Is NEUROTOXICITY a side effect of ZOCOR ? ( FactMed.com )

About this FactMed analysis covering adverse side effect reports of ZOCOR patients who developed NEUROTOXICITY.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 6 individuals taking ZOCOR reported NEUROTOXICITY to the FDA. A total of 41327 ZOCOR drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between ZOCOR and NEUROTOXICITY. In doing so, we compare ZOCOR with other drugs that cause NEUROTOXICITY, to help you evaluate whether or not ZOCOR causes NEUROTOXICITY. Likewise, this page shows the most highly-reported side effects of ZOCOR, so you can see if NEUROTOXICITY ranks among ZOCOR's most well-known side effects.

Summary Statistics
Reports of ZOCOR causing NEUROTOXICITY: 6
Reports of any side effect of ZOCOR : 41327
Percentage of ZOCOR patients where NEUROTOXICITY is a reported side effect: 0.0145%

FDA reports of any drug causing NEUROTOXICITY : 2683
Average percentage for all medicated patients where NEUROTOXICITY is reported as a complication: 0.0168%

Physician opinion on ZOCOR as adverse event culprit:

Overall opinion for all reports of this drug:

Most frequent diagnoses/indications for prescribing ZOCOR:

BLOOD CHOLESTEROL INCREASED ( 3844 patients )
HYPERCHOLESTEROLAEMIA ( 2265 patients )
HYPERLIPIDAEMIA ( 1576 patients )
PRODUCT USED FOR UNKNOWN INDICATION ( 920 patients )
DRUG USE FOR UNKNOWN INDICATION ( 870 patients )
BLOOD CHOLESTEROL ( 845 patients )
DYSLIPIDAEMIA ( 290 patients )
CORONARY ARTERY DISEASE ( 194 patients )
BLOOD CHOLESTEROL ABNORMAL ( 186 patients )
ACUTE CORONARY SYNDROME ( 129 patients )
MYOCARDIAL ISCHAEMIA ( 114 patients )
PROPHYLAXIS ( 111 patients )
HYPERTENSION ( 98 patients )
LIPIDS INCREASED ( 96 patients )
CARDIAC DISORDER ( 78 patients )
TYPE IIA HYPERLIPIDAEMIA ( 60 patients )
ILL-DEFINED DISORDER ( 55 patients )
CARDIOVASCULAR EVENT PROPHYLAXIS ( 54 patients )
BLOOD TRIGLYCERIDES INCREASED ( 54 patients )
MYOCARDIAL INFARCTION ( 53 patients )
METABOLIC DISORDER ( 50 patients )
LOW DENSITY LIPOPROTEIN INCREASED ( 44 patients )
DIABETES MELLITUS ( 41 patients )
HYPERTRIGLYCERIDAEMIA ( 38 patients )
BLOOD CHOLESTEROL DECREASED ( 32 patients )
CARDIOVASCULAR DISORDER ( 31 patients )
CEREBROVASCULAR ACCIDENT ( 31 patients )
ACUTE MYOCARDIAL INFARCTION ( 25 patients )
LIPIDS ( 23 patients )
TRANSIENT ISCHAEMIC ATTACK ( 22 patients )
LIPIDS ABNORMAL ( 18 patients )
TYPE V HYPERLIPIDAEMIA ( 16 patients )
