 patients )
PREMATURE BABY ( 3 patients )
ILL-DEFINED DISORDER ( 3 patients )
ATRIAL FIBRILLATION ( 2 patients )
MALABSORPTION ( 2 patients )
DRUG EXPOSURE DURING PREGNANCY ( 2 patients )
SUICIDE ATTEMPT ( 2 patients )
SUPPORTIVE CARE ( 2 patients )
ARTHROPATHY ( 2 patients )
FLUID REPLACEMENT ( 2 patients )
PREMEDICATION ( 2 patients )
STOMATITIS ( 1 patients )
EMPHYSEMA ( 1 patients )
ANOREXIA ( 1 patients )
NECROTISING COLITIS ( 1 patients )
GASTROINTESTINAL DISORDER ( 1 patients )
CELLULITIS ( 1 patients )
HEPATIC CIRRHOSIS ( 1 patients )
PANCREATITIS ( 1 patients )
CYTOGENETIC ABNORMALITY ( 1 patients )
INADEQUATE DIET ( 1 patients )
PROBIOTIC THERAPY ( 1 patients )
MATERNAL EXPOSURE DURING PREGNANCY ( 1 patients )
DYSPHAGIA ( 1 patients )
ACUTE LYMPHOCYTIC LEUKAEMIA ( 1 patients )
ENDOMETRIOSIS ( 1 patients )
NEUTROPENIC COLITIS ( 1 patients )
UNEVALUABLE EVENT ( 1 patients )
ORAL INTAKE REDUCED ( 1 patients )
HEPATECTOMY ( 1 patients )
CHOLECYSTITIS ( 1 patients )
PANCREATIC DUCT OBSTRUCTION ( 1 patients )
HISTIOCYTOSIS ( 1 patients )
( 0 patients )
Drugs with high FDA adverse event association with ADHESION:

FOSAMAX (219 patients)
VIOXX (200 patients)
HUMIRA (129 patients)
REMICADE (102 patients)
PEGASYS (82 patients)
ACCUTANE (70 patients)
LIPITOR (58 patients)
NEURONTIN (55 patients)
ASPIRIN (46 patients)
AVONEX (45 patients)
SYNTHROID (44 patients)
PRILOSEC (42 patients)
LORAZEPAM (41 patients)
COPEGUS (40 patients)
FOLIC ACID (40 patients)
VITAMIN E (39 patients)
PAXIL (38 patients)
METHOTREXATE (37 patients)
CELEBREX (37 patients)
DIANEAL (37 patients)
PREMARIN (37 patients)
LISINOPRIL (32 patients)
HYDROCHLOROTHIAZIDE (31 patients)
LYRICA (30 patients)
FLOVENT (30 patients)
XANAX (28 patients)
LIORESAL (28 patients)
NORVASC (27 patients)
PREDNISONE (27 patients)
IBUPROFEN (27 patients)
ACTONEL (26 patients)
ALBUTEROL (26 patients)
[THERAPY UNSPECIFIED] (26 patients)
CALCIUM (UNSPECIFIED) (26 patients)
DIGOXIN (25 patients)
AMBIEN (25 patients)
PROTONIX (25 patients)
FUROSEMIDE (24 patients)
ATENOLOL (24 patients)
LASIX (23 patients)
OXYCONTIN (23 patients)
NEXIUM (23 patients)
FLEXERIL (22 patients)
ACETAMINOPHEN (21 patients)
FOSAMAX PLUS D (21 patients)
ZANTAC (21 patients)
ZOLOFT (21 patients)
EVISTA (21 patients)
VITAMIN D (21 patients)
CIPRO (20 patients)
LEVOTHYROXINE SODIUM (20 patients)
FORTEO (19 patients)
PREDNISONE TAB (19 patients)
LANOXIN (19 patients)
LEXAPRO (18 patients)
ACIPHEX (18 patients)
LORTAB (18 patients)
COUMADIN (18 patients)
OMEPRAZOLE (18 patients)
FLUOROURACIL (18 patients)
VERAPAMIL (17 patients)
VITAMINS (UNSPECIFIED) (17 patients)
PERCOCET (17 patients)
HYDROCODONE BITARTRATE (17 patients)
TRAZODONE HYDROCHLORIDE (17 patients)
CLARITIN (17 patients)
CLONAZEPAM (17 patients)
MULTI-VITAMIN (17 patients)
MYCOPHENOLATE MOFETIL (16 patients)
DETROL LA (16 patients)
ACETAMINOPHEN AND HYDROCODONE BITARTRATE (16 patients)