ANGINA PECTORIS ( 16 patients )
TYPE 2 DIABETES MELLITUS ( 13 patients )
CEREBROVASCULAR ACCIDENT PROPHYLAXIS ( 13 patients )
LIPID METABOLISM DISORDER ( 12 patients )
HIGH DENSITY LIPOPROTEIN DECREASED ( 12 patients )
STENT PLACEMENT ( 11 patients )
MIXED HYPERLIPIDAEMIA ( 10 patients )
ARTERIOSCLEROSIS ( 9 patients )
METABOLIC SYNDROME ( 9 patients )
BLOOD PRESSURE ( 8 patients )
CORONARY ARTERY BYPASS ( 8 patients )
LOW DENSITY LIPOPROTEIN ( 8 patients )
DIABETES MELLITUS NON-INSULIN-DEPENDENT ( 8 patients )
ISCHAEMIC CARDIOMYOPATHY ( 8 patients )
ARTERIAL OCCLUSIVE DISEASE ( 7 patients )
ARTERIOSCLEROSIS CORONARY ARTERY ( 7 patients )
NEOPLASM ( 7 patients )
CHEST PAIN ( 7 patients )
ARTERIAL DISORDER ( 7 patients )
ISCHAEMIC HEART DISEASE PROPHYLAXIS ( 7 patients )
GASTROOESOPHAGEAL REFLUX DISEASE ( 7 patients )
ATRIAL FIBRILLATION ( 7 patients )
BLOOD TRIGLYCERIDES ( 6 patients )
ANGIOPLASTY ( 6 patients )
ATHEROSCLEROSIS ( 6 patients )
CARDIAC FAILURE ( 6 patients )
HIGH DENSITY LIPOPROTEIN INCREASED ( 6 patients )
UNEVALUABLE EVENT ( 6 patients )
BLOOD PRESSURE ABNORMAL ( 5 patients )
CORONARY ARTERY ATHEROSCLEROSIS ( 5 patients )
LOW DENSITY LIPOPROTEIN DECREASED ( 5 patients )
WEIGHT DECREASED ( 5 patients )
DRESSLER'S SYNDROME ( 5 patients )
ISCHAEMIC STROKE ( 4 patients )
MYALGIA ( 4 patients )
PULMONARY ARTERIAL HYPERTENSION ( 4 patients )
NEPHROTIC SYNDROME ( 4 patients )
URINARY INCONTINENCE ( 4 patients )
CARDIOMYOPATHY ( 4 patients )
PAIN IN EXTREMITY ( 4 patients )
MULTIPLE SCLEROSIS ( 4 patients )
BLOOD PRESSURE INCREASED ( 4 patients )
INTENTIONAL DRUG MISUSE ( 4 patients )
RENAL TRANSPLANT ( 4 patients )
ENDOSCOPY ( 3 patients )
CAROTID ARTERIOSCLEROSIS ( 3 patients )
FEMORAL ARTERY OCCLUSION ( 3 patients )
CORONARY ARTERY SURGERY ( 3 patients )
THROMBOSIS ( 3 patients )
CARDIAC ARREST ( 3 patients )
HEMIPARESIS ( 3 patients )
ANGINA UNSTABLE ( 3 patients )
HIV INFECTION ( 3 patients )
HYPERCHLORAEMIA ( 3 patients )
FATIGUE ( 3 patients )
DEPRESSION ( 3 patients )
HYPOLIPIDAEMIA ( 3 patients )
MEMORY IMPAIRMENT ( 3 patients )
ARRHYTHMIA ( 3 patients )
CORONARY ANGIOPLASTY ( 2 patients )
MULTIPLE DRUG OVERDOSE INTENTIONAL ( 2 patients )
RHABDOMYOLYSIS ( 2 patients )
SUICIDE ATTEMPT ( 2 patients )
CAROTID ARTERY STENOSIS ( 2 patients )
GENERAL SYMPTOM ( 2 patients )
BONE DISORDER ( 2 patients )
HYPOCHOLESTEROLAEMIA ( 2 patients )
TYPE 1 DIABETES MELLITUS ( 2 patients )
CARDIAC FAILURE CONGESTIVE ( 2 patients )
DRUG EXPOSURE DURING PREGNANCY ( 2 patients )
OSTEOARTHRITIS ( 2 patients )
CORONARY ARTERIAL STENT INSERTION ( 2 patients )
HYPERKALAEMIA ( 2 patients )
ARTHRALGIA ( 2 patients )
HYPERSENSITIVITY ( 2 patients )
CAROTID INTIMA-MEDIA THICKNESS INCREASED ( 2 patients )
ANGIOPATHY ( 2 patients )
RENAL AND PANCREAS TRANSPLANT ( 2 patients )
OEDEMA ( 2 patients )
CHOLESTEROSIS ( 2 patients )
PAIN ( 2 patients )
BLOOD GLUCOSE INCREASED ( 1 patients )
PELVIC FRACTURE ( 1 patients )
HYPERGLYCAEMIA ( 1 patients )
MUSCLE DISORDER ( 1 patients )
SILENT MYOCARDIAL INFARCTION ( 1 patients )
POLYMYOSITIS ( 1 patients )
ARTHRITIS ( 1 patients )
PRINZMETAL ANGINA ( 1 patients )
ATHEROSCLEROSIS PROPHYLAXIS ( 1 patients )
CEREBRAL HAEMORRHAGE ( 1 patients )
HEART DISEASE CONGENITAL ( 1 patients )
AMNESIA ( 1 patients )
AUTOIMMUNE DISORDER ( 1 patients )
CEREBRAL ISCHAEMIA ( 1 patients )
CARDIAC ENZYMES ( 1 patients )
DIVERTICULITIS ( 1 patients )
HYPOTENSION ( 1 patients )
LOWER RESPIRATORY TRACT INFECTION ( 1 patients )
RAYNAUD'S PHENOMENON ( 1 patients )
INFARCTION ( 1 patients )
OBSTRUCTION ( 1 patients )
RENAL FAILURE CHRONIC ( 1 patients )
AORTIC ANEURYSM ( 1 patients )
CARDIAC VALVE DISEASE ( 1 patients )
INTERNATIONAL NORMALISED RATIO ABNORMAL ( 1 patients )
BLOOD DISORDER ( 1 patients )
CHRONIC OBSTRUCTIVE PULMONARY DISEASE ( 1 patients )
RETINAL VEIN THROMBOSIS ( 1 patients )
EMPHYSEMA ( 1 patients )
HYPEREXPLEXIA ( 1 patients )
SCHIZOPHRENIA ( 1 patients )
LDL/HDL RATIO ( 1 patients )
PERIPHERAL VASCULAR DISORDER ( 1 patients )
MUSCULOSKELETAL CHEST PAIN ( 1 patients )
CAROTID ARTERY DISEASE ( 1 patients )
POST PROCEDURAL STROKE ( 1 patients )
ABDOMINAL PAIN UPPER ( 1 patients )
CORONARY ARTERY OCCLUSION ( 1 patients )
THERAPY CESSATION ( 1 patients )
HAEMOGLOBIN INCREASED ( 1 patients )
LIPIDS DECREASED ( 1 patients )
C-REACTIVE PROTEIN INCREASED ( 1 patients )
MYOPATHY ( 1 patients )
CEREBRAL INFARCTION ( 1 patients )
HEART TRANSPLANT ( 1 patients )
PROTEINURIA ( 1 patients )
NEOPLASM MALIGNANT ( 1 patients )
CEREBRAL THROMBOSIS ( 1 patients )
HIGH DENSITY LIPOPROTEIN ( 1 patients )
PULMONARY HYPERTENSION ( 1 patients )
NEUROPATHY PERIPHERAL ( 1 patients )
TYPE IIB HYPERLIPIDAEMIA ( 1 patients )
ANTACID THERAPY ( 1 patients )
CARDIAC OPERATION ( 1 patients )
DRUG THERAPY ( 1 patients )
BLOOD CHOLESTEROL NORMAL ( 1 patients )
HOT FLUSH ( 1 patients )
CARDIOMEGALY ( 1 patients )
VASCULAR OPERATION ( 1 patients )
( 0 patients )