SEROQUEL (16 patients)
AMITRIPTYLINE HYDROCHLORIDE (16 patients)
AMPICILLIN (16 patients)
ZOFRAN (16 patients)
VALIUM (15 patients)
CYANOCOBALAMIN (14 patients)
ALPRAZOLAM (14 patients)
WARFARIN SODIUM (14 patients)
VICODIN (14 patients)
ACYCLOVIR (13 patients)
LEVAQUIN (13 patients)
ROBAXIN (13 patients)
ALENDRONATE SODIUM (13 patients)
DECADRON (13 patients)
MORPHINE (13 patients)
VITAMIN B-12 (13 patients)
BACTRIM DS (13 patients)
ZELNORM (13 patients)
CIMZIA (13 patients)
ENTOCORT EC (13 patients)
ALTACE (12 patients)
VENTOLIN (12 patients)
K-DUR 10 (12 patients)
LEUCOVORIN CALCIUM (12 patients)
CYMBALTA (12 patients)
DEXAMETHASONE (12 patients)
MIRENA (12 patients)
GOLIMUMAB (12 patients)
HORMONES (UNSPECIFIED) (12 patients)
PREVACID (12 patients)
PRIMIDONE (12 patients)
CITALOPRAM HYDROBROMIDE (12 patients)
FENTANYL (12 patients)
VYTORIN (12 patients)
VITAMIN D (UNSPECIFIED) (11 patients)
ZOCOR (11 patients)
PREDNISOLONE (11 patients)
DOXORUBICIN HCL (11 patients)
POTASSIUM CHLORIDE (11 patients)
OYST CAL D (11 patients)
FAMOTIDINE (11 patients)
REGLAN (11 patients)
WELLBUTRIN (11 patients)
GABAPENTIN (11 patients)
OXYCODONE HCL (11 patients)
ZETIA (11 patients)
DULCOLAX (11 patients)
URBASON (11 patients)
CLOZARIL (11 patients)
CLONIDINE (11 patients)
RANITIDINE (11 patients)
REBIF (10 patients)
PREMPRO (10 patients)
YAZ (10 patients)
CLONOPIN (10 patients)
ESTRATEST (10 patients)
VITAMINS (10 patients)
ASCORBIC ACID (10 patients)
TOCILIZUMAB (10 patients)
DEPAKOTE (10 patients)
MIACALCIN (10 patients)
DOSTINEX (10 patients)
BACLOFEN (10 patients)
CELEXA (10 patients)
NITROSTAT (10 patients)
LANTUS (10 patients)
CALCIUM (10 patients)
DIFLUCAN (9 patients)
ENBREL (9 patients)
ONDANSETRON (9 patients)
TEGRETOL (9 patients)
PROMETHAZINE (9 patients)
INDAPAMIDE (9 patients)
ADVAIR DISKUS 100/50 (9 patients)
PLAVIX (9 patients)
LANSOPRAZOLE (9 patients)
TACROLIMUS (9 patients)
AMOXICILLIN (9 patients)
IMURAN (9 patients)
MULTI-VITAMINS (9 patients)
DIOVAN (9 patients)
MORPHINE SULFATE (9 patients)
CENTRUM (9 patients)
BIRTH CONTROL PILLS (9 patients)
ESTRADIOL (9 patients)
CALCIUM GLUCONATE (9 patients)
LUPRON DEPOT (9 patients)
FISH OIL (9 patients)
DICLOFENAC (9 patients)
CALCIUM CARBONATE (9 patients)
LOVENOX (8 patients)
MIRALAX (8 patients)
SALAGEN (8 patients)
CELECOXIB (8 patients)
ULTRAM (8 patients)
DEPO-PROVERA (8 patients)
TRAZODONE HCL (8 patients)
SK-ERYTHROMYCIN (8 patients)
MIRAPEX (8 patients)
VALTREX (8 patients)
TYLENOL (CAPLET) (8 patients)
YASMIN (8 patients)
RENAGEL (8 patients)
SERTRALINE HYDROCHLORIDE (8 patients)
CRESTOR (8 patients)
CARTICEL (8 patients)
AUGMENTIN '125' (8 patients)
DICLOFENAC SODIUM (8 patients)
AVASTIN (8 patients)
PENTASA (8 patients)
VELCADE (8 patients)
VANCOMYCIN (8 patients)
VINCRISTINE (8 patients)
PROGRAF (8 patients)
FLAGYL (8 patients)
UNCODEABLE ^UNCLASSIFIABLE^ (7 patients)
ELIDEL (7 patients)