Drugs with high FDA adverse event association with NEUROTOXICITY:

Most common side effects for patients taking ZOCOR:

PAIN (3183 patients)
MYOCARDIAL INFARCTION (3101 patients)
NAUSEA (3037 patients)
DYSPNOEA (2995 patients)
ANXIETY (2786 patients)
RHABDOMYOLYSIS (2729 patients)
ASTHENIA (2629 patients)
FATIGUE (2598 patients)
DIZZINESS (2483 patients)
MYALGIA (2441 patients)
CHEST PAIN (2283 patients)
FALL (2108 patients)
HYPERTENSION (2078 patients)
PAIN IN EXTREMITY (2070 patients)
DEPRESSION (2068 patients)
DIARRHOEA (1982 patients)
ARTHRALGIA (1905 patients)
CORONARY ARTERY DISEASE (1893 patients)
HEADACHE (1881 patients)
CEREBROVASCULAR ACCIDENT (1853 patients)
CARDIAC FAILURE CONGESTIVE (1810 patients)
BACK PAIN (1798 patients)
RENAL FAILURE (1762 patients)
DRUG INEFFECTIVE (1735 patients)
OEDEMA PERIPHERAL (1695 patients)
RENAL FAILURE ACUTE (1691 patients)
ANAEMIA (1571 patients)
WEIGHT DECREASED (1567 patients)
VOMITING (1561 patients)
INJURY (1458 patients)
DRUG INTERACTION (1386 patients)
PNEUMONIA (1340 patients)
INSOMNIA (1288 patients)
HYPOTENSION (1288 patients)
MUSCLE SPASMS (1231 patients)
ATRIAL FIBRILLATION (1222 patients)
MUSCULAR WEAKNESS (1209 patients)
BLOOD GLUCOSE INCREASED (1209 patients)
DEHYDRATION (1173 patients)
BLOOD CREATINE PHOSPHOKINASE INCREASED (1172 patients)
PYREXIA (1167 patients)
CONSTIPATION (1156 patients)
COUGH (1132 patients)
WEIGHT INCREASED (1101 patients)
ABDOMINAL PAIN (1091 patients)
URINARY TRACT INFECTION (1064 patients)
GASTROOESOPHAGEAL REFLUX DISEASE (1060 patients)
MALAISE (1055 patients)
EMOTIONAL DISTRESS (1015 patients)
DIABETES MELLITUS (972 patients)
DEATH (942 patients)
OSTEOARTHRITIS (929 patients)
HYPOAESTHESIA (929 patients)
RASH (920 patients)
CONFUSIONAL STATE (914 patients)
PARAESTHESIA (907 patients)
GAIT DISTURBANCE (907 patients)
BLOOD CHOLESTEROL INCREASED (885 patients)
CARDIAC DISORDER (882 patients)
ABDOMINAL PAIN UPPER (876 patients)
FEELING ABNORMAL (871 patients)
PALPITATIONS (820 patients)
SYNCOPE (816 patients)
DYSPHAGIA (805 patients)
HYPERLIPIDAEMIA (797 patients)
CHRONIC OBSTRUCTIVE PULMONARY DISEASE (795 patients)
BRONCHITIS (766 patients)
TRANSIENT ISCHAEMIC ATTACK (765 patients)
PRURITUS (759 patients)
LOSS OF CONSCIOUSNESS (748 patients)
DECREASED APPETITE (736 patients)
MITRAL VALVE INCOMPETENCE (733 patients)
BLOOD PRESSURE INCREASED (722 patients)
ANGINA PECTORIS (718 patients)
SOMNOLENCE (712 patients)
OSTEONECROSIS OF JAW (708 patients)
BONE DISORDER (706 patients)
PLEURAL EFFUSION (705 patients)
VISION BLURRED (704 patients)
HYPERHIDROSIS (692 patients)
ANHEDONIA (686 patients)
DYSPEPSIA (683 patients)
NEUROPATHY PERIPHERAL (676 patients)
BLOOD CREATININE INCREASED (673 patients)
CELLULITIS (665 patients)
SINUSITIS (637 patients)
CONVULSION (636 patients)
TREMOR (634 patients)
ARTHRITIS (633 patients)
OSTEOMYELITIS (625 patients)
CONTUSION (619 patients)
CHEST DISCOMFORT (612 patients)
SPINAL OSTEOARTHRITIS (608 patients)
MEMORY IMPAIRMENT (603 patients)
ACUTE MYOCARDIAL INFARCTION (589 patients)
UNEVALUABLE EVENT (588 patients)
ALANINE AMINOTRANSFERASE INCREASED (579 patients)
STRESS (578 patients)
RENAL IMPAIRMENT (575 patients)
NECK PAIN (556 patients)
HAEMOGLOBIN DECREASED (556 patients)
DEEP VEIN THROMBOSIS (546 patients)
RESPIRATORY FAILURE (543 patients)
ASPARTATE AMINOTRANSFERASE INCREASED (540 patients)