FLOXIN OTIC (7 patients)
ACTOS (7 patients)
CLINDAMYCIN (7 patients)
IMIPRAMINE (7 patients)
OXALIPLATIN (7 patients)
AMITRIPTYLINE HCL (7 patients)
CIPROFLOXACIN (7 patients)
NIFEDIPINE (7 patients)
LAMICTAL (7 patients)
COZAAR (7 patients)
WARFARIN (7 patients)
FLORINEF (7 patients)
METOPROLOL (7 patients)
HUMALOG (7 patients)
BEVACIZUMAB (7 patients)
ISONIAZID (7 patients)
KLONOPIN (7 patients)
PROZAC (7 patients)
CALCICHEW (7 patients)
PYRIDIUM (7 patients)
RAMIPRIL (7 patients)
NUVARING (7 patients)
Most common side effects for patients taking TPN:
PYREXIA (148 patients)
VOMITING (114 patients)
NAUSEA (88 patients)
SEPSIS (88 patients)
DYSPNOEA (76 patients)
DIARRHOEA (75 patients)
ABDOMINAL PAIN (73 patients)
ANAEMIA (72 patients)
PAIN (58 patients)
CONVULSION (58 patients)
HYPOTENSION (56 patients)
HAEMOGLOBIN DECREASED (54 patients)
CROHN'S DISEASE (51 patients)
ASTHENIA (50 patients)
CONDITION AGGRAVATED (49 patients)
PLATELET COUNT DECREASED (49 patients)
PNEUMONIA (48 patients)
WHITE BLOOD CELL COUNT DECREASED (47 patients)
THROMBOCYTOPENIA (46 patients)
OEDEMA PERIPHERAL (45 patients)
FATIGUE (44 patients)
MULTI-ORGAN FAILURE (44 patients)
RENAL FAILURE ACUTE (43 patients)
DRUG INEFFECTIVE (43 patients)
HYPERTENSION (42 patients)
RESPIRATORY FAILURE (42 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (41 patients)
SEPTIC SHOCK (39 patients)
LIVER FUNCTION TEST ABNORMAL (37 patients)
DISSEMINATED INTRAVASCULAR COAGULATION (34 patients)
FEBRILE NEUTROPENIA (33 patients)
RENAL FAILURE (33 patients)
ATRIAL FIBRILLATION (33 patients)
URINARY TRACT INFECTION (33 patients)
INTESTINAL OBSTRUCTION (32 patients)
WEIGHT DECREASED (32 patients)
DEATH (31 patients)
TACHYCARDIA (31 patients)
INTERNATIONAL NORMALISED RATIO INCREASED (31 patients)
CARDIO-RESPIRATORY ARREST (31 patients)
MALNUTRITION (31 patients)
CONFUSIONAL STATE (30 patients)
ALANINE AMINOTRANSFERASE INCREASED (30 patients)
PAIN IN EXTREMITY (30 patients)
RASH (30 patients)
PULMONARY EMBOLISM (29 patients)
PLEURAL EFFUSION (29 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (29 patients)
GASTROINTESTINAL HAEMORRHAGE (29 patients)
CARDIAC ARREST (29 patients)
BLOOD BILIRUBIN INCREASED (29 patients)
DEEP VEIN THROMBOSIS (28 patients)
JAUNDICE (27 patients)
PRURITUS (27 patients)
BLOOD ALKALINE PHOSPHATASE INCREASED (27 patients)
ABDOMINAL PAIN UPPER (26 patients)
RENAL IMPAIRMENT (25 patients)
STAPHYLOCOCCAL INFECTION (25 patients)
STEVENS-JOHNSON SYNDROME (25 patients)
SOMNOLENCE (25 patients)
COMA (25 patients)
BACK PAIN (25 patients)
RESPIRATORY DISORDER (25 patients)
HEADACHE (25 patients)
PNEUMONIA ASPIRATION (25 patients)
DEHYDRATION (25 patients)
METABOLIC ACIDOSIS (25 patients)
DRUG INTERACTION (24 patients)
DECREASED APPETITE (24 patients)
BACTERAEMIA (24 patients)
BRADYCARDIA (23 patients)
LEUKOPENIA (23 patients)
ILEUS (23 patients)
NEUTROPENIA (23 patients)
MALAISE (23 patients)
BLOOD PRESSURE INCREASED (23 patients)
CHEST PAIN (23 patients)
MELAENA (23 patients)
HAEMATEMESIS (23 patients)
GAIT DISTURBANCE (22 patients)
PANCREATITIS (22 patients)
HEPATIC FUNCTION ABNORMAL (22 patients)
INFECTION (22 patients)
MALIGNANT NEOPLASM PROGRESSION (22 patients)
MEDICATION ERROR (22 patients)
ABDOMINAL DISTENSION (21 patients)
ACTIVATED PARTIAL THROMBOPLASTIN TIME PROLONGED (21 patients)
DEPRESSION (21 patients)
DEPRESSED LEVEL OF CONSCIOUSNESS (21 patients)
ANXIETY (21 patients)
BLOOD LACTATE DEHYDROGENASE INCREASED (21 patients)
BLOOD PRESSURE DECREASED (21 patients)
ASCITES (20 patients)
MUSCULAR WEAKNESS (20 patients)
CHILLS (20 patients)
WHITE BLOOD CELL COUNT INCREASED (19 patients)
HAEMATOCHEZIA (19 patients)
HEPATIC FAILURE (19 patients)
OLIGURIA (19 patients)
DRUG EXPOSURE DURING PREGNANCY (19 patients)
FALL (19 patients)
PROTHROMBIN TIME PROLONGED (19 patients)
REVERSIBLE POSTERIOR LEUKOENCEPHALOPATHY SYNDROME (19 patients)
PULMONARY OEDEMA (18 patients)
HAEMATOCRIT DECREASED (18 patients)
TRANSAMINASES INCREASED (18 patients)
INFUSION RELATED REACTION (18 patients)
ARTHRALGIA (18 patients)
SHOCK (18 patients)
CHOLELITHIASIS (18 patients)
DYSPHAGIA (17 patients)
LIVER DISORDER (17 patients)
HAEMORRHAGE (17 patients)
DISEASE PROGRESSION (17 patients)
CARDIAC FAILURE CONGESTIVE (17 patients)
INJURY (17 patients)
CONSTIPATION (17 patients)
BLOOD ALBUMIN DECREASED (17 patients)
BLOOD CREATININE INCREASED (17 patients)
FISTULA (17 patients)
NEPHROGENIC SYSTEMIC FIBROSIS (16 patients)
COUGH (16 patients)
HEART RATE INCREASED (16 patients)
PERICARDIAL EFFUSION (16 patients)
INTESTINAL STENOSIS (15 patients)
GASTROINTESTINAL DISORDER (15 patients)
OVERDOSE (15 patients)
OVARIAN CANCER (15 patients)
COLOSTOMY (15 patients)
CARDIAC FAILURE (15 patients)
BLOOD CREATINE PHOSPHOKINASE INCREASED (15 patients)
HYPOKALAEMIA (15 patients)
CEREBROVASCULAR ACCIDENT (15 patients)
ILEOSTOMY (15 patients)
DIZZINESS (15 patients)
HYPOGLYCAEMIA (14 patients)
FLUSHING (14 patients)
STOMATITIS (14 patients)
UNRESPONSIVE TO STIMULI (14 patients)
NEUTROPHIL COUNT DECREASED (14 patients)
OEDEMA (14 patients)
CHEST DISCOMFORT (14 patients)
INTESTINAL RESECTION (13 patients)
MENTAL STATUS CHANGES (13 patients)
WEIGHT INCREASED (13 patients)
SUBILEUS (13 patients)
HYPOAESTHESIA (13 patients)
CHOLESTASIS (13 patients)
DRUG HYPERSENSITIVITY (13 patients)
HYPERSENSITIVITY (13 patients)
BRONCHITIS (13 patients)
SMALL INTESTINAL OBSTRUCTION (13 patients)
MUCOSAL INFLAMMATION (13 patients)
PRURITUS GENERALISED (13 patients)
GRAFT VERSUS HOST DISEASE (12 patients)
PANCREATITIS ACUTE (12 patients)
RESPIRATORY ARREST (12 patients)
VENTRICULAR TACHYCARDIA (12 patients)
PNEUMOCYSTIS JIROVECI PNEUMONIA (12 patients)
DEVICE RELATED INFECTION (12 patients)
TOXIC EPIDERMAL NECROLYSIS (12 patients)
CHOLECYSTITIS CHRONIC (12 patients)
INFLAMMATION (12 patients)
ASPIRATION (12 patients)