FEAR (537 patients)
AMNESIA (536 patients)
OSTEONECROSIS (529 patients)
BALANCE DISORDER (527 patients)
TYPE 2 DIABETES MELLITUS (525 patients)
CONDITION AGGRAVATED (524 patients)
GASTRITIS (519 patients)
RENAL FAILURE CHRONIC (512 patients)
THROMBOCYTOPENIA (510 patients)
FLUSHING (509 patients)
INFECTION (508 patients)
CARDIAC ARREST (507 patients)
PULMONARY EMBOLISM (503 patients)
DIVERTICULUM (494 patients)
SEPSIS (492 patients)
GASTROINTESTINAL HAEMORRHAGE (489 patients)
MYOPATHY (480 patients)
CATARACT (479 patients)
HEART RATE INCREASED (479 patients)
SWELLING (476 patients)
SLEEP APNOEA SYNDROME (473 patients)
PANCREATITIS (469 patients)
ABDOMINAL DISTENSION (468 patients)
LIVER FUNCTION TEST ABNORMAL (467 patients)
MYOSITIS (467 patients)
HYPERCHOLESTEROLAEMIA (466 patients)
TACHYCARDIA (466 patients)
GENERAL PHYSICAL HEALTH DETERIORATION (464 patients)
HYPERGLYCAEMIA (459 patients)
INTERVERTEBRAL DISC PROTRUSION (456 patients)
CARDIOMEGALY (454 patients)
MUSCULOSKELETAL PAIN (452 patients)
TRICUSPID VALVE INCOMPETENCE (447 patients)
ATELECTASIS (445 patients)
ERYTHEMA (444 patients)
OSTEOPOROSIS (444 patients)
ARTHROPATHY (444 patients)
UPPER RESPIRATORY TRACT INFECTION (442 patients)
DRY MOUTH (442 patients)
MYOCARDIAL ISCHAEMIA (440 patients)
MENTAL STATUS CHANGES (440 patients)
ASTHMA (438 patients)
INTERVERTEBRAL DISC DEGENERATION (431 patients)
CHOLELITHIASIS (430 patients)
INTERNATIONAL NORMALISED RATIO INCREASED (430 patients)
CHILLS (430 patients)
ADVERSE EVENT (426 patients)
HYPERSENSITIVITY (417 patients)
HYPOKALAEMIA (415 patients)
IMPAIRED HEALING (415 patients)
TOOTH EXTRACTION (414 patients)
ROTATOR CUFF SYNDROME (413 patients)
ANGINA UNSTABLE (412 patients)
DYSPNOEA EXERTIONAL (411 patients)
ARTERIOSCLEROSIS (410 patients)
RECTAL HAEMORRHAGE (409 patients)
HAEMORRHOIDS (409 patients)
HYPOGLYCAEMIA (408 patients)
PAIN IN JAW (408 patients)
HAEMATURIA (407 patients)
CORONARY ARTERY OCCLUSION (405 patients)
ECONOMIC PROBLEM (403 patients)
HYPONATRAEMIA (400 patients)
MULTI-ORGAN FAILURE (394 patients)
ABASIA (392 patients)
EPISTAXIS (392 patients)
SLEEP DISORDER (391 patients)
BLOOD TRIGLYCERIDES INCREASED (389 patients)
CARDIAC FAILURE (389 patients)
OVERDOSE (388 patients)
RENAL INJURY (386 patients)
THROMBOSIS (385 patients)
MUSCULOSKELETAL STIFFNESS (382 patients)
BRADYCARDIA (380 patients)
OEDEMA (379 patients)
ARRHYTHMIA (378 patients)
LETHARGY (372 patients)
PHARMACEUTICAL PRODUCT COMPLAINT (370 patients)
OSTEOPENIA (369 patients)
JOINT SWELLING (368 patients)
BLOOD GLUCOSE DECREASED (364 patients)
ALOPECIA (364 patients)
DIABETES MELLITUS INADEQUATE CONTROL (356 patients)
DRUG HYPERSENSITIVITY (352 patients)
MEDICATION ERROR (350 patients)
VERTIGO (349 patients)
NERVOUSNESS (344 patients)
HYPOTHYROIDISM (342 patients)
SWELLING FACE (342 patients)
RENAL DISORDER (340 patients)
AGITATION (334 patients)
HAEMORRHAGE (332 patients)
BONE PAIN (328 patients)
HEPATIC ENZYME INCREASED (327 patients)
ABDOMINAL DISCOMFORT (319 patients)
CARDIOMYOPATHY (319 patients)
ERECTILE DYSFUNCTION (318 patients)
URTICARIA (317 patients)
PULMONARY OEDEMA (315 patients)
ANOREXIA (314 patients)
RENAL CYST (313 patients)
CARPAL TUNNEL SYNDROME (312 patients)
HIATUS HERNIA (308 patients)
HYPERKALAEMIA (308 patients)
HEART RATE IRREGULAR (306 patients)
BURSITIS (305 patients)