HYPERHIDROSIS (12 patients)
C-REACTIVE PROTEIN INCREASED (12 patients)
LUNG INFILTRATION (12 patients)
IMPAIRED HEALING (12 patients)
BLOOD UREA INCREASED (12 patients)
ABDOMINAL ABSCESS (11 patients)
COAGULOPATHY (11 patients)
SYNCOPE (11 patients)
AGRANULOCYTOSIS (11 patients)
SKIN INDURATION (11 patients)
CANDIDA SEPSIS (11 patients)
DRUG TOXICITY (11 patients)
ASTERIXIS (11 patients)
COLITIS ULCERATIVE (11 patients)
ATELECTASIS (11 patients)
EMOTIONAL DISTRESS (11 patients)
NERVOUS SYSTEM DISORDER (11 patients)
LEUKOCYTOSIS (11 patients)
PANCYTOPENIA (11 patients)
MYALGIA (11 patients)
MYOCARDIAL INFARCTION (11 patients)
ERYTHROPENIA (11 patients)
HEPATIC CIRRHOSIS (11 patients)
BLOOD GLUCOSE INCREASED (11 patients)
URINE OUTPUT DECREASED (11 patients)
OXYGEN SATURATION DECREASED (11 patients)
VISUAL IMPAIRMENT (11 patients)
THROMBOSIS (10 patients)
GALLBLADDER DISORDER (10 patients)
HEPATOTOXICITY (10 patients)
GASTROINTESTINAL INFLAMMATION (10 patients)
CORONARY ARTERY DISEASE (10 patients)
COLITIS (10 patients)
JOINT SWELLING (10 patients)
FEELING ABNORMAL (10 patients)
HYPOPHAGIA (10 patients)
CIRCULATORY COLLAPSE (10 patients)
URTICARIA (10 patients)
DYSARTHRIA (10 patients)
UPPER GASTROINTESTINAL HAEMORRHAGE (10 patients)
HYPERTONIA (10 patients)
LOSS OF CONSCIOUSNESS (10 patients)
SUICIDAL IDEATION (10 patients)
CEREBRAL HAEMORRHAGE (10 patients)
HEPATOMEGALY (10 patients)
FUNGAL INFECTION (10 patients)

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Recent FactMed Activity for TPN


Issue Description / Topic Timestamp
QUESTION
NEUROPATHY
Can TPN cause neuropothy? Can neuropothy go away? 2015-07-21 21:14:20
QUESTION
DEHYDRATION
I have a small fistula just above my pelvis. I am on at home TPN for only about 1 week to rest my small intestine so the fistula can close. (I had most of my colon removed except for a small part in my rectum) . I am getting dehydrated. What should be done for the dehydration. 2015-08-12 18:25:51
QUESTION
BACK PAIN
Backpain, chills and fever with TPN administration, causes of 2015-10-25 07:25:53
QUESTION
OXYGEN SATURATION DECREASED
When using TPN low pre albumin level and intermittent assessing is what 2016-01-01 23:26:43
QUESTION
URINARY TRACT INFECTION
I am on TNP since August 2014 seem to be getting a lot of urine infections does anyone else have same problem? my tpn contains my fluids too as unable to keep fluids down either 2016-01-25 18:19:46
QUESTION
ANXIETY
Can tpn cause anxiety attacks 2016-02-05 20:58:12
QUESTION
HALLUCINATION
I have been on TPN for a fistula to heal for 3 months now, I have hallucinations, I also dream and gesture eating.? Is this common? 2016-04-19 21:06:11
QUESTION
HALLUCINATION
I have been on TPN for a fistula to heal for 3 months now, I have hallucinations, I also dream and gesture eating.? Is this common? 2016-04-19 22:56:19

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