In addition to reviewing our up-to-date FDA research, users may interact with the FactMed community - currently one million members and growing! FactMed online research and discussions are read by patients, scientists, physicians, and other interested health care parties. Post follow up Questions to learn from our diverse readership. Likewise, patients who have experienced unwanted effects are encouraged to share their Concerns to help educate and inform our members.

Recent FactMed Activity for ZOCOR

Issue	Description / Topic	Timestamp
QUESTION DRUG INTERACTION	XALACOM TAHOR OMEXEL EFFETS DANS LE CORPS	2015-03-17 06:47:34
QUESTION LUPUS-LIKE SYNDROME	Will your ANA go back to normal after stopping zocor and if so how long after?	2015-08-02 17:17:59
QUESTION HANGOVER	Why does Zocor produce a hangover effect after successfully taking it for twelve Years?	2016-07-04 08:21:02
QUESTION DYSPNOEA	Training has to be repetious, a daily routine, i would suggest to do some research for tips and tricks to training and making your dogs pefocrmanre much better, classes would be good also, good luck to you	2016-07-24 04:20:51
QUESTION MYOFASCIAL PAIN SYNDROME	Have been on Zocor 20mg.po 5x day x4-5 yrs. & Amlodipine 5mg po OD x 5yrs. Developed left neck & like shoulder pain 3mos. ago. Diagnosis with Cervical Radiculopathy & also Myofascial Pain Syndrome. Cervical Epidural (9days ago) & Dry Needling in 5 areas of Trapezius Muscle approx. 3-4wks.ago. Still have dull intermittent pain in left shoulder, upper trapezius & or neck. Is it possible that Myofascial Pain Syndrome is caused from combination of Zocor & Amlodipine???	2017-04-29 09:49:34

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